当前位置： SCI文献检索 > ACTA DIABETOLOGICA期刊下所有文献 > Impact of sirtuin-1 expression on H3K56 acetylation and oxidative stress: a double-blind randomized controlled trial with resveratrol supplementation.

Impact of sirtuin-1 expression on H3K56 acetylation and oxidative stress: a double-blind randomized controlled trial with resveratrol supplementation.

Abstract：

AIMS:Sirtuin-1 (SIRT-1) down-regulation in type 2 diabetes mellitus (T2DM) has been associated with epigenetic markers of oxidative stress. We herein aim to evaluate whether an increase in SIRT-1 expression affects histone 3 acetylation at the 56 lysine residue (H3K56ac) in T2DM patients randomly selected to receive either resveratrol (40 mg or 500 mg) or a placebo for 6 months. The primary outcome is changes in the H3K56ac level by variation in SIRT-1 expression and the secondary outcome is the evidence of association between SIRT-1 level, antioxidant markers (TAS), and metabolic variables. METHODS AND RESULTS:At baseline, peripheral blood mononuclear cell H3K56ac values among the SIRT-1 tertiles did not differ. At trial end, SIRT-1 levels were significantly higher in patients receiving 500 mg resveratrol. At follow-up, patients were divided into tertiles of delta (trial end minus baseline) SIRT-1 value. Significant reductions in H3K56ac and body fat percentage were found in the highest tertile as were increased TAS levels. A multiple logistic regression model showed that the highest delta SIRT-1 tertile was inversely associated with variations in H3K56ac (OR = 0.66; 95% CI 0.44-0.99), TAS (OR = 1.01; 95% CI 1.00-1.02), and body fat percentage (OR = 0.75; 95% CI 0.58-0.96). CONCLUSIONS:We provide new knowledge on H3K56ac and SIRT-1 association in T2DM. These data suggest that boosting SIRT-1 expression/activation may impact redox homeostasis in these patients. ClinicalTrials.gov Identifier NCT02244879.

journal_name

Acta Diabetol

journal_title

Acta diabetologica

authors

Bo S,Togliatto G,Gambino R,Ponzo V,Lombardo G,Rosato R,Cassader M,Brizzi MF

doi

10.1007/s00592-017-1097-4

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

331-340

issue

4

eissn

0940-5429

issn

1432-5233

pii

10.1007/s00592-017-1097-4

journal_volume

55

pub_type

杂志文章,随机对照试验

相关文献

ACTA DIABETOLOGICA文献大全
  • The prevalence and characteristics of latent autoimmune diabetes in adults (LADA) and its relation with chronic complications in a clinical department of a university hospital in Korea.

    abstract：:Few studies were performed to evaluate the prevalence of latent autoimmune diabetes in adults (LADA) and the difference of chronic complications between LADA, T1DM, and T2DM in Korean. The aim of this study is to establish the prevalence of LADA in a diabetic clinic of Soonchunhyang University hospital and to compare ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-010-0228-y

    authors： Roh MO,Jung CH,Kim BY,Mok JO,Kim CH

    更新日期：2013-04-01 00:00:00

  • Hyperglycaemia in critical illness is a risk factor for later development of type II diabetes mellitus.

    abstract：:Hyperglycaemia caused by stress and inflammation is common during critical illness. We hypothesised that a latent glucose metabolism disturbance contributes to development of hyperglycaemia and that those patients have increased risk for diabetes. We included patients with sepsis, acute coronary syndrome and acute hea...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-009-0115-6

    authors： Gornik I,Vujaklija A,Lukić E,Madžarac G,Gašparović V

    更新日期：2010-12-01 00:00:00

  • Association of obesity with diabetic retinopathy: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study (SN-DREAMS Report no. 8).

    abstract：:The aim of the study was to report the prevalence of obesity indices in individuals with diabetes and find out their association with diabetic retinopathy in the urban Indian population. Subjects (n = 1,414) were recruited from Sankara Nethralaya Diabetic Retinopathy Epidemiology And Molecular Genetics Study (SN-DREAM...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-009-0113-8

    authors： Raman R,Rani PK,Gnanamoorthy P,Sudhir RR,Kumaramanikavel G,Sharma T

    更新日期：2010-09-01 00:00:00

  • Animal insulin therapy induces a biased insulin antibody response that persists for years after introduction of human insulin.

