Abstract:
AIMS:Medication adherence and persistence are important determinants of treatment success in type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis evaluated the real-world adherence, persistence, and in-class switching among patients with T2DM prescribed dipeptidyl peptidase-4 (DPP4) inhibitors. METHODS:MEDLINE, EMBASE, Cochrane Library, PsychINFO, and CINAHL were searched for relevant observational studies published in the English language up to 20 December 2019. This was supplemented by manual screening of the references of included papers. Random-effects meta-analysis was performed. RESULTS:Thirty-four cohort studies involving 594,138 patients with T2DM prescribed DPP4 inhibitors from ten countries were included. The pooled proportion adherent (proportion of days covered (PDC) or medication possession ratio (MPR) ≥ 0.80) was 56.9% (95% confidence interval [CI] 49.3-64.4) at one year and 44.2% (95% CI 36.4-52.1) at two years. The proportion persistent with treatment decreased from 75.6% (95% CI 71.5-79.5) at six months to 52.8% (95% CI 51.6-59.8) at two years. No significant differences in adherence and persistence were observed between individual DPP4 inhibitors. At one year, just 3.2% (95% CI 3.1-3.3) of patients switched from one DPP4 inhibitor to another. Switching from saxagliptin and alogliptin to others was commonest. CONCLUSIONS:Adherence to and persistence with DPP4 inhibitors is suboptimal but similar across all medications within the class. While in-class switching is uncommon, saxagliptin and alogliptin are the DPP4 inhibitors most commonly switched. Interventions to improve treatment adherence and persistence among patients with T2DM prescribed DPP4 inhibitors may be warranted.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Ogundipe O,Mazidi M,Chin KL,Gor D,McGovern A,Sahle BW,Jermendy G,Korhonen MJ,Appiah B,Ademi Z,De Bruin ML,Liew D,Ofori-Asenso Rdoi
10.1007/s00592-020-01590-wsubject
Has Abstractpub_date
2021-01-01 00:00:00pages
39-46issue
1eissn
0940-5429issn
1432-5233pii
10.1007/s00592-020-01590-wjournal_volume
58pub_type
杂志文章abstract:AIMS:To evaluate the patients' perceptions of telemedicine visits during COVID-19 lockdown and their level of anxiety about COVID and diabetic foot (DF). METHODS:In May 2020, we contacted by phone all the patients who underwent in March and April to remote monitoring visits for DF during the lockdown for COVID-19, wit...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-020-01653-y
更新日期:2021-01-13 00:00:00
abstract:BACKGROUND:International comparisons of diabetes-related lower extremity amputation rates are still hampered by different criteria used for data collection and analysis. We aimed to evaluate trends and variation of major/minor amputations, using agreed definitions adopted by the Organization for Economic Cooperation an...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-019-01423-5
更新日期:2020-03-01 00:00:00
abstract::The purification of large numbers of human pancreatic islets remains one of the limiting factors in islet transplantation. This paper describes and validates a method for accurately and reproducibly determining the density of islets and exocrine tissue in pancreatic digest on the basis of their isopycnic distribution ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00572864
更新日期:1993-01-01 00:00:00
abstract::The objective of the study was to evaluate the association between infectious diseases and other events pertaining to childhood medical history and type 1 diabetes. A case-control study was carried out, taking as cases 159 type 1 diabetic patients (0-29 years) recorded from 1988 to 2000 within the population registry ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-007-0235-9
更新日期:2007-03-01 00:00:00
abstract:AIMS:Our aims were to investigate in several large samples, with a wide range of adiposity, whether: (1) the effect of BMI on insulin sensitivity is different between sexes; (2) also waist circumference plays a sex-specific role on insulin sensitivity; and (3) serum adiponectin and resistin are mediators of such sex-di...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0804-2
更新日期:2015-10-01 00:00:00
abstract::We determined in non-diabetic persons the risk of fasting and non-fasting glucose levels for pre-diabetes, diabetes, and coronary heart disease (CHD), including the roles of serum C-reactive protein (CRP) and HDL cholesterol, and delineated risk profiles of the pre-diabetic states. Over 7¼ years, 2,619 middle-aged Tur...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-011-0313-x
更新日期:2013-08-01 00:00:00
abstract::The aim of the study is to evaluate the prevalence and incidence of myocardial dysfunction (MD) and heart failure (HF) in long-lasting (≥10 years) type 1 diabetes without cardiovascular disorders or with hypertension or coronary heart disease (CHD). The study included 1,685 patients with type 1 diabetes (mean baseline...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-013-0455-0
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Despite advances in the medical management of type 1 diabetes mellitus (T1DM), for many, glycaemic control remains substandard. Other factors are clearly important in determining success, or lack thereof, with diabetes management. With this in mind, we have investigated whether family CHAOS may provide a nov...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0736-x
更新日期:2016-02-01 00:00:00
abstract:AIMS:Fetuin-A has been linked to insulin resistance and obesity. Its role in the pathogenesis of type 2 diabetes (T2DM) has also been discussed. We aimed to investigate the prospective association of fetuin-A and the risk of T2DM in a systematic review and meta-analysis. METHODS:A systematic search of studies from the...
