Failure of glycated hemoglobin drop after continuous subcutaneous insulin infusion initiation may indicate patients who discontinue: a 4-year follow-up study in children and adolescents with type 1 diabetes.


:Continuous subcutaneous insulin infusion (CSII) is effective and safe in children and adults with type 1 diabetes. Notwithstanding, some patients decide to discontinue using CSII. We evaluated the discontinuation rate, and its related factors, in a large group of children and adolescents with type 1 diabetes using CSII in Italy. Data on all patients with type 1 diabetes younger than 18 years were collected by 28 Pediatric Diabetologic referral Centers located throughout Italy. The primary endpoint was to measure the discontinuation rate using CSII. Among the study population (n = 6,644), 985 (14.8%) were using CSII. Sixty patients discontinued using CSII, representing the 6.1%. The discontinuation rate significantly increased (P = 0.002) with age: 0-6 years, 1/84 (1.2%), 7-11 years, 8/262 (3.1%), 12-18 years, 51/579 (8.8%). The average time to discontinuation was 1.8 ± 1.4 years. The average age of patients who discontinued using CSII was higher than in patients still on CSII (12.1 ± 3.2 vs. 10.3 ± 3.8, P = 0.0001), while their diabetes duration was significantly shorter (8.6 ± 2.7 vs. 10.2 ± 3.7, P = 0.0001). HbA1c decreased only in patients still on CSII (8.7 ± 1.3% vs. 7.8 ± 1.3%, P = 0.02), but not in patients who discontinued using CSII (8.5 ± 1.6% vs. 8.2 ± 1.3%, P = 0.213). HbA1c might be one important indicator helpful to identify patients at higher risk discontinuing using CSII.


Acta Diabetol


Acta diabetologica


Lombardo F,Scaramuzza AE,Iafusco D




Has Abstract


2012-12-01 00:00:00








49 Suppl 1


  • Effects of 20-mg oestradiol implant therapy on bone mineral density, fat distribution and muscle mass in postmenopausal women.

    abstract::This 64-week prospective cohort trial evaluated the effects of 20-mg oestradiol implants, replaced every 4 months, in healthy postmenopausal women aged 45-65 years. Of 20 implant and 14 control subjects who remained in the trial at 32 weeks, 13 implant and seven controls continued to 64 weeks, with no baseline differe...

    journal_title:Acta diabetologica

    pub_type: 临床试验,杂志文章


    authors: Hansen RD,Raja C,Baber RJ,Lieberman D,Allen BJ

    更新日期:2003-10-01 00:00:00

  • TNFR1 is associated with short-term mortality in patients with diabetes and acute dyspnea seeking care at the emergency department.

    abstract:BACKGROUND:Circulating levels of TNF alpha receptor 1 (TNFR1) and 2 (TNFR2) are associated with increased long-term mortality and impaired kidney function. AIM:To study association between circulating levels of TNFR1 and TNFR2 and short-term mortality in patients with diabetes and dyspnea. POPULATION AND METHODS:Pati...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Wändell P,Carlsson AC,Larsson A,Melander O,Wessman T,Ärnlöv J,Ruge T

    更新日期:2020-10-01 00:00:00

  • Binding characteristics and crossreactivity of insulin autoantibodies and insulin antibodies directed to three different insulin molecules.

    abstract::To evaluate ex vivo/in vitro the binding and dissociation characteristics and the level of crossreactivity of insulin antibodies and insulin autoantibodies directed to three different insulin molecules (human, bovine and porcine insulin). In this study sera from 17 diabetic patients were included, who were exclusively...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Jaeger C,Winter S,Eckhard M,Hardt P,Brendel MD,Bretzel RG

    更新日期:2008-09-01 00:00:00

  • Enhancement of the gluconeogenic flux of hepatic glycogen repletion by a phenacyl imidazolium compound in vivo.

