Infection of human dendritic cells by dengue virus activates and primes T cells towards Th0-like phenotype producing both Th1 and Th2 cytokines.

abstract：:Mice were immunized with 14 free (i.e. not conjugated to any carrier) synthetic peptides representing the entire human hemoglobin alpha-chain. Antibodies against each peptide were determined using solid phase radioimmunoassay, both with free peptides and peptides coupled to a protein carrier as the coating antigen. It...

journal_title：Immunological investigations

authors： Oshima M,Atassi MZ

更新日期：1989-08-01 00:00:00

abstract：:The loading of dendritic cells (DCs) with whole tumor cell lysates may circumvent the facts that few tumor-specific antigens have been identified in human solid tumors. The present study was designed to investigate whether ovarian cancer cells lysate-pulsed DCs activate T cell responses against autologous ovarian tumo...

journal_title：Immunological investigations

authors： Zhao X,Wei YQ,Peng ZL

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Grass pollen is a major cause of allergy throughout the world. The only treatment targeting the causes and not only the symptoms of allergy is specific immunotherapy (IT). A number of controlled trials demonstrated the efficacy of IT in grass pollen allergic subjects, most using extracts of multiple grasses ...

journal_title：Immunological investigations

authors： Marcucci F,Sensi L,Di Cara G,Incorvaia C,Puccinelli P,Scurati S,Frati F

更新日期：2010-01-01 00:00:00

abstract：:Hematological disorders like Aplastic anemia are quite frequent in Pakistan. Human leukocyte antigen (HLA) system, have been implicated in the development of Aplastic anemia in various population-based studies, The aim of this study was to determine the role of the HLA Class I and Class II alleles in genetic susceptib...

journal_title：Immunological investigations

authors： Rehman S,Saba N,Khalilullah,Munir S,Ahmed P,Mehmood T

更新日期：2009-01-01 00:00:00

abstract：:Disease associations of clonally restricted serum immunoglobulin (Ig) abnormalities were examined using methods for detecting and characterizing homogeneous Ig that are approximately forty times more sensitive than either cellulose acetate zone electrophoresis or immunoelectrophoresis. Medical records of three hundred...

journal_title：Immunological investigations

authors： Kelly RH,Hardy TJ,Shah PM

更新日期：1985-06-01 00:00:00

abstract：:Very little is known about the effects of acute psychological stress on the production of reactive oxygen species (ROS) by human phagocytic cells and the interplay between subjectively perceived stress, mediating hormones, variations in the number of peripheral leukocytes and ROS production. We measured psychological ...

journal_title：Immunological investigations

authors： Atanackovic D,Brunner-Weinzierl MC,Kröger H,Serke S,Deter HC

更新日期：2002-05-01 00:00:00

abstract：:Infections are a major cause of illness and death amongst elderly people. Peripheral blood CD8+ T lymphocytes --which play a crucial role in host defence against viral infections--, are divided in subsets based upon the expression of several cell and activation markers. In senescence changes and variations in peripher...

journal_title：Immunological investigations

authors： Esparza B,Rodriguez A,Puente M,Sabino E,Merino F

更新日期：1998-07-01 00:00:00

abstract：:In the last 15 years, it has become apparent that ovarian cancer is recognized by the immune system, taking into account that T cell infiltration can be associated with increased overall survival. Several studies indicate that a correct combination of cluster of differentiation 8 and cluster of differentiation 4 T cel...

journal_title：Immunological investigations

authors： Singh M,Loftus T,Webb E,Benencia F

更新日期：2016-11-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are widely distributed and relocated in the environment as a result of the incomplete combustion of organic matter. Many PAHs and their epoxides are highly toxic, mutagenic and/or carcinogenic to microorganisms as well as to higher systems including humans. BP is one of the most...

journal_title：Immunological investigations

authors： Ustinov VA,Studennikov AE,Vavilov VA,Tyumentseva MA,Morozova VV,Tikunova NV,Glushkov AN

更新日期：2015-01-01 00:00:00

abstract：:In this study we examined a panel of CD4+ antigen specific/MHC restricted T cell clones for their ability to secrete IL-2, IL-4, and IFN-gamma upon stimulation with con A, three lymphokines which are diagnostic for the TH1 and TH2 subtypes of helper T cells. Eight of the twelve clones we analyzed did not fit the class...