journal_title:Acta diabetologica
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00592-017-1068-9
更新日期:2018-01-01 00:00:00
abstract::Anorectic patients who achieve complete recovery from the eating disorder can obtain a favorable psychosocial outcome but the long-term nutritional outcome is ill-defined. We investigated the time course of total and distrectual body composition during and after refeeding in 32 female patients with anorexia nervosa. P...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-004-0139-x
更新日期:2004-03-01 00:00:00
abstract::The title "Plasma fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus" should be replaced by "Serum fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus". ...
journal_title:Acta diabetologica
pub_type: 已发布勘误
doi:10.1007/s00592-018-1177-0
更新日期:2018-10-01 00:00:00
abstract::Several conditions have been described to cause osteoporosis, including diabetes mellitus. While the relationship between type 1 diabetes and osteopenia is well documented in the literature, data on the presence of this complication in type 2 diabetes have not been well established. We studied a population composed of...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920050142
更新日期:1999-06-01 00:00:00
abstract::Post-prandial hyperglycemia is considered a relevant therapeutic target in type 2 diabetic patients, and it could represent per se an independent risk factor for diabetic complications. Aim of the present systematic review is to collect and summarize evidence from observational studies on the relationship between post...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-011-0355-0
更新日期:2012-08-01 00:00:00
abstract::The recent efforts in the study of fetal compartments could help us to a better recognition of the proper fetal growth and well being. Fat content correlates directly with energy stores. Fat mass and lean body mass is often used in the nutritional assessment of the individual. Moreover chromosomal abnormalities may be...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-003-0033-y
更新日期:2003-10-01 00:00:00
abstract::We have measured protein phosphatase (PP) activity in crude homogenates as well as in the total 105.000 x g supernatant and precipitate fractions from normal rat pancreatic islets. On the basis of the inhibition produced by either 1 nM or 1 microM okadaic acid, both PP1 and PP2A activity were present in crude islet ho...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920050057
更新日期:1997-03-01 00:00:00
abstract:AIMS:Radiolabeled Exendin-4 has been proposed as suitable imaging marker for pancreatic beta cell mass quantification mediated by Glucagon-like peptide-1 receptor (GLP-1R). However, noticeable species variations in basal pancreatic uptake as well as uptake reduction degree due to selective beta cell ablation were obser...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-017-1046-2
更新日期:2017-11-01 00:00:00
abstract::This study examined whether or not changes in plasma concentrations of motilin and other gastrointestinal hormones known to affect gastric motility are associated with the accelerated gastric emptying seen during hypoglycaemia. While studying gastric emptying by scintigraphy in eight healthy subjects, the plasma conce...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920050073
更新日期:1997-10-01 00:00:00
abstract::Recent studies have reported that elevated proinsulin levels are indicative of an increased cardiovascular risk. Renal proximal tubular cells represent a major site for the metabolism of insulin-like hormones after glomerular filtration into the tubular lumen. To determine the binding and degradation of proinsulin in ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00569428
更新日期:1996-07-01 00:00:00
abstract::Correct classification of diabetic patients in adulthood at the time of diagnosis is often difficult. Some may be initially diagnosed as having non-insulin-dependent diabetes mellitus and be treated with diet and/or oral hypoglycaemic agents (OHA) but later require insulin treatment. Islet cell antibodies and antibodi...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00571567
更新日期:1996-12-01 00:00:00
abstract::The aim of this research was the evaluation of polymorphonuclear leukocyte (PMN) membrane fluidity in subjects with insulin resistance. Insulin sensitivity, in fact, may be influenced by plasma membrane fluidity. We enrolled 19 subjects with insulin resistance previously demonstrated during an euglycemic hyperinsuline...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920070029
更新日期:2000-03-01 00:00:00
abstract::Elevated plasma CT-pro-vasopressin (copeptin) has been described as biomarkers for type 2 diabetes (T2D) and the metabolic syndrome (MetS), which, however, was not confirmed by all studies. Here, we analyzed the association of copeptin with T2D, MetS and MetS components in the population-based KORA F4 study. Plasma co...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-014-0609-8
更新日期:2015-02-01 00:00:00
abstract::Although the polymorphisms of PTPN22 and the variants of CTLA-4 have been reported to be the susceptibility genes, which increased risk of latent autoimmune diabetes in adults (LADA), the results remained inconclusive. The aim of this meta-analysis was to evaluate the association between the polymorphisms of two genes...