    abstract::The effect of a phenacyl imidazolium compound (LY177507 or Proglycosyn, Eli Lilly) on the direct (glucose-->glucose-6-phosphate-->glycogen) and indirect (three-carbon compounds-->glucose-6-phosphate-->glycogen) pathways of liver glycogen synthesis was studied in conscious rats. [1-13C]Glucose (99% enriched) was infuse...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Cline GW,Greenawalt K,Shulman GI

    更新日期:1993-01-01 00:00:00

  • Circulating tissue-type plasminogen activator and plasminogen activator inhibitor type 1 in proliferative diabetic retinopathy: a pilot study.

    abstract::Several haemostatic abnormalities are associated with proliferative diabetic retinopathy. While abnormalities in plasma fibrinolytic activity have been described in diabetic retinopathy, platelets (a rich source of plasminogen activator inhibitor type 1, PAI-1) have received little attention. As a result, little is kn...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Simpson AJ,Booth NA,Moore NR,Lewis SJ,Gray RS

    更新日期:1999-09-01 00:00:00

  • The novel loss of function Ile354Val mutation in PPARG causes familial partial lipodystrophy.

    abstract:AIMS:Familial partial lipodystrophy (FPLD) is a rare autosomal dominant disorder, mostly due to mutations in lamin A (LMNA) or in peroxisome proliferator-activated receptor gamma (PPARG) genes. In the present study, we aimed to identify and functionally characterize the genetic defect underlying FPLD in an Italian fami...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Padova G,Prudente S,Vinciguerra F,Sudano D,Baratta R,Bellacchio E,Trischitta V,Vallone A,Sciacca L,Frittitta L

    更新日期:2020-05-01 00:00:00

  • Vasoactive intestinal polypeptide increases whole pancreatic blood flow but does not affect islet blood flow in the rat.

    abstract::To evaluate the effects of vasoactive intestinal peptide (VIP) on whole pancreatic blood flow and islet blood flow in the rat, anaesthetized adult rats were injected intravenously for 90 s with VIP (500 ng/kg body weight). Immediately after the injection, the whole pancreatic and islet blood flows were measured with a...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Jansson L

    更新日期:1994-06-01 00:00:00

  • Metabolomic profile of diabetic retinopathy: a GC-TOFMS-based approach using vitreous and aqueous humor.

    abstract:AIM:To identify the potential metabolite markers in diabetic retinopathy (DR) by using gas chromatography coupled with time-of-flight mass spectrometry (GC-TOFMS). METHODS:GC-TOFMS spectra were acquired from vitreous and aqueous humor (AH) samples of patients with DR and non-diabetic participants. Comparative analysis...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Wang H,Fang J,Chen F,Sun Q,Xu X,Lin SH,Liu K

    更新日期:2020-01-01 00:00:00

  • Clustering of cases of type 1 diabetes in high socioeconomic communes in Santiago de Chile: spatio-temporal and geographical analysis.

    abstract::The objective of this study was to describe spatial and space-time patterns of type 1 diabetes in children less than 15 years old, diagnosed between 2000 and 2005 with residence in the Metropolitan Region of Chile. Knox and Mantel tests were used to detect space-time interaction between cases. An ecological Bayesian m...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Torres-Avilés F,Carrasco E,Icaza G,Pérez-Bravo F

    更新日期:2010-09-01 00:00:00

  • Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4.

    abstract:AIMS:Radiolabeled Exendin-4 has been proposed as suitable imaging marker for pancreatic beta cell mass quantification mediated by Glucagon-like peptide-1 receptor (GLP-1R). However, noticeable species variations in basal pancreatic uptake as well as uptake reduction degree due to selective beta cell ablation were obser...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Eriksson O,Rosenström U,Selvaraju RK,Eriksson B,Velikyan I

    更新日期:2017-11-01 00:00:00

  • Association between resting heart rate and incident diabetes risk: a Mendelian randomization study.

    abstract:AIMS:Observational studies indicated that resting heart rate (RHR) was associated with diabetes mellitus (DM) risk; however, it remains unclear whether the association between RHR and DM is causal. We aimed to examine whether there was causal association of RHR with DM risk. METHODS:A prospective study including 16,20...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Long T,Wang J,Han X,Wang F,Hu H,Yu C,Yuan J,Yao P,Wei S,Wang Y,Liang Y,Miao X,Zhang X,Guo H,Zheng D,Tang Y,Yang H,Huang S,He M

