当前位置： SCI文献检索 > ACTA DIABETOLOGICA期刊下所有文献 > Clinical manifestation and islet β-cell function of a subtype of latent autoimmune diabetes in adults (LADA): positive for T cell responses in phenotypic type 2 diabetes.

Clinical manifestation and islet β-cell function of a subtype of latent autoimmune diabetes in adults (LADA): positive for T cell responses in phenotypic type 2 diabetes.

Abstract：

AIMS:To investigate the possibility of identifying a subtype of latent autoimmune diabetes in adults (LADA), T-LADA (T cell responses-positive and autoantibody-negative) from patients with phenotypic type 2 diabetes (T2D) by enzyme-linked immunospot (ELISPOT). METHODS:Eighty-two patients with phenotypic T2D were studied. Autoantibodies against glutamic acid decarboxylase (GAD), insulinoma-associated protein-2 and zinc transporter 8 were measured by radioligand assay. Thirty-nine Ab+ and 43 Ab- patients with phenotypic T2D were enrolled for T cell assay of responses to GAD65 and C-peptide antigen by ELISPOT. RESULTS:(1) Eleven of 43 Ab- participants with phenotypic T2D were demonstrated interferon (IFN)-γ secreting T cells by ELISPOT, while 13 of 39 Ab+ patients with phenotypic T2D were positive for T cells responses to islet antigens. (2) The onset ages of T cell+ people with phenotypic T2D were younger than that of T cell- individuals (42.7 ± 9.3 vs. 48.2 ± 10.2 years, P = 0.025). Moreover, T cell+ patients with T2D displayed a significantly lower fasting C-peptide (FCP) compared with T cell- participants [0.28 (0.02-0.84) vs. 0.42 (0.05-1.26) nmol/L, P = 0.013]. (3) Ab-T+ group had a significantly lower FCP compared with Ab-T- group [0.31 (0.13-0.84) vs. 0.51 (0.07-1.26) nmol/L, P = 0.023]. CONCLUSIONS:By measuring T cell responses to islet antigens in patients with phenotypic T2D, we identified a specific subtype of LADA who may be associated with worse basal β-cell function than classic T2D (Ab-T-).

journal_name

Acta Diabetol

journal_title

Acta diabetologica

authors

Liang H,Cheng Y,Tang W,Cui Q,Yuan J,Huang G,Yang L,Zhou Z

doi

10.1007/s00592-019-01391-w

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

1225-1230

issue

11

eissn

0940-5429

issn

1432-5233

pii

10.1007/s00592-019-01391-w

journal_volume

56

pub_type

杂志文章

相关文献

ACTA DIABETOLOGICA文献大全
  • The effect of an antilipolytic agent (acipimox) on the insulin resistance of lipid and glucose metabolism in hypertriglyceridaemic patients.

    abstract：:Hypertriglyceridaemia is associated with insulin resistance of both lipid and glucose metabolism. It is not known whether the insulin resistance affects both glucose oxidation and glycogen formation. To study the oxidative and non-oxidative pathways of non-esterified fatty acids (NEFA) and glucose metabolism, eight ma...

    journal_title：Acta diabetologica

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00580753

    authors： Saloranta C,Groop L,Ekstrand A,Franssila-Kallunki A,Taskinen MR

    更新日期：1994-04-01 00:00:00

  • Effect of the introduction of dietary sucrose on metabolic control in children and adolescents with type I diabetes.

    abstract：:The effect of sucrose in the diet of children and adolescents with type I diabetes on long-term metabolic control was studied. For a mean observation period of 83 (range 42-127) days, a diet containing 5% of total calories as refined sugar was recommended to 11 children (group A, mean age 15.0, SD 5.4 years), while an...

    journal_title：Acta diabetologica

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00571952

    authors： Schwingshandl J,Rippel S,Unterluggauer M,Borkenstein M

    更新日期：1994-12-01 00:00:00

  • Decreased beta cell function and insulin sensitivity contributed to increasing fasting glucose in Chinese.

