Abstract：
:The purpose of this study was to determine the feasibility of a flexible multiple daily insulin (FMDI) regimen in routine pediatric diabetes care by comparing HbA(1c), body mass index (BMI), and episodes of severe hypoglycemia (SH) before and after initiation of FMDI therapy. Data from 44 patients (2-16 years old), on a conventional insulin (CI) regimen, were collected during quarterly diabetes clinic visits. These patients were transitioned from CI to FMDI regimen: pre-meal lispro (bolus) and once or twice daily Humulin Ultralente with or without bedtime Humulin NPH as the basal insulin. There was a significant improvement in HbA(1c) in prepubertal (9.3%+/-1.3% vs. 8.0%+/-1.1%, p<0.002) and pubertal subjects (9.2%+/-1.0% vs. 8.2%+/-0.9%, p<0.001). Pubertal subgroup demonstrated an increase in BMI (21.3+/-3.1 vs. 22.7+/-3.2 kg/m(2), p<0.0001) after one year. The rate of SH was decreased in both prepubertal ( p<0.01) and pubertal ( p<0.05) groups of patients on FMDI therapy. The use of FMDI in a general pediatric diabetic population is a feasible therapeutic option for maintenance and possible improvement of glycemic control. It may effectively decrease the HbA(1c), and reduce hypoglycemic episodes, without producing an abnormal increase in BMI.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Alemzadeh R,Palma-Sisto P,Parton E,Totka J,Kirby Mdoi
10.1007/s00592-003-0102-2subject
Has Abstractpub_date
2003-09-01 00:00:00pages
137-42issue
3eissn
0940-5429issn
1432-5233journal_volume
40pub_type
临床试验,杂志文章abstract：AIMS:The aim of our study was to estimate the overall rate of first hospitalizations for diabetic foot (DF) regardless of the outcome in amputations, as well as the mortality rate with their determinants in the period 2012-2016 in Piedmont Region in Italy. METHODS:The study included all the subjects registered in the ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-019-01412-8
更新日期：2020-02-01 00:00:00
abstract：:To determine the impact of glargine insulin therapy with different nutritional models on key parameters of diabetes including quality of life, behavior in children and adolescents with type 1 diabetes. Age, duration of diabetes, HbA1c, anthropometric data and episodes of severe hypoglycemia were taken from patients' c...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-007-0019-2
更新日期：2008-03-01 00:00:00
abstract：AIMS:Besides energy supply, β-hydroxybutyrate (BHB) acts as a bioactive molecule to play multiple protective roles, even in diabetes and its complications. The aim of this study was to investigate the antagonizing effects of BHB against diabetic glomerulosclerosis and the underlying mechanism. METHODS:Male Sprague-Daw...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-020-01552-2
更新日期：2020-12-01 00:00:00
abstract：:The objective of the study was to determine the prevalence of known diabetes among elderly subjects receiving nursing care in a north Norwegian population, to screen for new cases using HbA1c measurement and to evaluate the quality of care for those with diabetes. Men and women, with and without known diabetes, above ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-006-0212-8
更新日期：2006-08-01 00:00:00
abstract：AIMS:The aims of this study were: to develop new equations for predicting resting energy expenditure (REE) in obese Italian subjects according to body composition parameters; to compare them with predicted values estimated by other REE prediction equations; and to cross-validate our equations using a validation set coh...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-017-1061-3
更新日期：2018-01-01 00:00:00
abstract：:The objective of the study was to evaluate the association between infectious diseases and other events pertaining to childhood medical history and type 1 diabetes. A case-control study was carried out, taking as cases 159 type 1 diabetic patients (0-29 years) recorded from 1988 to 2000 within the population registry ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-007-0235-9
更新日期：2007-03-01 00:00:00
abstract：AIMS:Prognostic significance of apolipoproteins in diabetic retinopathy risk has not been well investigated. The aim of this study was to reveal the relationship between the risk of diabetic retinopathy and the levels of several apolipoproteins and their ratios in a 10-year prospective cohort. METHODS:A total of 1023 ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-018-1136-9
更新日期：2018-07-01 00:00:00
abstract：:The duration of diabetes before puberty is not considered relevant to the future development of complications. To evaluate the effects of diabetes on the neural retina, we analysed macular function by steady-state focal electroretinography in 20 prepubescent diabetic children without vascular retinopathy and in 39 sex...