    abstract：:Administration of exogenous insulin for the treatment of diabetes is often accompanied by the development of insulin antibodies (IA). These antibodies may affect the patient's requirement for insulin by acting as an insulin binding reservoir. The improvement of insulin purification in the 1970s and the development of ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-009-0135-2

    authors： Oak S,Phan TH,Gilliam LK,Hirsch IB,Hampe CS

    更新日期：2010-06-01 00:00:00

  • Angiotensin-(1-7) suppresses oxidative stress and improves glucose uptake via Mas receptor in adipocytes.

    abstract：:Although reactive oxygen species (ROS) contribute to glucose intolerance induced by the renin-angiotensin system (RAS) is well documented, the role of the newly discovered pathway of RAS, angiotensin (Ang)-(1-7)/Mas axis, in this process remains unknown. Here, we examined the effect of Ang-(1-7) on oxidative stress an...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-011-0348-z

    authors： Liu C,Lv XH,Li HX,Cao X,Zhang F,Wang L,Yu M,Yang JK

    更新日期：2012-08-01 00:00:00

  • Serum gamma-glutamyl transferase is associated with plasma total homocysteine in Japanese patients with type 2 diabetes.

    abstract：:Serum gamma-glutamyl transferase (gamma-GT), a marker of oxidative stress, predicts morbidity and mortality from cardiovascular disease. Plasma total homocysteine (tHcy), a pro-oxidant and also an independent risk factor for cardiovascular disease, correlates with gamma-GT among some populations. It is not known wheth...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-007-0001-z

    authors： Sakuta H,Suzuki T,Ito T

    更新日期：2007-12-01 00:00:00

  • Metabolomic profile of diabetic retinopathy: a GC-TOFMS-based approach using vitreous and aqueous humor.

    abstract：AIM:To identify the potential metabolite markers in diabetic retinopathy (DR) by using gas chromatography coupled with time-of-flight mass spectrometry (GC-TOFMS). METHODS:GC-TOFMS spectra were acquired from vitreous and aqueous humor (AH) samples of patients with DR and non-diabetic participants. Comparative analysis...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-019-01363-0

    authors： Wang H,Fang J,Chen F,Sun Q,Xu X,Lin SH,Liu K

    更新日期：2020-01-01 00:00:00

  • Glycemic variability indices can be used to diagnose islet transplantation success in type 1 diabetic patients.

    abstract：AIMS:High glycemic variability (GV) is the major indication for islet transplantation (IT) in patients with type 1 diabetes (T1D). The actual criteria used to assess graft function do not consider GV improvement. Our study aimed to describe GV indices' evolution in T1D patients who benefited from IT during the TRIMECO ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00592-019-01425-3

    authors： Jalbert M,Zheng F,Wojtusciszyn A,Forbes F,Bonnet S,Skaare K,Benhamou PY,Lablanche S,TRIMECO Study Group.

    更新日期：2020-03-01 00:00:00

  • Effects of intermittent high glucose on oxidative stress in endothelial cells.

    abstract：:The objective of this study is to explore the mechanism of oxidative stress induced by intermittent high glucose in porcine iliac endothelial cells (PIECs). The PIECs were exposed to intermittent or constant high glucose for 3 or 6 days, and the mean fluorescent intensity (MFI) was measured via intracellular reactive ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-009-0140-5

    authors： Ge QM,Dong Y,Zhang HM,Su Q

    更新日期：2010-12-01 00:00:00

  • The effect of maternal type 2 diabetes on fetal endothelial gene expression and function.

