Abstract：
AIMS:To evaluate the efficacy and safety of intravitreal dexamethasone implant (DEX-implant) for diabetic macular edema (DME) in real-life practice with an extended follow-up for up to 5 year. METHODS:This multicentric retrospective study reviewed 227 eyes of 152 patients with DME treated by DEX-implant. Main outcome measures included changes in best corrected visual acuity (BCVA), central macular thickness (CMT), time to retreatment and incidence of adverse effects. RESULTS:The mean number of DEX-implant received by patients was 2.6 (± 2.2) with a mean (SD) follow-up of 20.1 (± 15.8) months, median [IQR] 15.8 [7.4-30.1]. The mean time of retreatment was 6.9 months. The mean maximal BCVA gain during follow-up was 12.3 (± 12.7) letters. A gain of ≥ 5, ≥ 10 and ≥ 15 letters from baseline BCVA was obtained for 71.8%, 48.9% and 34.8% of eyes, respectively. A total of 62.6% of eyes presented a significant anatomical response (decrease of CMT ≥ 20%), and DME was resolved (absence of cystoid macular spaces on OCT) in 37% of cases at the end of the follow-up. A transient increase in intraocular pressure ≥ 25 mmHg occurred in 14.1% of eyes, and cataract surgery was performed for 49.1% of the phakic eyes during the follow-up. Four eyes developed a proliferative diabetic retinopathy. CONCLUSION:This large cohort study showed favorable long-term outcomes when using DEX-implant, which provides substantial long-term benefits in the treatment of DME in real life.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Mathis T,Lereuil T,Abukashabah A,Voirin N,Sudhalkar A,Bilgic A,Denis P,Dot C,Kodjikian Ldoi
10.1007/s00592-020-01561-1subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1413-1421issue
12eissn
0940-5429issn
1432-5233pii
10.1007/s00592-020-01561-1journal_volume
57pub_type
杂志文章,多中心研究abstract：:Diabetes mellitus and hyperglycaemia are both independent risk factors (RF) for cardiovascular (CV) events and increased general and CV mortality. Type 2 diabetes, which is often associated with obesity, hypertension and dyslipidaemia, is accompanied by an up to fourfold increase in the incidence of acute coronary hea...
journal_title：Acta diabetologica
pub_type： 共识发展会议,杂志文章
doi：10.1007/s00592-013-0508-4
更新日期：2013-12-01 00:00:00
abstract：AIMS:Many authors do not recommend hypoglycemic treatment during pregnancy in women affected by monogenic diabetes due to heterozygous glucokinase (GCK) mutations (MODY 2) in case of affected fetus, because maternal hyperglycemia would be necessary to achieve a normal birthweight. We aimed to evaluate differences in bi...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-018-1198-8
更新日期：2018-12-01 00:00:00
abstract：:The purpose of this study is to identify the recent characteristics and the developments of therapeutic education in diabetes through an analysis of the international articles published from 2004 to 2007. Studies were selected from several databases: Medline, Embase, Eric, Cochrane central database, using the followin...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-008-0044-9
更新日期：2008-12-01 00:00:00
abstract：AIMS:To investigate the associations of vitamin B12 (cobalamin and holotranscobalamin) status with depression, cognition and neuropathy in patients with type 2 diabetes using metformin. METHODS:In an observational study, among 550 type 2 diabetes patients using metformin, cobalamin and holotranscobalamin (holoTCII) le...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0661-4
更新日期：2015-04-01 00:00:00
abstract：AIMS:The role of neutrophils in diabetes and its complications is unclear. Upon challenge with microbes and inflammatory triggers, neutrophils release enzymes and nuclear material, forming neutrophils extracellular traps (NETs) and thereby dying by NETosis. We herein tested NET formation and NETosis products in high gl...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0676-x
更新日期：2015-06-01 00:00:00
abstract：AIMS:The relationship between bisphenol A (BPA) and diabetes remains controversial. This study aims to investigate whether serum BPA level could predict the 5-year incidence of type 2 diabetes (T2D). METHODS:A nested case-control study was performed among Chinese who participated in the environment, inflammation and m...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-018-1104-4
更新日期：2018-04-01 00:00:00
