Abstract:
:This study examined whether or not changes in plasma concentrations of motilin and other gastrointestinal hormones known to affect gastric motility are associated with the accelerated gastric emptying seen during hypoglycaemia. While studying gastric emptying by scintigraphy in eight healthy subjects, the plasma concentrations of glucagon, adrenaline, motilin, gastrin, neuropeptide Y and somatostatin were measured during normoglycaemia and hypoglycaemia with simultaneous infusion of either atropine or saline. Blood glucose concentrations were checked by an insulin-glucose clamp. The plasma levels of glucagon and adrenaline increased markedly during both hypoglycaemic examinations compared with normoglycaemia. Neither motilin nor any of the other hormones displayed considerable changes during hypoglycaemia with and without atropine compared with normoglycaemia. No further information about the mechanisms behind the accelerated gastric emptying rate during hypoglycaemia was obtained by analysing motilin and the other gastrointestinal hormones.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Schvarcz E,Palmér M,Aman J,Berne Cdoi
10.1007/s005920050073subject
Has Abstractpub_date
1997-10-01 00:00:00pages
194-8issue
3eissn
0940-5429issn
1432-5233journal_volume
34pub_type
杂志文章abstract:AIMS:To evaluate feasibility and effectiveness on short-term blood glucose control of using glycaemic load counting (GLC) versus carbohydrate counting (CC) for prandial insulin dosing in patients with type 1 diabetes (T1D). METHODS:Nine T1D patients on insulin pump, aged 26-58 years, HbA1c 7.7 ± 0.8 % (61 ± 8.7 mmol/m...
journal_title:Acta diabetologica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00592-015-0716-1
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Emerging adulthood is a challenging period for diabetes management. Our aim was to determine whether a dedicated transition clinic for emerging adults with type 1 diabetes can improve glycemic control and visit attendance. METHODS:An observational study of 53 emerging adults (30 males) treated during 2010-2...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0734-z
更新日期:2016-02-01 00:00:00
abstract::Kidney volume was measured during pregnancy in insulin-dependent diabetic women by an ultrasound technique and prognostic value of these measurements evaluated. A prospective study was performed on 87 pregnant women with insulin-dependent diabetes attending the maternity clinic of Aarhus Kommunehospital. Patients with...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00576254
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:Psychosocial factors like diabetes distress and social support, as well as the presence of complications, affect an individual's self-management ability; however, their role in adherence behaviours is not yet clear. We examined the role of psychosocial factors and complications in non-adherence behaviours in...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-020-01609-2
更新日期:2020-11-19 00:00:00
abstract::We report the results of bone mineral density (BMD) measurements in type 2 diabetic patients, in comparison to healthy controls. In this prospective study, a total of 277 subjects (aged 30-60 years) with type 2 diabetes mellitus, outpatients at the Cukurova Medical School Hospital, were evaluated for BMD at L(1)-L(4) ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920300014
更新日期:2003-06-01 00:00:00
abstract::Aim of this study was to formulate an index for glucose effectiveness (Sg), SgIo, based on 3-point (0, 30 and 120 min) 75 g oral glucose tolerance test (OGTT). The equation for SgI(O) was developed in the Chikuma cohort (n = 502). Firstly, post-loading plasma glucose without insulin action and Sg (PPG-without insulin ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-012-0417-y
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Despite advances in the medical management of type 1 diabetes mellitus (T1DM), for many, glycaemic control remains substandard. Other factors are clearly important in determining success, or lack thereof, with diabetes management. With this in mind, we have investigated whether family CHAOS may provide a nov...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0736-x
更新日期:2016-02-01 00:00:00
abstract::In late twentieth century, Ruderman and Reaven showed that insulin resistance might be fundamental to metabolic syndrome (MetS) which means a constellation of obesity-related metabolic derangements predisposing to type 2 diabetes and cardiovascular disease. In 2001, user-friendly National Cholesterol Education Program...
