Abstract：
:The objective of the study was to evaluate the association between infectious diseases and other events pertaining to childhood medical history and type 1 diabetes. A case-control study was carried out, taking as cases 159 type 1 diabetic patients (0-29 years) recorded from 1988 to 2000 within the population registry of the Pavia province (North Italy). As controls 318 non-diabetic subjects were matched by age and sex. A questionnaire was administered by standardised interviewers. Data were analysed by conditional logistic regression. Viral childhood diseases (OR 4.29; 95%CI 1.57-11.74) and bottle feeding (OR 1.83; 95%CI 1.08-3.09) were directly correlated to type 1 diabetes; an inverse correlation was found for vitamin D administration during lactation (0-14 years) (OR 0.31; 95%CI 0.11-0.86) and for history of scarlet fever in both sexes and age groups (OR 0.19; 95%CI 0.08-0.46). Most associations of the studied variables confirm already known findings. The significant inverse correlation of type 1 diabetes with scarlet fever history is a peculiar finding, the meaning of which is still obscure, although it has been recently described that streptococcal A infections are regulated by HLA class II alleles.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Tenconi MT,Devoti G,Comelli M,Pinon M,Capocchiano A,Calcaterra V,Pretti G,Pavia T1DM Registry Group.doi
10.1007/s00592-007-0235-9subject
Has Abstractpub_date
2007-03-01 00:00:00pages
14-9issue
1eissn
0940-5429issn
1432-5233journal_volume
44pub_type
杂志文章abstract：:We assessed the efficacy of noninsulin antidiabetic medications used in current clinical practice (metformin, sulfonylureas, α-glucosidase inhibitors, thiazolidinediones, glinides, dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 agonists) to reach the HbA1c target <7% in people with type 2 diabetes. MEDLINE...
journal_title：Acta diabetologica
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00592-012-0370-9
更新日期：2014-04-01 00:00:00
abstract：AIMS:Increasing evidence suggests a potential role of circulating miRNAs as clinical biomarkers, and loss of miRNA-126 has been proposed as a predictor of type 2 diabetes onset. However, a systematic analysis of circulating miRNAs in type 1 diabetic patients with micro-/macrovascular complications has not yet been perf...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-016-0915-4
更新日期：2017-02-01 00:00:00
abstract：AIMS:Maternal type 2 diabetes (T2D) can result in adverse pathological outcomes to both the mother and fetus. The present study aimed to investigate the pathological effects of maternal T2D on the gene expression patterns and functions of fetal human umbilical vein endothelial cells (HUVECs), a representative of fetal ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-018-1207-y
更新日期：2019-01-01 00:00:00
abstract：:Overload of reactive oxygen species during diabetes is known to impair cellular homeostasis and to promote deterioration of membrane function in the organism. The aim of the present study was to examine the effect of dietary supplementation with the pyridoindole atioxidant stobadine on functional properties of the ren...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-004-0162-y
更新日期：2004-12-01 00:00:00
abstract：:In the present study, we investigated whether the ameliorating effect of aminoguanidine on diabetes-related proteinuria and nephropathy is associated with glomerular basement membrane heparan sulphate contents. STZ-induced diabetic rats developed proteinuria (at the tenth week: diabetic rats, 713 +/- 418 mg protein pe...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920070022
更新日期：2000-01-01 00:00:00
abstract：AIMS:There is clinical evidence that fenofibrate, a PPARα agonist, arrests the progression of diabetic macular edema (DME). However, the underlying mechanisms of this beneficial effect remain to be elucidated. We previously reported that fenofibric acid (FA), the active metabolite of fenofibrate, prevents the disorgani...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-015-0759-3
更新日期：2016-02-01 00:00:00
abstract：AIMS:Besides energy supply, β-hydroxybutyrate (BHB) acts as a bioactive molecule to play multiple protective roles, even in diabetes and its complications. The aim of this study was to investigate the antagonizing effects of BHB against diabetic glomerulosclerosis and the underlying mechanism. METHODS:Male Sprague-Daw...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-020-01552-2
更新日期：2020-12-01 00:00:00
abstract：:Positron emission tomography/computed tomography (PET/CT) is a standard procedure for imaging cancer commonly used in the clinical practice for several diseases, in particular for cancer staging, restaging, treatment monitoring and radiation therapy planning. Despite the availability of many radiotracers, 18F-fluoro-2...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-019-01385-8
更新日期：2020-03-01 00:00:00
abstract：:The title "Plasma fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus" should be replaced by "Serum fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus". ...
