Abstract：
:In patients with type 1 diabetes (T1D), pancreatic β cells are destroyed by a selective autoimmune attack and their replacement with functional insulin-producing cells is the only possible cure for this disease. The field of islet transplantation has evolved significantly from the breakthrough of the Edmonton Protocol in 2000, since significant advances in islet isolation and engraftment, together with improved immunosuppressive strategies, have been reported. The main limitations, however, remain the insufficient supply of human tissue and the need for lifelong immunosuppression therapy. Great effort is then invested in finding innovative sources of insulin-producing β cells. One old alternative with new recent perspectives is the use of non-human donor cells, in particular porcine β cells. Also the field of preexisting β cell expansion has advanced, with the development of new human β cell lines. Yet, large-scale production of human insulin-producing cells from stem cells is the most recent and promising alternative. In particular, the optimization of in vitro strategies to differentiate human embryonic stem cells into mature insulin-secreting β cells has made considerable progress and recently led to the first clinical trial of stem cell treatment for T1D. Finally, the discovery that it is possible to derive human induced pluripotent stem cells from somatic cells has raised the possibility that a sufficient amount of patient-specific β cells can be derived from patients through cell reprogramming and differentiation, suggesting that in the future there might be a cell therapy without immunosuppression.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Pellegrini S,Cantarelli E,Sordi V,Nano R,Piemonti Ldoi
10.1007/s00592-016-0847-zsubject
Has Abstractpub_date
2016-10-01 00:00:00pages
683-91issue
5eissn
0940-5429issn
1432-5233pii
10.1007/s00592-016-0847-zjournal_volume
53pub_type
杂志文章,评审abstract：:Consistent with the postulated role of oxidative stress in the etiology of late diabetic complications, pharmacological interventions based on biological antioxidants have been suggested. The aim of the present study was to investigate the effect of dietary supplementation with the pyridoindole antioxidant stobadine o...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920070012
更新日期：2000-01-01 00:00:00
abstract：:Post-prandial hyperglycemia is considered a relevant therapeutic target in type 2 diabetic patients, and it could represent per se an independent risk factor for diabetic complications. Aim of the present systematic review is to collect and summarize evidence from observational studies on the relationship between post...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-011-0355-0
更新日期：2012-08-01 00:00:00
abstract：AIMS:Diabetic ketoacidosis (DKA) at diabetes diagnosis is a dangerous yet potentially preventable condition. Young age, low socioeconomic status, and low parental education have been found to be associated with increased risk of DKA. We aimed to evaluate the impact of religious affiliation on presentation with DKA at t...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0653-4
更新日期：2015-04-01 00:00:00
abstract：:The aim of this study was to evaluate the influence of endogenous insulin levels and of insulin administration on coronary heart disease (CHD) and on mortality in a cohort of patients with long-standing non-insulin-dependent diabetes mellitus (type 2). In a cross-sectional study, 93 patients (known duration 17 +/- 8 y...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920050101
更新日期：1998-04-01 00:00:00
abstract：:The aim was to investigate the long-term incidence of proliferative diabetic retinopathy (PDR), and progression and regression of diabetic retinopathy (DR) and associated risk factors in young Danish patients with Type 1 diabetes mellitus. In 1987-89, a pediatric cohort involving approximately 75 % of all children wit...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-013-0527-1
更新日期：2014-01-01 00:00:00
abstract：:The proinflammatory lysophosphatidic acid (LPA) is a potent activator of several transcriptional factors and signaling pathways and a potent modulator of genes involved in inflammation, angiogenesis and fibrosis. This study was conducted to measure the levels of LPA and LPA-producing enzymes, autotaxin (ATX) and acylg...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-012-0422-1
更新日期：2013-06-01 00:00:00
abstract：:Pancreatic volume and fat content might be associated with β-cell function or insulin resistance (IR). We investigated the difference in pancreatic volume and fat content between age- and body mass index (BMI)-matched normal subjects and patients with having different durations of type 2 diabetes (T2D). We compared pa...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0581-3
更新日期：2014-10-01 00:00:00
abstract：:Several haemostatic abnormalities are associated with proliferative diabetic retinopathy. While abnormalities in plasma fibrinolytic activity have been described in diabetic retinopathy, platelets (a rich source of plasminogen activator inhibitor type 1, PAI-1) have received little attention. As a result, little is kn...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920050159
更新日期：1999-09-01 00:00:00
abstract：AIMS:To evaluate the efficacy and safety of intravitreal dexamethasone implant (DEX-implant) for diabetic macular edema (DME) in real-life practice with an extended follow-up for up to 5 year. METHODS:This multicentric retrospective study reviewed 227 eyes of 152 patients with DME treated by DEX-implant. Main outcome ...
