Abstract:
:Mast cells have an important role in allergic reactions secreting histamine and other mediators of immediate hypersensitivity. In the present study we evaluated major histocompatibility complex (MHC) class II antigen expression in mast cells and their possible role in antigen presentation. In rats, 10% of mast cells isolated from the pleural cavity expressed MHC class II antigen; after incubation with gamma interferon (INF) 80% of the cells were positive. These findings suggest that mast cells, in addition to their secretory function in allergic reactions, may also function as antigen presenting cells.
journal_name
Immunol Investjournal_title
Immunological investigationsauthors
Banovac K,Neylan D,Leone J,Ghandur-Mnaymneh L,Rabinovitch Adoi
10.3109/08820138909050768subject
Has Abstractpub_date
1989-08-01 00:00:00pages
901-6issue
7eissn
0882-0139issn
1532-4311journal_volume
18pub_type
杂志文章abstract::Genome-wide association studies have led to the discovery of several susceptibility genes related to autoimmune thyroid diseases (AITDs). However, controversial results have been reported regarding the role of single-nucleotide polymorphism (SNP) of CD40 in the disease susceptibility. The objective of this study was t...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2017.1319382
更新日期:2017-08-01 00:00:00
abstract::Uric acid can be generated in the gastrointestinal (GI) tract from the breakdown of nucleotides ingested in the diet or from purines released from host cells as a result of pathogen-induced cell damage. Xanthine oxidase (XO) is the enzyme that converts hypoxanthine or xanthine into uric acid, a reaction that also gene...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2013.864667
更新日期:2014-01-01 00:00:00
abstract::CD44 comprises a family of type I transmembrane glycoproteins that is expressed on a wide range of cells including those of epithelial, lymphoid and myeloid lineage. Although expression of CD44 in the small intestine is typically localised in the crypts of Lieberkuhn, we have reported the expression of CD44 on mature,...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820130009060867
更新日期:2000-08-01 00:00:00
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journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138509042005
更新日期:1985-04-01 00:00:00
abstract::Electroeluted outer membrane proteins [(EOmp), (35-37 KDa, porins)] were highly immunogenic in New Zealand White rabbits. An ELISA peak titer of 51,200 to EOmp as compared to 6,400 for non-eluted outer membrane protein (Omp) was demonstrated. EOmp enhanced the antigenicity of Omp possibly due to epitopes which were ma...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139409087802
更新日期:1994-04-01 00:00:00
abstract::Although the T cell costimulatory molecules CD2 and CD28 are enriched within the immunological synapse (IS), it has been suggested that costimulatory molecules need not be localized to the contact site between a T cell and an antigen-presenting cell (APC) in order to costimulate T cell activation. To determine whether...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130701555035
更新日期:2008-01-01 00:00:00
abstract::Different studies described the antibacterial properties of Lavandula angustifolia (Mill.) essential oil and its anti-inflammatory effects. Besides, no data exist on its ability to activate human macrophages during the innate response against Staphylococcus aureus. The discovery of promising regulators of macrophage-m...
journal_title:Immunological investigations
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abstract::Thrombocytopenia as a complicating event in human immunodeficiency infection is a rather common hematological disorder and in many aspects resembles idiopathic(immune) thrombocytopenic purpura (ITP). Consequently, treatment of severe cases is similar to treating ITP, but steroids should be administered with particular...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
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更新日期:1991-04-01 00:00:00
abstract::Although cancer immunotherapy, which is able to target specifically cancer cells without detrimental effects to normal cell functions, would serve as an ideal therapeutic modality, most of the randomized clinical trials of cancer immunotherapy have not demonstrated a meaningful survival benefit to cancer patients over...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820139.2013.857352
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abstract::We tested by Western blot several thousand antibody-secreting human cell lines immortalized by hybridoma fusion or Epstein-Barr virus transformation of peripheral blood lymphocytes from patients with systemic lupus erythematosus or mixed connective tissue disease. The blots utilized total human Jurkat cell extract as ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138809041420
更新日期:1988-06-01 00:00:00
abstract::Many investigators have demonstrated alteration of gastric mucins in H. pylori infected individuals. The inflammatory environment induced by H. pylori leading to aberrant glycosylation of MUC1 and demasking of core peptide MUC1 epitope could enhance immune responses to MUC1. IgG and IgM immune response to MUC1 in pati...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130601109727
更新日期:2007-01-01 00:00:00
abstract::Experimental autoimmune uveoretinitis (EAU) was induced in rats by immunization with bovine interphotoreceptor retinoid-binding protein (IRBP) and studied by immunohistochemistry. In general, the IRBP induction of inflammatory cellular components and expression of immune-related antigens on various non-lymphoid cells ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709055713
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:Loquat leaf is an herb that is commonly used in traditional Chinese medicine (TCM) for its anti-inflammatory properties. Numerous studies have demonstrated that Th17 cells play a fundamental role in mediating SLE pathological deterioration. In our study, we investigated the inhibitory effect of pentacyclic t...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2019.1698599
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Grass pollen is a major cause of allergy throughout the world. The only treatment targeting the causes and not only the symptoms of allergy is specific immunotherapy (IT). A number of controlled trials demonstrated the efficacy of IT in grass pollen allergic subjects, most using extracts of multiple grasses ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820131003796876
更新日期:2010-01-01 00:00:00
abstract::Factors that suppress natural killer (NK) cell activity were examined in a random sample of 73 schizophrenic patients. NK activity in these patients were compared with 25 healthy age, sex and race matched controls. The mean percent of NK activity was 21% in the schizophrenic group compared with 30% percent in the cont...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139409066822
