Novel enzyme-linked immunosorbent assay for bivalent ZnT8 autoantibodies.

abstract：AIMS:The role of neutrophils in diabetes and its complications is unclear. Upon challenge with microbes and inflammatory triggers, neutrophils release enzymes and nuclear material, forming neutrophils extracellular traps (NETs) and thereby dying by NETosis. We herein tested NET formation and NETosis products in high gl...

journal_title：Acta diabetologica

authors： Menegazzo L,Ciciliot S,Poncina N,Mazzucato M,Persano M,Bonora B,Albiero M,Vigili de Kreutzenberg S,Avogaro A,Fadini GP

更新日期：2015-06-01 00:00:00

abstract：:A literature review of 37 papers cited by MEDLINE between 1986 and April 1996 under the terms "diabetes", "patient education" and "randomized" was carried out. The articles were analysed on the basis of a check list (Educational Procedure Check List), which contains 27 items grouped into 8 areas: study objectives, edu...

journal_title：Acta diabetologica

authors： Albano MG,Jacquemet S,Assal JP

更新日期：1998-12-01 00:00:00

abstract：:To evaluate ex vivo/in vitro the binding and dissociation characteristics and the level of crossreactivity of insulin antibodies and insulin autoantibodies directed to three different insulin molecules (human, bovine and porcine insulin). In this study sera from 17 diabetic patients were included, who were exclusively...

journal_title：Acta diabetologica

authors： Jaeger C,Winter S,Eckhard M,Hardt P,Brendel MD,Bretzel RG

更新日期：2008-09-01 00:00:00

abstract：:Selective loss of capillary pericytes occurs early and specifically in diabetic retinopathy. We have investigated whether blood derivatives from patients with long-term type 1 (insulin-dependent) diabetes and no retinopathy differ from those with retinopathy and/or non-diabetic controls in their ability to stimulate D...

journal_title：Acta diabetologica

authors： Williams FM,Dosso AA,Kohner EM,Porta M

更新日期：1993-01-01 00:00:00

abstract：:Consistent with the postulated role of oxidative stress in the etiology of late diabetic complications, pharmacological interventions based on biological antioxidants have been suggested. The aim of the present study was to investigate the effect of dietary supplementation with the pyridoindole antioxidant stobadine o...

journal_title：Acta diabetologica

authors： Stefek M,Sotnikova R,Okruhlicova L,Volkovova K,Kucharska J,Gajdosik A,Gajdosikova A,Mihalova D,Hozova R,Tribulova N,Gvozdjakova A

更新日期：2000-01-01 00:00:00

abstract：:Diabetic neuropathy is a significant complication of chronic diabetes. We wished to discover whether we were successfully identifying patients who had developed neuropathic problems. Specifically, Diabetologists are traditionally poor at asking about erectile dysfunction (ED) and patients themselves are not always for...

journal_title：Acta diabetologica

authors： Grant PS,Lipscomb D

更新日期：2009-12-01 00:00:00

abstract：:Type 2, non-insulin-dependent diabetes mellitus accounts for 60% of the end-stage renal disease attributed to diabetes in the United States, yet little is known about glomerular function or the development of renal disease in this type of diabetes. The Diabetic Renal Disease Study (DRDS) is a longitudinal study design...

journal_title：Acta diabetologica

authors： Nelson RG

更新日期：1991-01-01 00:00:00

abstract：:Insulin secretion is stimulated better by oral than by intravenous glucose (incretin effect). The contribution of the autonomic nervous system to the incretin effect after oral glucose in humans is unclear. We therefore examined nine type 1 diabetic (insulin-dependent) patients with end-stage nephropathy, studied afte...

journal_title：Acta diabetologica

authors： Nauck MA,Büsing M,Orskov C,Siegel EG,Talartschik J,Baartz A,Baartz T,Hopt UT,Becker HD,Creutzfeldt W

更新日期：1993-01-01 00:00:00

abstract：:To evaluate the role of insulin resistance and beta cell function to increasing fasting plasma glucose (FPG), 1,272 Chinese subjects (18-80 years of age) were divided into normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), combined glucose intolerance (CGI), and type 2 di...

journal_title：Acta diabetologica

authors： Bi Y,Zhu D,Jing Y,Hu Y,Feng W,Shen S,Tong G,Shen X,Yu T,Song D,Yang D

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Emerging adulthood is a challenging period for diabetes management. Our aim was to determine whether a dedicated transition clinic for emerging adults with type 1 diabetes can improve glycemic control and visit attendance. METHODS:An observational study of 53 emerging adults (30 males) treated during 2010-2...

journal_title：Acta diabetologica

authors： Levy-Shraga Y,Elisha N,Ben-Ami M,Boyko V,Lerner-Geva L,Ziv T,Konvalina N,Cohen O,Pinhas-Hamiel O

