Failure of glycated hemoglobin drop after continuous subcutaneous insulin infusion initiation may indicate patients who discontinue: a 4-year follow-up study in children and adolescents with type 1 diabetes.

Abstract:

:Continuous subcutaneous insulin infusion (CSII) is effective and safe in children and adults with type 1 diabetes. Notwithstanding, some patients decide to discontinue using CSII. We evaluated the discontinuation rate, and its related factors, in a large group of children and adolescents with type 1 diabetes using CSII in Italy. Data on all patients with type 1 diabetes younger than 18 years were collected by 28 Pediatric Diabetologic referral Centers located throughout Italy. The primary endpoint was to measure the discontinuation rate using CSII. Among the study population (n = 6,644), 985 (14.8%) were using CSII. Sixty patients discontinued using CSII, representing the 6.1%. The discontinuation rate significantly increased (P = 0.002) with age: 0-6 years, 1/84 (1.2%), 7-11 years, 8/262 (3.1%), 12-18 years, 51/579 (8.8%). The average time to discontinuation was 1.8 ± 1.4 years. The average age of patients who discontinued using CSII was higher than in patients still on CSII (12.1 ± 3.2 vs. 10.3 ± 3.8, P = 0.0001), while their diabetes duration was significantly shorter (8.6 ± 2.7 vs. 10.2 ± 3.7, P = 0.0001). HbA1c decreased only in patients still on CSII (8.7 ± 1.3% vs. 7.8 ± 1.3%, P = 0.02), but not in patients who discontinued using CSII (8.5 ± 1.6% vs. 8.2 ± 1.3%, P = 0.213). HbA1c might be one important indicator helpful to identify patients at higher risk discontinuing using CSII.

journal_name

Acta Diabetol

journal_title

Acta diabetologica

authors

Lombardo F,Scaramuzza AE,Iafusco D

doi

10.1007/s00592-011-0344-3

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

S99-105

eissn

0940-5429

issn

1432-5233

journal_volume

49 Suppl 1

pub_type

杂志文章,多中心研究
  • Profile of patients with diabetes in Eritrea: results of first phase registry analyses.

    abstract::A cross-sectional descriptive study was done on patients recently entered into the National Diabetes Registry in Eritrea where the prevalence was estimated to be 2.2% based on patient information in 2004. Of the 627 patients with diabetes, two thirds were type 2. Although type 1 had poorer control (42.9%) than type 2 ...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-009-0093-8

    authors: Seyum B,Mebrahtu G,Usman A,Mufunda J,Tewolde B,Haile S,Kosia A,Negassi E

    更新日期:2010-03-01 00:00:00

  • Binding characteristics and crossreactivity of insulin autoantibodies and insulin antibodies directed to three different insulin molecules.

    abstract::To evaluate ex vivo/in vitro the binding and dissociation characteristics and the level of crossreactivity of insulin antibodies and insulin autoantibodies directed to three different insulin molecules (human, bovine and porcine insulin). In this study sera from 17 diabetic patients were included, who were exclusively...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-008-0041-z

    authors: Jaeger C,Winter S,Eckhard M,Hardt P,Brendel MD,Bretzel RG

    更新日期:2008-09-01 00:00:00

  • Relationship between insulin responses to D-glucose and to L-arginine in women with a history of gestational diabetes.

    abstract::The relationship between insulin responses to glucose and to arginine was studied in non-obese women with previous gestational diabetes (PGD). One group, n = 10, had normal glucose tolerance (NGT) by WHO criteria and another, n = 8, had impaired glucose tolerance (IGT). A third group of women without PGD, n = 12, was ...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/BF00569563

    authors: Alvarsson M,Wajngot A,Efendic S,Grill V

    更新日期:1995-06-01 00:00:00

  • MicroRNA-126 and micro-/macrovascular complications of type 1 diabetes in the EURODIAB Prospective Complications Study.