    abstract：AIMS:Maternal type 2 diabetes (T2D) can result in adverse pathological outcomes to both the mother and fetus. The present study aimed to investigate the pathological effects of maternal T2D on the gene expression patterns and functions of fetal human umbilical vein endothelial cells (HUVECs), a representative of fetal ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-018-1207-y

    authors： Sultan S

    更新日期：2019-01-01 00:00:00

  • Implementation of effective transition from pediatric to adult diabetes care: epidemiological and clinical characteristics-a pioneering experience in North Africa.

    abstract：AIMS:Type 1 diabetes is increasing in children leading more T1D young adults to adult healthcare settings. This change is experienced as a tear and results in a disengagement from specialist services. This study reports on an implementation of an effective and pioneering program of transition in North Africa. METHODS:...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-018-1196-x

    authors： Essaddam L,Kallali W,Jemel M,Kandara H,Kammoun I,Hsairi M,Ben Salem L,Ben Becher S

    更新日期：2018-11-01 00:00:00

  • Pathophysiological characteristics in patients with latent autoimmune diabetes in adults using clamp tests: evidence of a continuous disease spectrum of diabetes.

    abstract：AIMS:This study aimed to assess islet insulin secretion and insulin resistance in Chinese patients with latent autoimmune diabetes in adults (LADA). METHODS:Twelve patients with LADA, 10 with type 1 diabetes mellitus (T1DM), 10 with type 2 diabetes mellitus (T2DM), and 10 nondiabetic healthy controls (HCs) were includ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-019-01387-6

    authors： Yang L,Liu X,Liang H,Cheng Y,Huang G,Zhou Z

    更新日期：2019-11-01 00:00:00

  • Total bilirubin is inversely associated with metabolic syndrome but not a risk factor for metabolic syndrome in Japanese men and women.

    abstract：:Serum total bilirubin (TB) is a potent antioxidant and inversely associated with metabolic syndrome (MetS) in Asian populations. However, there has been no study which is aimed to investigate whether TB is a risk factor for MetS or not. We investigated cross-sectional and longitudinal associations between TB and MetS ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-012-0447-5

    authors： Oda E,Aizawa Y

    更新日期：2013-06-01 00:00:00

  • Examining trends in prediabetes and its relationship with the metabolic syndrome in US adolescents, 1999-2014.

    abstract：AIMS:We sought to investigate temporal trends in prediabetes prevalence among US adolescents using two definitions and evaluate relationships with obesity and a MetS-severity score. METHODS:We evaluated data from 5418 non-Hispanic white, non-Hispanic black, and Hispanic adolescents aged 12-19 participating in the Nati...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-016-0958-6

    authors： Lee AM,Fermin CR,Filipp SL,Gurka MJ,DeBoer MD

    更新日期：2017-04-01 00:00:00

  • Oscillating glucose and constant high glucose induce endoglin expression in endothelial cells: the role of oxidative stress.

    abstract：AIM:High glucose-induced oxidative stress has been suggested as one of the mediators of endothelial damage in diabetes. The major endothelial protein, endoglin, has been found overexpressed in the vessels during pathological situations, but little is known about its relation to diabetic vascular complications. To clari...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-014-0670-3

    authors： La Sala L,Pujadas G,De Nigris V,Canivell S,Novials A,Genovese S,Ceriello A

    更新日期：2015-06-01 00:00:00

  • Cyclosporin and methotrexate therapy induces remission in type 1 diabetes mellitus.

    abstract：:Cyclosporin and methotrexate administration induces remission of type 1 diabetes mellitus. Administration of high-dose cyclosporin (cyclo) has been demonstrated to induce remission of type 1 diabetes mellitus (T1D). Its usefulness was limited by its toxicity. Since methotrexate (mtx) and cyclo synergistically inhibit ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-010-0188-2

    authors： Sobel DO,Henzke A,Abbassi V

    更新日期：2010-09-01 00:00:00

  • Incidence of hospitalization and mortality in patients with diabetic foot regardless of amputation: a population study.

    abstract：AIMS:The aim of our study was to estimate the overall rate of first hospitalizations for diabetic foot (DF) regardless of the outcome in amputations, as well as the mortality rate with their determinants in the period 2012-2016 in Piedmont Region in Italy. METHODS:The study included all the subjects registered in the ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-019-01412-8

    authors： Monge L,Gnavi R,Carnà P,Broglio F,Boffano GM,Giorda CB

    更新日期：2020-02-01 00:00:00

  • Detection of anti-myeloperoxidase antibodies in the serum of patients with type 1 diabetes mellitus.