    更新日期:2019-09-01 00:00:00

  • Detection of anti-myeloperoxidase antibodies in the serum of patients with type 1 diabetes mellitus.

    abstract::Anti-myeloperoxidase (anti-MPO) antibodies were detected in 34 of 88 (38%) patients with type 1 diabetes mellitus but in only 3 of 55 (5.7%) healthy subjects and in 4 of 20 patients with autoimmune disease. Specificity of anti-MPO antibodies was assessed by MPO inhibition studies. No relationship was found between the...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Accardo-Palumbo A,Triolo G,Giardina E,Carbone MC,Ferrante A,Triolo G

    更新日期:1996-07-01 00:00:00

  • Glucokinase deficit and birthweight: does maternal hyperglycemia always meet fetal needs?

    abstract:AIMS:Many authors do not recommend hypoglycemic treatment during pregnancy in women affected by monogenic diabetes due to heterozygous glucokinase (GCK) mutations (MODY 2) in case of affected fetus, because maternal hyperglycemia would be necessary to achieve a normal birthweight. We aimed to evaluate differences in bi...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Bitterman O,Tinto N,Franzese A,Iafusco F,Festa C,Mozzillo E,Napoli A,Iafusco D

    更新日期:2018-12-01 00:00:00

  • Beneficial effects of flexible insulin therapy in children and adolescents with type 1 diabetes mellitus.

    abstract::The purpose of this study was to determine the feasibility of a flexible multiple daily insulin (FMDI) regimen in routine pediatric diabetes care by comparing HbA(1c), body mass index (BMI), and episodes of severe hypoglycemia (SH) before and after initiation of FMDI therapy. Data from 44 patients (2-16 years old), on...

    journal_title:Acta diabetologica

    pub_type: 临床试验,杂志文章


    authors: Alemzadeh R,Palma-Sisto P,Parton E,Totka J,Kirby M

    更新日期:2003-09-01 00:00:00

  • Sleep quality and risk of diabetes and coronary artery disease among young men.

    abstract:AIMS:To assess the time-dependent effect of sleep quality on diabetes and coronary artery disease (CAD) incidence among young adults. METHODS:Incident rates of diabetes and CAD during a mean follow-up of 6.4 ± 4.1 years were assessed among 26,023 men (mean age 30.9 ± 5.6 years) of the Metabolic Lifestyle and Nutrition...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Twig G,Shina A,Afek A,Derazne E,Tzur D,Cukierman-Yaffe T,Shechter-Amir D,Gerstein HC,Tirosh A

    更新日期:2016-04-01 00:00:00

  • Inhibitory effect of sulfonylureas on protein phosphatase activity in rat pancreatic islets.

    abstract::We have measured protein phosphatase (PP) activity in crude homogenates as well as in the total 105.000 x g supernatant and precipitate fractions from normal rat pancreatic islets. On the basis of the inhibition produced by either 1 nM or 1 microM okadaic acid, both PP1 and PP2A activity were present in crude islet ho...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Gagliardino JJ,Rossi PF,García ME

    更新日期:1997-03-01 00:00:00

  • Effects of intermittent high glucose on oxidative stress in endothelial cells.

    abstract::The objective of this study is to explore the mechanism of oxidative stress induced by intermittent high glucose in porcine iliac endothelial cells (PIECs). The PIECs were exposed to intermittent or constant high glucose for 3 or 6 days, and the mean fluorescent intensity (MFI) was measured via intracellular reactive ...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Ge QM,Dong Y,Zhang HM,Su Q

    更新日期:2010-12-01 00:00:00

  • New single-nucleotide polymorphisms associated with differences in platelet reactivity and their influence on survival in patients with type 2 diabetes treated with acetylsalicylic acid: an observational study.

