Abstract:
:We examined the effect of various polyanions on mouse complement hemolytic activity, Fc receptor (FcR) subclass mediated antibody-dependent cellular cytotoxicity (ADCC) as well as binding by mouse peritoneal macrophages (M phi) of sheep erythrocyte targets. All the polyanions tested (dextran sulfate, carrageenan, polyvinyl sulfate, pentosan polysulfate and polyanethol sulfonic acid) inhibited the hemolytic activity of mouse serum complement to varying degrees. Polyanions inhibited ADCC mediated by either IgG2a or IgG2b in a reversible manner. FcR subclass mediated binding studies at 4 degrees C indicated that the various polyanions compete for FcR binding of sheep erythrocytes opsonized with murine IgG2a, IgG2b and polyclonal IgG. Polyanethol sulfonic acid was uniformly the most potent inhibitor of mouse CH50 and FcR dependent ADCC and binding functions, but did not affect C3b receptor mediated binding.
journal_name
Immunol Investjournal_title
Immunological investigationsauthors
Mocharla R,Mocharla H,Leu RWdoi
10.3109/08820138909057755subject
Has Abstractpub_date
1989-06-01 00:00:00pages
689-96issue
5eissn
0882-0139issn
1532-4311journal_volume
18pub_type
杂志文章abstract::Conjugated linoleic acid (CLA) is a dietary fatty acid which causes extensive remodeling and mast cell recruitment in the mouse mammary gland. Two CLA isomers, 9,11- and 10,12-CLA, have differing effects in vivo, with only 10,12-CLA increasing mast cell number. The purpose of this project is to test the hypothesis tha...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2011.647187
更新日期:2012-01-01 00:00:00
abstract::Different studies described the antibacterial properties of Lavandula angustifolia (Mill.) essential oil and its anti-inflammatory effects. Besides, no data exist on its ability to activate human macrophages during the innate response against Staphylococcus aureus. The discovery of promising regulators of macrophage-m...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2015.1085392
更新日期:2016-01-01 00:00:00
abstract::The objective of this study was to analyze how Staphylococcus epidermidis SCV and WT strains manipulate the PI3K/Akt/mTOR signaling pathway. Six S. epidermidis strains with normal phenotype (WT) and six S. epidermidis strains with SCV phenotype were isolated in parallel from six patients with the prosthetic hip joint ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2018.1423569
更新日期:2018-04-01 00:00:00
abstract::Th17 cells of the intestine and colon can produce several important cytokines during mucosal inflammation. However, few studies have focused on the role of IL-26 in intestinal inflammations. Colonic epithelial cells express receptors for IL-26, and this cytokine has been shown to induce the HT-29 colonic epithelial ce...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2019.1594247
更新日期:2019-11-01 00:00:00
abstract::Antigen (HSA) bound in immune complexes at equivalence with syngeneic anti-HSA antibodies elicit much stronger humoral immune response then soluble HSA. On the other hand, administration of immune complexes formed with xenogeneic (rabbit) anti-HSA antibodies suppressed humoral immune response against HSA, but not agai...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139209069398
更新日期:1992-12-01 00:00:00
abstract::Seven commercially available intravenous immunoglobulins (IVIG) preparations, a gamma globulin prepared by ethanol fractionation, and an experimental IgG isolated by a chromatographic procedure were compared in several tests. Split products were present in preparations manufactured by procedures involving protease tre...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138809055724
更新日期:1988-04-01 00:00:00
abstract::Very little is known about the effects of acute psychological stress on the production of reactive oxygen species (ROS) by human phagocytic cells and the interplay between subjectively perceived stress, mediating hormones, variations in the number of peripheral leukocytes and ROS production. We measured psychological ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-120004800
更新日期:2002-05-01 00:00:00
abstract::The role of innate immunity, e.g., complement activation and cytokine release in the hemodynamic alterations in the course of human septic shock is largely unknown. We prospectively studied 14 consecutive septic shock patients with a pulmonary artery catheter in place. For 3 days after admission, hemodynamic variables...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2010.502949
更新日期:2010-01-01 00:00:00