journal_title：Acta diabetologica
pub_type： 已发布勘误
doi：10.1007/s00592-018-1177-0
更新日期：2018-10-01 00:00:00
abstract：:The aim of the study was to evaluate the effects of a supervised physical training added to a healthy diet-rich in either carbohydrate and fibre (CHO/fibre) or monounsaturated fatty acids (MUFA)-on postprandial dyslipidaemia, an independent cardiovascular risk factor particularly relevant in type 2 diabetes (T2D). Par...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-013-0522-6
更新日期：2014-01-01 00:00:00
abstract：:In patients with type 1 diabetes (T1D), pancreatic β cells are destroyed by a selective autoimmune attack and their replacement with functional insulin-producing cells is the only possible cure for this disease. The field of islet transplantation has evolved significantly from the breakthrough of the Edmonton Protocol...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-016-0847-z
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Circulating levels of TNF alpha receptor 1 (TNFR1) and 2 (TNFR2) are associated with increased long-term mortality and impaired kidney function. AIM:To study association between circulating levels of TNFR1 and TNFR2 and short-term mortality in patients with diabetes and dyspnea. POPULATION AND METHODS:Pati...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-020-01527-3
更新日期：2020-10-01 00:00:00
abstract：:Islet autotransplantation (IAT) is performed at the time of total pancreatectomy (TP) to prevent or minimize post-surgical diabetes. Corticosteroids induce insulin resistance and present a risk to islet autografts, through glucotoxicity and increased metabolic demand on a marginal islet mass. We present four IAT recip...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-011-0315-8
更新日期：2014-02-01 00:00:00
abstract：AIMS:Diabetic retinopathy (DR) is characterized by early dropout of capillary pericytes, leading to loss of control on endothelial proliferation and, subsequently, angiogenesis. We have demonstrated that extracellular vesicles (EV) derived from mesenchymal stem cells (MSC) maintained in diabetic-like conditions may pla...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-015-0798-9
更新日期：2015-12-01 00:00:00
abstract：:The aim of the study was to report the prevalence of obesity indices in individuals with diabetes and find out their association with diabetic retinopathy in the urban Indian population. Subjects (n = 1,414) were recruited from Sankara Nethralaya Diabetic Retinopathy Epidemiology And Molecular Genetics Study (SN-DREAM...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-009-0113-8
更新日期：2010-09-01 00:00:00
abstract：:Our aim was to compare the effects of an intermediate acting human insulin (NPH) and a long-acting insulin analog, insulin glargine, in insulin naïve type 2 diabetes patients, stratified by the type of hyperglycemia (fasting or postprandial type). Based on different action profiles, we hypothesized that patients havin...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-013-0505-7
更新日期：2014-04-01 00:00:00
abstract：:Type 2, non-insulin-dependent diabetes mellitus accounts for 60% of the end-stage renal disease attributed to diabetes in the United States, yet little is known about glomerular function or the development of renal disease in this type of diabetes. The Diabetic Renal Disease Study (DRDS) is a longitudinal study design...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00579717
更新日期：1991-01-01 00:00:00
abstract：:Changes in the amounts and localization of protein kinase C (PKC) isoforms occur in galactosaemic lens epithelial cells. A link between PKC changes and myo-inositol depletion has been suggested. Raf-1, a component of a Ras pathway, is a substrate for PKC. Raf-1 levels were measured in galactosaemic lens epithelial cel...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920050119
更新日期：1998-10-01 00:00:00
abstract：:To evaluate the effects of vasoactive intestinal peptide (VIP) on whole pancreatic blood flow and islet blood flow in the rat, anaesthetized adult rats were injected intravenously for 90 s with VIP (500 ng/kg body weight). Immediately after the injection, the whole pancreatic and islet blood flows were measured with a...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00570545
更新日期：1994-06-01 00:00:00
