Abstract:
AIM:Cardio-metabolic disease and physical activity are closely related but large-scale objective studies which measure physical activity are lacking. Using the largest accelerometer cohort to date, we aimed to investigate whether there is an association between disease status and accelerometer variables after a 5-year follow-up. METHODS:106,053 UK Biobank participants wore a wrist-worn GENEactiv monitor. Those with acceptable wear time (> 3 days) were split into 4 cardio-metabolic disease groups based on self-report disease status which was collected 5 ± 1 years prior. Multiple linear regression models were used to investigate associations, controlling for confounders and stratified for gender. RESULTS:Average daily acceleration was lower in men ('healthy'-42 ± 15 mg v 'Type 2 diabetes + cardiovascular disease (CVD)'-31 ± 12 mg) and women ('healthy'-44 ± 13 mg v 'Type 2 diabetes + CVD'-31 ± 11 mg) with cardio-metabolic disease and this was consistent across both week and weekend days. Men and women with the worst cardio-metabolic disease perform around half of moderate to vigorous physical activity on a daily basis compared to healthy individuals, and spend almost 7 h per day in 30 min inactivity bouts. Significant associations were seen between cardio-metabolic disease and accelerometer variables 5 years on when controlling for confounders. CONCLUSION:In the largest accelerometer cohort to date, there are significant associations between cardio-metabolic disease and physical activity variables after 5 years of follow-up. Triaxial accelerometers provide enhanced measurement opportunities for measuring lifestyle behaviours in chronic disease.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Cassidy S,Fuller H,Chau J,Catt M,Bauman A,Trenell MIdoi
10.1007/s00592-018-1161-8subject
Has Abstractpub_date
2018-09-01 00:00:00pages
975-979issue
9eissn
0940-5429issn
1432-5233pii
10.1007/s00592-018-1161-8journal_volume
55pub_type
杂志文章abstract::We investigated the effect of sub-chronic soybean oil (SO) treatment on the insulin secretion and fatty acid composition of islets of Langerhans obtained from Goto-Kakizaki (GK), a model of type 2 diabetes, and normal Wistar rats. We observed that soybean-treated Wistar rats present insulin resistance and defective is...
journal_title:Acta diabetologica
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更新日期:2007-09-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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abstract::Serum total bilirubin (TB) is a potent antioxidant and inversely associated with metabolic syndrome (MetS) in Asian populations. However, there has been no study which is aimed to investigate whether TB is a risk factor for MetS or not. We investigated cross-sectional and longitudinal associations between TB and MetS ...
journal_title:Acta diabetologica
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journal_title:Acta diabetologica
pub_type: 杂志文章
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journal_title:Acta diabetologica
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pub_type: 杂志文章,评审
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journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920050109
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pub_type: 杂志文章,随机对照试验
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更新日期:1994-12-01 00:00:00
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更新日期:2015-04-01 00:00:00
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更新日期:2018-07-01 00:00:00
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更新日期:2020-09-01 00:00:00
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更新日期:2014-02-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 临床试验,杂志文章
doi:10.1007/BF00580753
更新日期:1994-04-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章
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更新日期:1994-06-01 00:00:00
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更新日期:2020-05-01 00:00:00