abstract::Patients with metastatic breast carcinoma (BCa) have defective peripheral blood lymphocyte (PBL) responsiveness to mitogenic and antigenic stimulation. In the following experiments, glycopeptides were isolated from the pronase digests of breast carcinoma tissue. After elution from Sephadex G-50, glycopeptides from BCa...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138809055715
更新日期:1988-03-01 00:00:00
abstract::Studies demonstrated that deficiency in 17β-estradiol (E2) in postmenopausal women influences their immune system. However, few studies have reported alterations in immunologic presentation during nonnatural menopause in young females. Here we compared the differences in immune response between young C57BL/6N mice wit...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2016.1267203
更新日期:2017-04-01 00:00:00
abstract::The transferrin receptor (TR), the HLA DR antigen (DR), and the antigen binding OKT10 (T10) are present on activated lymphocyte populations. The authors have studied their expression and that of antigens defined by eight commercial monoclonal antibodies on peripheral blood lymphocytes of 50 healthy hospital workers ag...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709087089
更新日期:1987-06-01 00:00:00
abstract::Previous work had implicated T cells within the stimulating population as having a significant role in the MLR. We now report that depletion of T cells from the stimulators caused a reduction in proliferative response in mixed leukocyte reaction (MLR) by 50% or more. This response could be restored by adding T-enriche...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138609042020
更新日期:1986-03-01 00:00:00
abstract::Interleukin (IL)-10 response is associated with mortality in patients with sepsis. IL-10 is primarily produced by monocytes and type 2 T helper (Th2) cells. The aim of this study was to investigate differences in IL-10 production between monocytes and Th2 cells in patients with sepsis. Forty patients with sepsis and 3...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2017.1288237
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Cancer immunotherapies have achieved much success and have become the forefront treatment of cancers previously associated with poor prognosis. However, a major challenge in cancer immunotherapies remains the heterogeneity of the immunoregulatory capacities of cancers, and not all patients of a given cancer ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2020.1778024
更新日期:2020-06-23 00:00:00
abstract::Mannan binding lectin (MBL) deficiency has been associated with increased susceptibility to vaginitis in humans due to Candida albicans. In these studies we assessed the utility of recombinant human MBL (rhMBL) as a therapeutic against experimental C. albicans vaginitis. After intravenous treatment of uninfected mice ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2011.569627
更新日期:2011-01-01 00:00:00
abstract::Factors that suppress natural killer (NK) cell activity were examined in a random sample of 73 schizophrenic patients. NK activity in these patients were compared with 25 healthy age, sex and race matched controls. The mean percent of NK activity was 21% in the schizophrenic group compared with 30% percent in the cont...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139409066822
更新日期:1994-08-01 00:00:00
abstract::Drug abuse has become a global health concern. Understanding how drug abuse modulates the immune system and how the immune system responds to pathogens associated with drug abuse, such hepatitis C virus (HCV) and human immunodeficiency virus (HIV-1), can be assessed by an integrated approach comparing proteomic analys...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130902874110
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:Diabetic peripheral neuropathy (DPN) is one of late complications of diabetes mellitus. The aim of this study was to evaluate the association between variable number tandem repeat (VNTR) polymorphism in intron 3 of interleukin-4 gene and risk of DPN. METHODS:We examined 926 T2DM patients and 420 healthy cont...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2017.1407334
更新日期:2018-02-01 00:00:00
abstract::Objectives: The aim of this study was to assess the genetic association between vascular endothelial growth factor (VEGF) gene polymorphisms and the risk of pre-eclampsia (PE).Methods: A systematic literature search of several databases (PubMed, Embase, and the China National Knowledge Infrastructure (CNKI)) was condu...
