Abstract:
AIMS:High glycemic variability (GV) is the major indication for islet transplantation (IT) in patients with type 1 diabetes (T1D). The actual criteria used to assess graft function do not consider GV improvement. Our study aimed to describe GV indices' evolution in T1D patients who benefited from IT during the TRIMECO trial and to evaluate if thresholds might be defined to diagnose IT success. METHODS:We collected data from 29 patients of the TRIMECO trial, a clinical trial (NCT01148680) comparing the metabolic efficacy of IT with intensive insulin therapy. Based on CGM data, we analyzed mean glucose level and four GV indices (standard deviation, coefficient of variation, MAGE and GVP) before (M0) and 6 months (M6) after IT. RESULTS:Each GV index decreased significantly between M0 and M6: SD 53.9 mg/dL [44.6-61.5] versus 20.1 mg/dL [13.5-24.3]; CV 35.2% [30.6-37.7] versus 17.3% [12.0-20.5]; MAGE 134.9 mg/dl [111.2-155.8] versus 51.9 mg/dL [32.4-62.4]; GVP 35.3% [24.9-47.2] versus 12.2% [6.2-18.8] (p ≤ 0.0001). Thresholds diagnosing IT success at 6 months post-transplant were an SD at 22.76 mg/dL (sensibility 88.89%, specificity 80.00%), a CV at 17.47% (sensibility 88.89%, specificity 70.00%), a MAGE at 54.81 mg/dL (sensibility 88.89%, specificity 80.00%) and a GVP at 12.27% (sensibility 88.89%, specificity 70.00%). CONCLUSIONS:This study confirms a positive impact of IT on GV. The proposed thresholds allow an easy evaluation of IT success using only CGM data and may be a clinical tool for the follow-up of transplanted patients.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Jalbert M,Zheng F,Wojtusciszyn A,Forbes F,Bonnet S,Skaare K,Benhamou PY,Lablanche S,TRIMECO Study Group.doi
10.1007/s00592-019-01425-3subject
Has Abstractpub_date
2020-03-01 00:00:00pages
335-345issue
3eissn
0940-5429issn
1432-5233pii
10.1007/s00592-019-01425-3journal_volume
57pub_type
杂志文章,随机对照试验abstract::We investigated the effect of sub-chronic soybean oil (SO) treatment on the insulin secretion and fatty acid composition of islets of Langerhans obtained from Goto-Kakizaki (GK), a model of type 2 diabetes, and normal Wistar rats. We observed that soybean-treated Wistar rats present insulin resistance and defective is...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-007-0252-8
更新日期:2007-09-01 00:00:00
abstract::To study the immune response to glutamic acid decarboxylase (GAD) in insulin-dependent diabetes mellitus, monoclonal GAD antibodies after fusion of splenocytes from a nondiabetes-susceptible BALB/c mouse immunized with human recombinant GAD65 were generated. Of the 44 monoclonals, 35 are specific for the GAD65 isoform...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF02048548
更新日期:1996-09-01 00:00:00
abstract:AIMS:Prognostic significance of apolipoproteins in diabetic retinopathy risk has not been well investigated. The aim of this study was to reveal the relationship between the risk of diabetic retinopathy and the levels of several apolipoproteins and their ratios in a 10-year prospective cohort. METHODS:A total of 1023 ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-018-1136-9
更新日期:2018-07-01 00:00:00
abstract::The effect of a phenacyl imidazolium compound (LY177507 or Proglycosyn, Eli Lilly) on the direct (glucose-->glucose-6-phosphate-->glycogen) and indirect (three-carbon compounds-->glucose-6-phosphate-->glycogen) pathways of liver glycogen synthesis was studied in conscious rats. [1-13C]Glucose (99% enriched) was infuse...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00578216
更新日期:1993-01-01 00:00:00
abstract:AIMS:Radiolabeled Exendin-4 has been proposed as suitable imaging marker for pancreatic beta cell mass quantification mediated by Glucagon-like peptide-1 receptor (GLP-1R). However, noticeable species variations in basal pancreatic uptake as well as uptake reduction degree due to selective beta cell ablation were obser...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-017-1046-2
更新日期:2017-11-01 00:00:00
abstract:AIMS:Diabetic ketoacidosis (DKA) at diabetes diagnosis is a dangerous yet potentially preventable condition. Young age, low socioeconomic status, and low parental education have been found to be associated with increased risk of DKA. We aimed to evaluate the impact of religious affiliation on presentation with DKA at t...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-014-0653-4
更新日期:2015-04-01 00:00:00
abstract::Hemoglobin A1c (HbA1c) has been recommended as an optional method for diagnosing diabetes. The impact of HbA1c on the diagnosis of diabetes has not been evaluated in China, a country with the greatest number of people with diabetes in the world. Hence, we aim to examine how well HbA1c performs as compared with fasting...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-013-0515-5
更新日期:2014-01-01 00:00:00
abstract::Fasting glucose and oral glucose tolerance test (OGTT) criteria for glucose homeostasis were compared in a cross-sectional cluster, community study in Accra, Ghana. A total of 4636 subjects without prior diagnosis of diabetes had fasting plasma glucose, 2-hour OGTT and measurement of cardiovascular risk factors. Mean ...