    abstract:AIMS:Increasing evidence suggests a potential role of circulating miRNAs as clinical biomarkers, and loss of miRNA-126 has been proposed as a predictor of type 2 diabetes onset. However, a systematic analysis of circulating miRNAs in type 1 diabetic patients with micro-/macrovascular complications has not yet been perf...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-016-0915-4

    authors: Barutta F,Bruno G,Matullo G,Chaturvedi N,Grimaldi S,Schalkwijk C,Stehouwer CD,Fuller JH,Gruden G

    更新日期:2017-02-01 00:00:00

  • Ten-year comparative analysis of incidence, prognosis, and associated factors for dialysis and renal transplantation in type 1 and type 2 diabetes versus non-diabetes.

    abstract:AIMS:To study the incidence of and the factors associated with renal dialysis and transplantation in type 1 (T1DM) and type 2 diabetes (T2DM). METHODS:Data on individuals who had received dialysis treatment or renal transplant between 1 January 2004 and 31 December 2013 were extracted from the regional administrative ...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-018-1142-y

    authors: Giorda CB,Carnà P,Salomone M,Picariello R,Costa G,Tartaglino B,Gnavi R

    更新日期:2018-07-01 00:00:00

  • Early changes in glial reactivity and lipid peroxidation in diabetic rat retina: effects of melatonin.

    abstract::Diabetes mellitus, the most common serious metabolic disorder, is characterized by functional and structural changes in the peripheral and central nervous systems. Glial cells provide structural and metabolic support for retinal neurons. During diabetes, one of the early pathogenic events is retinal glial reactivity. ...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-004-0155-x

    authors: Baydas G,Tuzcu M,Yasar A,Baydas B

    更新日期:2004-09-01 00:00:00

  • 31P-magnetic resonance spectroscopy (31P-MRS) detects early changes in kidney high-energy phosphate metabolism during a 6-month Valsartan treatment in diabetic and non-diabetic kidney-transplanted patients.

    abstract::(31)P-magnetic resonance spectroscopy ((31)P-MRS) is a non-invasive tool to study high-energy phosphate (HEP) metabolism. We evaluate whether 31P-MRS can detect early changes in kidney HEP metabolism during a 6-month trial with Valsartan. Twenty consecutive stable and normotensive kidney-transplanted patients were enr...

    journal_title:Acta diabetologica

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00592-012-0369-2

    authors: Fiorina P,Bassi R,Gremizzi C,Vergani A,Caldara R,Mello A,Del Maschio A,De Cobelli F,Perseghin G,Secchi A

    更新日期:2012-12-01 00:00:00

  • Effects of 6 months of resveratrol versus placebo on pentraxin 3 in patients with type 2 diabetes mellitus: a double-blind randomized controlled trial.

    abstract:AIMS:The anti-inflammatory effects of the polyphenol resveratrol in patients with type 2 diabetes mellitus (T2DM) are controversial. Its role on pentraxin 3 (PTX3) concentrations, a human acute phase protein, has never been evaluated. Our aim was to determine whether a two-dosage resveratrol supplementation (500 and 40...

    journal_title:Acta diabetologica

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00592-017-0977-y

    authors: Bo S,Ponzo V,Evangelista A,Ciccone G,Goitre I,Saba F,Procopio M,Cassader M,Gambino R

    更新日期:2017-05-01 00:00:00

  • Oscillating glucose and constant high glucose induce endoglin expression in endothelial cells: the role of oxidative stress.

    abstract:AIM:High glucose-induced oxidative stress has been suggested as one of the mediators of endothelial damage in diabetes. The major endothelial protein, endoglin, has been found overexpressed in the vessels during pathological situations, but little is known about its relation to diabetic vascular complications. To clari...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-014-0670-3

    authors: La Sala L,Pujadas G,De Nigris V,Canivell S,Novials A,Genovese S,Ceriello A

    更新日期:2015-06-01 00:00:00

  • Effect of the pyridoindole antioxidant stobadine on sodium handling of renal Na,K-ATPase in rats with streptozotocin-induced diabetes.

