Abstract:
AIMS:To determine whether blood glucose test strip (BGTS) utilization in patients with type 2 diabetes (T2D) is associated with the type of diabetes therapy, classified according to hypoglycemic risk. METHODS:A retrospective, longitudinal (2006-2012) study of Canadian private drug plans (PDP) and Ontario Public Drug Programs (OPDP) prescription claims was conducted. Analyses were restricted to patients with T2D with or without a claim for BGTS. Daily BGTS utilization (TS/patient/day) was evaluated by diabetes therapy classified by hypoglycemic risk. Multivariate analyses were conducted to identify determinants of BGTS utilization. RESULTS:The T2D cohort comprised 5,759,591 observations from 1,949,129 claimants. Mean BGTS utilization was 0.84 TS/patient/day and differed between PDP and OPDP (0.66 vs. 1.00). Daily utilization was greatest in patients receiving therapy associated with a pre-defined high risk of hypoglycemia [insulin: basal + bolus (2.16), premixed (1.65), basal (1.16), other insulin regimens (2.13), and sulfonylureas (0.74)] versus non-sulfonylurea non-insulin-based regimens (0.52). For non-insulin therapy, BGTS utilization was greater for patients on multiple non-insulin therapies versus monotherapy (0.74 vs. 0.53 TS/patient/day). In multivariate analyses, drivers for BGTS utilization included insulin use, previous BGTS use, and female gender. Previous diabetes therapy and duration of therapy were negatively correlated with BGTS utilization. CONCLUSIONS:BGTS utilization varies depending on the type of therapy used to treat T2D according to hypoglycemic risk. Decision making regarding BGTS needs to account for robust analyses of current utilization and its value in those settings, including in patients not receiving diabetes therapy and the prevalence of circumstances conducive to more intensive monitoring.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Tavares R,Duclos M,Brabant MJ,Checchin D,Bosnic N,Turvey K,Terres JAdoi
10.1007/s00592-015-0823-zsubject
Has Abstractpub_date
2016-06-01 00:00:00pages
483-92issue
3eissn
0940-5429issn
1432-5233pii
10.1007/s00592-015-0823-zjournal_volume
53pub_type
杂志文章abstract:AIMS:To assess the time-dependent effect of sleep quality on diabetes and coronary artery disease (CAD) incidence among young adults. METHODS:Incident rates of diabetes and CAD during a mean follow-up of 6.4 ± 4.1 years were assessed among 26,023 men (mean age 30.9 ± 5.6 years) of the Metabolic Lifestyle and Nutrition...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0779-z
更新日期:2016-04-01 00:00:00
abstract:AIMS:To evaluate the methodological quality of systematic reviews (SRs), and summarize evidence of important outcomes from dipeptidyl peptidase-4 inhibitors (DPP4-I) in treating type 2 diabetes mellitus (T2DM). METHODS:We included SRs of DPP4-I for the treatment of T2DM until January, 2018 by searching the Cochrane Li...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-018-1164-5
更新日期:2019-01-01 00:00:00
abstract:AIMS:The relationship between bisphenol A (BPA) and diabetes remains controversial. This study aims to investigate whether serum BPA level could predict the 5-year incidence of type 2 diabetes (T2D). METHODS:A nested case-control study was performed among Chinese who participated in the environment, inflammation and m...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-018-1104-4
更新日期:2018-04-01 00:00:00
abstract::Changes in the amounts and localization of protein kinase C (PKC) isoforms occur in galactosaemic lens epithelial cells. A link between PKC changes and myo-inositol depletion has been suggested. Raf-1, a component of a Ras pathway, is a substrate for PKC. Raf-1 levels were measured in galactosaemic lens epithelial cel...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920050119
更新日期:1998-10-01 00:00:00
abstract::In the present study, we investigated whether the ameliorating effect of aminoguanidine on diabetes-related proteinuria and nephropathy is associated with glomerular basement membrane heparan sulphate contents. STZ-induced diabetic rats developed proteinuria (at the tenth week: diabetic rats, 713 +/- 418 mg protein pe...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920070022
更新日期:2000-01-01 00:00:00
abstract:AIMS:Maternal type 2 diabetes (T2D) can result in adverse pathological outcomes to both the mother and fetus. The present study aimed to investigate the pathological effects of maternal T2D on the gene expression patterns and functions of fetal human umbilical vein endothelial cells (HUVECs), a representative of fetal ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-018-1207-y
更新日期:2019-01-01 00:00:00
abstract:AIMS:Radiolabeled Exendin-4 has been proposed as suitable imaging marker for pancreatic beta cell mass quantification mediated by Glucagon-like peptide-1 receptor (GLP-1R). However, noticeable species variations in basal pancreatic uptake as well as uptake reduction degree due to selective beta cell ablation were obser...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-017-1046-2
更新日期:2017-11-01 00:00:00
abstract::The purpose of this study was to determine the feasibility of a flexible multiple daily insulin (FMDI) regimen in routine pediatric diabetes care by comparing HbA(1c), body mass index (BMI), and episodes of severe hypoglycemia (SH) before and after initiation of FMDI therapy. Data from 44 patients (2-16 years old), on...