journal_title：Acta diabetologica
pub_type： 杂志文章,多中心研究
doi：10.1007/s00592-020-01561-1
更新日期：2020-12-01 00:00:00
abstract：AIMS:To determine whether blood glucose test strip (BGTS) utilization in patients with type 2 diabetes (T2D) is associated with the type of diabetes therapy, classified according to hypoglycemic risk. METHODS:A retrospective, longitudinal (2006-2012) study of Canadian private drug plans (PDP) and Ontario Public Drug P...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-015-0823-z
更新日期：2016-06-01 00:00:00
abstract：AIMS:The aim of our study was to estimate the overall rate of first hospitalizations for diabetic foot (DF) regardless of the outcome in amputations, as well as the mortality rate with their determinants in the period 2012-2016 in Piedmont Region in Italy. METHODS:The study included all the subjects registered in the ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-019-01412-8
更新日期：2020-02-01 00:00:00
abstract：AIMS:Our aims were to investigate in several large samples, with a wide range of adiposity, whether: (1) the effect of BMI on insulin sensitivity is different between sexes; (2) also waist circumference plays a sex-specific role on insulin sensitivity; and (3) serum adiponectin and resistin are mediators of such sex-di...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-015-0804-2
更新日期：2015-10-01 00:00:00
abstract：AIMS:Prognostic significance of apolipoproteins in diabetic retinopathy risk has not been well investigated. The aim of this study was to reveal the relationship between the risk of diabetic retinopathy and the levels of several apolipoproteins and their ratios in a 10-year prospective cohort. METHODS:A total of 1023 ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-018-1136-9
更新日期：2018-07-01 00:00:00
abstract：:Correct classification of diabetic patients in adulthood at the time of diagnosis is often difficult. Some may be initially diagnosed as having non-insulin-dependent diabetes mellitus and be treated with diet and/or oral hypoglycaemic agents (OHA) but later require insulin treatment. Islet cell antibodies and antibodi...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00571567
更新日期：1996-12-01 00:00:00
abstract：AIMS:We studied mortality in individuals of diabetes with or without Charcot neuroarthropathy (CN). METHODS:People attending diabetic foot care facility with CN of foot (Cohort 1) were prospectively evaluated. Details pertaining to the duration of diabetes, microvascular and macrovascular complications, foot ulcer, am...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-019-01376-9
更新日期：2019-12-01 00:00:00
abstract：:The aim of this study was to analyse the effect of the new oral antidiabetic drug repaglinide on antioxidant factors and lipid peroxidation in tissues of alloxan-induced diabetic rabbits after 4 and 8 weeks treatment. The activity of superoxide dismutase (diabetic vs. control values, mean+/-S.E.M., p<0.05) in diabetic...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-005-0182-2
更新日期：2005-06-01 00:00:00
abstract：:A meta-analysis was performed in order to test the hypothesis that Japanese have a greater amount of abdominal visceral fat (AVF) relative to abdominal subcutaneous fat (ASF) than Caucasians. Data were derived from published studies that included mean values for AVF and ASF areas, measured using computed tomography, a...
