Abstract:
:MicroRNAs (miRNAs) play a crucial role in the pathogenesis of type 2 diabetes (T2D); they regulate several metabolic pathways including insulin secretion, glucose homeostasis, so their potential as biomarkers of diagnosis and prognosis has became increasingly appreciated. In this study, we explore serum miRNA profiles in T2D patients. A total of ten candidate miRNAs were identified by Solexa sequencing scanning and followed by a stem-loop quantitative reverse transcription PCR (qRT-PCR) to assess these candidate serum miRNAs. The results of qRT-PCR assessment revealed low serum levels of miR-23a, let-7i, miR-486, miR-96, miR-186, miR-191, miR-192, and miR-146a in T2D. Except for significantly lower in T2D and pre-diabetes patients compared with normal glucose tolerance (NGT) controls (P = 2.87E-05 and P = 3.75E-02), the levels of miR-23a demonstrated also significant decline in T2D patients compared with pre-diabetes patients (P = 1.06E-02). This marker yielded an AUC of 0.835 (95 % CI 0.717-0.954). At a cutoff value of 1.645, the sensitivity was 79.2 % and the specificity was 75.0 % in discriminating T2D patients from NGT normal controls. These results revealed that serum miR-23a was a valuable biomarker for early detection of T2D and pre-diabetes with NGT.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Yang Z,Chen H,Si H,Li X,Ding X,Sheng Q,Chen P,Zhang Hdoi
10.1007/s00592-014-0617-8subject
Has Abstractpub_date
2014-10-01 00:00:00pages
823-31issue
5eissn
0940-5429issn
1432-5233journal_volume
51pub_type
杂志文章abstract:AIMS:To define the possible effect of diabetic conditions on megakaryocytes, the long-know precursors of platelets and lately characterized modulator of hematopoietic stem quiescence-activation transition. METHODS:Megakaryoblastic MEG-01 cell culture and TPO/SCF/IL-3-induced differentiation of human umbilical blood mo...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-018-1109-z
更新日期:2018-05-01 00:00:00
abstract::Islet autotransplantation (IAT) is performed at the time of total pancreatectomy (TP) to prevent or minimize post-surgical diabetes. Corticosteroids induce insulin resistance and present a risk to islet autografts, through glucotoxicity and increased metabolic demand on a marginal islet mass. We present four IAT recip...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-011-0315-8
更新日期:2014-02-01 00:00:00
abstract::We determined in non-diabetic persons the risk of fasting and non-fasting glucose levels for pre-diabetes, diabetes, and coronary heart disease (CHD), including the roles of serum C-reactive protein (CRP) and HDL cholesterol, and delineated risk profiles of the pre-diabetic states. Over 7¼ years, 2,619 middle-aged Tur...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-011-0313-x
更新日期:2013-08-01 00:00:00
abstract::To examine longitudinally the effect of diabetes on bone structure and metabolism, we measured bone mineral density (BMD) and turnover markers in 26 type 1 (mean age 49 years) and 27 type 2 (mean age 65 years) diabetic patients without known osteoporosis from a community-based sample at baseline and 5 years later. In ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-011-0324-7
更新日期:2012-04-01 00:00:00
abstract::Recent studies have reported that elevated proinsulin levels are indicative of an increased cardiovascular risk. Renal proximal tubular cells represent a major site for the metabolism of insulin-like hormones after glomerular filtration into the tubular lumen. To determine the binding and degradation of proinsulin in ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00569428
更新日期:1996-07-01 00:00:00
abstract::The purpose of this study is to identify the recent characteristics and the developments of therapeutic education in diabetes through an analysis of the international articles published from 2004 to 2007. Studies were selected from several databases: Medline, Embase, Eric, Cochrane central database, using the followin...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-008-0044-9
更新日期:2008-12-01 00:00:00
abstract:AIMS:Observational studies indicated that resting heart rate (RHR) was associated with diabetes mellitus (DM) risk; however, it remains unclear whether the association between RHR and DM is causal. We aimed to examine whether there was causal association of RHR with DM risk. METHODS:A prospective study including 16,20...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-019-01344-3
更新日期:2019-09-01 00:00:00
abstract::The aim was to investigate the long-term incidence of proliferative diabetic retinopathy (PDR), and progression and regression of diabetic retinopathy (DR) and associated risk factors in young Danish patients with Type 1 diabetes mellitus. In 1987-89, a pediatric cohort involving approximately 75 % of all children wit...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-013-0527-1
更新日期:2014-01-01 00:00:00
abstract::Continuous subcutaneous insulin infusion (CSII) is effective and safe in children and adults with type 1 diabetes. Notwithstanding, some patients decide to discontinue using CSII. We evaluated the discontinuation rate, and its related factors, in a large group of children and adolescents with type 1 diabetes using CSI...
