Multiple antigen recognition by individual human monoclonal antibodies of rheumatic disease patient origin.

abstract：:Two monoclonal antibodies, D2A1 and D5G3 were elicited by immunization with a preparation of chicken egg riboflavin carrier protein which had been reduced and carboxymethylated. Epitopes recognised by the monoclonal antibodies were mapped using the Pepscan method. Epitopic determinants for D2A1 as well as D5G3 were id...

journal_title：Immunological investigations

authors： Lobo SC,Karande AA,Adiga PR

更新日期：1998-12-01 00:00:00

abstract：:In the present study, we evaluated the effectiveness of a levamisole-based adjuvant (ADL) to enhance the ability of the Ag85B-ESAT6 fusion protein to boost immune responses after primary vaccination with recombinant bacillus Calmette-Guerin (rBCG) in Balb/c mice. The results were compared with that of the control adju...

journal_title：Immunological investigations

authors： You Q,Wu Y,Jiang D,Wu Y,Wang C,Wei W,Yu X,Zhang X,Kong W,Jiang C

更新日期：2012-01-01 00:00:00

abstract：:In recent studies, using a swine model of single lung transplantation, we demonstrated that IRI alone increased MHC II expression in the host's peripheral T lymphocytes. The inhibition of increased MHC II expression with TCV-309, a specific platelet-activating factor (PAF) antagonist suggested that PAF might play a ro...

journal_title：Immunological investigations

authors： Nikbakht-Sangari M,Qayumi AK,Keown P,Duronio V,Horley K

更新日期：1999-07-01 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) inhibits dendritric cells (DC) function in order to delay T cell response. Furthermore, there is increasing evidence that genetic diversity of Mtb strains can affect their interaction with the immune system. Beijing genotype has attracted attention because of its high prevalence and mu...

journal_title：Immunological investigations

authors： Reyes-Martínez JE,Nieto-Patlán E,Nieto-Patlán A,Gonzaga-Bernachi J,Santos-Mendoza T,Serafín-López J,Chávez-Blanco A,Sandoval-Montes C,Flores-Romo L,Estrada-Parra S,Estrada-García I,Chacón-Salinas R

更新日期：2014-01-01 00:00:00

abstract：:Cortical (immature) thymocytes are widely reported to express intermediate to high levels of receptors for the lectin, peanut agglutinin (PNA). Light-scatter studies of murine fetal thymocytes stained with PNA or anti-mouse CD4 and CD8 monoclonal antibodies indicated, however, that the most immature CD4-8- (DN) thymoc...

journal_title：Immunological investigations

authors： Holladay S,Blaylock B,Smith B,Luster M

更新日期：1993-12-01 00:00:00

abstract：:We investigated the functional and subset surface marker characteristics of supramammary lymph node T cell populations at sites proximal and distal to the mammary region of goats repeatedly injected with heat-treated Staphylococcus aureus antigen (HK-SAC). Flow cytometric studies showed quantitative differences in CD4...

journal_title：Immunological investigations

authors： Dobrzanski MJ,Yang TJ

更新日期：1992-04-01 00:00:00

abstract：:The aim of this study was to evaluate the possible association of IL12B gene polymorphisms with serum levels of IL-12p40, IL-23 and genetic susceptibility to rheumatoid arthritis (RA) in the Bulgarian population. Genotyping for IL12Bpro (rs17860508) and IL12B A/C - 3' UTR (rs3212227) polymorphisms was performed by pol...

journal_title：Immunological investigations

authors： Manolova I,Ivanova M,Vasilev G,Stoilov R,Miteva L,Stanilova S

更新日期：2020-02-01 00:00:00

abstract：:A simple and rapid method of ABH phenotyping baboons has been developed which takes advantage of the fact that blood group antigens are expressed on epithelial cells. Use of readily available monoclonal antibodies and phycoerythrin-conjugated second antibody permits rapid identification of ABH phenotypes directly on b...

journal_title：Immunological investigations

authors： Nehlsen-Cannarella SL,Bohn ML

更新日期：1987-03-01 00:00:00

abstract：:Two cell lines secreting Paul-Bunnell antibodies were established by means of Epstein-Barr virus-induced immortalization of B lymphocytes from patients with infectious mononucleosis. Progressive loss of antibody production, most probably due to a shutdown of antibody secretion by individual cells was, however, observe...

journal_title：Immunological investigations

authors： Wasik M,Milgrom F

更新日期：1986-06-01 00:00:00

abstract：:To determine the main mediators for mouse anaphylactic shock, the suppression of active anaphylactic shock by cyproheptadine, an antagonist of histamine/serotonin, and CV-6209, an antagonist of platelet-activating factor (PAF), was systematically evaluated using various mouse strains. The suppression was quite heterog...

