Safety aspects of intravenous immunoglobulins.

Abstract:

:Seven commercially available intravenous immunoglobulins (IVIG) preparations, a gamma globulin prepared by ethanol fractionation, and an experimental IgG isolated by a chromatographic procedure were compared in several tests. Split products were present in preparations manufactured by procedures involving protease treatment and in a sulphitolysed IgG. The same preparations and another chemically modified product displayed a loss in their capacity to bind staphylococcal protein A. None of the preparations exerted a high anticomplementary activity using concentrated human serum as a complement source. No strict correlation between aggregate content and anticomplementary activity could be established. None of the commercial IVIG preparations tested displayed a sizeable hypotensive action as assessed by a rat model involving potentiation of bradykinin action by an angiotensin convertase inhibitor. The chromatographically purified IgG and an intramuscular IgG prepared by Rivanol fractionation contained high endogenous protease and prekallikrein activator (PKA) activity, respectively and both were found markedly hypotensive. Neither endogenous protease nor PKA activity was detected in the Cohngammaglobulin fraction. However, it was very strongly hypotensive even without any previous blocking of angiotensin convertase. Our data support the view that immunoglobulin preparations may affect blood pressure without inducing bradykinin generation.

journal_name

Immunol Invest

authors

Medgyesi GA,Kovács J,Füst G,Merétey K

doi

10.3109/08820138809055724

subject

Has Abstract

pub_date

1988-04-01 00:00:00

pages

121-33

issue

2

eissn

0882-0139

issn

1532-4311

journal_volume

17

pub_type

杂志文章
  • miR-558 Reduces the Damage of HBE Cells Exposed to Cigarette Smoke Extract by Targeting TNFRSF1A and Inactivating TAK1/MAPK/NF-κB Pathway.

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a chronic smoking-related lung disease associated with higher mortality and morbidity. Herein, we attempted to investigate the function of miR-558/TNF Receptor Superfamily Member 1A (TNFRSF1A) in the progression of COPD. METHODS:GEO database was applied to fil...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2021.1874977

    authors: Jing X,Luan Z,Liu B

    更新日期:2021-01-17 00:00:00

  • Heterogeneity of drug susceptibility of mouse active anaphylactic shock.

    abstract::To determine the main mediators for mouse anaphylactic shock, the suppression of active anaphylactic shock by cyproheptadine, an antagonist of histamine/serotonin, and CV-6209, an antagonist of platelet-activating factor (PAF), was systematically evaluated using various mouse strains. The suppression was quite heterog...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139609055732

    authors: Kimura S,Watanabe A,Nagata M,Niinomi Y,Harada M

    更新日期:1996-09-01 00:00:00

  • Phenotypic and functional analysis of mucosal lymph node T cell subpopulations proximal and distal to chronic staphylococcal antigen challenge.

    abstract::We investigated the functional and subset surface marker characteristics of supramammary lymph node T cell populations at sites proximal and distal to the mammary region of goats repeatedly injected with heat-treated Staphylococcus aureus antigen (HK-SAC). Flow cytometric studies showed quantitative differences in CD4...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139209066184

    authors: Dobrzanski MJ,Yang TJ

    更新日期:1992-04-01 00:00:00

  • Which allergen extract for grass pollen immunotherapy? An in vitro study.

    abstract:BACKGROUND:Grass pollen is a major cause of allergy throughout the world. The only treatment targeting the causes and not only the symptoms of allergy is specific immunotherapy (IT). A number of controlled trials demonstrated the efficacy of IT in grass pollen allergic subjects, most using extracts of multiple grasses ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820131003796876

    authors: Marcucci F,Sensi L,Di Cara G,Incorvaia C,Puccinelli P,Scurati S,Frati F

    更新日期:2010-01-01 00:00:00

  • Employing XIAP to enhance the duration of antigen expression and immunity against an avian influenza H5 DNA vaccine.

    abstract::DNA vaccine represents a powerful approach for prevention of avian H5N1 influenza infection. Yet, DNA vaccine-induced immune responses might be limited by the short duration of antigen expression. As a strategy to enhance adaptive immune responses elicited by a hemagglutinin 5 (H5) DNA vaccine, we explored the effect ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2014.988718

    authors: Tabatabaeizadeh SE,Bassami MR,Haghparast A,Dehghani H

    更新日期:2015-01-01 00:00:00

  • Autoimmune regulator initiates the expression of promiscuous genes in thymic epithelial cells.

    abstract::The expression of peripheral antigens in the thymus, known as promiscuous gene expression, has been implicated in T cell tolerance and autoimmunity. Here we identified thymic epithelial cells (TECs) as the main cell type that expresses a diverse range of tissue-restricted antigens (TRAs). The TECs of a common autoimmu...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820130801967841

    authors: Chen J,Yang W,Yu C,Li Y

    更新日期:2008-01-01 00:00:00

  • Association of ADAM17 Expression Levels in Patients with Interstitial Lung Disease.

