Abstract:
AIMS:We sought to investigate temporal trends in prediabetes prevalence among US adolescents using two definitions and evaluate relationships with obesity and a MetS-severity score. METHODS:We evaluated data from 5418 non-Hispanic white, non-Hispanic black, and Hispanic adolescents aged 12-19 participating in the National Health and Nutrition Examination Survey 1999-2014 with complete data regarding MetS and hemoglobin A1c (HbA1c). Prediabetes status was defined by American Diabetes Association (ADA) criteria: fasting glucose 100-125 mg/dL or HbA1c 5.7%-6.4%. MetS severity was assessed with a MetS-severity Z-score. RESULTS:Prevalence of prediabetes as defined by HbA1c abnormalities significantly increased from 1999-2014, while prevalence of prediabetes as defined by fasting glucose abnormalities showed no significant temporal trend. There were variations in these trends across different racial/ethnic groups. MetS Z-score was overall more strongly correlated with HbA1c, fasting insulin, and the homeostasis model of insulin resistance than was BMI Z-score. These correlations were true in each racial/ethnic group with the exception that in non-Hispanic white adolescents, in whom the MetS Z-score was not significantly correlated with HbA1c measurements. CONCLUSION:We found conflicting findings of temporal trends of US adolescent prediabetes prevalence based on the ADA's prediabetes criteria. The increasing prevalence of prediabetes by HbA1c assessment is concerning and raises the urgency for increased awareness and appropriate measures of prediabetes status among physicians and patients.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Lee AM,Fermin CR,Filipp SL,Gurka MJ,DeBoer MDdoi
10.1007/s00592-016-0958-6subject
Has Abstractpub_date
2017-04-01 00:00:00pages
373-381issue
4eissn
0940-5429issn
1432-5233pii
10.1007/s00592-016-0958-6journal_volume
54pub_type
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journal_title:Acta diabetologica
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journal_title:Acta diabetologica
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Acta diabetologica
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pub_type: 临床试验,杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-020-01653-y
更新日期:2021-01-13 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-012-0422-1
更新日期:2013-06-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s005920050133
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pub_type: 临床试验,杂志文章
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journal_title:Acta diabetologica
pub_type: 杂志文章
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更新日期:1998-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-11-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章,多中心研究
doi:10.1007/s00592-018-1208-x
更新日期:2018-12-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-020-01523-7
更新日期:2020-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00592-004-0139-x
更新日期:2004-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0804-2
更新日期:2015-10-01 00:00:00
abstract::This 64-week prospective cohort trial evaluated the effects of 20-mg oestradiol implants, replaced every 4 months, in healthy postmenopausal women aged 45-65 years. Of 20 implant and 14 control subjects who remained in the trial at 32 weeks, 13 implant and seven controls continued to 64 weeks, with no baseline differe...
journal_title:Acta diabetologica
pub_type: 临床试验,杂志文章
doi:10.1007/s00592-003-0063-5
更新日期:2003-10-01 00:00:00
abstract:AIMS:To define the possible effect of diabetic conditions on megakaryocytes, the long-know precursors of platelets and lately characterized modulator of hematopoietic stem quiescence-activation transition. METHODS:Megakaryoblastic MEG-01 cell culture and TPO/SCF/IL-3-induced differentiation of human umbilical blood mo...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-018-1109-z
更新日期:2018-05-01 00:00:00