Abstract:
:The aim of the study was to report the prevalence of obesity indices in individuals with diabetes and find out their association with diabetic retinopathy in the urban Indian population. Subjects (n = 1,414) were recruited from Sankara Nethralaya Diabetic Retinopathy Epidemiology And Molecular Genetics Study (SN-DREAMS-I), a cross-sectional study between 2003 and 2006. Anthropometric measurements were carried out, and all patients' fundi were photographed using 45 degrees four-field stereoscopic digital photography. The diagnosis of diabetic retinopathy was based on the modified Klein classification. Generalized obesity and abdominal obesity were defined using WHO Asia Pacific guidelines with the BMI (body mass index) cutoff as > or =23 kg/m(2), WC (waist circumference) cutoffs as > or =90 cm in men and > or =80 cm in women and WHO guidelines using WHR (waist-to-hip ratio) cutoffs as > or =0.90 for men and > or =0.85 for women. Prevalence of obesity defined by BMI and WC was more in women compared to men, and that defined by WHR was more in men compared to women (P < 0.001). The prevalence of isolated generalized obesity, isolated abdominal obesity and combined obesity were 5.4, 10.1 and 58% in men and 4.5, 10.8 and 74.4% in women, respectively. The prevalence of any diabetic retinopathy and sight-threatening diabetic retinopathy was more in the isolated abdominal obesity group (26.35 and 6.08%, respectively) than in other subgroups. On logistic regression analysis, isolated abdominal obesity (OR 2.02, 95% CI: 1.06-3.86) and increased WHR in women (OR 1.48 95% CI: 1.10-2.38) were associated with diabetic retinopathy; BMI > or = 23 (OR 0.66, 95% CI: 0.48-0.90) and combined obesity (OR 0.72, 95% CI: 0.53-0.99) had a protective role for any diabetic retinopathy in the overall group. In the urban south Indian population, isolated abdominal obesity and higher WHR in women were associated with diabetic retinopathy, but not with the severity of diabetic retinopathy.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Raman R,Rani PK,Gnanamoorthy P,Sudhir RR,Kumaramanikavel G,Sharma Tdoi
10.1007/s00592-009-0113-8subject
Has Abstractpub_date
2010-09-01 00:00:00pages
209-15issue
3eissn
0940-5429issn
1432-5233journal_volume
47pub_type
杂志文章abstract:AIMS:This study aimed to assess islet insulin secretion and insulin resistance in Chinese patients with latent autoimmune diabetes in adults (LADA). METHODS:Twelve patients with LADA, 10 with type 1 diabetes mellitus (T1DM), 10 with type 2 diabetes mellitus (T2DM), and 10 nondiabetic healthy controls (HCs) were includ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-019-01387-6
更新日期:2019-11-01 00:00:00
abstract::The aim of this study was to evaluate the prevalence of thyroid autoantibodies and clinical significance of thyroid autoimmunity in children with the diagnosis of diabetes mellitus type 1. The study group comprised 222 children all with newly diagnosed diabetes mellitus type 1 (122 boys) with a mean age 9.92 +/- 4.5 y...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-007-0017-4
更新日期:2008-03-01 00:00:00
abstract::Cardiovascular diseases represent, today, the principal cause of mortality in the general population, especially in subjects with type 2 diabetes mellitus. In these patients the risk of death from cardiovascular diseases is equal to that of non-diabetic subjects with a previous episode of myocardial infarction. Many f...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-003-0121-z
更新日期:2003-12-01 00:00:00
abstract:AIMS:There is clinical evidence that fenofibrate, a PPARα agonist, arrests the progression of diabetic macular edema (DME). However, the underlying mechanisms of this beneficial effect remain to be elucidated. We previously reported that fenofibric acid (FA), the active metabolite of fenofibrate, prevents the disorgani...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0759-3
更新日期:2016-02-01 00:00:00
abstract::Urinary angiotensin-converting enzyme (ACE) and urinary N-acetyl-beta-D-glucosaminidase (NAG) were measured after a 5-year interval in 38 non-azotemic type 2 diabetic patients. Of these patients at baseline, 16 had nil nephropathy, 15 had incipient nephropathy, and 7 had overt nephropathy. During the follow-up, 6 and ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00838491
更新日期:1995-10-01 00:00:00
