Abstract:
:Competitive binding to polystyrene-bound antigens showed that human rye Group I (rye I)-specific IgG recognize the same three distinct epitopes of rye I as three monoclonal antibodies directed against the same antigens. Anti-idiotypic antibodies against one of the monoclonal antibodies (290A-167) inhibit completely the reaction between rye I and the relevant monoclonal antibodies but do not affect the reaction between other monoclonal antibodies (348A-6 and 539A-6) and the antigens. Furthermore, rabbit anti-idiotypic antibodies produced against F(ab' )2 of human rye I-specific IgG could inhibit the reaction between two monoclonal antibodies (290A-167 and 539A-6) and the relevant antigens. Those results were obtained by competitive binding to polystyrene or to nitrocellulose-bound antigens. These data indicate a cross-reactivity of idiotypic determinants between human rye I-specific IgG and mouse monoclonal antibodies, which implies structural similarity in the V gene coding for the variable region of the antibody.
journal_name
Immunol Investjournal_title
Immunological investigationsauthors
Mourad W,Hébert Jdoi
10.3109/08820138609036364subject
Has Abstractpub_date
1986-12-01 00:00:00pages
801-11issue
8eissn
0882-0139issn
1532-4311journal_volume
15pub_type
杂志文章abstract::The antiviral activity of cell-associated, non-elutable recombinant human gamma interferon (rHuIFN-gamma) was neutralized by antibody. The neutralization of cell-associated rHuIFN-gamma was maximal through 2 h (60-100%) and declined through 8 h (20-40%). Concomitantly, the antiviral activity of cell-associated [Met-Gl...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139009052977
更新日期:1990-10-01 00:00:00
abstract::DNA vaccine represents a powerful approach for prevention of avian H5N1 influenza infection. Yet, DNA vaccine-induced immune responses might be limited by the short duration of antigen expression. As a strategy to enhance adaptive immune responses elicited by a hemagglutinin 5 (H5) DNA vaccine, we explored the effect ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2014.988718
更新日期:2015-01-01 00:00:00
abstract::In the last 10 years many of the superantigens of the microbial world have been defined and the mechanisms of cellular interaction between lymphocytes and antigen presenting cells has been elucidated in great detail. The consequences of superantigen stimulation of the immune system, though less well defined, can be co...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820139709048933
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Association studies of genes encoding cytokines that play an important role in inflammatory response represent one approach to finding type 1 diabetes (T1D) disease genes. The aim of this study was to investigate the association of single nucleotide polymorphisms (SNPs) within cytokine genes with T1D in a co...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2017.1416398
更新日期:2018-04-01 00:00:00
abstract::The relationship between antibody avidity, measured by the dissociation of the antigen-antibody bond in antigen excess, and antibody affinity was studied. Complexes of radiolabelled antigen and antibody of known affinity were prepared in vitro and allowed to stand for seven days to reach equilibrium. Then nonlabelled ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709030567
更新日期:1987-04-01 00:00:00
abstract::Functional defects of polymorphonuclear leukocytes can lead to clinical immunodeficiency. Understanding these conditions requires a knowledge of normal polymorph physiology and the means to analyse various aspects of polymorph function. Primary diseases of polymorph function are rare, whereas disorders secondary to ot...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820138809055721
更新日期:1988-04-01 00:00:00
abstract::Adoptive immunotherapy is an attractive cancer treatment modality due to its capacity to target primary and metastatic lesions with large numbers of tumor-reactive, cytotoxic lymphocytes. The inability of fully armed lymphocytes to traffic into sites of tumor has been proposed as a causal factor for the minimal succes...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130701712867
更新日期:2007-01-01 00:00:00
abstract::The expression of peripheral antigens in the thymus, known as promiscuous gene expression, has been implicated in T cell tolerance and autoimmunity. Here we identified thymic epithelial cells (TECs) as the main cell type that expresses a diverse range of tissue-restricted antigens (TRAs). The TECs of a common autoimmu...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130801967841
更新日期:2008-01-01 00:00:00
abstract::Very little is known about the effects of acute psychological stress on the production of reactive oxygen species (ROS) by human phagocytic cells and the interplay between subjectively perceived stress, mediating hormones, variations in the number of peripheral leukocytes and ROS production. We measured psychological ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-120004800
更新日期:2002-05-01 00:00:00
abstract::Jeevaneeya rasayana is an ayurvedic polyherbal formulation, with antirheumatic potential. The present study investigates the therapeutic efficacy of isolated total alkaloid fraction of Jeevaneeya Rasayana (AJR) in treating rheumatoid arthritis in a rat model of Adjuvant-induced arthritis (AIA). Paw swelling, inflammat...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2014.936937
更新日期:2015-01-01 00:00:00
abstract::Experimental autoimmune uveoretinitis (EAU) was induced in rats by immunization with bovine interphotoreceptor retinoid-binding protein (IRBP) and studied by immunohistochemistry. In general, the IRBP induction of inflammatory cellular components and expression of immune-related antigens on various non-lymphoid cells ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709055713
更新日期:1987-03-01 00:00:00
abstract::Patients with metastatic breast carcinoma (BCa) have defective peripheral blood lymphocyte (PBL) responsiveness to mitogenic and antigenic stimulation. In the following experiments, glycopeptides were isolated from the pronase digests of breast carcinoma tissue. After elution from Sephadex G-50, glycopeptides from BCa...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138809055715
更新日期:1988-03-01 00:00:00
abstract::A previous study has demonstrated that both interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) were needed to induce the production of nitric oxide (NO) in BNL CL.2 cells, murine embryonic liver cells. We here demonstrate that when BNL CL.2 cells were cultured with serum-free medium, they were induced to produc...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139909061144
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:The objective of this study was to investigate serum levels of immunosuppressive cytokines TGF beta 1 and VEGF and count of immune cells in peripheral blood in stage II and III colorectal cancer patients. METHODS:Blood samples were collected from 22 colorectal patients and 25 healthy controls before the sta...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2018.1480030
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Grass pollen is a major cause of allergy throughout the world. The only treatment targeting the causes and not only the symptoms of allergy is specific immunotherapy (IT). A number of controlled trials demonstrated the efficacy of IT in grass pollen allergic subjects, most using extracts of multiple grasses ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820131003796876
更新日期:2010-01-01 00:00:00
abstract::Background: Polymorphisms in T-cell immunoglobulin and mucin domain 3 (TIM-3) gene have been implicated in susceptibility to autoimmune diseases (ADs) with inconsistent results. The aim of this study was to perform meta-analyses for clarifying the relationship between them. Methods: All relevant case-control studies w...
