Abstract:
:Autonomic nervous dysfunction is considered to be one of the mechanisms of metabolic syndrome (MetS). The aim of this study is to investigate whether resting heart rate, a marker of autonomic nervous dysfunction, is a predictor of MetS in apparently healthy non-obese [body mass index (BMI) <25 kg/m(2)] Japanese men. This is an observational study through 3 years in apparently healthy Japanese 1,265 men and 793 women without MetS and with no history of cardiovascular disease and no use of antihypertensive, antidiabetic, or antihyperlipidemic medication at baseline. Hazard ratios (HRs) of incident MetS were calculated for each 1 SD increase in heart rate stratified by gender and obesity. Incidence of MetS for each tertile of heart rate and HRs of MetS for the highest tertile (T3) compared with the lowest tertile (T1) were calculated stratified by gender and obesity. The HRs [95% confidence intervals (CIs)] of MetS for each 1 SD increase in heart rate were 1.319 (1.035-1.681) (p = 0.025) in non-obese men, 1.172 (0.825-1.665) (p = 0.377) in obese men, 1.115 (0.773-1.608) (p = 0.560) in non-obese women, and 1.401 (0.944-2.078) (p = 0.094) in obese women adjusted for BMI, age, smoking, alcohol drinking, and physical activity. The HRs (95% CIs) of MetS for T3 were 2.138 (1.071-4.269) (p = 0.031) in non-obese men and 1.341 (0.565-3.180) (p = 0.506) in obese men adjusted for pre-existing five components of MetS, age, smoking, alcohol drinking, and physical activity. In conclusion, an increase in resting heart rate was a significant predictor of MetS in non-obese Japanese men.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Oda E,Aizawa Ydoi
10.1007/s00592-013-0503-9subject
Has Abstractpub_date
2014-02-01 00:00:00pages
85-90issue
1eissn
0940-5429issn
1432-5233journal_volume
51pub_type
杂志文章abstract:AIMS:The aim of the current study was to investigate the association of type 2 diabetes (T2D) and insulin treatment with changes in muscle mass, muscle strength, and physical performance in older adults. METHODS:In 731 participants of the population-based KORA-Age study aged 74.6 ± 6.2 years (T2D: n = 118; insulin tre...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-020-01523-7
更新日期:2020-09-01 00:00:00
abstract::The effect of the insulinotropic gut hormone glucagon-like-peptide-1 (GLP-1) was studied on the residual insulin capacity of prediabetic nonobese diabetic (NOD) mice, a model of insulin-dependent diabetes mellitus (type 1). This was done using isolated pancreas perfusion and dynamic islet perifusion. Prediabetes was d...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00571935
更新日期:1996-03-01 00:00:00
abstract::Cytomegalovirus (CMV) infects 40 % of the world population and has been suggested to be associated with diabetes; however, no prospective study has ever examined diabetes mortality associated with the infection. A cohort of 14,404 non-diabetic adult participants aged 17-90 years from the Third National Health and Nutr...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-014-0573-3
更新日期:2014-10-01 00:00:00
abstract:AIMS:The aims of this study were: to develop new equations for predicting resting energy expenditure (REE) in obese Italian subjects according to body composition parameters; to compare them with predicted values estimated by other REE prediction equations; and to cross-validate our equations using a validation set coh...
journal_title:Acta diabetologica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00592-017-1061-3
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Psychosocial factors like diabetes distress and social support, as well as the presence of complications, affect an individual's self-management ability; however, their role in adherence behaviours is not yet clear. We examined the role of psychosocial factors and complications in non-adherence behaviours in...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-020-01609-2
更新日期:2020-11-19 00:00:00
abstract::To examine longitudinally the effect of diabetes on bone structure and metabolism, we measured bone mineral density (BMD) and turnover markers in 26 type 1 (mean age 49 years) and 27 type 2 (mean age 65 years) diabetic patients without known osteoporosis from a community-based sample at baseline and 5 years later. In ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-011-0324-7
更新日期:2012-04-01 00:00:00
abstract:AIMS:To assess the risk of adverse neonatal outcomes in women with gestational diabetes (GDM) by identifying subgroups of women at higher risk to recognize the characteristics most associated with an excess of risk. METHODS:Observational, retrospective, multicenter study involving consecutive women with GDM. To identi...