abstract::In the present study, we investigated whether the ameliorating effect of aminoguanidine on diabetes-related proteinuria and nephropathy is associated with glomerular basement membrane heparan sulphate contents. STZ-induced diabetic rats developed proteinuria (at the tenth week: diabetic rats, 713 +/- 418 mg protein pe...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920070022
更新日期:2000-01-01 00:00:00
abstract:AIMS:Increasing evidence suggests a potential role of circulating miRNAs as clinical biomarkers, and loss of miRNA-126 has been proposed as a predictor of type 2 diabetes onset. However, a systematic analysis of circulating miRNAs in type 1 diabetic patients with micro-/macrovascular complications has not yet been perf...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-016-0915-4
更新日期:2017-02-01 00:00:00
abstract::Diabetes mellitus is an independent risk factor for falling, particularly in the elderly. Due to chronic hyperglycemia and hyperinsulinemia patients with diabetes mellitus may have neurological deficits as peripheral neuropathy that is a debilitating micro-vascular complication affecting the proximal and distal periph...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-018-1183-2
更新日期:2018-12-01 00:00:00
abstract:AIMS:The aim of the study was to evaluate and compare continuous subcutaneous insulin infusion (CSII) use in pediatric and adult age groups. METHODS:Data were collected with a questionnaire sent by e-mail to CSII-experienced Diabetes Centers. The questionnaire assessed: (1) number of CSII-treated patients; (2) patient...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0810-4
更新日期:2016-06-01 00:00:00
abstract::Rosiglitazone often results in weight gain. We hypothesized that rosiglitazone may modulate circulating levels of ghrelin and peptide YY(3-36) and this modulation may be related to weight-gaining effect of this agent. This study was designed as an open-label, randomized, controlled trial of 3-month duration. Women wit...
journal_title:Acta diabetologica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00592-011-0352-3
更新日期:2012-12-01 00:00:00
abstract::Elevated plasma CT-pro-vasopressin (copeptin) has been described as biomarkers for type 2 diabetes (T2D) and the metabolic syndrome (MetS), which, however, was not confirmed by all studies. Here, we analyzed the association of copeptin with T2D, MetS and MetS components in the population-based KORA F4 study. Plasma co...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-014-0609-8
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Psychosocial factors like diabetes distress and social support, as well as the presence of complications, affect an individual's self-management ability; however, their role in adherence behaviours is not yet clear. We examined the role of psychosocial factors and complications in non-adherence behaviours in...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-020-01609-2
更新日期:2020-11-19 00:00:00
abstract::HLA-A, B, C, DR and DQ typing was performed in 381 Italian insulin-dependent diabetic patients and in 905 normal Italian subjects. The diabetic patients had significantly higher frequencies of HLA-Cw7, B8, B18, DR3, DR4, DQw2 and DQw3 and significantly lower frequencies of HLA-B17, Bw51, DR2, DR7 and DRw11. The freque...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00779004
更新日期:1992-01-01 00:00:00
abstract:AIMS:We sought to investigate temporal trends in prediabetes prevalence among US adolescents using two definitions and evaluate relationships with obesity and a MetS-severity score. METHODS:We evaluated data from 5418 non-Hispanic white, non-Hispanic black, and Hispanic adolescents aged 12-19 participating in the Nati...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-016-0958-6
更新日期:2017-04-01 00:00:00
abstract::Diabetes mellitus and hyperglycaemia are both independent risk factors (RF) for cardiovascular (CV) events and increased general and CV mortality. Type 2 diabetes, which is often associated with obesity, hypertension and dyslipidaemia, is accompanied by an up to fourfold increase in the incidence of acute coronary hea...
journal_title:Acta diabetologica
pub_type: 共识发展会议,杂志文章
doi:10.1007/s00592-013-0508-4
更新日期:2013-12-01 00:00:00
abstract:AIMS:Although diabetes is rapidly increasing in India, there is no national consensus on best practices for screening, diagnosis, and management of gestational diabetes mellitus (GDM). The goal of this study was to systematically review the literature for studies reporting the prevalence and screening and diagnostic me...
