Risk factor forlung infection in recipients after liver transplantation:a meta-analysis.

Abstract:

OBJECTIVE:Lung infection (LI) often occurs in patients with liver transplantation (LT). This meta-analysis was conducted to determine the risk factors associated with LI after LT. METHODS:We retrieved relevant research published as of February 2020 from 8 electronic databases. The studieswere reviewed against the inclusion and exclusion criteria. The Z test was used to determine the combined odds ratio (OR) or thestandardized mean difference (SMD) ofthe risk factors. We used the OR and its corresponding 95% confidence interval (CI) or theSMD and its corresponding 95% CI to identify significant differences in risk factors. RESULTS:A total of 9 studies were included, comprising a total of 1624 recipients. Six risk factors associated with LI were identified after LT: end-stage liver disease (MELD score) (SMD = 0.40), Child-Pugh class C (OR = 3.00), intensive care unit (ICU) hospital stay (SMD = 1.35), mechanical ventilation (SMD = 1.03), bilirubin (SMD = 0.39), and atelectasis (OR = 7.28). CONCLUSION:Although certain risk factors have been identified as important factors for LI after LT, which may provide a basis for clinical prevention, a well-designed prospective study should be conducted to validate the findings of this study.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Zhang J,He Q,Du L,Ji R,Yuan L,Zhang H,Yuan X,Shen L,Li Y

doi

10.1111/aor.13826

subject

Has Abstract

pub_date

2020-09-26 00:00:00

eissn

0160-564X

issn

1525-1594

pub_type

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