journal_title：Acta diabetologica
pub_type： 临床试验,杂志文章
doi：10.1007/BF00570544
更新日期：1994-06-01 00:00:00
abstract：:Cardiovascular diseases represent, today, the principal cause of mortality in the general population, especially in subjects with type 2 diabetes mellitus. In these patients the risk of death from cardiovascular diseases is equal to that of non-diabetic subjects with a previous episode of myocardial infarction. Many f...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-003-0121-z
更新日期：2003-12-01 00:00:00
abstract：:Concentrations of soluble receptors for tumor necrosis factor (p55 and p75) strongly correlate with clinical stage and progression of infectious diseases, and may be useful in monitoring autoimmune diseases. However, the role of soluble TNF receptors in insulin-dependent diabetes mellitus (type 1 DM) is not clear. We ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920050152
更新日期：1999-06-01 00:00:00
abstract：:The purpose of this study was to compare bioelectrical impedance analysis (BIA) to hydrostatic weighing (HW) in male weight lifters and body builders. Twenty-two male body builders and weight lifters, 23 +/- 3 years of age (mean +/- SD), were studied to determine the efficacy of BIA to HW in this population. Subjects ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-009-0098-3
更新日期：2010-03-01 00:00:00
abstract：AIMS:Lipohypertrophy (LH) represents the most common skin-related complication associated with insulin therapy. Our aim is to estimate the prevalence of LH among insulin-treated patients, to identify its association with errors in insulin injection technique and storage, and the correlation between LH, risk of hypoglyc...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-017-1066-y
更新日期：2018-01-01 00:00:00
abstract：:Positron emission tomography/computed tomography (PET/CT) is a standard procedure for imaging cancer commonly used in the clinical practice for several diseases, in particular for cancer staging, restaging, treatment monitoring and radiation therapy planning. Despite the availability of many radiotracers, 18F-fluoro-2...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-019-01385-8
更新日期：2020-03-01 00:00:00
abstract：:Kidney volume was measured during pregnancy in insulin-dependent diabetic women by an ultrasound technique and prognostic value of these measurements evaluated. A prospective study was performed on 87 pregnant women with insulin-dependent diabetes attending the maternity clinic of Aarhus Kommunehospital. Patients with...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00576254
更新日期：1995-12-01 00:00:00
abstract：AIMS:The main objective of this study was to estimate the incidence rate and prevalence of pediatric type 1 diabetes mellitus (T1DM; population 0-18 years of age) in the northeastern Italian region Friuli Venezia Giulia and to characterize the subjects affected by the disease. METHODS:This was a retrospective populati...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-016-0854-0
更新日期：2016-08-01 00:00:00
abstract：:The aim of this study was to analyse the effect of the new oral antidiabetic drug repaglinide on antioxidant factors and lipid peroxidation in tissues of alloxan-induced diabetic rabbits after 4 and 8 weeks treatment. The activity of superoxide dismutase (diabetic vs. control values, mean+/-S.E.M., p<0.05) in diabetic...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-005-0182-2
更新日期：2005-06-01 00:00:00
abstract：:The recent efforts in the study of fetal compartments could help us to a better recognition of the proper fetal growth and well being. Fat content correlates directly with energy stores. Fat mass and lean body mass is often used in the nutritional assessment of the individual. Moreover chromosomal abnormalities may be...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-003-0033-y
更新日期：2003-10-01 00:00:00
abstract：:The aim of this study was to compare the efficacy of treatment with insulin alone, insulin plus acarbose, insulin plus metformin, or insulin plus rosiglitazone in type 2 diabetic subjects who were previously on insulin monotherapy, and to evaluate the effects of these treatments on cardiovascular risk factors includin...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-007-0004-9
更新日期：2007-12-01 00:00:00
abstract：AIM:To identify the potential metabolite markers in diabetic retinopathy (DR) by using gas chromatography coupled with time-of-flight mass spectrometry (GC-TOFMS). METHODS:GC-TOFMS spectra were acquired from vitreous and aqueous humor (AH) samples of patients with DR and non-diabetic participants. Comparative analysis...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-019-01363-0