journal_title:Acta diabetologica
pub_type: 杂志文章,多中心研究
doi:10.1007/s005920200006
更新日期:2002-04-01 00:00:00
abstract::A cross-sectional descriptive study was done on patients recently entered into the National Diabetes Registry in Eritrea where the prevalence was estimated to be 2.2% based on patient information in 2004. Of the 627 patients with diabetes, two thirds were type 2. Although type 1 had poorer control (42.9%) than type 2 ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-009-0093-8
更新日期:2010-03-01 00:00:00
abstract:AIMS:Glucagon is used to resolve severe hypoglycemia in unconscious patients with diabetes, requiring third-party assistance. A few studies have shown that intranasal (IN) glucagon causes resolution of hypoglycemia in insulin-treated patients with type 1 (T1DM) diabetes. This systematic review and meta-analysis updates...
journal_title:Acta diabetologica
pub_type: 杂志文章,meta分析
doi:10.1007/s00592-020-01483-y
更新日期:2020-06-01 00:00:00
abstract:AIMS:Although diabetes is rapidly increasing in India, there is no national consensus on best practices for screening, diagnosis, and management of gestational diabetes mellitus (GDM). The goal of this study was to systematically review the literature for studies reporting the prevalence and screening and diagnostic me...
journal_title:Acta diabetologica
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00592-018-1131-1
更新日期:2018-06-01 00:00:00
abstract::Recent studies have reported that elevated proinsulin levels are indicative of an increased cardiovascular risk. Renal proximal tubular cells represent a major site for the metabolism of insulin-like hormones after glomerular filtration into the tubular lumen. To determine the binding and degradation of proinsulin in ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00569428
更新日期:1996-07-01 00:00:00
abstract::The original report on the microencapsulation of islets of Langerhans used sodium alginate and poly-L-lysine (PLL) to form the capsules. Although several alternative materials have subsequently been used with vary-mg degrees of success, it is those studies using islets encapsulated in alginate-PLL-alginate which are r...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/BF00569928
更新日期:1993-01-01 00:00:00
abstract::Although the polymorphisms of PTPN22 and the variants of CTLA-4 have been reported to be the susceptibility genes, which increased risk of latent autoimmune diabetes in adults (LADA), the results remained inconclusive. The aim of this meta-analysis was to evaluate the association between the polymorphisms of two genes...
journal_title:Acta diabetologica
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00592-014-0613-z
更新日期:2014-10-01 00:00:00
abstract:AIMS:The aim of the study was to evaluate and compare continuous subcutaneous insulin infusion (CSII) use in pediatric and adult age groups. METHODS:Data were collected with a questionnaire sent by e-mail to CSII-experienced Diabetes Centers. The questionnaire assessed: (1) number of CSII-treated patients; (2) patient...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0810-4
更新日期:2016-06-01 00:00:00
abstract:AIM:It is unclear whether any breastfeeding or a certain duration of breastfeeding is protective against the development of diabetes in adult offspring. METHODS:We followed a sub-sample of 3,595 offspring born in the Mater Hospital in Brisbane, Australia between 1981 and 1983 and for whom we had doctor diagnosed self-...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-014-0690-z
更新日期:2015-10-01 00:00:00
abstract:AIMS:To evaluate the methodological quality of systematic reviews (SRs), and summarize evidence of important outcomes from dipeptidyl peptidase-4 inhibitors (DPP4-I) in treating type 2 diabetes mellitus (T2DM). METHODS:We included SRs of DPP4-I for the treatment of T2DM until January, 2018 by searching the Cochrane Li...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-018-1164-5
更新日期:2019-01-01 00:00:00
abstract::Most reports of outcome following obesity surgery report weight and co-morbidity changes only. We studied body composition changes in 17 adult patients (15 F, 2 M, age 43+/-2 years, range 28-58 years), with morbid obesity (initial BMI 40.4+/-4.9 kg/m(2), range 34.7-48.8) who were managed surgically by laparoscopically...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-003-0083-1
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Despite advances in the medical management of type 1 diabetes mellitus (T1DM), for many, glycaemic control remains substandard. Other factors are clearly important in determining success, or lack thereof, with diabetes management. With this in mind, we have investigated whether family CHAOS may provide a nov...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0736-x
