Neutrophil Functions in Immunodeficiency Due to DOCK8 Deficiency.

abstract：BACKGROUND:Association studies of genes encoding cytokines that play an important role in inflammatory response represent one approach to finding type 1 diabetes (T1D) disease genes. The aim of this study was to investigate the association of single nucleotide polymorphisms (SNPs) within cytokine genes with T1D in a co...

journal_title：Immunological investigations

authors： Allam G,Nasr A,Talaat IM,Abuelsaad ASA,Bakheit AM,Nemenqani D,Alsulaimani AA

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Mouse experimental autoimmune encephalomyelitis (EAE) is widely used model of multiple sclerosis (MS). The role of autoreactive CD4+ and CD8+ T cells in the development of mouse EAE has been demonstrated. However, little information is available about the relation between the frequency and reactivity of myel...

journal_title：Immunological investigations

authors： Wan X,Pei W,Zhang Y,Zhang L,Shahzad KA,Xu T,Shen C

更新日期：2018-01-01 00:00:00

abstract：:Porphyromonas gingivalis (P.g) is the primary bacterial agent in many forms of chronic periodontitis. Since polymorphonuclear leukocytes (PMNs) are first-line responders to P.g.- induced inflammation, and fibrinogen is important for in vivo PMN in this disease, we have studied the effect of N-formyl-methionyl-leucyl-p...

journal_title：Immunological investigations

authors： Sahingur SE,Boehm TK,Sojar HT,Sharma A,De Nardin E

更新日期：2006-01-01 00:00:00

abstract：:We examined the blocking ability of poly(vinyl alcohol) (PVA) in enzyme immunoassays by coating polystyrene microtiter wells with PVA of different molecular weights (MW) and percent hydrolysis (%Hyd). Blocking ability was measured by the differences in non-specific binding of an anti-rabbit IgG-horseradish peroxidase ...

journal_title：Immunological investigations

authors： Rodda DJ,Yamazaki H

更新日期：1994-11-01 00:00:00

abstract：:Thrombocytopenia as a complicating event in human immunodeficiency infection is a rather common hematological disorder and in many aspects resembles idiopathic(immune) thrombocytopenic purpura (ITP). Consequently, treatment of severe cases is similar to treating ITP, but steroids should be administered with particular...

journal_title：Immunological investigations

authors： Nydegger UE,Castelli D

更新日期：1991-04-01 00:00:00

abstract：:The objectives were to determine the prevalence and clinical significance of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with juvenile idiopathic arthritis (JIA). Anti-CCP antibodies were checked by ELISA in 68 children with JIA, 38 males and 30 females with mean age of 10.6 (+/-4.02) years and...

journal_title：Immunological investigations

authors： Habib HM,Mosaad YM,Youssef HM

更新日期：2008-01-01 00:00:00

abstract：:Regulatory T cells (Tregs) play pivotal roles in limiting the duration and magnitude of immune response against infectious agents and self-antigens. This is accomplished through contact-dependent and -independent mechanisms that involve crosstalk between Treg cells and other immune and tissue-specific cell types. The ...

journal_title：Immunological investigations

authors： Wang K,Vella AT

更新日期：2016-11-01 00:00:00

abstract：:The expression of peripheral antigens in the thymus, known as promiscuous gene expression, has been implicated in T cell tolerance and autoimmunity. Here we identified thymic epithelial cells (TECs) as the main cell type that expresses a diverse range of tissue-restricted antigens (TRAs). The TECs of a common autoimmu...

journal_title：Immunological investigations

authors： Chen J,Yang W,Yu C,Li Y

更新日期：2008-01-01 00:00:00

abstract：:Although the T cell costimulatory molecules CD2 and CD28 are enriched within the immunological synapse (IS), it has been suggested that costimulatory molecules need not be localized to the contact site between a T cell and an antigen-presenting cell (APC) in order to costimulate T cell activation. To determine whether...

journal_title：Immunological investigations

authors： Watson CL,Furlong SJ,Hoskin DW

更新日期：2008-01-01 00:00:00

abstract：:A colorimetric microadhesion assay that allows the quantitative determination of carcinoembryonic antigen (CEA)-mediated homophilic cell adhesion to CEA immobilized on 96-well polyvinyl chloride plates is described. Chinese hamster ovary (CHO) cells transfected with a full-length CEA cDNA were used as indicator cells....

journal_title：Immunological investigations

authors： Kuwahara M,Kuroki M,Haruno M,Murakami M,Arakawa F,Oikawa S,Nakazato H,Matsuoka Y