abstract：:The effect of a phenacyl imidazolium compound (LY177507 or Proglycosyn, Eli Lilly) on the direct (glucose-->glucose-6-phosphate-->glycogen) and indirect (three-carbon compounds-->glucose-6-phosphate-->glycogen) pathways of liver glycogen synthesis was studied in conscious rats. [1-13C]Glucose (99% enriched) was infuse...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00578216
更新日期：1993-01-01 00:00:00
abstract：:The aim of the present work was to investigate the impact of gender on resting cerebral blood flow velocity and cerebrovascular reserve capacity among diabetic patients. Middle cerebral artery mean blood flow velocity (MCAV) was measured in 72 patients suffering from type 1 diabetes mellitus at rest and 5, 10, 15 and ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920170006
更新日期：2001-01-01 00:00:00
abstract：AIMS:To evaluate the patients' perceptions of telemedicine visits during COVID-19 lockdown and their level of anxiety about COVID and diabetic foot (DF). METHODS:In May 2020, we contacted by phone all the patients who underwent in March and April to remote monitoring visits for DF during the lockdown for COVID-19, wit...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-020-01653-y
更新日期：2021-01-13 00:00:00
abstract：:The assessment of body composition and energy requirements is important for the nutrition of healthy and pathological states such as gastrointestinal disorders, which are known to be associated with abnormalities in body composition among persons with malnutrition and malabsorption. Careful monitoring of body composit...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-003-0053-7
更新日期：2003-10-01 00:00:00
abstract：:(31)P-magnetic resonance spectroscopy ((31)P-MRS) is a non-invasive tool to study high-energy phosphate (HEP) metabolism. We evaluate whether 31P-MRS can detect early changes in kidney HEP metabolism during a 6-month trial with Valsartan. Twenty consecutive stable and normotensive kidney-transplanted patients were enr...
journal_title：Acta diabetologica
pub_type： 临床试验,杂志文章
doi：10.1007/s00592-012-0369-2
更新日期：2012-12-01 00:00:00
abstract：:Consistent with the postulated role of oxidative stress in the etiology of late diabetic complications, pharmacological interventions based on biological antioxidants have been suggested. The aim of the present study was to investigate the effect of dietary supplementation with the pyridoindole antioxidant stobadine o...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920070012
更新日期：2000-01-01 00:00:00
abstract：AIMS:The aim of the current study was to investigate the association of type 2 diabetes (T2D) and insulin treatment with changes in muscle mass, muscle strength, and physical performance in older adults. METHODS:In 731 participants of the population-based KORA-Age study aged 74.6 ± 6.2 years (T2D: n = 118; insulin tre...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-020-01523-7
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Psychosocial factors like diabetes distress and social support, as well as the presence of complications, affect an individual's self-management ability; however, their role in adherence behaviours is not yet clear. We examined the role of psychosocial factors and complications in non-adherence behaviours in...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-020-01609-2
更新日期：2020-11-19 00:00:00
abstract：:Cytomegalovirus (CMV) infects 40 % of the world population and has been suggested to be associated with diabetes; however, no prospective study has ever examined diabetes mortality associated with the infection. A cohort of 14,404 non-diabetic adult participants aged 17-90 years from the Third National Health and Nutr...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0573-3
更新日期：2014-10-01 00:00:00
abstract：:Several conditions have been described to cause osteoporosis, including diabetes mellitus. While the relationship between type 1 diabetes and osteopenia is well documented in the literature, data on the presence of this complication in type 2 diabetes have not been well established. We studied a population composed of...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920050142
更新日期：1999-06-01 00:00:00
abstract：AIMS:This subanalysis of a cross-sectional, nationwide study was undertaken to assess the relationship between healthy lifestyle behaviors and multiple cardiovascular risk factors among people with type 2 diabetes mellitus (T2DM). METHODS:Data collected from 25,454 participants, including demographics, lifestyle behav...