journal_title:Acta diabetologica
pub_type: 历史文章,杂志文章,评审
doi:10.1007/s00592-011-0309-6
更新日期:2012-04-01 00:00:00
abstract::Left atrial (LA) structural, functional and mechanical changes have important role in development of diabetic cardiomyopathy and it was discovered that LA remodeling has important prognostic role in the patients with diabetes (DM). Previously the focus of echocardiographic studies in DM population was on the left vent...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-020-01557-x
更新日期:2020-06-09 00:00:00
abstract::The original report on the microencapsulation of islets of Langerhans used sodium alginate and poly-L-lysine (PLL) to form the capsules. Although several alternative materials have subsequently been used with vary-mg degrees of success, it is those studies using islets encapsulated in alginate-PLL-alginate which are r...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/BF00569928
更新日期:1993-01-01 00:00:00
abstract::To examine longitudinally the effect of diabetes on bone structure and metabolism, we measured bone mineral density (BMD) and turnover markers in 26 type 1 (mean age 49 years) and 27 type 2 (mean age 65 years) diabetic patients without known osteoporosis from a community-based sample at baseline and 5 years later. In ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-011-0324-7
更新日期:2012-04-01 00:00:00
abstract:AIM:Cardio-metabolic disease and physical activity are closely related but large-scale objective studies which measure physical activity are lacking. Using the largest accelerometer cohort to date, we aimed to investigate whether there is an association between disease status and accelerometer variables after a 5-year ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-018-1161-8
更新日期:2018-09-01 00:00:00
abstract::Bacterial endotoxins have been associated with chronic inflammation and the development and progression of diabetic nephropathy. We hypothesized that subjects with high serum lipopolysaccharide activity also carry remains of bacterial DNA in their system. Serum-derived bacterial DNA clones were isolated and identified...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-012-0421-2
更新日期:2013-06-01 00:00:00
abstract:AIMS:Lipohypertrophy (LH) represents the most common skin-related complication associated with insulin therapy. Our aim is to estimate the prevalence of LH among insulin-treated patients, to identify its association with errors in insulin injection technique and storage, and the correlation between LH, risk of hypoglyc...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-017-1066-y
更新日期:2018-01-01 00:00:00
abstract::Autoantibodies to zinc transporter 8 (ZnT8A) are a powerful diagnostic or predictive marker in type 1 diabetes. However, the widely used current ZnT8A radioligand binding assay (RBA) has proved to be difficult for many laboratories to implement. The aim of this study was the development and characterization of the per...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-013-0532-4
更新日期:2014-01-01 00:00:00
abstract::Genetic markers may be used to improve the prediction of insulin-dependent diabetes mellitus (type 1) in individuals with islet autoantibodies. In order to develop a risk assessment strategy for the Lombardy region of northern Italy based on genetic and immunological markers, we analyzed HLA DQA1 and DQB1 alleles in 6...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00838481
更新日期:1995-10-01 00:00:00
abstract::The possible occurrence of increased non-enzymatic glycosylation of serum insulin-like growth factor binding protein-3 (IGFBP-3) in vivo and the changes that would simultaneously occur in serum levels of IGFBP-3 and insulin-like growth factor-1 (IGF-I) were investigated. We measured levels of IGF-I and IGFBP-3 and the...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920050109
更新日期:1998-07-01 00:00:00
abstract:AIMS:Type 2 diabetes (T2D) is a metabolic disorder requiring intensive self-care to maintain optimal glycemic control. Sleep disturbance is common in T2D patients and likely impairs glycemic control. Our aim was to examine the relationship between sleep disturbance and self-care in adults with T2D. METHODS:This study ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-018-1181-4
更新日期:2018-09-01 00:00:00
abstract:AIMS:There is clinical evidence that fenofibrate, a PPARα agonist, arrests the progression of diabetic macular edema (DME). However, the underlying mechanisms of this beneficial effect remain to be elucidated. We previously reported that fenofibric acid (FA), the active metabolite of fenofibrate, prevents the disorgani...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0759-3
更新日期:2016-02-01 00:00:00
abstract:AIMS:To assess the risk of adverse neonatal outcomes in women with gestational diabetes (GDM) by identifying subgroups of women at higher risk to recognize the characteristics most associated with an excess of risk. METHODS:Observational, retrospective, multicenter study involving consecutive women with GDM. To identi...