    abstract::Overload of reactive oxygen species during diabetes is known to impair cellular homeostasis and to promote deterioration of membrane function in the organism. The aim of the present study was to examine the effect of dietary supplementation with the pyridoindole atioxidant stobadine on functional properties of the ren...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-004-0162-y

    authors: Vrbjar N,Strelková S,Stefek M,Kyselová Z,Gajdosíková A

    更新日期:2004-12-01 00:00:00

  • The effect of an antilipolytic agent (acipimox) on the insulin resistance of lipid and glucose metabolism in hypertriglyceridaemic patients.

    abstract::Hypertriglyceridaemia is associated with insulin resistance of both lipid and glucose metabolism. It is not known whether the insulin resistance affects both glucose oxidation and glycogen formation. To study the oxidative and non-oxidative pathways of non-esterified fatty acids (NEFA) and glucose metabolism, eight ma...

    journal_title:Acta diabetologica

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF00580753

    authors: Saloranta C,Groop L,Ekstrand A,Franssila-Kallunki A,Taskinen MR

    更新日期:1994-04-01 00:00:00

  • Assessing body composition in gastrointestinal disorders.

    abstract::The assessment of body composition and energy requirements is important for the nutrition of healthy and pathological states such as gastrointestinal disorders, which are known to be associated with abnormalities in body composition among persons with malnutrition and malabsorption. Careful monitoring of body composit...

    journal_title:Acta diabetologica

    pub_type: 杂志文章,评审

    doi:10.1007/s00592-003-0053-7

    authors: De Lorenzo A,Maiolo C,Mohamed EI,Casini A

    更新日期:2003-10-01 00:00:00

  • Prospective study of cytomegalovirus seropositivity and risk of mortality from diabetes.

    abstract::Cytomegalovirus (CMV) infects 40 % of the world population and has been suggested to be associated with diabetes; however, no prospective study has ever examined diabetes mortality associated with the infection. A cohort of 14,404 non-diabetic adult participants aged 17-90 years from the Third National Health and Nutr...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-014-0573-3

    authors: Mendy A,Gasana J,Vieira ER,Diallo H

    更新日期:2014-10-01 00:00:00

  • Effects of renin-angiotensin system blockade on the islet morphology and function in rats with long-term high-fat diet.

    abstract::The renin-angiotensin system (RAS) has an important role in the endocrine pancreas. Multiple researches have shown that even in the insulin resistance phase, there are many abnormalities in islets morphology and function. This study aimed at investigating the effects of RAS blockade on the islets function in rats with...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-010-0210-8

    authors: Yuan L,Li X,Li J,Li HL,Cheng SS

    更新日期:2013-08-01 00:00:00

  • Body composition and respiratory function.

    abstract::Although the effects of sex, ageing, height, race, and current and past health on pulmonary function tests have been described, only non-significant associations have been observed between body weight and lung function among healthy persons after having accounted for the effects of age and height. However, few studies...

    journal_title:Acta diabetologica

    pub_type: 杂志文章,评审

    doi:10.1007/s00592-003-0023-0

    authors: Maiolo C,Mohamed EI,Carbonelli MG

    更新日期:2003-10-01 00:00:00

  • Increased risk of severe diabetic ketoacidosis among Jewish ultra-orthodox children.

    abstract:AIMS:Diabetic ketoacidosis (DKA) at diabetes diagnosis is a dangerous yet potentially preventable condition. Young age, low socioeconomic status, and low parental education have been found to be associated with increased risk of DKA. We aimed to evaluate the impact of religious affiliation on presentation with DKA at t...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-014-0653-4

    authors: Gruber N,Reichman B,Lerner-Geva L,Pinhas-Hamiel O

    更新日期:2015-04-01 00:00:00

  • Identification of megakaryocytes as a target of advanced glycation end products in diabetic complications in bone marrow.

    abstract:AIMS:To define the possible effect of diabetic conditions on megakaryocytes, the long-know precursors of platelets and lately characterized modulator of hematopoietic stem quiescence-activation transition. METHODS:Megakaryoblastic MEG-01 cell culture and TPO/SCF/IL-3-induced differentiation of human umbilical blood mo...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-018-1109-z

    authors: Wang B,Yu J,Wang T,Shen Y,Lin D,Xu X,Wang Y

    更新日期:2018-05-01 00:00:00

  • Incidence of hospitalization and mortality in patients with diabetic foot regardless of amputation: a population study.