    abstract：:Anti-myeloperoxidase (anti-MPO) antibodies were detected in 34 of 88 (38%) patients with type 1 diabetes mellitus but in only 3 of 55 (5.7%) healthy subjects and in 4 of 20 patients with autoimmune disease. Specificity of anti-MPO antibodies was assessed by MPO inhibition studies. No relationship was found between the...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/BF00569418

    authors： Accardo-Palumbo A,Triolo G,Giardina E,Carbone MC,Ferrante A,Triolo G

    更新日期：1996-07-01 00:00:00

  • Preserved incretin effect in type 1 diabetic patients with end-stage nephropathy treated by combined heterotopic pancreas and kidney transplantation.

    abstract：:Insulin secretion is stimulated better by oral than by intravenous glucose (incretin effect). The contribution of the autonomic nervous system to the incretin effect after oral glucose in humans is unclear. We therefore examined nine type 1 diabetic (insulin-dependent) patients with end-stage nephropathy, studied afte...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/BF00572873

    authors： Nauck MA,Büsing M,Orskov C,Siegel EG,Talartschik J,Baartz A,Baartz T,Hopt UT,Becker HD,Creutzfeldt W

    更新日期：1993-01-01 00:00:00

  • Characterization of Japanese families with early-onset type 2 (non-insulin dependent) diabetes mellitus and screening for mutations in the glucokinase and mitochondrial tRNA(Leu(UUR)) genes.

    abstract：:Genetic linkage studies of families with early-onset type 2 diabetes have facilitated the identification of diabetes-susceptibility genes. In order to assess the feasibility of using linkage approaches to identify genes responsible for the development of type 2 diabetes in Japanese subjects, we examined our clinical r...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/BF00581039

    authors： Iwasaki N,Ohgawara H,Nagahara H,Kawamura M,Bell GI,Omori Y

    更新日期：1995-03-01 00:00:00

  • Expression of lysophosphatidic acid, autotaxin and acylglycerol kinase as biomarkers in diabetic retinopathy.

    abstract：:The proinflammatory lysophosphatidic acid (LPA) is a potent activator of several transcriptional factors and signaling pathways and a potent modulator of genes involved in inflammation, angiogenesis and fibrosis. This study was conducted to measure the levels of LPA and LPA-producing enzymes, autotaxin (ATX) and acylg...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-012-0422-1

    authors： Abu El-Asrar AM,Mohammad G,Nawaz MI,Siddiquei MM,Kangave D,Opdenakker G

    更新日期：2013-06-01 00:00:00

  • Ten-year comparative analysis of incidence, prognosis, and associated factors for dialysis and renal transplantation in type 1 and type 2 diabetes versus non-diabetes.

    abstract：AIMS:To study the incidence of and the factors associated with renal dialysis and transplantation in type 1 (T1DM) and type 2 diabetes (T2DM). METHODS:Data on individuals who had received dialysis treatment or renal transplant between 1 January 2004 and 31 December 2013 were extracted from the regional administrative ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-018-1142-y

    authors： Giorda CB,Carnà P,Salomone M,Picariello R,Costa G,Tartaglino B,Gnavi R

    更新日期：2018-07-01 00:00:00

  • Endothelial nitric oxide synthase gene polymorphism and type 2 diabetic retinopathy among Asian Indians.

    abstract：:Endothelial nitric oxide synthase (eNOS) has been shown to play an essential role in retinal vascular function, and disequilibrium in its production can lead to diabetic retinopathy (DR). Genetic polymorphisms of eNOS gene have been suggested to play a role in nitric oxide (NO) abnormalities which may contribute to th...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-012-0437-7

    authors： Cheema BS,kohli HS,Sharma R,Bhansali A,Khullar M

    更新日期：2012-12-01 00:00:00

  • Metabolic syndrome: its history, mechanisms, and limitations.

