Abstract:
:Most reports of outcome following obesity surgery report weight and co-morbidity changes only. We studied body composition changes in 17 adult patients (15 F, 2 M, age 43+/-2 years, range 28-58 years), with morbid obesity (initial BMI 40.4+/-4.9 kg/m(2), range 34.7-48.8) who were managed surgically by laparoscopically inserting an adjustable gastric band. Body composition was studied before and after surgery (mean interval of 909+/-51 days, range 441-1155 days) using anthropometry (abdominal circumference, AC, sum of four skinfold thicknesses, SFSUM), whole-body potassium counting (TBK), in vivo neutron activation analysis total body nitrogen (TBProtein) and whole-body dual-energy ray absorptiometry (total body percent fat TBF%, and total body bone mineral density TBBMD). Weight loss over the study period was 23.4+/-2.5 kg. ( p<0.0003) with an AC reduction of 20.0+/-4.5 cm ( p<0.008). Both SFSUM and TBF% were significantly reduced ( p<0.02 and p<0.0005 respectively). Both TBK and TBProtein after normalization for sex and height, were significantly ( p<0.0054 and p<0.001 respectively) reduced, but the ratio of loss of fat mass to fat-free mass, at 4.4:1 was usual for weight loss, and there was no significant changes in the ratio of potassium to protein. TBBMD, after normalization relative to a young same sex adult, was not significantly changed. In this group of patients, most of the substantial weight loss over a 2- to 3-year period was due to loss of fat mass, with relatively less reduction in the components of fat-free mass. Adjustable laparoscopic gastric banding induces fat loss without significant other deleterious effects on body composition.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Strauss BJ,Marks SJ,Growcott JP,Stroud DB,Lo CS,Dixon JB,O'Brien PEdoi
10.1007/s00592-003-0083-1subject
Has Abstractpub_date
2003-10-01 00:00:00pages
S266-9eissn
0940-5429issn
1432-5233journal_volume
40 Suppl 1pub_type
杂志文章abstract:BACKGROUND:Circulating levels of TNF alpha receptor 1 (TNFR1) and 2 (TNFR2) are associated with increased long-term mortality and impaired kidney function. AIM:To study association between circulating levels of TNFR1 and TNFR2 and short-term mortality in patients with diabetes and dyspnea. POPULATION AND METHODS:Pati...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-020-01527-3
更新日期:2020-10-01 00:00:00
abstract:AIMS:There is clinical evidence that fenofibrate, a PPARα agonist, arrests the progression of diabetic macular edema (DME). However, the underlying mechanisms of this beneficial effect remain to be elucidated. We previously reported that fenofibric acid (FA), the active metabolite of fenofibrate, prevents the disorgani...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0759-3
更新日期:2016-02-01 00:00:00
abstract::To evaluate the role of insulin resistance and beta cell function to increasing fasting plasma glucose (FPG), 1,272 Chinese subjects (18-80 years of age) were divided into normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), combined glucose intolerance (CGI), and type 2 di...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-010-0194-4
更新日期:2012-12-01 00:00:00
abstract:AIMS:The role of neutrophils in diabetes and its complications is unclear. Upon challenge with microbes and inflammatory triggers, neutrophils release enzymes and nuclear material, forming neutrophils extracellular traps (NETs) and thereby dying by NETosis. We herein tested NET formation and NETosis products in high gl...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-014-0676-x
更新日期:2015-06-01 00:00:00
abstract:AIMS:To investigate the short-term effects of intravitreal ranibizumab on retinal vessel functionality in patients with diabetic macular edema (DME) by Dynamic Vessel Analyzer (DVA). METHODS:Patients presenting with DME were enrolled in the study. All patients underwent a complete ophthalmic evaluation, including opti...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-016-0908-3
更新日期:2017-01-01 00:00:00
abstract::Studies suggest that diabetes may specifically elevate the risk of sudden cardiac death in excess of other heart disease outcomes. In this study, we examined the association of type 2 diabetes with the incidence of sudden cardiac death when compared to the incidence of non-sudden cardiac death and non-fatal myocardial...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-009-0157-9
更新日期:2010-12-01 00:00:00