journal_title:Immunological investigations
pub_type: 杂志文章,meta分析
doi:10.1080/08820139.2019.1659812
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a chronic smoking-related lung disease associated with higher mortality and morbidity. Herein, we attempted to investigate the function of miR-558/TNF Receptor Superfamily Member 1A (TNFRSF1A) in the progression of COPD. METHODS:GEO database was applied to fil...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2021.1874977
更新日期:2021-01-17 00:00:00
abstract:OBJECTIVE:This study determined whether tumor necrosis factor alpha (TNF-α) and Interleukin-10 (IL-10) polymorphisms are associated with susceptibility to dengue. METHODS:a systematic review with meta-analysis was conducted of the associations between the TNF-α (-308G/A) and IL-10 (-819C/T) polymorphisms and dengue. ...
journal_title:Immunological investigations
pub_type: 杂志文章,meta分析
doi:10.1080/08820139.2016.1248560
更新日期:2017-02-01 00:00:00
abstract::To determine the main mediators for mouse anaphylactic shock, the suppression of active anaphylactic shock by cyproheptadine, an antagonist of histamine/serotonin, and CV-6209, an antagonist of platelet-activating factor (PAF), was systematically evaluated using various mouse strains. The suppression was quite heterog...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139609055732
更新日期:1996-09-01 00:00:00
abstract::Porphyromonas gingivalis (P.g) is the primary bacterial agent in many forms of chronic periodontitis. Since polymorphonuclear leukocytes (PMNs) are first-line responders to P.g.- induced inflammation, and fibrinogen is important for in vivo PMN in this disease, we have studied the effect of N-formyl-methionyl-leucyl-p...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130500496811
更新日期:2006-01-01 00:00:00
abstract::Endomyocardial biopsy is generally used to quantify heart allograft rejection and guide immunotherapy. Biopsy, however, is invasive, costly, and risky. Since rejection requires lymphocyte activation, the purpose of this study was to assess alternative methods to evaluate rejection dynamics by investigating serum level...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139609059287
更新日期:1996-01-01 00:00:00
abstract::Dengue viruses (DV) infection is an important public health issue all over the world. Although the pathogenesis remains unclear, the overwhelmingly triggered immune responses have been consistently observed. Recently, we and other researchers demonstrated that the natural hosts for DV are dendritic cells (DC), the pri...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-200038680
更新日期:2004-01-01 00:00:00
abstract::In the present study, we evaluated the effectiveness of a levamisole-based adjuvant (ADL) to enhance the ability of the Ag85B-ESAT6 fusion protein to boost immune responses after primary vaccination with recombinant bacillus Calmette-Guerin (rBCG) in Balb/c mice. The results were compared with that of the control adju...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2012.658940
更新日期:2012-01-01 00:00:00
abstract::VH4-34 gene encoded autoantibodies are elevated in systemic lupus erythematosus (SLE) and in other diseases associated with B-cell hyperproliferation/dysfunction. One of the autoantigens recognized by VH4-34-encoded antibodies are branched/linear poly N-acetyl lactosamine chains. Since the anti-carbohydrate response i...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2015.1015682
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Infections are usually involved in the pathogenesis of spondyloarthritis (SpA). Mannose-binding lectin (MBL) is a component of the innate immune system with an important role in microbial defense. OBJECTIVE:To study the prevalence of MBL deficiency in SpA patients as well as its influence in the clinical pr...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2016.1237525
更新日期:2017-02-01 00:00:00
abstract::Alveolar macrophages (AM) freshly obtained by bronchoalveolar lavage suppressed significantly, in a dose-dependent fashion, lung interstitial lymphocytes cytotoxicity against the NK-sensitive target cells, YAC-1. Kinetic experiments revealed that AM-mediated suppression of NK activity was seen following short-term inc...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139009042023
更新日期:1990-02-01 00:00:00
abstract::Objectives: Ataxia-telangiectasia (A-T) is an autosomal recessive neurodegenerative disorder with multisystem involvement caused by homozygous or compound heterozygous mutations in the ataxia telangiectasia mutated (ATM) gene which encodes a serine/threonine protein kinase. The aims of this study were to investigate c...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2020.1723104
更新日期:2021-02-01 00:00:00