    abstract：:To evaluate the role of insulin resistance and beta cell function to increasing fasting plasma glucose (FPG), 1,272 Chinese subjects (18-80 years of age) were divided into normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), combined glucose intolerance (CGI), and type 2 di...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-010-0194-4

    authors： Bi Y,Zhu D,Jing Y,Hu Y,Feng W,Shen S,Tong G,Shen X,Yu T,Song D,Yang D

    更新日期：2012-12-01 00:00:00

  • Strong evidence of sexual dimorphic effect of adiposity excess on insulin sensitivity.

    abstract：AIMS:Our aims were to investigate in several large samples, with a wide range of adiposity, whether: (1) the effect of BMI on insulin sensitivity is different between sexes; (2) also waist circumference plays a sex-specific role on insulin sensitivity; and (3) serum adiponectin and resistin are mediators of such sex-di...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-015-0804-2

    authors： Marucci A,Menzaghi C,Copetti M,Vinciguerra F,Baratta R,Salvemini L,Morini E,Frittitta L,Di Paola R,Trischitta V

    更新日期：2015-10-01 00:00:00

  • Enhancement of the gluconeogenic flux of hepatic glycogen repletion by a phenacyl imidazolium compound in vivo.

    abstract：:The effect of a phenacyl imidazolium compound (LY177507 or Proglycosyn, Eli Lilly) on the direct (glucose-->glucose-6-phosphate-->glycogen) and indirect (three-carbon compounds-->glucose-6-phosphate-->glycogen) pathways of liver glycogen synthesis was studied in conscious rats. [1-13C]Glucose (99% enriched) was infuse...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/BF00578216

    authors： Cline GW,Greenawalt K,Shulman GI

    更新日期：1993-01-01 00:00:00

  • Ten-year comparative analysis of incidence, prognosis, and associated factors for dialysis and renal transplantation in type 1 and type 2 diabetes versus non-diabetes.

    abstract：AIMS:To study the incidence of and the factors associated with renal dialysis and transplantation in type 1 (T1DM) and type 2 diabetes (T2DM). METHODS:Data on individuals who had received dialysis treatment or renal transplant between 1 January 2004 and 31 December 2013 were extracted from the regional administrative ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-018-1142-y

    authors： Giorda CB,Carnà P,Salomone M,Picariello R,Costa G,Tartaglino B,Gnavi R

    更新日期：2018-07-01 00:00:00

  • Undiagnosed diabetes and impaired glucose regulation in adult Ghanaians using the ADA and WHO diagnostic criteria.

    abstract：:Fasting glucose and oral glucose tolerance test (OGTT) criteria for glucose homeostasis were compared in a cross-sectional cluster, community study in Accra, Ghana. A total of 4636 subjects without prior diagnosis of diabetes had fasting plasma glucose, 2-hour OGTT and measurement of cardiovascular risk factors. Mean ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s005920200006

    authors： Amoah AG

    更新日期：2002-04-01 00:00:00

  • Failure of glycated hemoglobin drop after continuous subcutaneous insulin infusion initiation may indicate patients who discontinue: a 4-year follow-up study in children and adolescents with type 1 diabetes.

    abstract：:Continuous subcutaneous insulin infusion (CSII) is effective and safe in children and adults with type 1 diabetes. Notwithstanding, some patients decide to discontinue using CSII. We evaluated the discontinuation rate, and its related factors, in a large group of children and adolescents with type 1 diabetes using CSI...

    journal_title：Acta diabetologica

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00592-011-0344-3

    authors： Lombardo F,Scaramuzza AE,Iafusco D

    更新日期：2012-12-01 00:00:00

  • Patient education and diabetes research: a failure! Going beyond the empirical approaches.

    abstract：:A literature review of 37 papers cited by MEDLINE between 1986 and April 1996 under the terms "diabetes", "patient education" and "randomized" was carried out. The articles were analysed on the basis of a check list (Educational Procedure Check List), which contains 27 items grouped into 8 areas: study objectives, edu...

    journal_title：Acta diabetologica

    pub_type： 杂志文章,评审

    doi：10.1007/s005920050133

    authors： Albano MG,Jacquemet S,Assal JP

    更新日期：1998-12-01 00:00:00

  • Index of glucose effectiveness derived from oral glucose tolerance test.

