Abstract：
:Diabetes mellitus is an independent risk factor for falling, particularly in the elderly. Due to chronic hyperglycemia and hyperinsulinemia patients with diabetes mellitus may have neurological deficits as peripheral neuropathy that is a debilitating micro-vascular complication affecting the proximal and distal peripheral sensory and motor nerves. Sensory neuropathy is prominent and represents the chief contributor to postural instability in diabetic subjects. Diabetic retinopathy is another complication consequent to a breakdown of the inner blood-retinal barrier with accumulation of extracellular fluids in the macula and growth of new vessels causing retinal detachment. Together peripheral neuropathy and retinopathy contribute to increase the risk of falls in diabetic patients, but a certain vestibular organs impairment should not be underestimated. Nevertheless, the exact mechanism and localization of peripheral vestibular damage consequent to chronic hyperglycemia and hyperinsulinemia are currently not still understood. Moreover it is not defined the possible role of these two blood conditions in worsening the prognosis of typical vestibular pathologies like "benign paroxysmal positional vertigo" and "Meniere disease". The aim of this review was to retrieve all studies investigating about the balance system alterations in patients suffering of diabetes. A search thorough Ovid MEDLINE was performed to enroll all eligible articles. Fourteen studies comprising a total of 1364 patients were included and analyzed in detail. On the basis of data reported in our review it appears plausible to hypothesize a direct connection among chronic hyperglycemic/hyperinsulinemic damage and peripheral vestibular organ dysfunction.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Gioacchini FM,Albera R,Re M,Scarpa A,Cassandro C,Cassandro Edoi
10.1007/s00592-018-1183-2subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1201-1207issue
12eissn
0940-5429issn
1432-5233pii
10.1007/s00592-018-1183-2journal_volume
55pub_type
杂志文章,评审abstract：:Post-prandial hyperglycemia is considered a relevant therapeutic target in type 2 diabetic patients, and it could represent per se an independent risk factor for diabetic complications. Aim of the present systematic review is to collect and summarize evidence from observational studies on the relationship between post...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-011-0355-0
更新日期：2012-08-01 00:00:00
abstract：:Despite advances in technology, the frequent self-measurement of blood glucose (SMBG) remains fundamental to the management of 1 diabetes mellitus (T1DM). Once measured, SMBG results are routinely reported back to health professionals and other interested parties, either verbally, via a logbook, or electronically down...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-016-0907-4
更新日期：2017-01-01 00:00:00
abstract：:This study was aimed at the assessment of incidence of malignancies in type 2 diabetic patients treated with different sulphonylureas. A matched case-control study was performed. Cases were 195 diabetic patients aged 69.0 +/- 9.2 years who had an incident malignancy. Controls were 195 diabetic patients, unaffected by ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-008-0083-2
更新日期：2009-12-01 00:00:00
abstract：:Anti-myeloperoxidase (anti-MPO) antibodies were detected in 34 of 88 (38%) patients with type 1 diabetes mellitus but in only 3 of 55 (5.7%) healthy subjects and in 4 of 20 patients with autoimmune disease. Specificity of anti-MPO antibodies was assessed by MPO inhibition studies. No relationship was found between the...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00569418
更新日期：1996-07-01 00:00:00
abstract：:The aim of the present work was to investigate the impact of gender on resting cerebral blood flow velocity and cerebrovascular reserve capacity among diabetic patients. Middle cerebral artery mean blood flow velocity (MCAV) was measured in 72 patients suffering from type 1 diabetes mellitus at rest and 5, 10, 15 and ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920170006
更新日期：2001-01-01 00:00:00
abstract：:To determine the impact of glargine insulin therapy with different nutritional models on key parameters of diabetes including quality of life, behavior in children and adolescents with type 1 diabetes. Age, duration of diabetes, HbA1c, anthropometric data and episodes of severe hypoglycemia were taken from patients' c...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-007-0019-2
更新日期：2008-03-01 00:00:00
abstract：:The renin-angiotensin system (RAS) has an important role in the endocrine pancreas. Multiple researches have shown that even in the insulin resistance phase, there are many abnormalities in islets morphology and function. This study aimed at investigating the effects of RAS blockade on the islets function in rats with...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-010-0210-8
更新日期：2013-08-01 00:00:00
abstract：:Hypertriglyceridaemia is associated with insulin resistance of both lipid and glucose metabolism. It is not known whether the insulin resistance affects both glucose oxidation and glycogen formation. To study the oxidative and non-oxidative pathways of non-esterified fatty acids (NEFA) and glucose metabolism, eight ma...