journal_title：Acta diabetologica
pub_type： 杂志文章,多中心研究
doi：10.1007/s00592-017-0981-2
更新日期：2017-06-01 00:00:00
abstract：AIMS:Prognostic significance of apolipoproteins in diabetic retinopathy risk has not been well investigated. The aim of this study was to reveal the relationship between the risk of diabetic retinopathy and the levels of several apolipoproteins and their ratios in a 10-year prospective cohort. METHODS:A total of 1023 ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-018-1136-9
更新日期：2018-07-01 00:00:00
abstract：:Elevated plasma CT-pro-vasopressin (copeptin) has been described as biomarkers for type 2 diabetes (T2D) and the metabolic syndrome (MetS), which, however, was not confirmed by all studies. Here, we analyzed the association of copeptin with T2D, MetS and MetS components in the population-based KORA F4 study. Plasma co...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0609-8
更新日期：2015-02-01 00:00:00
abstract：:For many diabetic patients, years of blood glucose self-monitoring (SM) with readings taken several times daily is an inevitable aspect of insulin therapy. We investigated whether SM from abdominal skin might be an alternative to the established fingertip method. A total of 63 diabetic patients and 16 nondiabetic volu...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920200020
更新日期：2002-06-01 00:00:00
abstract：:The objective of the study was to determine the prevalence of known diabetes among elderly subjects receiving nursing care in a north Norwegian population, to screen for new cases using HbA1c measurement and to evaluate the quality of care for those with diabetes. Men and women, with and without known diabetes, above ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-006-0212-8
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND:Circulating levels of TNF alpha receptor 1 (TNFR1) and 2 (TNFR2) are associated with increased long-term mortality and impaired kidney function. AIM:To study association between circulating levels of TNFR1 and TNFR2 and short-term mortality in patients with diabetes and dyspnea. POPULATION AND METHODS:Pati...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-020-01527-3
更新日期：2020-10-01 00:00:00
abstract：:Although reactive oxygen species (ROS) contribute to glucose intolerance induced by the renin-angiotensin system (RAS) is well documented, the role of the newly discovered pathway of RAS, angiotensin (Ang)-(1-7)/Mas axis, in this process remains unknown. Here, we examined the effect of Ang-(1-7) on oxidative stress an...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-011-0348-z
更新日期：2012-08-01 00:00:00
abstract：:Autonomic nervous dysfunction is considered to be one of the mechanisms of metabolic syndrome (MetS). The aim of this study is to investigate whether resting heart rate, a marker of autonomic nervous dysfunction, is a predictor of MetS in apparently healthy non-obese [body mass index (BMI) <25 kg/m(2)] Japanese men. T...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-013-0503-9
更新日期：2014-02-01 00:00:00
abstract：AIMS:The aim of our study was to estimate the overall rate of first hospitalizations for diabetic foot (DF) regardless of the outcome in amputations, as well as the mortality rate with their determinants in the period 2012-2016 in Piedmont Region in Italy. METHODS:The study included all the subjects registered in the ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-019-01412-8
更新日期：2020-02-01 00:00:00
abstract：AIMS:Diabetic retinopathy (DR) is characterized by early dropout of capillary pericytes, leading to loss of control on endothelial proliferation and, subsequently, angiogenesis. We have demonstrated that extracellular vesicles (EV) derived from mesenchymal stem cells (MSC) maintained in diabetic-like conditions may pla...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-015-0798-9
更新日期：2015-12-01 00:00:00
abstract：:In late twentieth century, Ruderman and Reaven showed that insulin resistance might be fundamental to metabolic syndrome (MetS) which means a constellation of obesity-related metabolic derangements predisposing to type 2 diabetes and cardiovascular disease. In 2001, user-friendly National Cholesterol Education Program...
journal_title：Acta diabetologica
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s00592-011-0309-6
更新日期：2012-04-01 00:00:00
abstract：:Positron emission tomography/computed tomography (PET/CT) is a standard procedure for imaging cancer commonly used in the clinical practice for several diseases, in particular for cancer staging, restaging, treatment monitoring and radiation therapy planning. Despite the availability of many radiotracers, 18F-fluoro-2...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-019-01385-8
更新日期：2020-03-01 00:00:00
abstract：AIMS:Sirtuin-1 (SIRT-1) down-regulation in type 2 diabetes mellitus (T2DM) has been associated with epigenetic markers of oxidative stress. We herein aim to evaluate whether an increase in SIRT-1 expression affects histone 3 acetylation at the 56 lysine residue (H3K56ac) in T2DM patients randomly selected to receive ei...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-017-1097-4
更新日期：2018-04-01 00:00:00
abstract：:Hypertriglyceridaemia is associated with insulin resistance of both lipid and glucose metabolism. It is not known whether the insulin resistance affects both glucose oxidation and glycogen formation. To study the oxidative and non-oxidative pathways of non-esterified fatty acids (NEFA) and glucose metabolism, eight ma...
journal_title：Acta diabetologica
pub_type： 临床试验,杂志文章
doi：10.1007/BF00580753
更新日期：1994-04-01 00:00:00