    abstract：:Aim of this study was to formulate an index for glucose effectiveness (Sg), SgIo, based on 3-point (0, 30 and 120 min) 75 g oral glucose tolerance test (OGTT). The equation for SgI(O) was developed in the Chikuma cohort (n = 502). Firstly, post-loading plasma glucose without insulin action and Sg (PPG-without insulin ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-012-0417-y

    authors： Nagasaka S,Kusaka I,Yamashita K,Funase Y,Yamauchi K,Katakura M,Ishibashi S,Aizawa T

    更新日期：2012-12-01 00:00:00

  • Mortality in Asian Indians with Charcot's neuroarthropathy: a nested cohort prospective study.

    abstract：AIMS:We studied mortality in individuals of diabetes with or without Charcot neuroarthropathy (CN). METHODS:People attending diabetic foot care facility with CN of foot (Cohort 1) were prospectively evaluated. Details pertaining to the duration of diabetes, microvascular and macrovascular complications, foot ulcer, am...

    journal_title：Acta diabetologica

    pub_type： 杂志文章,评审

    doi：10.1007/s00592-019-01376-9

    authors： Chaudhary S,Bhansali A,Rastogi A

    更新日期：2019-12-01 00:00:00

  • Molecular mechanisms of extracellular vesicle-induced vessel destabilization in diabetic retinopathy.

    abstract：AIMS:Diabetic retinopathy (DR) is characterized by early dropout of capillary pericytes, leading to loss of control on endothelial proliferation and, subsequently, angiogenesis. We have demonstrated that extracellular vesicles (EV) derived from mesenchymal stem cells (MSC) maintained in diabetic-like conditions may pla...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-015-0798-9

    authors： Mazzeo A,Beltramo E,Iavello A,Carpanetto A,Porta M

    更新日期：2015-12-01 00:00:00

  • Mediterranean meal versus Western meal effects on postprandial ox-LDL, oxidative and inflammatory gene expression in healthy subjects: a randomized controlled trial for nutrigenomic approach in cardiometabolic risk.

    abstract：AIMS:Inflammation and oxidative damage contribute significantly to the development of cardiovascular diseases (CVD). Postprandial oxidative stress and inflammation are characterized by an increased susceptibility of the organism toward oxidative damage after consumption of a meal rich in lipids and/or carbohydrates. Mi...

    journal_title：Acta diabetologica

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00592-016-0917-2

    authors： De Lorenzo A,Bernardini S,Gualtieri P,Cabibbo A,Perrone MA,Giambini I,Di Renzo L

    更新日期：2017-02-01 00:00:00

  • Modulation of gut microbiota contributes to effects of intensive insulin therapy on intestinal morphological alteration in high-fat-diet-treated mice.

    abstract：AIMS:Disturbance of intestinal homeostasis promotes the development of type 2 diabetes. Although intensive insulin therapy has been shown to promote extended glycemic remission in newly diagnosed type 2 diabetic patients through multiple mechanisms, its effect on intestinal homeostasis remains unknown. METHODS:This st...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-019-01436-0

    authors： Wang H,Tang W,Zhang P,Zhang Z,He J,Zhu D,Bi Y

    更新日期：2020-04-01 00:00:00

  • Myocardial dysfunction and chronic heart failure in patients with long-lasting type 1 diabetes: a 7-year prospective cohort study.

    abstract：:The aim of the study is to evaluate the prevalence and incidence of myocardial dysfunction (MD) and heart failure (HF) in long-lasting (≥10 years) type 1 diabetes without cardiovascular disorders or with hypertension or coronary heart disease (CHD). The study included 1,685 patients with type 1 diabetes (mean baseline...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-013-0455-0

    authors： Konduracka E,Cieslik G,Galicka-Latala D,Rostoff P,Pietrucha A,Latacz P,Gajos G,Malecki MT,Nessler J

    更新日期：2013-08-01 00:00:00

  • Preserved incretin effect in type 1 diabetic patients with end-stage nephropathy treated by combined heterotopic pancreas and kidney transplantation.