journal_title：Acta diabetologica
pub_type： 临床试验,杂志文章
doi：10.1007/BF00580753
更新日期：1994-04-01 00:00:00
abstract：:A meta-analysis was performed in order to test the hypothesis that Japanese have a greater amount of abdominal visceral fat (AVF) relative to abdominal subcutaneous fat (ASF) than Caucasians. Data were derived from published studies that included mean values for AVF and ASF areas, measured using computed tomography, a...
journal_title：Acta diabetologica
pub_type： 杂志文章,meta分析
doi：10.1007/s00592-003-0093-z
更新日期：2003-10-01 00:00:00
abstract：:Correct classification of diabetic patients in adulthood at the time of diagnosis is often difficult. Some may be initially diagnosed as having non-insulin-dependent diabetes mellitus and be treated with diet and/or oral hypoglycaemic agents (OHA) but later require insulin treatment. Islet cell antibodies and antibodi...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00571567
更新日期：1996-12-01 00:00:00
abstract：:Administration of exogenous insulin for the treatment of diabetes is often accompanied by the development of insulin antibodies (IA). These antibodies may affect the patient's requirement for insulin by acting as an insulin binding reservoir. The improvement of insulin purification in the 1970s and the development of ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-009-0135-2
更新日期：2010-06-01 00:00:00
abstract：:Diabetes cardiomyopathy is a specific form of cardiac disease characteristic for diabetic patients. Development of echocardiography enabled diagnosis of diabetic cardiomyopathy significantly before the occurrence of heart failure. Previously was believed that left ventricular (LV) diastolic dysfunction represents the ...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-020-01528-2
更新日期：2020-09-01 00:00:00
abstract：AIMS:Prognostic significance of apolipoproteins in diabetic retinopathy risk has not been well investigated. The aim of this study was to reveal the relationship between the risk of diabetic retinopathy and the levels of several apolipoproteins and their ratios in a 10-year prospective cohort. METHODS:A total of 1023 ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-018-1136-9
更新日期：2018-07-01 00:00:00
abstract：AIMS:To evaluate feasibility and effectiveness on short-term blood glucose control of using glycaemic load counting (GLC) versus carbohydrate counting (CC) for prandial insulin dosing in patients with type 1 diabetes (T1D). METHODS:Nine T1D patients on insulin pump, aged 26-58 years, HbA1c 7.7 ± 0.8 % (61 ± 8.7 mmol/m...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-015-0716-1
更新日期：2015-10-01 00:00:00
abstract：AIMS:To investigate the possibility of identifying a subtype of latent autoimmune diabetes in adults (LADA), T-LADA (T cell responses-positive and autoantibody-negative) from patients with phenotypic type 2 diabetes (T2D) by enzyme-linked immunospot (ELISPOT). METHODS:Eighty-two patients with phenotypic T2D were studi...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-019-01391-w
更新日期：2019-11-01 00:00:00
abstract：:Studies suggest that diabetes may specifically elevate the risk of sudden cardiac death in excess of other heart disease outcomes. In this study, we examined the association of type 2 diabetes with the incidence of sudden cardiac death when compared to the incidence of non-sudden cardiac death and non-fatal myocardial...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-009-0157-9
更新日期：2010-12-01 00:00:00
abstract：:Most reports of outcome following obesity surgery report weight and co-morbidity changes only. We studied body composition changes in 17 adult patients (15 F, 2 M, age 43+/-2 years, range 28-58 years), with morbid obesity (initial BMI 40.4+/-4.9 kg/m(2), range 34.7-48.8) who were managed surgically by laparoscopically...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-003-0083-1
更新日期：2003-10-01 00:00:00
abstract：AIMS:Besides energy supply, β-hydroxybutyrate (BHB) acts as a bioactive molecule to play multiple protective roles, even in diabetes and its complications. The aim of this study was to investigate the antagonizing effects of BHB against diabetic glomerulosclerosis and the underlying mechanism. METHODS:Male Sprague-Daw...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-020-01552-2
更新日期：2020-12-01 00:00:00
abstract：AIMS:Sirtuin-1 (SIRT-1) down-regulation in type 2 diabetes mellitus (T2DM) has been associated with epigenetic markers of oxidative stress. We herein aim to evaluate whether an increase in SIRT-1 expression affects histone 3 acetylation at the 56 lysine residue (H3K56ac) in T2DM patients randomly selected to receive ei...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-017-1097-4