    abstract：:In late twentieth century, Ruderman and Reaven showed that insulin resistance might be fundamental to metabolic syndrome (MetS) which means a constellation of obesity-related metabolic derangements predisposing to type 2 diabetes and cardiovascular disease. In 2001, user-friendly National Cholesterol Education Program...

    journal_title：Acta diabetologica

    pub_type： 历史文章,杂志文章,评审

    doi：10.1007/s00592-011-0309-6

    authors： Oda E

    更新日期：2012-04-01 00:00:00

  • Profile of patients with diabetes in Eritrea: results of first phase registry analyses.

    abstract：:A cross-sectional descriptive study was done on patients recently entered into the National Diabetes Registry in Eritrea where the prevalence was estimated to be 2.2% based on patient information in 2004. Of the 627 patients with diabetes, two thirds were type 2. Although type 1 had poorer control (42.9%) than type 2 ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-009-0093-8

    authors： Seyum B,Mebrahtu G,Usman A,Mufunda J,Tewolde B,Haile S,Kosia A,Negassi E

    更新日期：2010-03-01 00:00:00

  • Macrophage-derived cytokine and nitric oxide profiles in type I and type II diabetes mellitus: effect of thymoquinone.

    abstract：:Comparing macrophage-derived cytokine and nitric oxide (NO) profiles in type I and type II diabetes mellitus (DM); and determining whether thymoquinone (TQ) has any modulatory effect were the main objectives of the present study. Peritoneal macrophages have been collected from Otsuka Long-Evans Tokushima Fatty (OLETF)...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-005-0170-6

    authors： El-Mahmoudy A,Shimizu Y,Shiina T,Matsuyama H,Nikami H,Takewaki T

    更新日期：2005-03-01 00:00:00

  • Pericyte mitogenic activity is reduced in the blood of type 1 diabetic patients with and without retinopathy.

    abstract：:Selective loss of capillary pericytes occurs early and specifically in diabetic retinopathy. We have investigated whether blood derivatives from patients with long-term type 1 (insulin-dependent) diabetes and no retinopathy differ from those with retinopathy and/or non-diabetic controls in their ability to stimulate D...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/BF00572854

    authors： Williams FM,Dosso AA,Kohner EM,Porta M

    更新日期：1993-01-01 00:00:00

  • Body composition and respiratory function.

    abstract：:Although the effects of sex, ageing, height, race, and current and past health on pulmonary function tests have been described, only non-significant associations have been observed between body weight and lung function among healthy persons after having accounted for the effects of age and height. However, few studies...

    journal_title：Acta diabetologica

    pub_type： 杂志文章,评审

    doi：10.1007/s00592-003-0023-0

    authors： Maiolo C,Mohamed EI,Carbonelli MG

    更新日期：2003-10-01 00:00:00

  • Effect of pioglitazone on systemic inflammation is independent of metabolic control and cardiac autonomic function in patients with type 2 diabetes.

    abstract：:The aim of this article is to investigate the relation of the anti-inflammatory effect of pioglitazone with cardiac autonomic function and metabolic control in diabetic patients. In this prospective open label trial, 36 type 2 diabetic patients (age 60 ± 10, 20 M) without overt cardiovascular disease were randomized t...

    journal_title：Acta diabetologica

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00592-009-0150-3

    authors： Nerla R,Pitocco D,Zaccardi F,Scalone G,Coviello I,Mollo R,Ghirlanda G,Lanza GA,Crea F

    更新日期：2010-12-01 00:00:00

  • Decreases in Raf-1 levels in galactosaemic lens epithelial cells are partially reversed by myo-inositol.

    abstract：:Changes in the amounts and localization of protein kinase C (PKC) isoforms occur in galactosaemic lens epithelial cells. A link between PKC changes and myo-inositol depletion has been suggested. Raf-1, a component of a Ras pathway, is a substrate for PKC. Raf-1 levels were measured in galactosaemic lens epithelial cel...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s005920050119

    authors： Takemoto DJ

    更新日期：1998-10-01 00:00:00