journal_title:Acta diabetologica
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00592-018-1131-1
更新日期:2018-06-01 00:00:00
abstract::Patients with diabetes represent an increasing proportion of end-stage renal disease (ESRD) patients. Cardiovascular risk, already formidable among patients on dialysis, is significantly higher among those who also have diabetes. Diabetic ESRD patients are not only at higher risk of ischaemic events, but are also subj...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s005920200003
更新日期:2002-04-01 00:00:00
abstract::To evaluate the effects of vasoactive intestinal peptide (VIP) on whole pancreatic blood flow and islet blood flow in the rat, anaesthetized adult rats were injected intravenously for 90 s with VIP (500 ng/kg body weight). Immediately after the injection, the whole pancreatic and islet blood flows were measured with a...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00570545
更新日期:1994-06-01 00:00:00
abstract::This study examined whether or not changes in plasma concentrations of motilin and other gastrointestinal hormones known to affect gastric motility are associated with the accelerated gastric emptying seen during hypoglycaemia. While studying gastric emptying by scintigraphy in eight healthy subjects, the plasma conce...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920050073
更新日期:1997-10-01 00:00:00
abstract::Diabetic kidney disease (DKD) is a devastating complication of Type 1 and Type 2 diabetes and leads to increased morbidity and mortality. Earlier work in families has provided strong evidence that heredity is a major determinant of DKD. Previous linkage analyses and candidate gene studies have identified potential DKD...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-018-1193-0
更新日期:2018-11-01 00:00:00
abstract::We analysed the risk factors associated with diabetic complications in the cohort of patients assisted by a type 2 diabetes mellitus (T2DM) shared-care program. We analysed registry data from 16,136 T2DM patients. Of them, 4,781 had microangiopathy, 3,469 CV events. They were 70.5 ± 17.1 years old, 50% were male, dise...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-010-0186-4
更新日期:2010-12-01 00:00:00
abstract:AIMS:Maternal type 2 diabetes (T2D) can result in adverse pathological outcomes to both the mother and fetus. The present study aimed to investigate the pathological effects of maternal T2D on the gene expression patterns and functions of fetal human umbilical vein endothelial cells (HUVECs), a representative of fetal ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-018-1207-y
更新日期:2019-01-01 00:00:00
abstract::Hypertriglyceridaemia is associated with insulin resistance of both lipid and glucose metabolism. It is not known whether the insulin resistance affects both glucose oxidation and glycogen formation. To study the oxidative and non-oxidative pathways of non-esterified fatty acids (NEFA) and glucose metabolism, eight ma...
journal_title:Acta diabetologica
pub_type: 临床试验,杂志文章
doi:10.1007/BF00580753
更新日期:1994-04-01 00:00:00
abstract:AIMS:Glucagon is used to resolve severe hypoglycemia in unconscious patients with diabetes, requiring third-party assistance. A few studies have shown that intranasal (IN) glucagon causes resolution of hypoglycemia in insulin-treated patients with type 1 (T1DM) diabetes. This systematic review and meta-analysis updates...
journal_title:Acta diabetologica
pub_type: 杂志文章,meta分析
doi:10.1007/s00592-020-01483-y
更新日期:2020-06-01 00:00:00
abstract::A cross-sectional descriptive study was done on patients recently entered into the National Diabetes Registry in Eritrea where the prevalence was estimated to be 2.2% based on patient information in 2004. Of the 627 patients with diabetes, two thirds were type 2. Although type 1 had poorer control (42.9%) than type 2 ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-009-0093-8
更新日期:2010-03-01 00:00:00
abstract:AIMS:Many authors do not recommend hypoglycemic treatment during pregnancy in women affected by monogenic diabetes due to heterozygous glucokinase (GCK) mutations (MODY 2) in case of affected fetus, because maternal hyperglycemia would be necessary to achieve a normal birthweight. We aimed to evaluate differences in bi...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-018-1198-8
更新日期:2018-12-01 00:00:00
abstract::Several haemostatic abnormalities are associated with proliferative diabetic retinopathy. While abnormalities in plasma fibrinolytic activity have been described in diabetic retinopathy, platelets (a rich source of plasminogen activator inhibitor type 1, PAI-1) have received little attention. As a result, little is kn...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920050159
更新日期:1999-09-01 00:00:00
abstract:AIMS:Our aims were to investigate in several large samples, with a wide range of adiposity, whether: (1) the effect of BMI on insulin sensitivity is different between sexes; (2) also waist circumference plays a sex-specific role on insulin sensitivity; and (3) serum adiponectin and resistin are mediators of such sex-di...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0804-2
更新日期:2015-10-01 00:00:00
abstract::The assessment of body composition and energy requirements is important for the nutrition of healthy and pathological states such as gastrointestinal disorders, which are known to be associated with abnormalities in body composition among persons with malnutrition and malabsorption. Careful monitoring of body composit...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-003-0053-7
更新日期:2003-10-01 00:00:00
abstract::The objective of this study was to describe spatial and space-time patterns of type 1 diabetes in children less than 15 years old, diagnosed between 2000 and 2005 with residence in the Metropolitan Region of Chile. Knox and Mantel tests were used to detect space-time interaction between cases. An ecological Bayesian m...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-010-0189-1
更新日期:2010-09-01 00:00:00