    abstract::A disintegrin and metalloproteinases (ADAMs) are believed to be involved in the pathogenesis of many fibrosis-related diseases. However, little is known regarding the significance of ADAM17 as a biomarker for interstitial lung disease (ILD). In this study, by using the RT-PCR, western blotting and ELISA, we detected t...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2019.1660367

    authors: Ge J,Tang L,Mu P,Zhu F,Xie L,Tang Y

    更新日期:2020-02-01 00:00:00

  • The hemodynamics of human septic shock relate to circulating innate immunity factors.

    abstract::The role of innate immunity, e.g., complement activation and cytokine release in the hemodynamic alterations in the course of human septic shock is largely unknown. We prospectively studied 14 consecutive septic shock patients with a pulmonary artery catheter in place. For 3 days after admission, hemodynamic variables...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2010.502949

    authors: Hartemink KJ,Groeneveld AB

    更新日期:2010-01-01 00:00:00

  • Association of Interleukin-23R Gene Polymorphisms with Behcet's Disease Susceptibility: A Meta-Analysis of Case-control Studies.

    abstract:BACKGROUND:The pathological mechanisms associated with the occurrence and development of Behcet's disease (BD) are not yet known. Two large genome-wide association surveys revealed an association between interleukin (IL)-23R single nucleotide polymorphism and BD. This study aimed to investigate the association between ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2019.1698600

    authors: Gong HB,Wu XJ,Pu XM,Kang XJ

    更新日期:2020-08-01 00:00:00

  • Evaluation of IL1B rs1143634 and IL6 rs1800796 Polymorphisms with Autism Spectrum Disorder in the Turkish Children.

    abstract::Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder caused by genetic, environmental and immunological factors. It is known that neural development processes are affected by immune functions. The aim of this study is to evaluate the relationship between cytokines IL6 and IL1B gene polymorphisms...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2020.1870489

    authors: Pekkoc Uyanik KC,Kalayci Yigin A,Dogangun B,Seven M

    更新日期:2021-01-12 00:00:00

  • Implication of Increased Serum IL-31 for Primary Biliary Cholangitis.

    abstract::Interleukin-31 (IL-31) has diverse biological functions. Increased IL-31 has been found in some skin and autoimmune diseases. There has been no study reporting the association between IL-31 and primary biliary cholangitis (PBC). This study was designed to determine serum IL-31 level and to explore its diagnostic value...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2020.1785490

    authors: Mu N,Lin F,Jiang Z,Liang Y,Yang Z

    更新日期:2020-07-02 00:00:00

  • Association between cytokine genes polymorphisms and type 1 diabetes: a case-control study on Saudi population.

    abstract:BACKGROUND:Association studies of genes encoding cytokines that play an important role in inflammatory response represent one approach to finding type 1 diabetes (T1D) disease genes. The aim of this study was to investigate the association of single nucleotide polymorphisms (SNPs) within cytokine genes with T1D in a co...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2017.1416398

    authors: Allam G,Nasr A,Talaat IM,Abuelsaad ASA,Bakheit AM,Nemenqani D,Alsulaimani AA

    更新日期:2018-04-01 00:00:00

  • Two Novel Technologies for the Detection of Anti-cardiolipin and Anti β2-Glycoprotein Antibodies in the Real Life: Chemiluminescent in Comparison to the Addressable Laser Bead Immunoassays.

    abstract::In the present study, we evaluated two novel technologies, the chemiluminescent immunoassay (CIA) QUANTA Flash on BIO-FLASH (Inova Diagnostics, San Diego, CA, USA) and the addressable laser bead immunoassay (ALBIA) on BioPlex™ 2200 (Bio-Rad, Hercules, CA, USA) for the detection of anti-cardiolipin IgG/IgM (aCL) and an...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2019.1647233

    authors: Grossi V,Infantino M,Benucci M,Li Gobbi F,Bandinelli F,Damiani A,Bodio C,Borghi MO,Mahler M,Aure MA,Bentow C,Manfredi M

    更新日期:2020-02-01 00:00:00

  • Modulation of B cell stimulation by maternal serum.

    abstract::Anti-IgM stimulation of B cells is decreased in the presence of maternal serum as compared to control media. This inhibiting influence of maternal serum is observed during the priming of the B cells. The progression of B cells into cellular proliferation was not influenced by maternal serum. At the level of the immuno...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139109026231

    authors: Vanderbeeken YE,Duchateau J,Gregoire M,Vandermeersch B,Collet H,Lucas A

    更新日期:1991-06-01 00:00:00

  • Monoclonal antibodies to acetylcholine receptor secreted by human x human hybridomas derived from lymphocytes of a patient with myasthenia gravis.