journal_title：Acta diabetologica
pub_type： 杂志文章,meta分析
doi：10.1007/s00592-003-0093-z
更新日期：2003-10-01 00:00:00
abstract：AIMS:Medication adherence and persistence are important determinants of treatment success in type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis evaluated the real-world adherence, persistence, and in-class switching among patients with T2DM prescribed dipeptidyl peptidase-4 (DPP4) inhibitors. ME...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-020-01590-w
更新日期：2021-01-01 00:00:00
abstract：AIMS:The relationship between bisphenol A (BPA) and diabetes remains controversial. This study aims to investigate whether serum BPA level could predict the 5-year incidence of type 2 diabetes (T2D). METHODS:A nested case-control study was performed among Chinese who participated in the environment, inflammation and m...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-018-1104-4
更新日期：2018-04-01 00:00:00
abstract：AIMS:There is clinical evidence that fenofibrate, a PPARα agonist, arrests the progression of diabetic macular edema (DME). However, the underlying mechanisms of this beneficial effect remain to be elucidated. We previously reported that fenofibric acid (FA), the active metabolite of fenofibrate, prevents the disorgani...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-015-0759-3
更新日期：2016-02-01 00:00:00
abstract：:The purpose of this study was to compare bioelectrical impedance analysis (BIA) to hydrostatic weighing (HW) in male weight lifters and body builders. Twenty-two male body builders and weight lifters, 23 +/- 3 years of age (mean +/- SD), were studied to determine the efficacy of BIA to HW in this population. Subjects ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-009-0098-3
更新日期：2010-03-01 00:00:00
abstract：:The effect of the insulinotropic gut hormone glucagon-like-peptide-1 (GLP-1) was studied on the residual insulin capacity of prediabetic nonobese diabetic (NOD) mice, a model of insulin-dependent diabetes mellitus (type 1). This was done using isolated pancreas perfusion and dynamic islet perifusion. Prediabetes was d...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00571935
更新日期：1996-03-01 00:00:00
abstract：:Autonomic nervous dysfunction is considered to be one of the mechanisms of metabolic syndrome (MetS). The aim of this study is to investigate whether resting heart rate, a marker of autonomic nervous dysfunction, is a predictor of MetS in apparently healthy non-obese [body mass index (BMI) <25 kg/m(2)] Japanese men. T...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-013-0503-9
更新日期：2014-02-01 00:00:00
abstract：:Insulin resistance is a major factor in the pathogenesis of type 2 diabetes mellitus (T2DM) and is related to the fatty acid profile of the plasma membranes. The purpose of the present study was to investigate fatty acid composition and cholesterol content of cell membranes in patients with type 2 diabetes and, thus, ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-007-0224-4
更新日期：2006-12-01 00:00:00
abstract：:The original report on the microencapsulation of islets of Langerhans used sodium alginate and poly-L-lysine (PLL) to form the capsules. Although several alternative materials have subsequently been used with vary-mg degrees of success, it is those studies using islets encapsulated in alginate-PLL-alginate which are r...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/BF00569928
更新日期：1993-01-01 00:00:00
abstract：:The effect of a phenacyl imidazolium compound (LY177507 or Proglycosyn, Eli Lilly) on the direct (glucose-->glucose-6-phosphate-->glycogen) and indirect (three-carbon compounds-->glucose-6-phosphate-->glycogen) pathways of liver glycogen synthesis was studied in conscious rats. [1-13C]Glucose (99% enriched) was infuse...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00578216
更新日期：1993-01-01 00:00:00
abstract：:MicroRNAs (miRNAs) play a crucial role in the pathogenesis of type 2 diabetes (T2D); they regulate several metabolic pathways including insulin secretion, glucose homeostasis, so their potential as biomarkers of diagnosis and prognosis has became increasingly appreciated. In this study, we explore serum miRNA profiles...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0617-8
更新日期：2014-10-01 00:00:00
abstract：AIMS:To evaluate the methodological quality of systematic reviews (SRs), and summarize evidence of important outcomes from dipeptidyl peptidase-4 inhibitors (DPP4-I) in treating type 2 diabetes mellitus (T2DM). METHODS:We included SRs of DPP4-I for the treatment of T2DM until January, 2018 by searching the Cochrane Li...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-018-1164-5
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:International comparisons of diabetes-related lower extremity amputation rates are still hampered by different criteria used for data collection and analysis. We aimed to evaluate trends and variation of major/minor amputations, using agreed definitions adopted by the Organization for Economic Cooperation an...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-019-01423-5
更新日期：2020-03-01 00:00:00
abstract：:To evaluate ex vivo/in vitro the binding and dissociation characteristics and the level of crossreactivity of insulin antibodies and insulin autoantibodies directed to three different insulin molecules (human, bovine and porcine insulin). In this study sera from 17 diabetic patients were included, who were exclusively...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-008-0041-z
更新日期：2008-09-01 00:00:00