    abstract:AIMS:Genetic polymorphisms may contribute to platelet reactivity in diabetic patients; however, the information on their influence on long-term antiplatelet therapy is lacking. Our aim was to evaluate the role of previously described genetic variants and platelet reactivity on risk of all-cause mortality and cardiovasc...

    journal_title:Acta diabetologica

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Milanowski L,Pordzik J,Janicki PK,Kaplon-Cieslicka A,Rosiak M,Peller M,Tyminska A,Ozieranski K,Filipiak KJ,Opolski G,Mirowska-Guzel D,Postula M

    更新日期:2017-04-01 00:00:00

  • Implementation of effective transition from pediatric to adult diabetes care: epidemiological and clinical characteristics-a pioneering experience in North Africa.

    abstract:AIMS:Type 1 diabetes is increasing in children leading more T1D young adults to adult healthcare settings. This change is experienced as a tear and results in a disengagement from specialist services. This study reports on an implementation of an effective and pioneering program of transition in North Africa. METHODS:...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Essaddam L,Kallali W,Jemel M,Kandara H,Kammoun I,Hsairi M,Ben Salem L,Ben Becher S

    更新日期:2018-11-01 00:00:00

  • Examining trends in prediabetes and its relationship with the metabolic syndrome in US adolescents, 1999-2014.

    abstract:AIMS:We sought to investigate temporal trends in prediabetes prevalence among US adolescents using two definitions and evaluate relationships with obesity and a MetS-severity score. METHODS:We evaluated data from 5418 non-Hispanic white, non-Hispanic black, and Hispanic adolescents aged 12-19 participating in the Nati...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Lee AM,Fermin CR,Filipp SL,Gurka MJ,DeBoer MD

    更新日期:2017-04-01 00:00:00

  • Preserved incretin effect in type 1 diabetic patients with end-stage nephropathy treated by combined heterotopic pancreas and kidney transplantation.

    abstract::Insulin secretion is stimulated better by oral than by intravenous glucose (incretin effect). The contribution of the autonomic nervous system to the incretin effect after oral glucose in humans is unclear. We therefore examined nine type 1 diabetic (insulin-dependent) patients with end-stage nephropathy, studied afte...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Nauck MA,Büsing M,Orskov C,Siegel EG,Talartschik J,Baartz A,Baartz T,Hopt UT,Becker HD,Creutzfeldt W

    更新日期:1993-01-01 00:00:00

  • Screening and diagnosis of gestational diabetes in India: a systematic review and meta-analysis.

    abstract:AIMS:Although diabetes is rapidly increasing in India, there is no national consensus on best practices for screening, diagnosis, and management of gestational diabetes mellitus (GDM). The goal of this study was to systematically review the literature for studies reporting the prevalence and screening and diagnostic me...

    journal_title:Acta diabetologica

    pub_type: 杂志文章,meta分析,评审


    authors: Li KT,Naik S,Alexander M,Mathad JS

    更新日期:2018-06-01 00:00:00

  • Impact of sirtuin-1 expression on H3K56 acetylation and oxidative stress: a double-blind randomized controlled trial with resveratrol supplementation.

    abstract:AIMS:Sirtuin-1 (SIRT-1) down-regulation in type 2 diabetes mellitus (T2DM) has been associated with epigenetic markers of oxidative stress. We herein aim to evaluate whether an increase in SIRT-1 expression affects histone 3 acetylation at the 56 lysine residue (H3K56ac) in T2DM patients randomly selected to receive ei...

    journal_title:Acta diabetologica

    pub_type: 杂志文章,随机对照试验


    authors: Bo S,Togliatto G,Gambino R,Ponzo V,Lombardo G,Rosato R,Cassader M,Brizzi MF

    更新日期:2018-04-01 00:00:00

  • The use of continuous density gradients for the assessment of islet and exocrine tissue densities and islet purification.

    abstract::The purification of large numbers of human pancreatic islets remains one of the limiting factors in islet transplantation. This paper describes and validates a method for accurately and reproducibly determining the density of islets and exocrine tissue in pancreatic digest on the basis of their isopycnic distribution ...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Robertson GS,Chadwick DR,Contractor H,James RF,Bell PR,London NJ

