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Serum gamma-glutamyl transferase is associated with plasma total homocysteine in Japanese patients with type 2 diabetes.

Abstract：

:Serum gamma-glutamyl transferase (gamma-GT), a marker of oxidative stress, predicts morbidity and mortality from cardiovascular disease. Plasma total homocysteine (tHcy), a pro-oxidant and also an independent risk factor for cardiovascular disease, correlates with gamma-GT among some populations. It is not known whether tHcy correlates with gamma-GT among type 2 diabetic patients in whom oxidative stress is increased and implicated for the development of diabetic complications. In the present study, we analyzed the association between gamma-GT, tHcy and related vitamins cross-sectionally among patients with type 2 diabetes without overt nephropathy (age range 17-76 years; n = 110). In a univariate regression analysis model, gamma-GT (logarithm) was positively associated with tHcy (beta = 0.288, P = 0.002) but not with folate or vitamin B(12). The association between tHcy and gamma-GT (logarithm) remained significant in a multivariate analysis model including age, lifestyle factors, folate, vitamin B(12), creatinine, HbA(1c) and medical history (beta = 0.219, P = 0.027). These results suggest that tHcy generates oxidative stress among type 2 diabetic patients and may partly explain the reported association between gamma-GT and cardiovascular disease.

journal_name

Acta Diabetol

journal_title

Acta diabetologica

authors

Sakuta H,Suzuki T,Ito T

doi

10.1007/s00592-007-0001-z

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

177-80

issue

4

eissn

0940-5429

issn

1432-5233

journal_volume

44

pub_type

杂志文章

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