journal_title：Immunological investigations

authors： Kimura S,Watanabe A,Nagata M,Niinomi Y,Harada M

更新日期：1996-09-01 00:00:00

abstract：:Experimental autoimmune uveoretinitis (EAU) was induced in rats by immunization with bovine interphotoreceptor retinoid-binding protein (IRBP) and studied by immunohistochemistry. In general, the IRBP induction of inflammatory cellular components and expression of immune-related antigens on various non-lymphoid cells ...

journal_title：Immunological investigations

authors： Chan CC,Nussenblatt RB,Wiggert B,Redmond TM,Fujikawa LS,Chader GJ,Gery I

更新日期：1987-03-01 00:00:00

abstract：:The relationships between polymorphisms in pro-inflammatory cytokines and the risk of inflammatory bowel disease (IBD) remain discrepant. Therefore, the authors conducted a meta-analysis to robustly explore relationships between polymorphisms in pro-inflammatory cytokines and the risk of IBD by integrating the results...

journal_title：Immunological investigations

authors： Liu W,Wang C,Tang L,Yang H

更新日期：2020-08-26 00:00:00

abstract：:White cell infiltration of solid tumors is an important prognostic indicator in malignant disease. Although macrophage infiltration is associated with good outcome in colorectal cancer, a high macrophage content is associated with poor prognosis in breast cancer. Suppressor macrophages prevent T cell activation in nor...

journal_title：Immunological investigations

authors： Toomey D,Harmey J,Condron C,Kay E,Bouchier-Hayes D

更新日期：1999-01-01 00:00:00

abstract：:We examined the effect of various polyanions on mouse complement hemolytic activity, Fc receptor (FcR) subclass mediated antibody-dependent cellular cytotoxicity (ADCC) as well as binding by mouse peritoneal macrophages (M phi) of sheep erythrocyte targets. All the polyanions tested (dextran sulfate, carrageenan, poly...

journal_title：Immunological investigations

authors： Mocharla R,Mocharla H,Leu RW

更新日期：1989-06-01 00:00:00

abstract：:Thrombocytopenia as a complicating event in human immunodeficiency infection is a rather common hematological disorder and in many aspects resembles idiopathic(immune) thrombocytopenic purpura (ITP). Consequently, treatment of severe cases is similar to treating ITP, but steroids should be administered with particular...

journal_title：Immunological investigations

authors： Nydegger UE,Castelli D

更新日期：1991-04-01 00:00:00

abstract：PURPOSE:To assess cellular composition and local cytokine response in vitreous humor of tubercular uveitis. METHODS:Cells were collected from vitreous cassettes and peripheral blood of 8 tubercular uveitis and 5 control subjects, undergoing vitrectomy and analyzed by flow cytometry for cellular composition, activation...

journal_title：Immunological investigations

authors： Sharma RK M.Sc,Gupta V M.S,Bansal R M.S,Sharma K M.D,Gupta A M.S,Sachdeva N Ph.D

更新日期：2018-08-01 00:00:00

abstract：:The susceptibility of cataract Shionogi (CTS) mice as young as 8 to 10 weeks of age to passive anaphylactic shock mediated by anti-benzylpenicilloyl IgE and IgG1 monoclonal antibodies was compared with those of other strains of the same age including sister strains such as nonobese-diabetic (NOD) and nonobese-nondiabe...

journal_title：Immunological investigations

authors： Harada M,Nagata M,Takeuchi M,Makino S,Aburahi S

更新日期：1991-06-01 00:00:00

abstract：:Objectives: Type 1 diabetes mellitus (T1D) has been disclosed to be associated with an elevated risk of cardiovascular disease (CVD), as well as increased risks of losing bone mass and progression of osteoporosis (OP). Osteoprotegerin (OPG), as a decoy receptor, has been demonstrated to play a critical role in bone me...

journal_title：Immunological investigations

authors： Duan CC,Ma C,Tang HQ

更新日期：2021-02-01 00:00:00

abstract：:Anti-IgM stimulation of B cells is decreased in the presence of maternal serum as compared to control media. This inhibiting influence of maternal serum is observed during the priming of the B cells. The progression of B cells into cellular proliferation was not influenced by maternal serum. At the level of the immuno...

journal_title：Immunological investigations

authors： Vanderbeeken YE,Duchateau J,Gregoire M,Vandermeersch B,Collet H,Lucas A

更新日期：1991-06-01 00:00:00

abstract：:Although cancer immunotherapy, which is able to target specifically cancer cells without detrimental effects to normal cell functions, would serve as an ideal therapeutic modality, most of the randomized clinical trials of cancer immunotherapy have not demonstrated a meaningful survival benefit to cancer patients over...