更新日期：2016-02-01 00:00:00

abstract：:The duration of diabetes before puberty is not considered relevant to the future development of complications. To evaluate the effects of diabetes on the neural retina, we analysed macular function by steady-state focal electroretinography in 20 prepubescent diabetic children without vascular retinopathy and in 39 sex...

journal_title：Acta diabetologica

authors： Greco AV,Di Leo MA,Caputo S,Falsini B,Porciatti V,Marietti G,Ghirlanda G

更新日期：1994-06-01 00:00:00

abstract：:Cytomegalovirus (CMV) infects 40 % of the world population and has been suggested to be associated with diabetes; however, no prospective study has ever examined diabetes mortality associated with the infection. A cohort of 14,404 non-diabetic adult participants aged 17-90 years from the Third National Health and Nutr...

journal_title：Acta diabetologica

authors： Mendy A,Gasana J,Vieira ER,Diallo H

更新日期：2014-10-01 00:00:00

abstract：:Several haemostatic abnormalities are associated with proliferative diabetic retinopathy. While abnormalities in plasma fibrinolytic activity have been described in diabetic retinopathy, platelets (a rich source of plasminogen activator inhibitor type 1, PAI-1) have received little attention. As a result, little is kn...

journal_title：Acta diabetologica

authors： Simpson AJ,Booth NA,Moore NR,Lewis SJ,Gray RS

更新日期：1999-09-01 00:00:00

abstract：AIMS:High glycemic variability (GV) is the major indication for islet transplantation (IT) in patients with type 1 diabetes (T1D). The actual criteria used to assess graft function do not consider GV improvement. Our study aimed to describe GV indices' evolution in T1D patients who benefited from IT during the TRIMECO ...

journal_title：Acta diabetologica

authors： Jalbert M,Zheng F,Wojtusciszyn A,Forbes F,Bonnet S,Skaare K,Benhamou PY,Lablanche S,TRIMECO Study Group.

更新日期：2020-03-01 00:00:00

abstract：AIMS:Medication adherence and persistence are important determinants of treatment success in type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis evaluated the real-world adherence, persistence, and in-class switching among patients with T2DM prescribed dipeptidyl peptidase-4 (DPP4) inhibitors. ME...

journal_title：Acta diabetologica

authors： Ogundipe O,Mazidi M,Chin KL,Gor D,McGovern A,Sahle BW,Jermendy G,Korhonen MJ,Appiah B,Ademi Z,De Bruin ML,Liew D,Ofori-Asenso R

更新日期：2021-01-01 00:00:00

abstract：:This study was aimed at the assessment of incidence of malignancies in type 2 diabetic patients treated with different sulphonylureas. A matched case-control study was performed. Cases were 195 diabetic patients aged 69.0 +/- 9.2 years who had an incident malignancy. Controls were 195 diabetic patients, unaffected by ...

journal_title：Acta diabetologica

authors： Monami M,Lamanna C,Balzi D,Marchionni N,Mannucci E

更新日期：2009-12-01 00:00:00

abstract：:In the perfused pancreas of adult rats that were injected with streptozotocin (STZ) during the neonatal period, the release of insulin caused by glucose is more severely affected than that evoked by other secretagogues. We have now examined whether a comparable situation prevails in vivo. In anesthetised rats, the 0-1...

journal_title：Acta diabetologica

authors： Vicent D,Villanueva-Peñacarrillo ML,Valverde I,Malaisse WJ

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Despite advances in the medical management of type 1 diabetes mellitus (T1DM), for many, glycaemic control remains substandard. Other factors are clearly important in determining success, or lack thereof, with diabetes management. With this in mind, we have investigated whether family CHAOS may provide a nov...

journal_title：Acta diabetologica

authors： Chae M,Taylor BJ,Lawrence J,Healey D,Reith DM,Gray A,Wheeler BJ

更新日期：2016-02-01 00:00:00

abstract：:Pancreatic volume and fat content might be associated with β-cell function or insulin resistance (IR). We investigated the difference in pancreatic volume and fat content between age- and body mass index (BMI)-matched normal subjects and patients with having different durations of type 2 diabetes (T2D). We compared pa...

journal_title：Acta diabetologica

authors： Lim S,Bae JH,Chun EJ,Kim H,Kim SY,Kim KM,Choi SH,Park KS,Florez JC,Jang HC

更新日期：2014-10-01 00:00:00

abstract：AIMS:Type 2 diabetes (DM2) is associated to oxidative modifications of high-density lipoproteins (HDL), which can interfere with their function. Pioglitazone has proved effective in raising HDL cholesterol (HDL-C) and lowering small dense low-density lipoprotein (LDL), but no clinical studies have examined its effect o...

journal_title：Acta diabetologica

authors： Sartore G,Chilelli NC,Seraglia R,Ragazzi E,Marin R,Roverso M,Cosma C,Vaccaro O,Burlina S,Lapolla A

更新日期：2019-05-01 00:00:00

abstract：:The objective of this study is to explore the mechanism of oxidative stress induced by intermittent high glucose in porcine iliac endothelial cells (PIECs). The PIECs were exposed to intermittent or constant high glucose for 3 or 6 days, and the mean fluorescent intensity (MFI) was measured via intracellular reactive ...