journal_title：Immunological investigations

authors： Hatfield SM,Rodgers GH,Marder P,Roehm NW

更新日期：1991-02-01 00:00:00

abstract：:The processing of antigenic peptides for presentation by MHC molecules to T cells, may depend upon the function of a second, consensus sequence in or near the T cell-presented epitope. One such processing-regulating sequence appears to be composed of amino acids Leu, Ile, Val, Phe, and Met recurring in a fashion to fo...

journal_title：Immunological investigations

authors： Goldschmidt TG,Reyes VE,You G,Nelson DJ,Reisert PS,Anderson J,Mole J,Humphreys RE

更新日期：1993-02-01 00:00:00

abstract：:CD44 comprises a family of type I transmembrane glycoproteins that is expressed on a wide range of cells including those of epithelial, lymphoid and myeloid lineage. Although expression of CD44 in the small intestine is typically localised in the crypts of Lieberkuhn, we have reported the expression of CD44 on mature,...

journal_title：Immunological investigations

authors： Reid SD,Pockley AG

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Natural killer (NK) cells are the potential modulators of inflammatory reactions that exert several unique biological effects and could lead to future adverse events of coronary artery disease (CAD). HYPOTHESIS:The purpose of this study was to find out the possible association of modulation in NK cell, TNK ...

journal_title：Immunological investigations

authors： Jabir NR,Firoz CK,Ahmed F,Kamal MA,Hindawi S,Damanhouri GA,Almehdar HA,Tabrez S

更新日期：2017-07-01 00:00:00

abstract：:Identification and characterization of antigenic proteins of Setaria cervi (bovine filarial parasite) adults and microfilariae was done by immunoblotting technique using hyperimmune rabbit sera against S. cervi and Brugia malayi. The antigens recognized by these sera were detected by using 125I protein-A followed by a...

journal_title：Immunological investigations

authors： Kaushal NA,Kaushal DC,Ghatak S

更新日期：1987-04-01 00:00:00

abstract：:A rapid, quantitative enzyme-linked immunosorbent assay (ELISA) for the immunodiagnosis of Chagas' disease is described. The ELISA was standardized with the Falcon assay screening test (F.A.S.T.) system using a purified Trypanosoma cruzi epimastigote fraction (PEF) obtained by ion exchange chromatography. The ELISA te...

journal_title：Immunological investigations

authors： Partel CD,Rossi CL

更新日期：1998-01-01 00:00:00

abstract：:We tested by Western blot several thousand antibody-secreting human cell lines immortalized by hybridoma fusion or Epstein-Barr virus transformation of peripheral blood lymphocytes from patients with systemic lupus erythematosus or mixed connective tissue disease. The blots utilized total human Jurkat cell extract as ...

journal_title：Immunological investigations

authors： Vanderslice WE,Takeda Y,Chen J,Sharp GC,Pettersson I,Rosen A,Wigzell H,Wang RJ

更新日期：1988-06-01 00:00:00

abstract：:IL-3-like activity (IL-3-LA) is a growth factor that stimulates stem cell maturation. We examined the production of IL-3-LA by peripheral blood mononuclear cells of 10 patients with relapsing-remitting multiple sclerosis (MS) following one year of treatment with intravenous immunoglobulins (IVIG). The results were com...

journal_title：Immunological investigations

authors： Djaldetti R,Achiron A,Ziv I,Djaldetti M,Melamed E,Fishman P

更新日期：1995-08-01 00:00:00

abstract：:Recently, we reported the preparation and antigen-presenting properties of hybridoma B-cell clones obtained after fusing non-secreting, non-antigen presenting Balb/c 653-myeloma cells with non-immune SJL spleen cells. It was found that antigen presentation at the clonal level can be specific or non-specific, depending...

journal_title：Immunological investigations

authors： Cohly HH,Morrison DR,Atassi MZ

更新日期：1989-10-01 00:00:00

abstract：:Many investigators have demonstrated alteration of gastric mucins in H. pylori infected individuals. The inflammatory environment induced by H. pylori leading to aberrant glycosylation of MUC1 and demasking of core peptide MUC1 epitope could enhance immune responses to MUC1. IgG and IgM immune response to MUC1 in pati...

journal_title：Immunological investigations

authors： Klaamas K,Kurtenkov O,von Mensdorff-Pouilly S,Shljapnikova L,Miljukhina L,Brjalin V,Lipping A

更新日期：2007-01-01 00:00:00

abstract：:Adoptive immunotherapy is an attractive cancer treatment modality due to its capacity to target primary and metastatic lesions with large numbers of tumor-reactive, cytotoxic lymphocytes. The inability of fully armed lymphocytes to traffic into sites of tumor has been proposed as a causal factor for the minimal succes...