journal_title:Acta diabetologica
pub_type: 临床试验,杂志文章
doi:10.1007/s00592-003-0102-2
更新日期:2003-09-01 00:00:00
abstract::MicroRNAs (miRNAs) play a crucial role in the pathogenesis of type 2 diabetes (T2D); they regulate several metabolic pathways including insulin secretion, glucose homeostasis, so their potential as biomarkers of diagnosis and prognosis has became increasingly appreciated. In this study, we explore serum miRNA profiles...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-014-0617-8
更新日期:2014-10-01 00:00:00
abstract:AIMS:Diabetic ketoacidosis (DKA) at diabetes diagnosis is a dangerous yet potentially preventable condition. Young age, low socioeconomic status, and low parental education have been found to be associated with increased risk of DKA. We aimed to evaluate the impact of religious affiliation on presentation with DKA at t...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-014-0653-4
更新日期:2015-04-01 00:00:00
abstract::Anti-myeloperoxidase (anti-MPO) antibodies were detected in 34 of 88 (38%) patients with type 1 diabetes mellitus but in only 3 of 55 (5.7%) healthy subjects and in 4 of 20 patients with autoimmune disease. Specificity of anti-MPO antibodies was assessed by MPO inhibition studies. No relationship was found between the...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00569418
更新日期:1996-07-01 00:00:00
abstract::Postreceptor insulin resistance was studied in liver, muscle and adipose tissue from NMRI mice of both sexes made diabetic by long-term fat-feeding. Intravenous glucose tolerance tests showed a combination of impaired glucose tolerance and increased plasma insulin concentrations consistent with insulin resistance and ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00572823
更新日期:1992-01-01 00:00:00
abstract::Cytomegalovirus (CMV) infects 40 % of the world population and has been suggested to be associated with diabetes; however, no prospective study has ever examined diabetes mortality associated with the infection. A cohort of 14,404 non-diabetic adult participants aged 17-90 years from the Third National Health and Nutr...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-014-0573-3
更新日期:2014-10-01 00:00:00
abstract::The objective of this study is to explore the mechanism of oxidative stress induced by intermittent high glucose in porcine iliac endothelial cells (PIECs). The PIECs were exposed to intermittent or constant high glucose for 3 or 6 days, and the mean fluorescent intensity (MFI) was measured via intracellular reactive ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-009-0140-5
更新日期:2010-12-01 00:00:00
abstract::Our aim was to compare the effects of an intermediate acting human insulin (NPH) and a long-acting insulin analog, insulin glargine, in insulin naïve type 2 diabetes patients, stratified by the type of hyperglycemia (fasting or postprandial type). Based on different action profiles, we hypothesized that patients havin...
journal_title:Acta diabetologica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00592-013-0505-7
更新日期:2014-04-01 00:00:00
abstract:AIMS:To evaluate the patients' perceptions of telemedicine visits during COVID-19 lockdown and their level of anxiety about COVID and diabetic foot (DF). METHODS:In May 2020, we contacted by phone all the patients who underwent in March and April to remote monitoring visits for DF during the lockdown for COVID-19, wit...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-020-01653-y
更新日期:2021-01-13 00:00:00
abstract:AIMS:To investigate the possibility of identifying a subtype of latent autoimmune diabetes in adults (LADA), T-LADA (T cell responses-positive and autoantibody-negative) from patients with phenotypic type 2 diabetes (T2D) by enzyme-linked immunospot (ELISPOT). METHODS:Eighty-two patients with phenotypic T2D were studi...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-019-01391-w
更新日期:2019-11-01 00:00:00
abstract::Autoantibodies to zinc transporter 8 (ZnT8A) are a powerful diagnostic or predictive marker in type 1 diabetes. However, the widely used current ZnT8A radioligand binding assay (RBA) has proved to be difficult for many laboratories to implement. The aim of this study was the development and characterization of the per...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-013-0532-4
更新日期:2014-01-01 00:00:00
abstract:AIMS:To assess the risk of adverse neonatal outcomes in women with gestational diabetes (GDM) by identifying subgroups of women at higher risk to recognize the characteristics most associated with an excess of risk. METHODS:Observational, retrospective, multicenter study involving consecutive women with GDM. To identi...