journal_title:Acta diabetologica
pub_type: 杂志文章,多中心研究
doi:10.1007/s00592-018-1208-x
更新日期:2018-12-01 00:00:00
abstract::The aim of the study was to report the prevalence of obesity indices in individuals with diabetes and find out their association with diabetic retinopathy in the urban Indian population. Subjects (n = 1,414) were recruited from Sankara Nethralaya Diabetic Retinopathy Epidemiology And Molecular Genetics Study (SN-DREAM...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-009-0113-8
更新日期:2010-09-01 00:00:00
abstract:AIMS:The aim of the study was to evaluate and compare continuous subcutaneous insulin infusion (CSII) use in pediatric and adult age groups. METHODS:Data were collected with a questionnaire sent by e-mail to CSII-experienced Diabetes Centers. The questionnaire assessed: (1) number of CSII-treated patients; (2) patient...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0810-4
更新日期:2016-06-01 00:00:00
abstract::Endothelial nitric oxide synthase (eNOS) has been shown to play an essential role in retinal vascular function, and disequilibrium in its production can lead to diabetic retinopathy (DR). Genetic polymorphisms of eNOS gene have been suggested to play a role in nitric oxide (NO) abnormalities which may contribute to th...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-012-0437-7
更新日期:2012-12-01 00:00:00
abstract:AIMS:Hypoglycaemia represents a critical burden with clinical and social consequences in the management of diabetes. Serum uric acid (SUA) has been associated with cardiovascular diseases (CVD), but no conclusive findings are available nowadays in patients suffering from hypoglycaemia. We investigated whether SUA level...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-017-1094-7
更新日期:2018-04-01 00:00:00
abstract::We investigated the effect of sub-chronic soybean oil (SO) treatment on the insulin secretion and fatty acid composition of islets of Langerhans obtained from Goto-Kakizaki (GK), a model of type 2 diabetes, and normal Wistar rats. We observed that soybean-treated Wistar rats present insulin resistance and defective is...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-007-0252-8
更新日期:2007-09-01 00:00:00
abstract:AIMS:This subanalysis of a cross-sectional, nationwide study was undertaken to assess the relationship between healthy lifestyle behaviors and multiple cardiovascular risk factors among people with type 2 diabetes mellitus (T2DM). METHODS:Data collected from 25,454 participants, including demographics, lifestyle behav...
journal_title:Acta diabetologica
pub_type: 杂志文章,多中心研究
doi:10.1007/s00592-017-0981-2
更新日期:2017-06-01 00:00:00
abstract::To determine the impact of glargine insulin therapy with different nutritional models on key parameters of diabetes including quality of life, behavior in children and adolescents with type 1 diabetes. Age, duration of diabetes, HbA1c, anthropometric data and episodes of severe hypoglycemia were taken from patients' c...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-007-0019-2
更新日期:2008-03-01 00:00:00
abstract::Postreceptor insulin resistance was studied in liver, muscle and adipose tissue from NMRI mice of both sexes made diabetic by long-term fat-feeding. Intravenous glucose tolerance tests showed a combination of impaired glucose tolerance and increased plasma insulin concentrations consistent with insulin resistance and ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00572823
更新日期:1992-01-01 00:00:00
abstract::Despite advances in technology, the frequent self-measurement of blood glucose (SMBG) remains fundamental to the management of 1 diabetes mellitus (T1DM). Once measured, SMBG results are routinely reported back to health professionals and other interested parties, either verbally, via a logbook, or electronically down...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-016-0907-4
更新日期:2017-01-01 00:00:00
abstract::Few studies were performed to evaluate the prevalence of latent autoimmune diabetes in adults (LADA) and the difference of chronic complications between LADA, T1DM, and T2DM in Korean. The aim of this study is to establish the prevalence of LADA in a diabetic clinic of Soonchunhyang University hospital and to compare ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-010-0228-y
更新日期:2013-04-01 00:00:00
abstract::Although reactive oxygen species (ROS) contribute to glucose intolerance induced by the renin-angiotensin system (RAS) is well documented, the role of the newly discovered pathway of RAS, angiotensin (Ang)-(1-7)/Mas axis, in this process remains unknown. Here, we examined the effect of Ang-(1-7) on oxidative stress an...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-011-0348-z
更新日期:2012-08-01 00:00:00
abstract:AIM:High glucose-induced oxidative stress has been suggested as one of the mediators of endothelial damage in diabetes. The major endothelial protein, endoglin, has been found overexpressed in the vessels during pathological situations, but little is known about its relation to diabetic vascular complications. To clari...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-014-0670-3