journal_title:Acta diabetologica
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00592-014-0613-z
更新日期:2014-10-01 00:00:00
abstract::Concentrations of soluble receptors for tumor necrosis factor (p55 and p75) strongly correlate with clinical stage and progression of infectious diseases, and may be useful in monitoring autoimmune diseases. However, the role of soluble TNF receptors in insulin-dependent diabetes mellitus (type 1 DM) is not clear. We ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920050152
更新日期:1999-06-01 00:00:00
abstract::A meta-analysis was performed in order to test the hypothesis that Japanese have a greater amount of abdominal visceral fat (AVF) relative to abdominal subcutaneous fat (ASF) than Caucasians. Data were derived from published studies that included mean values for AVF and ASF areas, measured using computed tomography, a...
journal_title:Acta diabetologica
pub_type: 杂志文章,meta分析
doi:10.1007/s00592-003-0093-z
更新日期:2003-10-01 00:00:00
abstract::The duration of diabetes before puberty is not considered relevant to the future development of complications. To evaluate the effects of diabetes on the neural retina, we analysed macular function by steady-state focal electroretinography in 20 prepubescent diabetic children without vascular retinopathy and in 39 sex...
journal_title:Acta diabetologica
pub_type: 临床试验,杂志文章
doi:10.1007/BF00570544
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:Emerging adulthood is a challenging period for diabetes management. Our aim was to determine whether a dedicated transition clinic for emerging adults with type 1 diabetes can improve glycemic control and visit attendance. METHODS:An observational study of 53 emerging adults (30 males) treated during 2010-2...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0734-z
更新日期:2016-02-01 00:00:00
abstract::We investigated whether food supplementation within the first year life or age at introduction of gluten-containing foods influenced the risk of developing islet autoimmunity and type 1 diabetes. A total of 2,291 children with a family history of type 1 diabetes were prospectively followed from birth for 28,983 patien...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-014-0628-5
更新日期:2015-06-01 00:00:00
abstract::Although reactive oxygen species (ROS) contribute to glucose intolerance induced by the renin-angiotensin system (RAS) is well documented, the role of the newly discovered pathway of RAS, angiotensin (Ang)-(1-7)/Mas axis, in this process remains unknown. Here, we examined the effect of Ang-(1-7) on oxidative stress an...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-011-0348-z
更新日期:2012-08-01 00:00:00
abstract::Genetic linkage studies of families with early-onset type 2 diabetes have facilitated the identification of diabetes-susceptibility genes. In order to assess the feasibility of using linkage approaches to identify genes responsible for the development of type 2 diabetes in Japanese subjects, we examined our clinical r...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00581039
更新日期:1995-03-01 00:00:00
abstract::Bovine insulin was glycated by in vitro incubation with 20-220 mM D-glucose for 1-48 h. The percentage of glycation was dependent on time, glucose concentration, temperature and pH, attaining values up to 28%. Glucose-lowering activities of glycated and control (non-glycated) insulin preparations were assessed in mice...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920050086
更新日期:1997-12-01 00:00:00