journal_title:Acta diabetologica
pub_type: 杂志文章,多中心研究
doi:10.1007/s00592-018-1208-x
更新日期:2018-12-01 00:00:00
abstract:AIMS:Glucose-dependent insulinotropic polypeptide (GIP) is released primarily from the proximal small intestine and glucagon-like peptide-1 (GLP-1) from the more distal small intestine and colon. Their relative importance to the incretin effect in health has been contentious in the past, although it now appears that GI...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-019-01461-z
更新日期:2020-05-01 00:00:00
abstract:AIMS:The anti-inflammatory effects of the polyphenol resveratrol in patients with type 2 diabetes mellitus (T2DM) are controversial. Its role on pentraxin 3 (PTX3) concentrations, a human acute phase protein, has never been evaluated. Our aim was to determine whether a two-dosage resveratrol supplementation (500 and 40...
journal_title:Acta diabetologica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00592-017-0977-y
更新日期:2017-05-01 00:00:00
abstract:AIMS:Diabetic retinopathy (DR) is characterized by early dropout of capillary pericytes, leading to loss of control on endothelial proliferation and, subsequently, angiogenesis. We have demonstrated that extracellular vesicles (EV) derived from mesenchymal stem cells (MSC) maintained in diabetic-like conditions may pla...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0798-9
更新日期:2015-12-01 00:00:00
abstract::The recent efforts in the study of fetal compartments could help us to a better recognition of the proper fetal growth and well being. Fat content correlates directly with energy stores. Fat mass and lean body mass is often used in the nutritional assessment of the individual. Moreover chromosomal abnormalities may be...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-003-0033-y
更新日期:2003-10-01 00:00:00
abstract::The duration of diabetes before puberty is not considered relevant to the future development of complications. To evaluate the effects of diabetes on the neural retina, we analysed macular function by steady-state focal electroretinography in 20 prepubescent diabetic children without vascular retinopathy and in 39 sex...
journal_title:Acta diabetologica
pub_type: 临床试验,杂志文章
doi:10.1007/BF00570544
更新日期:1994-06-01 00:00:00
abstract::Bovine insulin was glycated by in vitro incubation with 20-220 mM D-glucose for 1-48 h. The percentage of glycation was dependent on time, glucose concentration, temperature and pH, attaining values up to 28%. Glucose-lowering activities of glycated and control (non-glycated) insulin preparations were assessed in mice...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920050086
更新日期:1997-12-01 00:00:00
abstract::Diabetes cardiomyopathy is a specific form of cardiac disease characteristic for diabetic patients. Development of echocardiography enabled diagnosis of diabetic cardiomyopathy significantly before the occurrence of heart failure. Previously was believed that left ventricular (LV) diastolic dysfunction represents the ...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-020-01528-2
更新日期:2020-09-01 00:00:00
abstract::The aim of this study was to evaluate lipid peroxidation and scavenging enzyme activity in streptozotocin-induced diabetes, and then to establish whether moderate doses of nonenzymatic antioxidant vitamin E play a role in the antioxidant defence system in diabetic pregnant rats and their offspring. The study group con...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920070002
更新日期:2000-01-01 00:00:00
abstract::We analysed the risk factors associated with diabetic complications in the cohort of patients assisted by a type 2 diabetes mellitus (T2DM) shared-care program. We analysed registry data from 16,136 T2DM patients. Of them, 4,781 had microangiopathy, 3,469 CV events. They were 70.5 ± 17.1 years old, 50% were male, dise...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-010-0186-4
更新日期:2010-12-01 00:00:00
abstract::Cardiovascular risk is determined by multiple risk factors, all of which greatly increase the chance of morbidity and mortality. So-called "normal" levels of these factors are not biologically normal, so current strategy is based on estimations of a person's global cardiovascular risk, and then using appropriate combi...
journal_title:Acta diabetologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00592-005-0181-3
更新日期:2005-04-01 00:00:00