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVE:Diabetic peripheral neuropathy (DPN) is one of late complications of diabetes mellitus. The aim of this study was to evaluate the association between variable number tandem repeat (VNTR) polymorphism in intron 3 of interleukin-4 gene and risk of DPN. METHODS:We examined 926 T2DM patients and 420 healthy cont...

journal_title：Immunological investigations

authors： Buraczynska M,Buraczynska K,Zukowski P,Ksiazek A

更新日期：2018-02-01 00:00:00

abstract：:A. actinomycetemcomitans is a facultative Gram-negative coccobacillus which has been implicated in the etiology and pathogenesis of localized juvenile periodontitis and has also been recognized for its potential to cause serious extraoral infections, particularly endocarditis. The polymorphonuclear neutrophil has been...

journal_title：Immunological investigations

authors： Wilson ME,Genco RJ

更新日期：1989-01-01 00:00:00

abstract：:Woodchucks infected with woodchuck hepatitis virus (WHV) represent the closest natural animal model to study the immunopathogenesis of liver injury caused by essentially noncytopathic, highly human specific hepatitis B virus (HBV). The importance of antiviral T cell response in induction of hepatitis and in control of...

journal_title：Immunological investigations

authors： Gujar SA,Michalak TI

更新日期：2005-01-01 00:00:00

abstract：:Dengue viruses (DV) infection is an important public health issue all over the world. Although the pathogenesis remains unclear, the overwhelmingly triggered immune responses have been consistently observed. Recently, we and other researchers demonstrated that the natural hosts for DV are dendritic cells (DC), the pri...

journal_title：Immunological investigations

authors： Ho LJ,Shaio MF,Chang DM,Liao CL,Lai JH

更新日期：2004-01-01 00:00:00

abstract：:DNA vaccine represents a powerful approach for prevention of avian H5N1 influenza infection. Yet, DNA vaccine-induced immune responses might be limited by the short duration of antigen expression. As a strategy to enhance adaptive immune responses elicited by a hemagglutinin 5 (H5) DNA vaccine, we explored the effect ...

journal_title：Immunological investigations

authors： Tabatabaeizadeh SE,Bassami MR,Haghparast A,Dehghani H

更新日期：2015-01-01 00:00:00

abstract：:In this study we demonstrate a differential transcription of H-2K and H-2D class-I genes in two different tumor cell clones; one is highly metastatic (IE-7) and the other is not metastatic (IC-9), both derived from the same fibrosarcoma, T-10, induced in an (H-2b x H-2k)F1 mouse. The expression of the two parental H-2...

journal_title：Immunological investigations

authors： Aboud M,Amitai H,Huleihel M,Har-vardi I,Gopas J,Segal S

更新日期：1991-08-01 00:00:00

abstract：:Spleen cells of C57BL/6 mice injected with corticosterone were compared with cells from mice injected with saline in their ability to respond to the mitogens PHA, Con A, and LPS. Both unseparated cells and cells separated into T-enriched and B-enriched fractions were studied. After either seven daily injections or fou...

journal_title：Immunological investigations

authors： Stevenson JR,Kreiling JA,Taylor R

更新日期：1989-10-01 00:00:00

abstract：:The bacterial superantigen Staphylococcal enterotoxin-A (SEA), produced by some strains of Staphylococcus aureus, causes proliferation of cytotoxic T-lymphocytes and cytokine production in vivo. SEA has been shown to be highly efficient for antibody-targeted superantegen immunotherapy for different tumor models. A can...

journal_title：Immunological investigations

authors： Mondal TK,Bhatta D,Biswas S,Pal P

更新日期：2002-02-01 00:00:00

abstract：:Monocyte chemoattractant protein 1 (MCP-1) plays an important role in the development of periodontitis. The purpose of this investigation was to evaluate association of the  MCP-1 gene polymorphism with chronic periodontitis in patients with end-stage renal disease (ESRD). One hundred fifty ESRD patients with chronic ...

journal_title：Immunological investigations

authors： Ksiazek K,Buraczynska M

更新日期：2020-11-01 00:00:00

abstract：:Plasmodium falciparum CTL epitope minigenes containing HLA-A2 and HLA-B7 subtype supermotifs were cloned into a plasmid expression vector; this expression was measured in eight human HLA class I molecule specific cell lines. Three assays for in vitro antigen presentation analysis were developed to examine the cross-bi...

journal_title：Immunological investigations

authors： Tang Y,Lin Y,Mao Y,Dong M,Wang H

更新日期：2003-02-01 00:00:00

abstract：:The cardinal features of asthma include pulmonary inflammation and airway hyperresponsiveness (AHR). Classically, asthma, specifically allergic asthma, has been attributed to a hyperactive Th2 cell immune response. However, the Th2 cell-mediated inflammation model has failed to adequately explain many of the clinical ...