abstract:AIMS:Type 1 diabetes is increasing in children leading more T1D young adults to adult healthcare settings. This change is experienced as a tear and results in a disengagement from specialist services. This study reports on an implementation of an effective and pioneering program of transition in North Africa. METHODS:...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-018-1196-x
更新日期:2018-11-01 00:00:00
abstract::We determined in non-diabetic persons the risk of fasting and non-fasting glucose levels for pre-diabetes, diabetes, and coronary heart disease (CHD), including the roles of serum C-reactive protein (CRP) and HDL cholesterol, and delineated risk profiles of the pre-diabetic states. Over 7¼ years, 2,619 middle-aged Tur...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-011-0313-x
更新日期:2013-08-01 00:00:00
abstract::The possible occurrence of increased non-enzymatic glycosylation of serum insulin-like growth factor binding protein-3 (IGFBP-3) in vivo and the changes that would simultaneously occur in serum levels of IGFBP-3 and insulin-like growth factor-1 (IGF-I) were investigated. We measured levels of IGF-I and IGFBP-3 and the...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920050109
更新日期:1998-07-01 00:00:00
abstract::Consistent with the postulated role of oxidative stress in the etiology of late diabetic complications, pharmacological interventions based on biological antioxidants have been suggested. The aim of the present study was to investigate the effect of dietary supplementation with the pyridoindole antioxidant stobadine o...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920070012
更新日期:2000-01-01 00:00:00
abstract::Administration of exogenous insulin for the treatment of diabetes is often accompanied by the development of insulin antibodies (IA). These antibodies may affect the patient's requirement for insulin by acting as an insulin binding reservoir. The improvement of insulin purification in the 1970s and the development of ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-009-0135-2
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Emerging adulthood is a challenging period for diabetes management. Our aim was to determine whether a dedicated transition clinic for emerging adults with type 1 diabetes can improve glycemic control and visit attendance. METHODS:An observational study of 53 emerging adults (30 males) treated during 2010-2...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0734-z
更新日期:2016-02-01 00:00:00
abstract::Serum total bilirubin (TB) is a potent antioxidant and inversely associated with metabolic syndrome (MetS) in Asian populations. However, there has been no study which is aimed to investigate whether TB is a risk factor for MetS or not. We investigated cross-sectional and longitudinal associations between TB and MetS ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-012-0447-5
更新日期:2013-06-01 00:00:00
abstract::Fasting glucose and oral glucose tolerance test (OGTT) criteria for glucose homeostasis were compared in a cross-sectional cluster, community study in Accra, Ghana. A total of 4636 subjects without prior diagnosis of diabetes had fasting plasma glucose, 2-hour OGTT and measurement of cardiovascular risk factors. Mean ...
journal_title:Acta diabetologica
pub_type: 杂志文章,多中心研究
doi:10.1007/s005920200006
更新日期:2002-04-01 00:00:00
abstract::Post-prandial hyperglycemia is considered a relevant therapeutic target in type 2 diabetic patients, and it could represent per se an independent risk factor for diabetic complications. Aim of the present systematic review is to collect and summarize evidence from observational studies on the relationship between post...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-011-0355-0
更新日期:2012-08-01 00:00:00
abstract::The effect of a phenacyl imidazolium compound (LY177507 or Proglycosyn, Eli Lilly) on the direct (glucose-->glucose-6-phosphate-->glycogen) and indirect (three-carbon compounds-->glucose-6-phosphate-->glycogen) pathways of liver glycogen synthesis was studied in conscious rats. [1-13C]Glucose (99% enriched) was infuse...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00578216
更新日期:1993-01-01 00:00:00
abstract::The aim of this article is to investigate the relation of the anti-inflammatory effect of pioglitazone with cardiac autonomic function and metabolic control in diabetic patients. In this prospective open label trial, 36 type 2 diabetic patients (age 60 ± 10, 20 M) without overt cardiovascular disease were randomized t...