    更新日期:1993-01-01 00:00:00

  • Glycemic variability indices can be used to diagnose islet transplantation success in type 1 diabetic patients.

    abstract:AIMS:High glycemic variability (GV) is the major indication for islet transplantation (IT) in patients with type 1 diabetes (T1D). The actual criteria used to assess graft function do not consider GV improvement. Our study aimed to describe GV indices' evolution in T1D patients who benefited from IT during the TRIMECO ...

    journal_title:Acta diabetologica

    pub_type: 杂志文章,随机对照试验


    authors: Jalbert M,Zheng F,Wojtusciszyn A,Forbes F,Bonnet S,Skaare K,Benhamou PY,Lablanche S,TRIMECO Study Group.

    更新日期:2020-03-01 00:00:00

  • Risk of cancer in patients treated with dipeptidyl peptidase-4 inhibitors: an extensive meta-analysis of randomized controlled trials.

    abstract:AIMS:Observational studies and meta-analyses of randomized trials on dipeptidyl peptidase-4 inhibitors (DPP4i) reported discordant results on the risk of malignancies with this class of drugs. Aim of the present meta-analysis is the assessment of the effect of DPP4i treatment on the incidence of different types of canc...

    journal_title:Acta diabetologica

    pub_type: 杂志文章,meta分析


    authors: Dicembrini I,Nreu B,Montereggi C,Mannucci E,Monami M

    更新日期:2020-06-01 00:00:00

  • Breastfeeding is protective to diabetes risk in young adults: a longitudinal study.

    abstract:AIM:It is unclear whether any breastfeeding or a certain duration of breastfeeding is protective against the development of diabetes in adult offspring. METHODS:We followed a sub-sample of 3,595 offspring born in the Mater Hospital in Brisbane, Australia between 1981 and 1983 and for whom we had doctor diagnosed self-...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Al Mamun A,O'Callaghan MJ,Williams GM,Najman JM,Callaway L,McIntyre HD

    更新日期:2015-10-01 00:00:00

  • Renal growth during pregnancy in insulin-dependent diabetic women. A prospective study of renal volume and clinical variables.

    abstract::Kidney volume was measured during pregnancy in insulin-dependent diabetic women by an ultrasound technique and prognostic value of these measurements evaluated. A prospective study was performed on 87 pregnant women with insulin-dependent diabetes attending the maternity clinic of Aarhus Kommunehospital. Patients with...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Lauszus FF,Klebe JG,Rasmussen OW,Klebe TM,Dørup J,Christensen T

    更新日期:1995-12-01 00:00:00

  • Diabetes and the risk of sudden cardiac death, the Atherosclerosis Risk in Communities study.

    abstract::Studies suggest that diabetes may specifically elevate the risk of sudden cardiac death in excess of other heart disease outcomes. In this study, we examined the association of type 2 diabetes with the incidence of sudden cardiac death when compared to the incidence of non-sudden cardiac death and non-fatal myocardial...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Kucharska-Newton AM,Couper DJ,Pankow JS,Prineas RJ,Rea TD,Sotoodehnia N,Chakravarti A,Folsom AR,Siscovick DS,Rosamond WD

    更新日期:2010-12-01 00:00:00

  • Hepatic insulin resistance in NAFLD: relationship with markers of atherosclerosis and metabolic syndrome components.

    abstract:AIMS:Fat accumulation in the liver and in the muscle results in hepatic and muscle insulin resistance and has been associated with increased cardiovascular risk. It is unclear whether the individual role of hepatic and muscle insulin resistance in the onset of dyslipidaemia is observed in nonalcoholic fatty liver disea...

    journal_title:Acta diabetologica

    pub_type: 杂志文章


    authors: Privitera G,Spadaro L,Alagona C,Calanna S,Piro S,Rabuazzo AM,Purrello F

    更新日期:2016-06-01 00:00:00