    abstract:AIMS:The aim of our study was to estimate the overall rate of first hospitalizations for diabetic foot (DF) regardless of the outcome in amputations, as well as the mortality rate with their determinants in the period 2012-2016 in Piedmont Region in Italy. METHODS:The study included all the subjects registered in the ...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-019-01412-8

    authors: Monge L,Gnavi R,Carnà P,Broglio F,Boffano GM,Giorda CB

    更新日期:2020-02-01 00:00:00

  • Strong evidence of sexual dimorphic effect of adiposity excess on insulin sensitivity.

    abstract:AIMS:Our aims were to investigate in several large samples, with a wide range of adiposity, whether: (1) the effect of BMI on insulin sensitivity is different between sexes; (2) also waist circumference plays a sex-specific role on insulin sensitivity; and (3) serum adiponectin and resistin are mediators of such sex-di...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-015-0804-2

    authors: Marucci A,Menzaghi C,Copetti M,Vinciguerra F,Baratta R,Salvemini L,Morini E,Frittitta L,Di Paola R,Trischitta V

    更新日期:2015-10-01 00:00:00

  • Starting bedtime glargine versus NPH insulin in poorly controlled type 2 diabetic patients with various hyperglycemia types (fasting type or postprandial type).

    abstract::Our aim was to compare the effects of an intermediate acting human insulin (NPH) and a long-acting insulin analog, insulin glargine, in insulin naïve type 2 diabetes patients, stratified by the type of hyperglycemia (fasting or postprandial type). Based on different action profiles, we hypothesized that patients havin...

    journal_title:Acta diabetologica

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00592-013-0505-7

    authors: Vähätalo MA,Viikari J,Rönnemaa T

    更新日期:2014-04-01 00:00:00

  • Soluble tumor necrosis factor receptors in sera from patients with insulin-dependent diabetes mellitus: relations to duration and complications of disease.

    abstract::Concentrations of soluble receptors for tumor necrosis factor (p55 and p75) strongly correlate with clinical stage and progression of infectious diseases, and may be useful in monitoring autoimmune diseases. However, the role of soluble TNF receptors in insulin-dependent diabetes mellitus (type 1 DM) is not clear. We ...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s005920050152

    authors: Kulseng B,Vatten L,Espevik T

    更新日期:1999-06-01 00:00:00

  • Modulation of gut microbiota contributes to effects of intensive insulin therapy on intestinal morphological alteration in high-fat-diet-treated mice.

    abstract:AIMS:Disturbance of intestinal homeostasis promotes the development of type 2 diabetes. Although intensive insulin therapy has been shown to promote extended glycemic remission in newly diagnosed type 2 diabetic patients through multiple mechanisms, its effect on intestinal homeostasis remains unknown. METHODS:This st...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-019-01436-0

    authors: Wang H,Tang W,Zhang P,Zhang Z,He J,Zhu D,Bi Y

    更新日期:2020-04-01 00:00:00

  • Sourdough-leavened bread improves postprandial glucose and insulin plasma levels in subjects with impaired glucose tolerance.

    abstract::Sourdough bread has been reported to improve glucose metabolism in healthy subjects. In this study postprandial glycaemic and insulinaemic responses were evaluated in subjects with impaired glucose tolerance (IGT) who had a meal containing sourdough bread leavened with lactobacilli, in comparison to a reference meal c...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-008-0029-8

    authors: Maioli M,Pes GM,Sanna M,Cherchi S,Dettori M,Manca E,Farris GA

    更新日期:2008-06-01 00:00:00

  • Examining trends in prediabetes and its relationship with the metabolic syndrome in US adolescents, 1999-2014.