journal_title:Acta diabetologica
pub_type: 杂志文章,多中心研究
doi:10.1007/s00592-011-0344-3
更新日期:2012-12-01 00:00:00
abstract::The aim of the study was to evaluate the effects of a supervised physical training added to a healthy diet-rich in either carbohydrate and fibre (CHO/fibre) or monounsaturated fatty acids (MUFA)-on postprandial dyslipidaemia, an independent cardiovascular risk factor particularly relevant in type 2 diabetes (T2D). Par...
journal_title:Acta diabetologica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00592-013-0522-6
更新日期:2014-01-01 00:00:00
abstract::Patients with diabetes represent an increasing proportion of end-stage renal disease (ESRD) patients. Cardiovascular risk, already formidable among patients on dialysis, is significantly higher among those who also have diabetes. Diabetic ESRD patients are not only at higher risk of ischaemic events, but are also subj...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s005920200003
更新日期:2002-04-01 00:00:00
abstract:AIMS:We studied mortality in individuals of diabetes with or without Charcot neuroarthropathy (CN). METHODS:People attending diabetic foot care facility with CN of foot (Cohort 1) were prospectively evaluated. Details pertaining to the duration of diabetes, microvascular and macrovascular complications, foot ulcer, am...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-019-01376-9
更新日期:2019-12-01 00:00:00
abstract::Considering that changes in exercise routines might have relevance in treatment of adolescents with type 1 diabetes mellitus, we sought to assess whether spontaneous modifications to weekly exercise habits might occur in these patients and whether such variations would be accompanied by alterations in autonomic profil...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-012-0416-z
更新日期:2013-06-01 00:00:00
abstract::The relationship between insulin responses to glucose and to arginine was studied in non-obese women with previous gestational diabetes (PGD). One group, n = 10, had normal glucose tolerance (NGT) by WHO criteria and another, n = 8, had impaired glucose tolerance (IGT). A third group of women without PGD, n = 12, was ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00569563
更新日期:1995-06-01 00:00:00
abstract::The aim of the study is to evaluate the prevalence and incidence of myocardial dysfunction (MD) and heart failure (HF) in long-lasting (≥10 years) type 1 diabetes without cardiovascular disorders or with hypertension or coronary heart disease (CHD). The study included 1,685 patients with type 1 diabetes (mean baseline...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-013-0455-0
更新日期:2013-08-01 00:00:00
abstract:AIMS:To investigate whether intravitreal conbercept injection affects contralateral untreated eyes in bilateral diabetic macular edema (DME) patients. METHODS:In this retrospective study, 15 patients (30 eyes) with type 2 diabetes were followed after bilateral DME diagnosis in the Department of Ophthalmology, Peking U...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-020-01511-x
更新日期:2020-08-01 00:00:00
abstract::Diabetes mellitus and hyperglycaemia are both independent risk factors (RF) for cardiovascular (CV) events and increased general and CV mortality. Type 2 diabetes, which is often associated with obesity, hypertension and dyslipidaemia, is accompanied by an up to fourfold increase in the incidence of acute coronary hea...
journal_title:Acta diabetologica
pub_type: 共识发展会议,杂志文章
doi:10.1007/s00592-013-0508-4
更新日期:2013-12-01 00:00:00
abstract::Autoantibodies to zinc transporter 8 (ZnT8A) are a powerful diagnostic or predictive marker in type 1 diabetes. However, the widely used current ZnT8A radioligand binding assay (RBA) has proved to be difficult for many laboratories to implement. The aim of this study was the development and characterization of the per...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-013-0532-4
更新日期:2014-01-01 00:00:00
abstract:AIMS:We sought to investigate temporal trends in prediabetes prevalence among US adolescents using two definitions and evaluate relationships with obesity and a MetS-severity score. METHODS:We evaluated data from 5418 non-Hispanic white, non-Hispanic black, and Hispanic adolescents aged 12-19 participating in the Nati...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-016-0958-6
更新日期:2017-04-01 00:00:00
abstract::The recent efforts in the study of fetal compartments could help us to a better recognition of the proper fetal growth and well being. Fat content correlates directly with energy stores. Fat mass and lean body mass is often used in the nutritional assessment of the individual. Moreover chromosomal abnormalities may be...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-003-0033-y
更新日期:2003-10-01 00:00:00
abstract:AIMS:This subanalysis of a cross-sectional, nationwide study was undertaken to assess the relationship between healthy lifestyle behaviors and multiple cardiovascular risk factors among people with type 2 diabetes mellitus (T2DM). METHODS:Data collected from 25,454 participants, including demographics, lifestyle behav...