journal_title:Immunological investigations
pub_type: 杂志文章,meta分析
doi:10.1080/08820139.2019.1599009
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Mouse experimental autoimmune encephalomyelitis (EAE) is widely used model of multiple sclerosis (MS). The role of autoreactive CD4+ and CD8+ T cells in the development of mouse EAE has been demonstrated. However, little information is available about the relation between the frequency and reactivity of myel...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2017.1367008
更新日期:2018-01-01 00:00:00
abstract::Polyclonal immune monkey serum raised against schizonts of Plasmodium knowlesi (H-strain) showed the presence of antibodies to lactate dehydrogenase (LDH) of P. knowlesi by immunodot enzyme staining method. The anti-LDH antibodies are most probably directed towards an epitope distinct from the catalytic site as shown ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138809030584
更新日期:1988-08-01 00:00:00
abstract::It has become apparent that extreme environmental conditions of Antarctic continent alters many immune responses. The present study was conducted on 28th Indian Antarctic expeditioners. The investigations were carried out to explore the effect of multiple stresses like isolation, cold and UV exposure on human immunity...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2010.494194
更新日期:2010-01-01 00:00:00
abstract::Whole-body hyperthermia (WBH) has been used as an adjunct approach to radio-/ chemotherapy for tumor therapy for many years. However, the molecular mechanism underlying the enhancement of tumor control is not clearly understood. It has been hypothesized that WBH might activate immune system by inducing the expression ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-200064460
更新日期:2005-01-01 00:00:00
abstract::Factors that suppress natural killer (NK) cell activity were examined in a random sample of 73 schizophrenic patients. NK activity in these patients were compared with 25 healthy age, sex and race matched controls. The mean percent of NK activity was 21% in the schizophrenic group compared with 30% percent in the cont...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139409066822
更新日期:1994-08-01 00:00:00
abstract::Immunological parameters previously shown to constitute an increased risk for progression towards AIDS have been observed in clinically asymptomatic individuals considered to be at risk for this syndrome. These parameters include severely decreased numbers of T helper cells (count below 400/mm3 blood for CD4+ cells we...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138809055726
更新日期:1988-04-01 00:00:00
abstract::Regulatory T cells (Tregs) play pivotal roles in limiting the duration and magnitude of immune response against infectious agents and self-antigens. This is accomplished through contact-dependent and -independent mechanisms that involve crosstalk between Treg cells and other immune and tissue-specific cell types. The ...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.1080/08820139.2016.1197242
更新日期:2016-11-01 00:00:00
abstract::The extent of immunological adjuvancy of silicone-gel, from mammary implants, up to now, has not been determined definitively. This study compares the immune potentiation effects of silicone-gel with that of Freund's adjuvant, using bovine serum albumin (BSA) as the test antigen in rats. Sixty, 250 gr., male Sprague D...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139309063397
更新日期:1993-03-01 00:00:00
abstract::Woodchucks infected with woodchuck hepatitis virus (WHV) represent the closest natural animal model to study the immunopathogenesis of liver injury caused by essentially noncytopathic, highly human specific hepatitis B virus (HBV). The importance of antiviral T cell response in induction of hepatitis and in control of...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::The critical contribution of CD4+CD25+Foxp3+ T-regulatory cells (Treg) to immune suppression in the tumor microenvironment is well-established. Whereas the mechanisms that drive the generation and accumulation of Treg in tumors have been an active area of study, the information on their origin and population dynamics ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2016.1220390
更新日期:2016-11-01 00:00:00
abstract::IL-3-like activity (IL-3-LA) is a growth factor that stimulates stem cell maturation. We examined the production of IL-3-LA by peripheral blood mononuclear cells of 10 patients with relapsing-remitting multiple sclerosis (MS) following one year of treatment with intravenous immunoglobulins (IVIG). The results were com...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139509060704
更新日期:1995-08-01 00:00:00
abstract::Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. Matrix metalloproteinases (MMPs) play an important role in breakdown of blood-brain barrier, transmigration, and invasion of immune cells and formation of MS lesions. The aim of present study was to investigate the influence of MMP-...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2016.1180303
更新日期:2016-08-01 00:00:00
abstract::The purpose of this presentation was to demonstrate that the red blood cell is not a hapless sac of hemoglobin and that much research is still needed for better understanding of its complexities. After a brief historical introduction the following subjects are presented: 1). Phosphofructokinase is the rate limiting st...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820139509062760
更新日期:1995-01-01 00:00:00
abstract::A. actinomycetemcomitans is a facultative Gram-negative coccobacillus which has been implicated in the etiology and pathogenesis of localized juvenile periodontitis and has also been recognized for its potential to cause serious extraoral infections, particularly endocarditis. The polymorphonuclear neutrophil has been...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820138909112237
更新日期:1989-01-01 00:00:00