Abstract:
:Developmental language disorders are characterized by a maturational trajectory that deviates or lags that of normal children. Given the wide variation in the rate of normal language development, diagnosis and classification of these disorders poses severe problems for the clinician. Our laboratory has been searching for anatomical signatures that could aid the development of a neurobiologically based classification. Quantitative analysis of the magnetic resonance imaging (MRI) brain scans of a series of samples of children and adults with reading and language disorders has identified two clusters with contrasting anatomical and reading profiles. Individuals with small symmetrical brain structures tend to have deficits in multiple domains of written and oral language whereas those with larger asymmetrical structures are more likely to have the isolated phonological deficits seen in adults with compensated dyslexia. Surprisingly, the anatomical risk factors that define these clusters do not form a continuum of increasing severity but deviate in opposite directions from normal. Individuals with moderate brain size and asymmetry typically demonstrate the best overall performance. Further research should determine if phonological impairments in the two clusters are associated with differing genetic and environmental risk factors requiring different types of intervention.
journal_name
Dev Neuropsycholjournal_title
Developmental neuropsychologyauthors
Leonard CM,Eckert MAdoi
10.1080/87565640802418597subject
Has Abstractpub_date
2008-01-01 00:00:00pages
663-81issue
6eissn
8756-5641issn
1532-6942pii
905451873journal_volume
33pub_type
杂志文章,评审abstract::The objective of the study was to determine the prevalence of low scores in a diverse Latin American population for two neuropsychological commonly used tests to evaluate executive functions and to compare the number of low scores obtained using normative data from a Spanish-speaking population from Latin America vers...
journal_title:Developmental neuropsychology
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更新日期:2021-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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