    abstract::Peripheral blood lymphocytes of a patient with myasthenia gravis (MG) were fused to the non-secreting human lymphoblastoid line HuNSI to produce human x human hybridomas that secrete monoclonal antibodies (mAb) to acetylcholine receptor (AChR). Screening of hybridomas for antibody production involved an enzyme-linked ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138609052954

    authors: Blair DA,Richman DP,Taves CJ,Koethe S

    更新日期:1986-06-01 00:00:00

  • Identification of individuals at increased risk for AIDS among clinically asymptomatic homosexuals and abusers of intravenous drugs.

    abstract::Immunological parameters previously shown to constitute an increased risk for progression towards AIDS have been observed in clinically asymptomatic individuals considered to be at risk for this syndrome. These parameters include severely decreased numbers of T helper cells (count below 400/mm3 blood for CD4+ cells we...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138809055726

    authors: Mannhalter JW,Wolf HM,Pum M,Banekovich M,Hutterer J,Brandstätter R,Eibl MM

    更新日期:1988-04-01 00:00:00

  • Stimulator T-cells and the regulation of growth factors produced in the murine mixed leukocyte reaction.

    abstract::Previous work had implicated T cells within the stimulating population as having a significant role in the MLR. We now report that depletion of T cells from the stimulators caused a reduction in proliferative response in mixed leukocyte reaction (MLR) by 50% or more. This response could be restored by adding T-enriche...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138609042020

    authors: Roy C,Brown DL,Kaplan JG

    更新日期:1986-03-01 00:00:00

  • Effect of immuno-modulating agents on murine IL-2 production.

    abstract::The effect of two Chinese traditional drugs, Dang Gui injection prepared from Angelica sinensis and C 21 Ester glucoside (GB) extracted from Cynanchus auriculatus on in vitro production of IL-2 has been studied. The IL-2 was produced by Con A stimulation of mouse spleen mononuclear cells. The IL-2 activity was assayed...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138709030565

    authors: Weng XC,Zhang P,Gong SS,Xiai SW

    更新日期:1987-04-01 00:00:00

  • Enhanced antigen-specific antibody and cytokine responses when targeting antigen to human FcGAMMA receptor type I using an anti-human FcGAMMA receptor type I-streptavidin fusion protein in an adjuvant-free system.

    abstract::There is a continuing need for alternatives to current human adjuvants. Recombinant protein vaccines, which target antigen to human Fc gamma receptor type I (hFcgammaRI) on hFcgammaRI-expressing antigen presenting cells, provide one potential alternative. Using a recombinant anti-hFcgammaRI-antigen fusion protein and ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820130500265372

    authors: Adamova E,Walsh MC,Gosselin DR,Hale K,Preissler MT,Graziano RF,Gosselin EJ

    更新日期:2005-01-01 00:00:00

  • Tracking the elusive lymphocyte: methods of detection during adoptive immunotherapy.

    abstract::Adoptive immunotherapy is an attractive cancer treatment modality due to its capacity to target primary and metastatic lesions with large numbers of tumor-reactive, cytotoxic lymphocytes. The inability of fully armed lymphocytes to traffic into sites of tumor has been proposed as a causal factor for the minimal succes...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820130701712867

    authors: Skitzki JJ,Muhitch JB,Evans SS

    更新日期:2007-01-01 00:00:00

  • Review on therapeutic options in HIV associated thrombocytopenia with emphasis on i.v. immunoglobulin treatment.

    abstract::Thrombocytopenia as a complicating event in human immunodeficiency infection is a rather common hematological disorder and in many aspects resembles idiopathic(immune) thrombocytopenic purpura (ITP). Consequently, treatment of severe cases is similar to treating ITP, but steroids should be administered with particular...

    journal_title:Immunological investigations

    pub_type: 杂志文章,评审

    doi:10.3109/08820139109050791

    authors: Nydegger UE,Castelli D

    更新日期:1991-04-01 00:00:00

  • Antibodies to lactate dehydrogenase of Plasmodium knowlesi are specific to Plasmodium species.

    abstract::Polyclonal immune monkey serum raised against schizonts of Plasmodium knowlesi (H-strain) showed the presence of antibodies to lactate dehydrogenase (LDH) of P. knowlesi by immunodot enzyme staining method. The anti-LDH antibodies are most probably directed towards an epitope distinct from the catalytic site as shown ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138809030584

    authors: Kaushal DC,Watts R,Haider S,Singh N,Kaushal NA,Dutta GP

    更新日期:1988-08-01 00:00:00

  • Myeloid-derived suppressor cells (MDSCs) in gliomas and glioma-development.