更新日期:1994-08-01 00:00:00
abstract::IL-2 production by the phytohemaglutinin (PHA)-stimulated mononuclear cells (MNC) of peripheral blood (PB) and synovial fluid (SF) from patients with rheumatoid arthritis (RA), other arthritic diseases (OAD) and age-matched normal controls were studied, and the activity of IL-2 inhibitor in sera of studied subject was...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139509060720
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:Molecular epidemiological studies have sought associations between interleukin-6 (IL-6) polymorphisms and the risk of systemic lupus erythematosus (SLE); however, the results are controversial. Therefore, we conducted a meta-analysis with trial sequential analysis to evaluate a more accurate estimation of th...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2020.1769646
更新日期:2021-02-01 00:00:00
abstract::In the present study, we evaluated the effectiveness of a levamisole-based adjuvant (ADL) to enhance the ability of the Ag85B-ESAT6 fusion protein to boost immune responses after primary vaccination with recombinant bacillus Calmette-Guerin (rBCG) in Balb/c mice. The results were compared with that of the control adju...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2012.658940
更新日期:2012-01-01 00:00:00
abstract::Conjugated linoleic acid (CLA) is a dietary fatty acid which causes extensive remodeling and mast cell recruitment in the mouse mammary gland. Two CLA isomers, 9,11- and 10,12-CLA, have differing effects in vivo, with only 10,12-CLA increasing mast cell number. The purpose of this project is to test the hypothesis tha...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2011.647187
更新日期:2012-01-01 00:00:00
abstract::Objectives: Type 1 diabetes mellitus (T1D) has been disclosed to be associated with an elevated risk of cardiovascular disease (CVD), as well as increased risks of losing bone mass and progression of osteoporosis (OP). Osteoprotegerin (OPG), as a decoy receptor, has been demonstrated to play a critical role in bone me...
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doi:10.1080/08820139.2019.1710531
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abstract::The cardinal features of asthma include pulmonary inflammation and airway hyperresponsiveness (AHR). Classically, asthma, specifically allergic asthma, has been attributed to a hyperactive Th2 cell immune response. However, the Th2 cell-mediated inflammation model has failed to adequately explain many of the clinical ...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
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更新日期:2010-01-01 00:00:00
abstract::Mycobacterium tuberculosis (Mtb) inhibits dendritric cells (DC) function in order to delay T cell response. Furthermore, there is increasing evidence that genetic diversity of Mtb strains can affect their interaction with the immune system. Beijing genotype has attracted attention because of its high prevalence and mu...
journal_title:Immunological investigations
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doi:10.3109/08820139.2014.880120
更新日期:2014-01-01 00:00:00
abstract::We investigated the functional and subset surface marker characteristics of supramammary lymph node T cell populations at sites proximal and distal to the mammary region of goats repeatedly injected with heat-treated Staphylococcus aureus antigen (HK-SAC). Flow cytometric studies showed quantitative differences in CD4...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139209066184
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Mouse experimental autoimmune encephalomyelitis (EAE) is widely used model of multiple sclerosis (MS). The role of autoreactive CD4+ and CD8+ T cells in the development of mouse EAE has been demonstrated. However, little information is available about the relation between the frequency and reactivity of myel...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2017.1367008
更新日期:2018-01-01 00:00:00
abstract::Each functional gene illustrates the complexity of genetic predisposition to disease; however, it is difficult to bring out these traits with reference to autoimmune diseases like type 1 diabetes (T1D). To find out the genetic contribution of CTLA-4 + 49A/G, CTLA-4 -318C/T and CD28 + 17T/C polymorphisms toward T1D, th...
journal_title:Immunological investigations
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更新日期:2019-08-01 00:00:00
abstract::Rapid and accurate diagnosis of cytomegalovirus (CMV) infection is imperative with the advent of effective antiviral therapy (gangiclovir, foscarnet, CMV hyperimmune globin). Applications of conventional cell culture (CC), shell vial assay (SV), serological testing, antigenemia assay (AG) as well as molecular methods ...
journal_title:Immunological investigations
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更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:The pathological mechanisms associated with the occurrence and development of Behcet's disease (BD) are not yet known. Two large genome-wide association surveys revealed an association between interleukin (IL)-23R single nucleotide polymorphism and BD. This study aimed to investigate the association between ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2019.1698600
更新日期:2020-08-01 00:00:00
abstract::Mice were immunized with 14 free (i.e. not conjugated to any carrier) synthetic peptides representing the entire human hemoglobin alpha-chain. Antibodies against each peptide were determined using solid phase radioimmunoassay, both with free peptides and peptides coupled to a protein carrier as the coating antigen. It...
journal_title:Immunological investigations
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doi:10.3109/08820138909050764
更新日期:1989-08-01 00:00:00
abstract::VH4-34 gene encoded autoantibodies are elevated in systemic lupus erythematosus (SLE) and in other diseases associated with B-cell hyperproliferation/dysfunction. One of the autoantigens recognized by VH4-34-encoded antibodies are branched/linear poly N-acetyl lactosamine chains. Since the anti-carbohydrate response i...
journal_title:Immunological investigations
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更新日期:2015-01-01 00:00:00
abstract::Neutrophil chemotactic defects have been reported previously in patients with hyper-IgE syndrome. Bi-allelic mutations in dedicator of cytokinesis 8 (DOCK8) gene usually cause an autosomal recessive hyper-IgE syndrome phenotype. Data are lacking about expression of DOCK8 protein in neutrophils or the possible role of ...
journal_title:Immunological investigations
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更新日期:2019-05-01 00:00:00