journal_title：Immunological investigations

authors： Skitzki JJ,Muhitch JB,Evans SS

更新日期：2007-01-01 00:00:00

abstract：:Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been reported in autoimmune diseases. However, their role in Behçet's disease (BD) and scleroderma remains inconclusive. Our aim was to evaluate vitamin D receptor (ApaI, TaqI) gene polymorphisms in relation to Behçet's disease and scleroderma i...

journal_title：Immunological investigations

authors： Kamal A,Gamal SM,Elgengehy FT,Alkemary AK,Siam I

更新日期：2016-08-01 00:00:00

abstract：:The contribution of interleukin-2 (IL-2)-responsive bystander cells to the proliferative responses of human peripheral blood T lymphocytes to antigens used for sensitization such as Purified Protein Derivative (PPD), Tetanus toxoid (T T) and Influenza virus was investigated. Marked proliferation of the unfractionated ...

journal_title：Immunological investigations

authors： Sia DY,Chou JL

更新日期：1988-03-01 00:00:00

abstract：:Rapid and accurate diagnosis of cytomegalovirus (CMV) infection is imperative with the advent of effective antiviral therapy (gangiclovir, foscarnet, CMV hyperimmune globin). Applications of conventional cell culture (CC), shell vial assay (SV), serological testing, antigenemia assay (AG) as well as molecular methods ...

journal_title：Immunological investigations

authors： Myers JB,Amsterdam D

更新日期：1997-04-01 00:00:00

abstract：:To determine the main mediators for mouse anaphylactic shock, the suppression of active anaphylactic shock by cyproheptadine, an antagonist of histamine/serotonin, and CV-6209, an antagonist of platelet-activating factor (PAF), was systematically evaluated using various mouse strains. The suppression was quite heterog...

journal_title：Immunological investigations

authors： Kimura S,Watanabe A,Nagata M,Niinomi Y,Harada M

更新日期：1996-09-01 00:00:00

abstract：:Two cell lines secreting Paul-Bunnell antibodies were established by means of Epstein-Barr virus-induced immortalization of B lymphocytes from patients with infectious mononucleosis. Progressive loss of antibody production, most probably due to a shutdown of antibody secretion by individual cells was, however, observe...

journal_title：Immunological investigations

authors： Wasik M,Milgrom F

更新日期：1986-06-01 00:00:00

abstract：:Rotaviruses were first recognized about 15 years ago in association with diarrhea in children and animals. Since then, rotaviruses have been determined to be the most important viral agent that causes clinically significant diarrhea in children and a need for an effective vaccination program has been recognized. This ...

journal_title：Immunological investigations

authors： Estes MK,Conner ME,Gilger MA,Graham DY

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Infections are usually involved in the pathogenesis of spondyloarthritis (SpA). Mannose-binding lectin (MBL) is a component of the innate immune system with an important role in microbial defense. OBJECTIVE:To study the prevalence of MBL deficiency in SpA patients as well as its influence in the clinical pr...

journal_title：Immunological investigations

authors： Skare TL,Nisihara R,Cieslinski JZ,Zeni JO,Rasera HN,Messias-Reason I,Utiyama SR

更新日期：2017-02-01 00:00:00

abstract：:The critical contribution of CD4+CD25+Foxp3+ T-regulatory cells (Treg) to immune suppression in the tumor microenvironment is well-established. Whereas the mechanisms that drive the generation and accumulation of Treg in tumors have been an active area of study, the information on their origin and population dynamics ...

journal_title：Immunological investigations

authors： Li Q,Egilmez NK

更新日期：2016-11-01 00:00:00

abstract：:The role of ICAM-1 in contact activation of the bronchial epithelial cells is elucidated. Direct contact between epithelial cells and leukocytes is required to change transepithelial electrical resistance (TER) of the epithelium. Migration of human neutrophils across the layers of cultured human airway epithelial cell...

journal_title：Immunological investigations

authors： Choi H,Fleming NW,Serikov VB

更新日期：2007-01-01 00:00:00

abstract：:Hashimoto's thyroiditis (HT) is a T cell-mediated autoimmune disease. However, little is known about the role of different subsets of natural killer (NK) and natural killer T (NKT) cells at the early stage of the HT process. A total of 45 euthyroid patients with new onset HT and 40 age/gender-matched healthy controls ...

journal_title：Immunological investigations

authors： Guo H,Xu B,Yang X,Wang Y,Liu X,Cui C,Jiang Y

更新日期：2014-01-01 00:00:00