    abstract::Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of cells that inhibit anti-tumor immunity through a variety of mechanisms. Malignant gliomas are heavily infiltrated by myeloid cells, some of which appear to share biological functions of MDSCs. Our data with mouse de novo gliomas indicate critic...

    journal_title:Immunological investigations

    pub_type: 杂志文章,评审

    doi:10.3109/08820139.2012.689591

    authors: Kohanbash G,Okada H

    更新日期:2012-01-01 00:00:00

  • Mapping of IgE binding regions in the major rat urinary protein, alpha 2u-globulin, using overlapping peptides.

    abstract::Exposure to laboratory animals poses a hazard for development of occupational allergy. Identification of antigenic determinants of allergenic proteins may be valuable for immunotherapeutic purposes. Overlapping peptides of the major allergen in rat urine, Rat n 1.02, corresponding to the protein alpha2u-globulin were ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139909062266

    authors: Bayard C,Siddique AB,Berzins K,Troye-Blomberg M,Hellman U,Vesterberg O

    更新日期:1999-09-01 00:00:00

  • MHC-restricted presentation of a single repeat of MUC1 mucin.

    abstract::Major histocompatibility complex (MHC) restriction of antigen presentation of a single mucin1 (MUC1) variable number of tandem repeats peptide (VNTR1) was examined by generating cytotoxic T lymphocytes (CTL) derived from peripheral blood mononuclear cells (PBMC) stimulated with a single repeat MUC1 peptide presented b...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820130601187384

    authors: Orr MK,Burnside JS,Phillips CA,Philip R,Dombrowski KE,Wright SE

    更新日期:2007-01-01 00:00:00

  • Analysis of responsive cells in tolerance by the oral administration of ovalbumin.

    abstract::The induction of immune tolerance is the most common consequence of protein feeding, i.e., "oral tolerance". In this study we investigated the genetic basis of oral tolerance using various kinds of recombinant and congenic mice, and the cells involved in the development of this phenomenon in mice. The footpad swelling...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139309063423

    authors: Ishii N,Moriguchi N,Sugita Y,Nakajima H,Tanaka S,Aoki I

    更新日期:1993-08-01 00:00:00

  • Synthetic antigens as immunogens: Part IV. Specificity of antisera developed to Gal beta 1-3(GlcNAc beta 1-6)GalNAc and GlcNAc beta 1-6GalNAc.

    abstract::Antisera to the chemically synthesized trisaccharide, Gal beta 1-3(GlcNAc beta 1-6)GalNAc, and disaccharide, GlcNAc beta 1-6GalNAc, were developed using the diazophenyl bovine serum albumin derivatives. The binding specificity of the antisera were analyzed by enzyme immunoassays with structurally related, chemically s...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139109082633

    authors: Matta KL,Piskorz CF,Abbas SA,Diakun KR

    更新日期:1991-08-01 00:00:00

  • Enhanced maturation and function of dendritic cells using hydrogel coated plate and antigen electroporation.

    abstract::Dendritic cells (DCs) are potent antigen-presenting cells that can be matured in vitro from immature dendritic cells (iDCs) in the presence of several biological agents such as cytokine cocktail, CD40L, TNF-a and antigen loading, which are necessary and achieved using various protocols, such as lipofection, passive pu...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2012.757234

    authors: Son CH,Bae JH,Shin DY,Lee HR,Choi YH,Yang K,Park YS

    更新日期:2013-01-01 00:00:00

  • Anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells.

    abstract::This research was undertaken to test the in vitro anti-inflammatory action of 5,7,4'-trimethoxy-4-phenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin produced by Streptomyces aureofaciens CMUAc130. The effects of the two coumarins were investigated on the formation of NO, PGE2, and TNF-alpha and also on inducible nitric...

    journal_title:Immunological investigations

    pub_type: 杂志文章,收录出版

    doi:10.1080/08820130600992115

    authors: Taechowisan T,Tuntiwachwuttikul P,Lu C,Shen Y,Lumyong S,Taylor WC

    更新日期:2007-01-01 00:00:00

  • BK virus terminates tolerance to dsDNA and histone antigens in vivo.

    abstract::In order to characterize the immune response to BK virus, a human polyomavirus containing dsDNA and host cell histones, we followed the appearance of antibodies in five outbred rabbits after intravenous inoculation with purified infectious BK virus without any adjuvant. The animals were followed for 15 weeks after the...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139009042033

    authors: Fredriksen K,Traavik T,Flaegstad T,Rekvig OP

    更新日期:1990-04-01 00:00:00