journal_title：Acta diabetologica

authors： Ge QM,Dong Y,Zhang HM,Su Q

更新日期：2010-12-01 00:00:00

abstract：:The proinflammatory lysophosphatidic acid (LPA) is a potent activator of several transcriptional factors and signaling pathways and a potent modulator of genes involved in inflammation, angiogenesis and fibrosis. This study was conducted to measure the levels of LPA and LPA-producing enzymes, autotaxin (ATX) and acylg...

journal_title：Acta diabetologica

authors： Abu El-Asrar AM,Mohammad G,Nawaz MI,Siddiquei MM,Kangave D,Opdenakker G

更新日期：2013-06-01 00:00:00

abstract：AIM:To assess the association between alcohol consumption and/or cigarette smoking with other unhealthy behaviors and clinical cardiovascular risk factors in youth with type 1 diabetes. METHODS:Two hundred and twenty-eight youth with type 1 diabetes (age 13-19 years) were consecutively enrolled in three Regional Pedia...

journal_title：Acta diabetologica

authors： Valerio G,Mozzillo E,Zito E,De Nitto E,Maltoni G,Marigliano M,Zucchini S,Maffeis C,Franzese A

更新日期：2019-12-01 00:00:00

abstract：AIMS:To assess the metabolic health of obese and non-obese women at high GDM risk 5 years postpartum. METHODS:This is a secondary analysis of the 5-year follow-up of the RADIEL GDM prevention study including 333 women at high GDM risk (BMI ≥ 30 kg/m2 and/or previous GDM). Five years postpartum metabolic health was ass...

journal_title：Acta diabetologica

authors： Huvinen E,Eriksson JG,Koivusalo SB,Grotenfelt N,Tiitinen A,Stach-Lempinen B,Rönö K

更新日期：2018-05-01 00:00:00

abstract：:For many diabetic patients, years of blood glucose self-monitoring (SM) with readings taken several times daily is an inevitable aspect of insulin therapy. We investigated whether SM from abdominal skin might be an alternative to the established fingertip method. A total of 63 diabetic patients and 16 nondiabetic volu...

journal_title：Acta diabetologica

authors： Holstein A,Thiessen E,Kaufmann N,Plaschke A,Egberts EH

更新日期：2002-06-01 00:00:00

abstract：:Anti-myeloperoxidase (anti-MPO) antibodies were detected in 34 of 88 (38%) patients with type 1 diabetes mellitus but in only 3 of 55 (5.7%) healthy subjects and in 4 of 20 patients with autoimmune disease. Specificity of anti-MPO antibodies was assessed by MPO inhibition studies. No relationship was found between the...

journal_title：Acta diabetologica

authors： Accardo-Palumbo A,Triolo G,Giardina E,Carbone MC,Ferrante A,Triolo G

更新日期：1996-07-01 00:00:00

abstract：:Rosiglitazone often results in weight gain. We hypothesized that rosiglitazone may modulate circulating levels of ghrelin and peptide YY(3-36) and this modulation may be related to weight-gaining effect of this agent. This study was designed as an open-label, randomized, controlled trial of 3-month duration. Women wit...

journal_title：Acta diabetologica

authors： Berberoglu Z,Yazici AC,Bayraktar N,Demirag NG

更新日期：2012-12-01 00:00:00

abstract：:Although the polymorphisms of PTPN22 and the variants of CTLA-4 have been reported to be the susceptibility genes, which increased risk of latent autoimmune diabetes in adults (LADA), the results remained inconclusive. The aim of this meta-analysis was to evaluate the association between the polymorphisms of two genes...

journal_title：Acta diabetologica

authors： Dong F,Yang G,Pan HW,Huang WH,Jing LP,Liang WK,Zhang N,Zhang BH,Wang M,Liu Y,Zhang LJ,Zhang SH,Li H,Chen C,Nie LH,Jing CX

更新日期：2014-10-01 00:00:00

abstract：AIM:The study evaluated the effect of different concentrations of sildenafil-containing ointment on wound healing in healthy and streptozotocin (STZ)-induced diabetic rats. METHODS:A total of 108 Sprague Dawley male rats aged 5 months were randomly divided into two groups: healthy and diabetes-inducing rats. Following...

journal_title：Acta diabetologica

authors： Abu Dayyih W,Abu Rayyan W,Al-Matubsi HY

更新日期：2020-11-01 00:00:00

abstract：:The relationship between insulin responses to glucose and to arginine was studied in non-obese women with previous gestational diabetes (PGD). One group, n = 10, had normal glucose tolerance (NGT) by WHO criteria and another, n = 8, had impaired glucose tolerance (IGT). A third group of women without PGD, n = 12, was ...

journal_title：Acta diabetologica

authors： Alvarsson M,Wajngot A,Efendic S,Grill V

更新日期：1995-06-01 00:00:00