更新日期:2016-02-01 00:00:00
abstract::We report the results of bone mineral density (BMD) measurements in type 2 diabetic patients, in comparison to healthy controls. In this prospective study, a total of 277 subjects (aged 30-60 years) with type 2 diabetes mellitus, outpatients at the Cukurova Medical School Hospital, were evaluated for BMD at L(1)-L(4) ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920300014
更新日期:2003-06-01 00:00:00
abstract::The aim of this study was to evaluate the prevalence of thyroid autoantibodies and clinical significance of thyroid autoimmunity in children with the diagnosis of diabetes mellitus type 1. The study group comprised 222 children all with newly diagnosed diabetes mellitus type 1 (122 boys) with a mean age 9.92 +/- 4.5 y...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-007-0017-4
更新日期:2008-03-01 00:00:00
abstract::Diabetic kidney disease (DKD) is a devastating complication of Type 1 and Type 2 diabetes and leads to increased morbidity and mortality. Earlier work in families has provided strong evidence that heredity is a major determinant of DKD. Previous linkage analyses and candidate gene studies have identified potential DKD...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-018-1193-0
更新日期:2018-11-01 00:00:00
abstract::Anti-myeloperoxidase (anti-MPO) antibodies were detected in 34 of 88 (38%) patients with type 1 diabetes mellitus but in only 3 of 55 (5.7%) healthy subjects and in 4 of 20 patients with autoimmune disease. Specificity of anti-MPO antibodies was assessed by MPO inhibition studies. No relationship was found between the...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00569418
更新日期:1996-07-01 00:00:00
abstract::The purification of large numbers of human pancreatic islets remains one of the limiting factors in islet transplantation. This paper describes and validates a method for accurately and reproducibly determining the density of islets and exocrine tissue in pancreatic digest on the basis of their isopycnic distribution ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00572864
更新日期:1993-01-01 00:00:00
abstract::The effect of sucrose in the diet of children and adolescents with type I diabetes on long-term metabolic control was studied. For a mean observation period of 83 (range 42-127) days, a diet containing 5% of total calories as refined sugar was recommended to 11 children (group A, mean age 15.0, SD 5.4 years), while an...
journal_title:Acta diabetologica
pub_type: 临床试验,杂志文章
doi:10.1007/BF00571952
更新日期:1994-12-01 00:00:00
abstract:AIMS:To investigate the possibility of identifying a subtype of latent autoimmune diabetes in adults (LADA), T-LADA (T cell responses-positive and autoantibody-negative) from patients with phenotypic type 2 diabetes (T2D) by enzyme-linked immunospot (ELISPOT). METHODS:Eighty-two patients with phenotypic T2D were studi...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-019-01391-w
更新日期:2019-11-01 00:00:00
abstract:AIMS:Sirtuin-1 (SIRT-1) down-regulation in type 2 diabetes mellitus (T2DM) has been associated with epigenetic markers of oxidative stress. We herein aim to evaluate whether an increase in SIRT-1 expression affects histone 3 acetylation at the 56 lysine residue (H3K56ac) in T2DM patients randomly selected to receive ei...
journal_title:Acta diabetologica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00592-017-1097-4
更新日期:2018-04-01 00:00:00
abstract:AIMS:We sought to investigate temporal trends in prediabetes prevalence among US adolescents using two definitions and evaluate relationships with obesity and a MetS-severity score. METHODS:We evaluated data from 5418 non-Hispanic white, non-Hispanic black, and Hispanic adolescents aged 12-19 participating in the Nati...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-016-0958-6
更新日期:2017-04-01 00:00:00
abstract::In the perfused pancreas of adult rats that were injected with streptozotocin (STZ) during the neonatal period, the release of insulin caused by glucose is more severely affected than that evoked by other secretagogues. We have now examined whether a comparable situation prevails in vivo. In anesthetised rats, the 0-1...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00570366
更新日期:1994-09-01 00:00:00
abstract:AIMS:Type 2 diabetes (DM2) is associated to oxidative modifications of high-density lipoproteins (HDL), which can interfere with their function. Pioglitazone has proved effective in raising HDL cholesterol (HDL-C) and lowering small dense low-density lipoprotein (LDL), but no clinical studies have examined its effect o...
journal_title:Acta diabetologica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00592-018-01278-2
更新日期:2019-05-01 00:00:00