journal_title：Immunological investigations

authors： Durrant DM,Metzger DW

更新日期：2010-01-01 00:00:00

abstract：:This study was conducted to evaluate the adjuvant potential of sulfated Radix Cyathulae officinalis Kuan polysaccharides (sRCPS) and their effects on specific cellular and humoral immune responses to hepatitis B subunit vaccine in mice. Our data demonstrated that sRCPS significantly promoted the rHBsAg-specific IgG, I...

journal_title：Immunological investigations

authors： Feng H,Fan J,Du X,Song Z,Wang Z,Han X,Zhao B,Liu J

更新日期：2015-01-01 00:00:00

abstract：:Whole-body hyperthermia (WBH) has been used as an adjunct approach to radio-/ chemotherapy for tumor therapy for many years. However, the molecular mechanism underlying the enhancement of tumor control is not clearly understood. It has been hypothesized that WBH might activate immune system by inducing the expression ...

journal_title：Immunological investigations

authors： Zhang H,Wang W,Zhang S,Huang W

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Changes in cytokine expression have been frequently found in patients with inflammatory bowel disease (IBD). Cytokine values outside the normal range may be somewhat related to common polymorphisms within cytokine genes. OBJECTIVE:The present study was designed to investigate the possible association betwee...

journal_title：Immunological investigations

authors： Ebrahimi Daryani N,Saghazadeh A,Moossavi S,Sadr M,Shahkarami S,Soltani S,Farhadi E,Rezaei N

更新日期：2017-10-01 00:00:00

abstract：:Objectives: Ataxia-telangiectasia (A-T) is an autosomal recessive neurodegenerative disorder with multisystem involvement caused by homozygous or compound heterozygous mutations in the ataxia telangiectasia mutated (ATM) gene which encodes a serine/threonine protein kinase. The aims of this study were to investigate c...

journal_title：Immunological investigations

authors： Amirifar P,Mozdarani H,Yazdani R,Kiaei F,Moeini Shad T,Shahkarami S,Abolhassani H,Delavari S,Sohani M,Rezaei A,Hassanpour G,Akrami SM,Aghamohammadi A

更新日期：2021-02-01 00:00:00

abstract：:The processing of antigenic peptides for presentation by MHC molecules to T cells, may depend upon the function of a second, consensus sequence in or near the T cell-presented epitope. One such processing-regulating sequence appears to be composed of amino acids Leu, Ile, Val, Phe, and Met recurring in a fashion to fo...

journal_title：Immunological investigations

authors： Goldschmidt TG,Reyes VE,You G,Nelson DJ,Reisert PS,Anderson J,Mole J,Humphreys RE

更新日期：1993-02-01 00:00:00

abstract：:DNA vaccines have been widely used to induce immune responses against molecular targets. In this study, we explored the possibility of using DNA vaccine combined with the immunosuppressant FK506 (tacrolimus) to antigen-specifically suppress unwanted immune responses and prevent autoimmune ovarian disease. To that end,...

journal_title：Immunological investigations

authors： Kang Y,Zheng G,Chen A,Wang J,Hu Y,Li J,Zhang J,Gao W,Fu H,Xia G,Wang B

更新日期：2012-01-01 00:00:00

abstract：:White cell infiltration of solid tumors is an important prognostic indicator in malignant disease. Although macrophage infiltration is associated with good outcome in colorectal cancer, a high macrophage content is associated with poor prognosis in breast cancer. Suppressor macrophages prevent T cell activation in nor...

journal_title：Immunological investigations

authors： Toomey D,Harmey J,Condron C,Kay E,Bouchier-Hayes D

更新日期：1999-01-01 00:00:00

abstract：:To determine the main mediators for mouse anaphylactic shock, the suppression of active anaphylactic shock by cyproheptadine, an antagonist of histamine/serotonin, and CV-6209, an antagonist of platelet-activating factor (PAF), was systematically evaluated using various mouse strains. The suppression was quite heterog...

journal_title：Immunological investigations

authors： Kimura S,Watanabe A,Nagata M,Niinomi Y,Harada M

更新日期：1996-09-01 00:00:00

abstract：:Plasmin activity induced by different concentrations of added urokinase (UK) in serum from 20 patients with AIDS (P) and 10 healthy control (HC) subjects was measured using the fibrin plate assay. 125I-fibrin coated 24 well plates were exposed to UK (0.34-6.8 ng/ml) or to trypsin (T) (2.5 micrograms/ml) in the presenc...

journal_title：Immunological investigations

authors： Auci DL,Durkin HG,Murali MR

更新日期：1992-07-01 00:00:00