journal_title：Immunological investigations

authors： Kim SJ,Ha GH,Kim SH,Kang CD

更新日期：2014-01-01 00:00:00

abstract：:To investigate whether phospholipase D1 (PLD1) is involved in autoimmune damage to the eyes, we used Western blotting and immunohistochemistry to examine the expression and distribution of PLD1 in the retinas of Lewis rats with experimental autoimmune uveoretinitis (EAU). Western blot analysis showed that the level of...

journal_title：Immunological investigations

authors： Kang J,Ahn M,Moon C,Min DS,Matsumoto Y,Shin T

更新日期：2005-01-01 00:00:00

abstract：:The cardinal features of asthma include pulmonary inflammation and airway hyperresponsiveness (AHR). Classically, asthma, specifically allergic asthma, has been attributed to a hyperactive Th2 cell immune response. However, the Th2 cell-mediated inflammation model has failed to adequately explain many of the clinical ...

journal_title：Immunological investigations

authors： Durrant DM,Metzger DW

更新日期：2010-01-01 00:00:00

abstract：:Many investigators have demonstrated alteration of gastric mucins in H. pylori infected individuals. The inflammatory environment induced by H. pylori leading to aberrant glycosylation of MUC1 and demasking of core peptide MUC1 epitope could enhance immune responses to MUC1. IgG and IgM immune response to MUC1 in pati...

journal_title：Immunological investigations

authors： Klaamas K,Kurtenkov O,von Mensdorff-Pouilly S,Shljapnikova L,Miljukhina L,Brjalin V,Lipping A

更新日期：2007-01-01 00:00:00

abstract：:Anti-α-galactoside antibody (anti-Gal) from human plasma that bound to α-galactoside-bearing guar galactomannan gel and was eluted with specific sugar (affinity-purified anti-Gal ; APAG) invariably contained apo(a) and apo B subunits in a proportion close to that in plasma lipoprotein(a) [Lp(a)]. Since LDL does not co...

journal_title：Immunological investigations

authors： Mandagini G,Subramanian SP,Vasantha K,Appukuttan PS

更新日期：2013-01-01 00:00:00

abstract：:Functional defects of polymorphonuclear leukocytes can lead to clinical immunodeficiency. Understanding these conditions requires a knowledge of normal polymorph physiology and the means to analyse various aspects of polymorph function. Primary diseases of polymorph function are rare, whereas disorders secondary to ot...

journal_title：Immunological investigations

authors： Thompson RA

更新日期：1988-04-01 00:00:00

abstract：:This study was conducted to evaluate the adjuvant potential of sulfated Radix Cyathulae officinalis Kuan polysaccharides (sRCPS) and their effects on specific cellular and humoral immune responses to hepatitis B subunit vaccine in mice. Our data demonstrated that sRCPS significantly promoted the rHBsAg-specific IgG, I...

journal_title：Immunological investigations

authors： Feng H,Fan J,Du X,Song Z,Wang Z,Han X,Zhao B,Liu J

更新日期：2015-01-01 00:00:00

abstract：:Results of recent studies indicated that a monoclonal ART18 antibody recognizes the receptor sites or closely related structures for IL-2 on activated rat T-cells. The major histocompatibility complex (MHC) class II (Ia) antigens (RT1B and RT1D in rat), detected with OX6 antibody, and OX17 antibody, may be present on ...

journal_title：Immunological investigations

authors： Chan CC,Caspi R,Mochizuki M,Diamantstein T,Gery I,Nussenblatt RB

更新日期：1987-06-01 00:00:00

abstract：:Different studies described the antibacterial properties of Lavandula angustifolia (Mill.) essential oil and its anti-inflammatory effects. Besides, no data exist on its ability to activate human macrophages during the innate response against Staphylococcus aureus. The discovery of promising regulators of macrophage-m...

journal_title：Immunological investigations

authors： Giovannini D,Gismondi A,Basso A,Canuti L,Braglia R,Canini A,Mariani F,Cappelli G

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To study the relation between CD226 rs763361 gene polymorphism and CD226 serum level and to evaluate their role in susceptibility and disease activity of RA in a cohort of Egyptian individuals. METHODS:The serum level of CD226 was measured using a suitable ELISA kit and the CD226 rs763361 gene polymorphism w...

journal_title：Immunological investigations

authors： Mosaad YM,El-Toraby EE,Tawhid ZM,Abdelsalam AI,Enin AF,Hasson AM,Shafeek GM

更新日期：2018-04-01 00:00:00

abstract：:This study investigated the intestinal anti-inflammatory action of ginsenoside Rf in inflammatory bowel disease (IBD). IBD is a chronic inflammatory disease that affects the intestinal tract. It is associated with elevated levels of various inflammatory mediators, including interleukin (IL)-1β, IL-6, tumor necrosis fa...

journal_title：Immunological investigations

authors： Ahn S,Siddiqi MH,Aceituno VC,Simu SY,Yang DC

更新日期：2016-07-01 00:00:00