更新日期：2020-01-01 00:00:00
abstract：:Comparing macrophage-derived cytokine and nitric oxide (NO) profiles in type I and type II diabetes mellitus (DM); and determining whether thymoquinone (TQ) has any modulatory effect were the main objectives of the present study. Peritoneal macrophages have been collected from Otsuka Long-Evans Tokushima Fatty (OLETF)...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-005-0170-6
更新日期：2005-03-01 00:00:00
abstract：BACKGROUND:Circulating levels of TNF alpha receptor 1 (TNFR1) and 2 (TNFR2) are associated with increased long-term mortality and impaired kidney function. AIM:To study association between circulating levels of TNFR1 and TNFR2 and short-term mortality in patients with diabetes and dyspnea. POPULATION AND METHODS:Pati...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-020-01527-3
更新日期：2020-10-01 00:00:00
abstract：:Pancreatic volume and fat content might be associated with β-cell function or insulin resistance (IR). We investigated the difference in pancreatic volume and fat content between age- and body mass index (BMI)-matched normal subjects and patients with having different durations of type 2 diabetes (T2D). We compared pa...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0581-3
更新日期：2014-10-01 00:00:00
abstract：:In patients with type 1 diabetes (T1D), pancreatic β cells are destroyed by a selective autoimmune attack and their replacement with functional insulin-producing cells is the only possible cure for this disease. The field of islet transplantation has evolved significantly from the breakthrough of the Edmonton Protocol...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-016-0847-z
更新日期：2016-10-01 00:00:00
abstract：:Aim To summarize, critically review, and interpret the evidence related to the systematic reviews on health literacy (HL) amongst type 2 diabetes mellitus (T2DM). Methods The methodology for this study consisted of a systematic review of systematic reviews, using the PRISMA statement and flowchart to select studies, a...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-017-1071-1
更新日期：2018-01-01 00:00:00
abstract：:Cytomegalovirus (CMV) infects 40 % of the world population and has been suggested to be associated with diabetes; however, no prospective study has ever examined diabetes mortality associated with the infection. A cohort of 14,404 non-diabetic adult participants aged 17-90 years from the Third National Health and Nutr...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0573-3
更新日期：2014-10-01 00:00:00
abstract：:The aim was to investigate the long-term incidence of proliferative diabetic retinopathy (PDR), and progression and regression of diabetic retinopathy (DR) and associated risk factors in young Danish patients with Type 1 diabetes mellitus. In 1987-89, a pediatric cohort involving approximately 75 % of all children wit...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-013-0527-1
更新日期：2014-01-01 00:00:00
abstract：:To define whether reference values for bioimpedance analysis (BIA) can be predicted in healthy individuals, individual characteristics and BIA variables (resistance index=height(2)/parallel resistance and reactance index= height(2)/parallel reactance) were evaluated in non-obese healthy individuals: 863 men and 769 wo...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-003-0073-3
更新日期：2003-10-01 00:00:00
abstract：:We determined in non-diabetic persons the risk of fasting and non-fasting glucose levels for pre-diabetes, diabetes, and coronary heart disease (CHD), including the roles of serum C-reactive protein (CRP) and HDL cholesterol, and delineated risk profiles of the pre-diabetic states. Over 7¼ years, 2,619 middle-aged Tur...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-011-0313-x
更新日期：2013-08-01 00:00:00
abstract：:The aim of the present work was to investigate the impact of gender on resting cerebral blood flow velocity and cerebrovascular reserve capacity among diabetic patients. Middle cerebral artery mean blood flow velocity (MCAV) was measured in 72 patients suffering from type 1 diabetes mellitus at rest and 5, 10, 15 and ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920170006
更新日期：2001-01-01 00:00:00
abstract：AIMS:To investigate the associations of vitamin B12 (cobalamin and holotranscobalamin) status with depression, cognition and neuropathy in patients with type 2 diabetes using metformin. METHODS:In an observational study, among 550 type 2 diabetes patients using metformin, cobalamin and holotranscobalamin (holoTCII) le...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0661-4
更新日期：2015-04-01 00:00:00