journal_title:Acta diabetologica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00592-009-0150-3
更新日期:2010-12-01 00:00:00
abstract::Cardiovascular diseases represent, today, the principal cause of mortality in the general population, especially in subjects with type 2 diabetes mellitus. In these patients the risk of death from cardiovascular diseases is equal to that of non-diabetic subjects with a previous episode of myocardial infarction. Many f...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-003-0121-z
更新日期:2003-12-01 00:00:00
abstract::The objective of the study was to evaluate the association between infectious diseases and other events pertaining to childhood medical history and type 1 diabetes. A case-control study was carried out, taking as cases 159 type 1 diabetic patients (0-29 years) recorded from 1988 to 2000 within the population registry ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-007-0235-9
更新日期:2007-03-01 00:00:00
abstract:AIMS:Increasing evidence suggests a potential role of circulating miRNAs as clinical biomarkers, and loss of miRNA-126 has been proposed as a predictor of type 2 diabetes onset. However, a systematic analysis of circulating miRNAs in type 1 diabetic patients with micro-/macrovascular complications has not yet been perf...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-016-0915-4
更新日期:2017-02-01 00:00:00
abstract:AIMS:Hypoglycaemia represents a critical burden with clinical and social consequences in the management of diabetes. Serum uric acid (SUA) has been associated with cardiovascular diseases (CVD), but no conclusive findings are available nowadays in patients suffering from hypoglycaemia. We investigated whether SUA level...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-017-1094-7
更新日期:2018-04-01 00:00:00
abstract:AIMS:The relationship between bisphenol A (BPA) and diabetes remains controversial. This study aims to investigate whether serum BPA level could predict the 5-year incidence of type 2 diabetes (T2D). METHODS:A nested case-control study was performed among Chinese who participated in the environment, inflammation and m...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-018-1104-4
更新日期:2018-04-01 00:00:00
abstract:AIMS:The purpose of this study was to investigate the mechanism of vascular endothelial cell apoptosis induced by acute blood glucose fluctuation. METHODS:Thirty rats were assigned to three groups: normal saline (SAL group), constant high glucose (CHG group) and acute blood glucose fluctuation (AFG) group. Other forty...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-017-0999-5
更新日期:2017-08-01 00:00:00
abstract::Insulin secretion is stimulated better by oral than by intravenous glucose (incretin effect). The contribution of the autonomic nervous system to the incretin effect after oral glucose in humans is unclear. We therefore examined nine type 1 diabetic (insulin-dependent) patients with end-stage nephropathy, studied afte...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00572873
更新日期:1993-01-01 00:00:00
abstract::The duration of diabetes before puberty is not considered relevant to the future development of complications. To evaluate the effects of diabetes on the neural retina, we analysed macular function by steady-state focal electroretinography in 20 prepubescent diabetic children without vascular retinopathy and in 39 sex...
journal_title:Acta diabetologica
pub_type: 临床试验,杂志文章
doi:10.1007/BF00570544
更新日期:1994-06-01 00:00:00
abstract::Autoantibodies to zinc transporter 8 (ZnT8A) are a powerful diagnostic or predictive marker in type 1 diabetes. However, the widely used current ZnT8A radioligand binding assay (RBA) has proved to be difficult for many laboratories to implement. The aim of this study was the development and characterization of the per...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-013-0532-4
更新日期:2014-01-01 00:00:00
abstract:AIMS:We studied mortality in individuals of diabetes with or without Charcot neuroarthropathy (CN). METHODS:People attending diabetic foot care facility with CN of foot (Cohort 1) were prospectively evaluated. Details pertaining to the duration of diabetes, microvascular and macrovascular complications, foot ulcer, am...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-019-01376-9
更新日期:2019-12-01 00:00:00
abstract::The objective of the study was to determine the prevalence of known diabetes among elderly subjects receiving nursing care in a north Norwegian population, to screen for new cases using HbA1c measurement and to evaluate the quality of care for those with diabetes. Men and women, with and without known diabetes, above ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-006-0212-8
更新日期:2006-08-01 00:00:00
abstract:AIMS:The aim of the study was to evaluate and compare continuous subcutaneous insulin infusion (CSII) use in pediatric and adult age groups. METHODS:Data were collected with a questionnaire sent by e-mail to CSII-experienced Diabetes Centers. The questionnaire assessed: (1) number of CSII-treated patients; (2) patient...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0810-4
更新日期:2016-06-01 00:00:00
abstract::Although the polymorphisms of PTPN22 and the variants of CTLA-4 have been reported to be the susceptibility genes, which increased risk of latent autoimmune diabetes in adults (LADA), the results remained inconclusive. The aim of this meta-analysis was to evaluate the association between the polymorphisms of two genes...
journal_title:Acta diabetologica
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00592-014-0613-z
更新日期:2014-10-01 00:00:00