    abstract：:Insulin secretion is stimulated better by oral than by intravenous glucose (incretin effect). The contribution of the autonomic nervous system to the incretin effect after oral glucose in humans is unclear. We therefore examined nine type 1 diabetic (insulin-dependent) patients with end-stage nephropathy, studied afte...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/BF00572873

    authors： Nauck MA,Büsing M,Orskov C,Siegel EG,Talartschik J,Baartz A,Baartz T,Hopt UT,Becker HD,Creutzfeldt W

    更新日期：1993-01-01 00:00:00

  • A nomogram to estimate the proportion of patients at hemoglobin A1c target

    abstract：:We assessed the efficacy of noninsulin antidiabetic medications used in current clinical practice (metformin, sulfonylureas, α-glucosidase inhibitors, thiazolidinediones, glinides, dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 agonists) to reach the HbA1c target <7% in people with type 2 diabetes. MEDLINE...

    journal_title：Acta diabetologica

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s00592-012-0370-9

    authors： Esposito K,Chiodini P,Ceriello A,Giugliano D

    更新日期：2014-04-01 00:00:00

  • Markers of insulin resistance are associated with cardiovascular morbidity and predict overall mortality in long-standing non-insulin-dependent diabetes mellitus.

    abstract：:The aim of this study was to evaluate the influence of endogenous insulin levels and of insulin administration on coronary heart disease (CHD) and on mortality in a cohort of patients with long-standing non-insulin-dependent diabetes mellitus (type 2). In a cross-sectional study, 93 patients (known duration 17 +/- 8 y...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s005920050101

    authors： Pontiroli AE,Pacchioni M,Camisasca R,Lattanzio R

    更新日期：1998-04-01 00:00:00

  • Effect of different sports on body cell mass in highly trained athletes.

    abstract：:The objective of this study was to verify the impact of various sports on body cell mass (BCM). Ninety-eight male subjects, 17-33 years of age, participated in the study. The sample included athletes from three professional Italian football (soccer) teams, representing three different divisions (A, n=16; B, n=14; and ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-003-0043-9

    authors： Andreoli A,Melchiorri G,Brozzi M,Di Marco A,Volpe SL,Garofano P,Di Daniele N,De Lorenzo A

    更新日期：2003-10-01 00:00:00

  • Clinical reliability of multi-drug intracavernous vasoactive pharmacotherapy for diabetic impotence.

    abstract：:The aim of this study was to assess the effectiveness and safety of intracavernous injections of a four-drug vasoactive mixture in diabetic patients with organic impotence. A group of 60 diabetic patients with either pure neurogenic, pure vasculogenic or mixed neurovasculogenic impotence were treated with intracaverno...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/BF00580752

    authors： Montorsi F,Guazzoni G,Bergamaschi F,Zucconi M,Rigatti P,Pizzini G,Miani A,Pozza G

    更新日期：1994-04-01 00:00:00

  • Screening for diabetes using HbA1c in elderly subjects.

    abstract：:The objective of the study was to determine the prevalence of known diabetes among elderly subjects receiving nursing care in a north Norwegian population, to screen for new cases using HbA1c measurement and to evaluate the quality of care for those with diabetes. Men and women, with and without known diabetes, above ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-006-0212-8

    authors： Jorde R,Hagen T

    更新日期：2006-08-01 00:00:00

  • Relationship between non-enzymatic glycosylation and changes in serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in patients with type 2 diabetes mellitus.

    abstract：:The possible occurrence of increased non-enzymatic glycosylation of serum insulin-like growth factor binding protein-3 (IGFBP-3) in vivo and the changes that would simultaneously occur in serum levels of IGFBP-3 and insulin-like growth factor-1 (IGF-I) were investigated. We measured levels of IGF-I and IGFBP-3 and the...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s005920050109

    authors： Cortizo AM,Lee PD,Cédola NV,Jasper H,Gagliardino JJ

    更新日期：1998-07-01 00:00:00

  • Diabetes-related burden and distress in people with diabetes mellitus at primary care level in Germany.

    abstract：AIMS:The importance of diabetes-related distress for the treatment of diabetes is emphasised in national and international guidelines recommending routinely screening for psychosocial problems. Data of investigations regarding diabetes-related distress on primary care are rare in Germany though most people with diabete...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-017-0972-3

    authors： Kuniss N,Rechtacek T,Kloos C,Müller UA,Roth J,Burghardt K,Kramer G

    更新日期：2017-05-01 00:00:00

  • Vasoactive intestinal polypeptide increases whole pancreatic blood flow but does not affect islet blood flow in the rat.