更新日期：2018-04-01 00:00:00
abstract：AIMS:The importance of diabetes-related distress for the treatment of diabetes is emphasised in national and international guidelines recommending routinely screening for psychosocial problems. Data of investigations regarding diabetes-related distress on primary care are rare in Germany though most people with diabete...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-017-0972-3
更新日期：2017-05-01 00:00:00
abstract：:We have measured protein phosphatase (PP) activity in crude homogenates as well as in the total 105.000 x g supernatant and precipitate fractions from normal rat pancreatic islets. On the basis of the inhibition produced by either 1 nM or 1 microM okadaic acid, both PP1 and PP2A activity were present in crude islet ho...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920050057
更新日期：1997-03-01 00:00:00
abstract：:The aim of this study was to test whether the augmentation index adjusted for heart rate (AIx@HR75) can be used as a substitute for aortic pulse wave velocity (aPWV) in the measurement of arterial stiffness (AS) in type 1 diabetes. Sixty-eight patients with type 1 diabetes and 68 age- and sex-matched controls were eva...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-012-0433-y
更新日期：2012-12-01 00:00:00
abstract：AIMS:We sought to investigate temporal trends in prediabetes prevalence among US adolescents using two definitions and evaluate relationships with obesity and a MetS-severity score. METHODS:We evaluated data from 5418 non-Hispanic white, non-Hispanic black, and Hispanic adolescents aged 12-19 participating in the Nati...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-016-0958-6
更新日期：2017-04-01 00:00:00
abstract：AIMS:Although diabetes is rapidly increasing in India, there is no national consensus on best practices for screening, diagnosis, and management of gestational diabetes mellitus (GDM). The goal of this study was to systematically review the literature for studies reporting the prevalence and screening and diagnostic me...
journal_title：Acta diabetologica
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00592-018-1131-1
更新日期：2018-06-01 00:00:00
abstract：:Urinary angiotensin-converting enzyme (ACE) and urinary N-acetyl-beta-D-glucosaminidase (NAG) were measured after a 5-year interval in 38 non-azotemic type 2 diabetic patients. Of these patients at baseline, 16 had nil nephropathy, 15 had incipient nephropathy, and 7 had overt nephropathy. During the follow-up, 6 and ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00838491
更新日期：1995-10-01 00:00:00
abstract：:The aim of this study was to evaluate the prevalence of thyroid autoantibodies and clinical significance of thyroid autoimmunity in children with the diagnosis of diabetes mellitus type 1. The study group comprised 222 children all with newly diagnosed diabetes mellitus type 1 (122 boys) with a mean age 9.92 +/- 4.5 y...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-007-0017-4
更新日期：2008-03-01 00:00:00
abstract：:The duration of diabetes before puberty is not considered relevant to the future development of complications. To evaluate the effects of diabetes on the neural retina, we analysed macular function by steady-state focal electroretinography in 20 prepubescent diabetic children without vascular retinopathy and in 39 sex...
journal_title：Acta diabetologica
pub_type： 临床试验,杂志文章
doi：10.1007/BF00570544
更新日期：1994-06-01 00:00:00
abstract：:Recent studies have reported that elevated proinsulin levels are indicative of an increased cardiovascular risk. Renal proximal tubular cells represent a major site for the metabolism of insulin-like hormones after glomerular filtration into the tubular lumen. To determine the binding and degradation of proinsulin in ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00569428
更新日期：1996-07-01 00:00:00
abstract：AIM:High glucose-induced oxidative stress has been suggested as one of the mediators of endothelial damage in diabetes. The major endothelial protein, endoglin, has been found overexpressed in the vessels during pathological situations, but little is known about its relation to diabetic vascular complications. To clari...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0670-3
更新日期：2015-06-01 00:00:00
abstract：AIMS:To examine the relationships between type 2 diabetes (T2D) status, glycemic control, and T2D duration with magnetic resonance imaging (MRI)-derived neuroimaging measures in European Americans from the Diabetes Heart Study (DHS) Mind cohort. METHODS:Relationships were examined using marginal models with generalize...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-015-0815-z
更新日期：2016-06-01 00:00:00