journal_title:Acta diabetologica
pub_type: 杂志文章,多中心研究
doi:10.1007/s00592-018-1208-x
更新日期:2018-12-01 00:00:00
abstract::The duration of diabetes before puberty is not considered relevant to the future development of complications. To evaluate the effects of diabetes on the neural retina, we analysed macular function by steady-state focal electroretinography in 20 prepubescent diabetic children without vascular retinopathy and in 39 sex...
journal_title:Acta diabetologica
pub_type: 临床试验,杂志文章
doi:10.1007/BF00570544
更新日期:1994-06-01 00:00:00
abstract::Although reactive oxygen species (ROS) contribute to glucose intolerance induced by the renin-angiotensin system (RAS) is well documented, the role of the newly discovered pathway of RAS, angiotensin (Ang)-(1-7)/Mas axis, in this process remains unknown. Here, we examined the effect of Ang-(1-7) on oxidative stress an...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-011-0348-z
更新日期:2012-08-01 00:00:00
abstract::The title "Plasma fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus" should be replaced by "Serum fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus". ...
journal_title:Acta diabetologica
pub_type: 已发布勘误
doi:10.1007/s00592-018-1177-0
更新日期:2018-10-01 00:00:00
abstract:AIMS:There is clinical evidence that fenofibrate, a PPARα agonist, arrests the progression of diabetic macular edema (DME). However, the underlying mechanisms of this beneficial effect remain to be elucidated. We previously reported that fenofibric acid (FA), the active metabolite of fenofibrate, prevents the disorgani...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0759-3
更新日期:2016-02-01 00:00:00
abstract::The effect of sucrose in the diet of children and adolescents with type I diabetes on long-term metabolic control was studied. For a mean observation period of 83 (range 42-127) days, a diet containing 5% of total calories as refined sugar was recommended to 11 children (group A, mean age 15.0, SD 5.4 years), while an...
journal_title:Acta diabetologica
pub_type: 临床试验,杂志文章
doi:10.1007/BF00571952
更新日期:1994-12-01 00:00:00
abstract:AIMS:The importance of diabetes-related distress for the treatment of diabetes is emphasised in national and international guidelines recommending routinely screening for psychosocial problems. Data of investigations regarding diabetes-related distress on primary care are rare in Germany though most people with diabete...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-017-0972-3
更新日期:2017-05-01 00:00:00
abstract:AIMS:The main objective of this study was to estimate the incidence rate and prevalence of pediatric type 1 diabetes mellitus (T1DM; population 0-18 years of age) in the northeastern Italian region Friuli Venezia Giulia and to characterize the subjects affected by the disease. METHODS:This was a retrospective populati...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-016-0854-0
更新日期:2016-08-01 00:00:00
abstract::The aim of this study was to test whether the augmentation index adjusted for heart rate (AIx@HR75) can be used as a substitute for aortic pulse wave velocity (aPWV) in the measurement of arterial stiffness (AS) in type 1 diabetes. Sixty-eight patients with type 1 diabetes and 68 age- and sex-matched controls were eva...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-012-0433-y
更新日期:2012-12-01 00:00:00
abstract:AIMS:The role of neutrophils in diabetes and its complications is unclear. Upon challenge with microbes and inflammatory triggers, neutrophils release enzymes and nuclear material, forming neutrophils extracellular traps (NETs) and thereby dying by NETosis. We herein tested NET formation and NETosis products in high gl...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-014-0676-x
更新日期:2015-06-01 00:00:00
abstract::To evaluate the role of insulin resistance and beta cell function to increasing fasting plasma glucose (FPG), 1,272 Chinese subjects (18-80 years of age) were divided into normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), combined glucose intolerance (CGI), and type 2 di...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-010-0194-4
更新日期:2012-12-01 00:00:00
abstract::To examine longitudinally the effect of diabetes on bone structure and metabolism, we measured bone mineral density (BMD) and turnover markers in 26 type 1 (mean age 49 years) and 27 type 2 (mean age 65 years) diabetic patients without known osteoporosis from a community-based sample at baseline and 5 years later. In ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-011-0324-7
更新日期:2012-04-01 00:00:00