journal_title:Acta diabetologica
pub_type: 杂志文章,多中心研究
doi:10.1007/s00592-017-0981-2
更新日期:2017-06-01 00:00:00
abstract:AIMS:Genetic polymorphisms may contribute to platelet reactivity in diabetic patients; however, the information on their influence on long-term antiplatelet therapy is lacking. Our aim was to evaluate the role of previously described genetic variants and platelet reactivity on risk of all-cause mortality and cardiovasc...
journal_title:Acta diabetologica
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00592-016-0945-y
更新日期:2017-04-01 00:00:00
abstract::This study examined whether or not changes in plasma concentrations of motilin and other gastrointestinal hormones known to affect gastric motility are associated with the accelerated gastric emptying seen during hypoglycaemia. While studying gastric emptying by scintigraphy in eight healthy subjects, the plasma conce...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920050073
更新日期:1997-10-01 00:00:00
abstract::Anorectic patients who achieve complete recovery from the eating disorder can obtain a favorable psychosocial outcome but the long-term nutritional outcome is ill-defined. We investigated the time course of total and distrectual body composition during and after refeeding in 32 female patients with anorexia nervosa. P...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-004-0139-x
更新日期:2004-03-01 00:00:00
abstract:AIMS:To evaluate the methodological quality of systematic reviews (SRs), and summarize evidence of important outcomes from dipeptidyl peptidase-4 inhibitors (DPP4-I) in treating type 2 diabetes mellitus (T2DM). METHODS:We included SRs of DPP4-I for the treatment of T2DM until January, 2018 by searching the Cochrane Li...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-018-1164-5
更新日期:2019-01-01 00:00:00
abstract::Anti-myeloperoxidase (anti-MPO) antibodies were detected in 34 of 88 (38%) patients with type 1 diabetes mellitus but in only 3 of 55 (5.7%) healthy subjects and in 4 of 20 patients with autoimmune disease. Specificity of anti-MPO antibodies was assessed by MPO inhibition studies. No relationship was found between the...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00569418
更新日期:1996-07-01 00:00:00
abstract:AIMS:Our aims were to investigate in several large samples, with a wide range of adiposity, whether: (1) the effect of BMI on insulin sensitivity is different between sexes; (2) also waist circumference plays a sex-specific role on insulin sensitivity; and (3) serum adiponectin and resistin are mediators of such sex-di...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0804-2
更新日期:2015-10-01 00:00:00
abstract::We hypothesize that type 2 diabetic patients with different phenotypes may show different response to incretin-based therapies. Therefore, we tested whether the presence of metabolic syndrome (MS) influences glycemic response to these drugs. We prospectively followed 211 patients, treated with the GLP-1 analog exenati...
journal_title:Acta diabetologica
pub_type: 临床试验,杂志文章
doi:10.1007/s00592-011-0296-7
更新日期:2011-09-01 00:00:00
abstract::The aim of this study was to assess the effectiveness and safety of intracavernous injections of a four-drug vasoactive mixture in diabetic patients with organic impotence. A group of 60 diabetic patients with either pure neurogenic, pure vasculogenic or mixed neurovasculogenic impotence were treated with intracaverno...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00580752
更新日期:1994-04-01 00:00:00
abstract::Endothelial nitric oxide synthase (eNOS) has been shown to play an essential role in retinal vascular function, and disequilibrium in its production can lead to diabetic retinopathy (DR). Genetic polymorphisms of eNOS gene have been suggested to play a role in nitric oxide (NO) abnormalities which may contribute to th...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-012-0437-7
更新日期:2012-12-01 00:00:00