    abstract：:To evaluate the effects of vasoactive intestinal peptide (VIP) on whole pancreatic blood flow and islet blood flow in the rat, anaesthetized adult rats were injected intravenously for 90 s with VIP (500 ng/kg body weight). Immediately after the injection, the whole pancreatic and islet blood flows were measured with a...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/BF00570545

    authors： Jansson L

    更新日期：1994-06-01 00:00:00

  • Novel enzyme-linked immunosorbent assay for bivalent ZnT8 autoantibodies.

    abstract：:Autoantibodies to zinc transporter 8 (ZnT8A) are a powerful diagnostic or predictive marker in type 1 diabetes. However, the widely used current ZnT8A radioligand binding assay (RBA) has proved to be difficult for many laboratories to implement. The aim of this study was the development and characterization of the per...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-013-0532-4

    authors： Kawasaki E,Tanaka M,Miwa M,Abiru N,Kawakami A

    更新日期：2014-01-01 00:00:00

  • Glucokinase deficit and birthweight: does maternal hyperglycemia always meet fetal needs?

    abstract：AIMS:Many authors do not recommend hypoglycemic treatment during pregnancy in women affected by monogenic diabetes due to heterozygous glucokinase (GCK) mutations (MODY 2) in case of affected fetus, because maternal hyperglycemia would be necessary to achieve a normal birthweight. We aimed to evaluate differences in bi...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-018-1198-8

    authors： Bitterman O,Tinto N,Franzese A,Iafusco F,Festa C,Mozzillo E,Napoli A,Iafusco D

    更新日期：2018-12-01 00:00:00

  • A five-year prospective study of bone mineral density in men and women with diabetes: the Fremantle Diabetes Study.

    abstract：:To examine longitudinally the effect of diabetes on bone structure and metabolism, we measured bone mineral density (BMD) and turnover markers in 26 type 1 (mean age 49 years) and 27 type 2 (mean age 65 years) diabetic patients without known osteoporosis from a community-based sample at baseline and 5 years later. In ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-011-0324-7

    authors： Hamilton EJ,Rakic V,Davis WA,Paul Chubb SA,Kamber N,Prince RL,Davis TM

    更新日期：2012-04-01 00:00:00

  • Diabetes distress and peripheral neuropathy are associated with medication non-adherence in individuals with type 2 diabetes in primary care.

    abstract：BACKGROUND:Psychosocial factors like diabetes distress and social support, as well as the presence of complications, affect an individual's self-management ability; however, their role in adherence behaviours is not yet clear. We examined the role of psychosocial factors and complications in non-adherence behaviours in...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-020-01609-2

    authors： Zhang ZP,Premikha M,Luo M,Venkataraman K

    更新日期：2020-11-19 00:00:00

  • Soybean oil treatment impairs glucose-stimulated insulin secretion and changes fatty acid composition of normal and diabetic islets.

    abstract：:We investigated the effect of sub-chronic soybean oil (SO) treatment on the insulin secretion and fatty acid composition of islets of Langerhans obtained from Goto-Kakizaki (GK), a model of type 2 diabetes, and normal Wistar rats. We observed that soybean-treated Wistar rats present insulin resistance and defective is...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-007-0252-8

    authors： Nunes E,Peixoto F,Louro T,Sena CM,Santos MS,Matafome P,Moreira PI,Seiça R

    更新日期：2007-09-01 00:00:00

  • Resting heart rate predicts metabolic syndrome in apparently healthy non-obese Japanese men.

    abstract：:Autonomic nervous dysfunction is considered to be one of the mechanisms of metabolic syndrome (MetS). The aim of this study is to investigate whether resting heart rate, a marker of autonomic nervous dysfunction, is a predictor of MetS in apparently healthy non-obese [body mass index (BMI) <25 kg/m(2)] Japanese men. T...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-013-0503-9

    authors： Oda E,Aizawa Y

    更新日期：2014-02-01 00:00:00