    abstract:AIMS:We sought to investigate temporal trends in prediabetes prevalence among US adolescents using two definitions and evaluate relationships with obesity and a MetS-severity score. METHODS:We evaluated data from 5418 non-Hispanic white, non-Hispanic black, and Hispanic adolescents aged 12-19 participating in the Nati...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-016-0958-6

    authors: Lee AM,Fermin CR,Filipp SL,Gurka MJ,DeBoer MD

    更新日期:2017-04-01 00:00:00

  • Left atrial function in diabetes: does it help?

    abstract::Left atrial (LA) structural, functional and mechanical changes have important role in development of diabetic cardiomyopathy and it was discovered that LA remodeling has important prognostic role in the patients with diabetes (DM). Previously the focus of echocardiographic studies in DM population was on the left vent...

    journal_title:Acta diabetologica

    pub_type: 杂志文章,评审

    doi:10.1007/s00592-020-01557-x

    authors: Tadic M,Cuspidi C

    更新日期:2020-06-09 00:00:00

  • NETosis is induced by high glucose and associated with type 2 diabetes.

    abstract:AIMS:The role of neutrophils in diabetes and its complications is unclear. Upon challenge with microbes and inflammatory triggers, neutrophils release enzymes and nuclear material, forming neutrophils extracellular traps (NETs) and thereby dying by NETosis. We herein tested NET formation and NETosis products in high gl...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-014-0676-x

    authors: Menegazzo L,Ciciliot S,Poncina N,Mazzucato M,Persano M,Bonora B,Albiero M,Vigili de Kreutzenberg S,Avogaro A,Fadini GP

    更新日期:2015-06-01 00:00:00

  • Accelerated gastric emptying during hypoglycaemia is not associated with changes in plasma motilin levels.

    abstract::This study examined whether or not changes in plasma concentrations of motilin and other gastrointestinal hormones known to affect gastric motility are associated with the accelerated gastric emptying seen during hypoglycaemia. While studying gastric emptying by scintigraphy in eight healthy subjects, the plasma conce...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s005920050073

    authors: Schvarcz E,Palmér M,Aman J,Berne C

    更新日期:1997-10-01 00:00:00

  • Alcohol consumption or cigarette smoking and cardiovascular disease risk in youth with type 1 diabetes.

    abstract:AIM:To assess the association between alcohol consumption and/or cigarette smoking with other unhealthy behaviors and clinical cardiovascular risk factors in youth with type 1 diabetes. METHODS:Two hundred and twenty-eight youth with type 1 diabetes (age 13-19 years) were consecutively enrolled in three Regional Pedia...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-019-01415-5

    authors: Valerio G,Mozzillo E,Zito E,De Nitto E,Maltoni G,Marigliano M,Zucchini S,Maffeis C,Franzese A

    更新日期:2019-12-01 00:00:00

  • Characterization of Japanese families with early-onset type 2 (non-insulin dependent) diabetes mellitus and screening for mutations in the glucokinase and mitochondrial tRNA(Leu(UUR)) genes.

    abstract::Genetic linkage studies of families with early-onset type 2 diabetes have facilitated the identification of diabetes-susceptibility genes. In order to assess the feasibility of using linkage approaches to identify genes responsible for the development of type 2 diabetes in Japanese subjects, we examined our clinical r...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/BF00581039

    authors: Iwasaki N,Ohgawara H,Nagahara H,Kawamura M,Bell GI,Omori Y

    更新日期:1995-03-01 00:00:00

  • Using the Internet-based upload blood glucose monitoring and therapy management system in patients with type 1 diabetes.

    abstract::The aim of this study is to assess the impact of the internet-based upload blood glucose monitoring and therapy management system (Carelink(®)) in patients with type 1 diabetes. Diabetic patients treated with pump infusion for ≥3 months were prospectively randomized to use the CareLink(®) with (4 months) and without (...

    journal_title:Acta diabetologica

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00592-013-0510-x

    authors: Shalitin S,Ben-Ari T,Yackobovitch-Gavan M,Tenenbaum A,Lebenthal Y,de Vries L,Phillip M

    更新日期:2014-04-01 00:00:00