abstract：:This study examined whether or not changes in plasma concentrations of motilin and other gastrointestinal hormones known to affect gastric motility are associated with the accelerated gastric emptying seen during hypoglycaemia. While studying gastric emptying by scintigraphy in eight healthy subjects, the plasma conce...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920050073
更新日期：1997-10-01 00:00:00
abstract：:The aim of this study was to evaluate the prevalence of thyroid autoantibodies and clinical significance of thyroid autoimmunity in children with the diagnosis of diabetes mellitus type 1. The study group comprised 222 children all with newly diagnosed diabetes mellitus type 1 (122 boys) with a mean age 9.92 +/- 4.5 y...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-007-0017-4
更新日期：2008-03-01 00:00:00
abstract：:The proinflammatory lysophosphatidic acid (LPA) is a potent activator of several transcriptional factors and signaling pathways and a potent modulator of genes involved in inflammation, angiogenesis and fibrosis. This study was conducted to measure the levels of LPA and LPA-producing enzymes, autotaxin (ATX) and acylg...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-012-0422-1
更新日期：2013-06-01 00:00:00
abstract：AIMS:To investigate the associations of vitamin B12 (cobalamin and holotranscobalamin) status with depression, cognition and neuropathy in patients with type 2 diabetes using metformin. METHODS:In an observational study, among 550 type 2 diabetes patients using metformin, cobalamin and holotranscobalamin (holoTCII) le...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0661-4
更新日期：2015-04-01 00:00:00
abstract：:Rosiglitazone often results in weight gain. We hypothesized that rosiglitazone may modulate circulating levels of ghrelin and peptide YY(3-36) and this modulation may be related to weight-gaining effect of this agent. This study was designed as an open-label, randomized, controlled trial of 3-month duration. Women wit...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-011-0352-3
更新日期：2012-12-01 00:00:00
abstract：:Obesity, insulin resistance (IR), and progressive decline in pancreatic β-cell function are major features of type 2 diabetes mellitus (T2DM). Altered adipokines contribute to obesity-induced IR. Hence understanding of adipokines' relation to obesity and glycemic control could be useful to improve disease outcomes. We...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-012-0373-6
更新日期：2013-10-01 00:00:00
abstract：:To examine longitudinally the effect of diabetes on bone structure and metabolism, we measured bone mineral density (BMD) and turnover markers in 26 type 1 (mean age 49 years) and 27 type 2 (mean age 65 years) diabetic patients without known osteoporosis from a community-based sample at baseline and 5 years later. In ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-011-0324-7
更新日期：2012-04-01 00:00:00
abstract：AIMS:Type 2 diabetes (T2D) is a metabolic disorder requiring intensive self-care to maintain optimal glycemic control. Sleep disturbance is common in T2D patients and likely impairs glycemic control. Our aim was to examine the relationship between sleep disturbance and self-care in adults with T2D. METHODS:This study ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-018-1181-4
更新日期：2018-09-01 00:00:00
abstract：AIM:Cardio-metabolic disease and physical activity are closely related but large-scale objective studies which measure physical activity are lacking. Using the largest accelerometer cohort to date, we aimed to investigate whether there is an association between disease status and accelerometer variables after a 5-year ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-018-1161-8
更新日期：2018-09-01 00:00:00
abstract：AIMS:Inflammation and oxidative damage contribute significantly to the development of cardiovascular diseases (CVD). Postprandial oxidative stress and inflammation are characterized by an increased susceptibility of the organism toward oxidative damage after consumption of a meal rich in lipids and/or carbohydrates. Mi...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-016-0917-2
更新日期：2017-02-01 00:00:00
abstract：:Fasting glucose and oral glucose tolerance test (OGTT) criteria for glucose homeostasis were compared in a cross-sectional cluster, community study in Accra, Ghana. A total of 4636 subjects without prior diagnosis of diabetes had fasting plasma glucose, 2-hour OGTT and measurement of cardiovascular risk factors. Mean ...
journal_title：Acta diabetologica
pub_type： 杂志文章,多中心研究
doi：10.1007/s005920200006
更新日期：2002-04-01 00:00:00