更新日期:2015-06-01 00:00:00
abstract::The aim of this study was to assess the effectiveness and safety of intracavernous injections of a four-drug vasoactive mixture in diabetic patients with organic impotence. A group of 60 diabetic patients with either pure neurogenic, pure vasculogenic or mixed neurovasculogenic impotence were treated with intracaverno...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00580752
更新日期:1994-04-01 00:00:00
abstract:AIMS:Observational studies indicated that resting heart rate (RHR) was associated with diabetes mellitus (DM) risk; however, it remains unclear whether the association between RHR and DM is causal. We aimed to examine whether there was causal association of RHR with DM risk. METHODS:A prospective study including 16,20...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-019-01344-3
更新日期:2019-09-01 00:00:00
abstract::Diabetes cardiomyopathy is a specific form of cardiac disease characteristic for diabetic patients. Development of echocardiography enabled diagnosis of diabetic cardiomyopathy significantly before the occurrence of heart failure. Previously was believed that left ventricular (LV) diastolic dysfunction represents the ...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-020-01528-2
更新日期:2020-09-01 00:00:00
abstract::Anti-myeloperoxidase (anti-MPO) antibodies were detected in 34 of 88 (38%) patients with type 1 diabetes mellitus but in only 3 of 55 (5.7%) healthy subjects and in 4 of 20 patients with autoimmune disease. Specificity of anti-MPO antibodies was assessed by MPO inhibition studies. No relationship was found between the...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00569418
更新日期:1996-07-01 00:00:00
abstract::The aim of this study is to assess the impact of the internet-based upload blood glucose monitoring and therapy management system (Carelink(®)) in patients with type 1 diabetes. Diabetic patients treated with pump infusion for ≥3 months were prospectively randomized to use the CareLink(®) with (4 months) and without (...
journal_title:Acta diabetologica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00592-013-0510-x
更新日期:2014-04-01 00:00:00
abstract::HLA-A, B, C, DR and DQ typing was performed in 381 Italian insulin-dependent diabetic patients and in 905 normal Italian subjects. The diabetic patients had significantly higher frequencies of HLA-Cw7, B8, B18, DR3, DR4, DQw2 and DQw3 and significantly lower frequencies of HLA-B17, Bw51, DR2, DR7 and DRw11. The freque...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00779004
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Emerging adulthood is a challenging period for diabetes management. Our aim was to determine whether a dedicated transition clinic for emerging adults with type 1 diabetes can improve glycemic control and visit attendance. METHODS:An observational study of 53 emerging adults (30 males) treated during 2010-2...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0734-z
更新日期:2016-02-01 00:00:00
abstract:AIMS:Sirtuin-1 (SIRT-1) down-regulation in type 2 diabetes mellitus (T2DM) has been associated with epigenetic markers of oxidative stress. We herein aim to evaluate whether an increase in SIRT-1 expression affects histone 3 acetylation at the 56 lysine residue (H3K56ac) in T2DM patients randomly selected to receive ei...
journal_title:Acta diabetologica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00592-017-1097-4
更新日期:2018-04-01 00:00:00
abstract:AIMS:Although diabetes is rapidly increasing in India, there is no national consensus on best practices for screening, diagnosis, and management of gestational diabetes mellitus (GDM). The goal of this study was to systematically review the literature for studies reporting the prevalence and screening and diagnostic me...
journal_title:Acta diabetologica
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00592-018-1131-1
更新日期:2018-06-01 00:00:00
abstract::Cardiovascular risk is determined by multiple risk factors, all of which greatly increase the chance of morbidity and mortality. So-called "normal" levels of these factors are not biologically normal, so current strategy is based on estimations of a person's global cardiovascular risk, and then using appropriate combi...
journal_title:Acta diabetologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00592-005-0181-3
更新日期:2005-04-01 00:00:00
abstract::Autoantibodies to zinc transporter 8 (ZnT8A) are a powerful diagnostic or predictive marker in type 1 diabetes. However, the widely used current ZnT8A radioligand binding assay (RBA) has proved to be difficult for many laboratories to implement. The aim of this study was the development and characterization of the per...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-013-0532-4
更新日期:2014-01-01 00:00:00