Abstract:
:The objectives were to determine the prevalence and clinical significance of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with juvenile idiopathic arthritis (JIA). Anti-CCP antibodies were checked by ELISA in 68 children with JIA, 38 males and 30 females with mean age of 10.6 (+/-4.02) years and disease duration of 3.7 (+/-1.8) years. Thirty-eight (56%) patients had polyarticular disease, 20 (29%) patients had oligoarticular disease and 10 (15%) patients had systemic onset disease. All patients had their antinuclear antibodies (ANA), rheumatoid factor (RF) and ESR checked and x-rays performed to look for erosions. Results were compared to those of 20 healthy children, 14 children with juvenile systemic lupus erythematosus (JSLE) and 30 adults with rheumatoid arthritis (RA). Anti-CCP antibodies were positive in 14/68 (20.6%) patients with JIA, all had polyarticular-onset disease. All patients with positive anti-CCP antibodies had RF-positive polyarthritis. Anti-CCP antibodies were negative in all patients with oligoarticular-onset and systemic-onset disease including 2 patients with extended oligoarthritis. Anti-CCP antibodies were negative in healthy and JSLE controls but were positive in 20/30 (66.5%) adults with RA. Anti-CCP antibodies correlated significantly with joint erosions in patients with JIA (p = 0.004) but no significant relation was found between anti-CCP antibodies and ANA positivity or raised ESR. These data confirm that anti-CCP antibodies are less prevalent in JIA than adult RA but are detectable in a significant proportion of RF-positive patients with polyarticular-onset JIA. The current study showed significant relation between anti-CCP positivity and erosive joint disease in JIA.
journal_name
Immunol Investjournal_title
Immunological investigationsauthors
Habib HM,Mosaad YM,Youssef HMdoi
10.1080/08820130802438057subject
Has Abstractpub_date
2008-01-01 00:00:00pages
849-57issue
8eissn
0882-0139issn
1532-4311pii
905241027journal_volume
37pub_type
杂志文章abstract::CD44 comprises a family of type I transmembrane glycoproteins that is expressed on a wide range of cells including those of epithelial, lymphoid and myeloid lineage. Although expression of CD44 in the small intestine is typically localised in the crypts of Lieberkuhn, we have reported the expression of CD44 on mature,...
journal_title:Immunological investigations
pub_type: 杂志文章
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journal_title:Immunological investigations
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journal_title:Immunological investigations
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journal_title:Immunological investigations
pub_type: 杂志文章,meta分析
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journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2014.988720
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journal_title:Immunological investigations
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doi:10.3109/08820138809055720
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journal_title:Immunological investigations
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doi:10.1080/08820139.2020.1787438
更新日期:2020-08-26 00:00:00
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journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-200038680
更新日期:2004-01-01 00:00:00
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journal_title:Immunological investigations
pub_type: 杂志文章
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journal_title:Immunological investigations
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doi:10.3109/08820139209066184
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abstract:PURPOSE:To assess cellular composition and local cytokine response in vitreous humor of tubercular uveitis. METHODS:Cells were collected from vitreous cassettes and peripheral blood of 8 tubercular uveitis and 5 control subjects, undergoing vitrectomy and analyzed by flow cytometry for cellular composition, activation...
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pub_type: 杂志文章
doi:10.1080/08820139.2018.1470640
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journal_title:Immunological investigations
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journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2014.888447
更新日期:2014-01-01 00:00:00
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journal_title:Immunological investigations
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