Abstract：
AIMS:To investigate whether intravitreal conbercept injection affects contralateral untreated eyes in bilateral diabetic macular edema (DME) patients. METHODS:In this retrospective study, 15 patients (30 eyes) with type 2 diabetes were followed after bilateral DME diagnosis in the Department of Ophthalmology, Peking Union Medical College Hospital from 2015 to 2018. Patients underwent examinations including best corrected visual acuity (BCVA), slit-lamp microscopy, indirect ophthalmoscope, color fundus photography, fundus fluorescein angiography, optical coherence tomography, and glycated hemoglobin (HbA1c). Each patient received conbercept (0.5 mg) intravitreally in the severe eye. Nonparametric Wilcoxon signed-rank tests and Pearson's correlation coefficient were used to assess changes in BCVA and central retinal thickness (CRT) and relations between BCVA changes in treated and untreated eyes, respectively. RESULTS:The mean follow-up time was 10.60 ± 2.29 months, and the mean injection number of 15 treated eyes was 9.13 ± 0.68. HbA1c remained below 10% during treatment with no significant changes between the initial and final visits (7.81 ± 1.17 vs 7.62 ± 1.19%) (P = 0.576). In untreated eyes, CRT significantly decreased from the initial to final visits (368.93 ± 125.45 vs 306.27 ± 89.70 μm) (P = 0.028). In untreated eyes, BCVA showed no significant difference between the initial and final visits (0.38 ± 0.30 vs 0.40 ± 0.30 logMAR) (P = 0.937), but BCVA changes in treated and untreated eyes were positively correlated (r = 0.527, P = 0.044). CONCLUSIONS:Intravitreal conbercept injection results in decreased CRT and increased BCVA in untreated eyes, which is consistent with the changes in treated eyes for patients with bilateral DME.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Di Y,Li Z,Ye J,Li L,Li B,Yu Rdoi
10.1007/s00592-020-01511-xsubject
Has Abstractpub_date
2020-08-01 00:00:00pages
1001-1007issue
8eissn
0940-5429issn
1432-5233pii
10.1007/s00592-020-01511-xjournal_volume
57pub_type
杂志文章abstract：:The objective of the study was to determine the prevalence of known diabetes among elderly subjects receiving nursing care in a north Norwegian population, to screen for new cases using HbA1c measurement and to evaluate the quality of care for those with diabetes. Men and women, with and without known diabetes, above ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-006-0212-8
更新日期：2006-08-01 00:00:00
abstract：:The effect of sucrose in the diet of children and adolescents with type I diabetes on long-term metabolic control was studied. For a mean observation period of 83 (range 42-127) days, a diet containing 5% of total calories as refined sugar was recommended to 11 children (group A, mean age 15.0, SD 5.4 years), while an...
journal_title：Acta diabetologica
pub_type： 临床试验,杂志文章
doi：10.1007/BF00571952
更新日期：1994-12-01 00:00:00
abstract：:Insulin resistance is a major factor in the pathogenesis of type 2 diabetes mellitus (T2DM) and is related to the fatty acid profile of the plasma membranes. The purpose of the present study was to investigate fatty acid composition and cholesterol content of cell membranes in patients with type 2 diabetes and, thus, ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-007-0224-4
更新日期：2006-12-01 00:00:00
abstract：AIMS:Type 1 diabetes is increasing in children leading more T1D young adults to adult healthcare settings. This change is experienced as a tear and results in a disengagement from specialist services. This study reports on an implementation of an effective and pioneering program of transition in North Africa. METHODS:...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-018-1196-x
更新日期：2018-11-01 00:00:00
abstract：:The objective of the study was to evaluate the association between infectious diseases and other events pertaining to childhood medical history and type 1 diabetes. A case-control study was carried out, taking as cases 159 type 1 diabetic patients (0-29 years) recorded from 1988 to 2000 within the population registry ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-007-0235-9
更新日期：2007-03-01 00:00:00
abstract：:Our aim was to compare the effects of an intermediate acting human insulin (NPH) and a long-acting insulin analog, insulin glargine, in insulin naïve type 2 diabetes patients, stratified by the type of hyperglycemia (fasting or postprandial type). Based on different action profiles, we hypothesized that patients havin...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-013-0505-7
更新日期：2014-04-01 00:00:00
abstract：:The aim of this study was to compare the efficacy of treatment with insulin alone, insulin plus acarbose, insulin plus metformin, or insulin plus rosiglitazone in type 2 diabetic subjects who were previously on insulin monotherapy, and to evaluate the effects of these treatments on cardiovascular risk factors includin...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-007-0004-9
更新日期：2007-12-01 00:00:00
abstract：:Elevated plasma CT-pro-vasopressin (copeptin) has been described as biomarkers for type 2 diabetes (T2D) and the metabolic syndrome (MetS), which, however, was not confirmed by all studies. Here, we analyzed the association of copeptin with T2D, MetS and MetS components in the population-based KORA F4 study. Plasma co...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0609-8
更新日期：2015-02-01 00:00:00
abstract：:A literature review of 37 papers cited by MEDLINE between 1986 and April 1996 under the terms "diabetes", "patient education" and "randomized" was carried out. The articles were analysed on the basis of a check list (Educational Procedure Check List), which contains 27 items grouped into 8 areas: study objectives, edu...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s005920050133
更新日期：1998-12-01 00:00:00
abstract：:Preliminary evidence from trials with the HMG-CoA reductase inhibitors (statins), simvastatin and pravastatin, suggests that aggressive treatment of diabetic dyslipidaemia will reduce coronary events. Questions regarding the prevention of cardiovascular events in diabetic patients are now being addressed in prospectiv...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s005920170005
更新日期：2001-01-01 00:00:00
abstract：AIM:High glucose-induced oxidative stress has been suggested as one of the mediators of endothelial damage in diabetes. The major endothelial protein, endoglin, has been found overexpressed in the vessels during pathological situations, but little is known about its relation to diabetic vascular complications. To clari...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0670-3
更新日期：2015-06-01 00:00:00
abstract：AIMS:Our previous studies demonstrated that serum 1,5-anhydroglucitol (1,5-AG) levels increased slightly rather than declined after an acute glucose load. Therefore, the current study aims at exploring the transport and metabolic characteristics of 1,5-AG, as well as the effect of glucose on 1,5-AG transport. METHODS:...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-017-1093-8
更新日期：2018-03-01 00:00:00
abstract：AIMS:High glycemic variability (GV) is the major indication for islet transplantation (IT) in patients with type 1 diabetes (T1D). The actual criteria used to assess graft function do not consider GV improvement. Our study aimed to describe GV indices' evolution in T1D patients who benefited from IT during the TRIMECO ...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-019-01425-3
更新日期：2020-03-01 00:00:00
abstract：:This study was aimed at the assessment of incidence of malignancies in type 2 diabetic patients treated with different sulphonylureas. A matched case-control study was performed. Cases were 195 diabetic patients aged 69.0 +/- 9.2 years who had an incident malignancy. Controls were 195 diabetic patients, unaffected by ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-008-0083-2
更新日期：2009-12-01 00:00:00
abstract：:The aim of this study was to assess the effectiveness and safety of intracavernous injections of a four-drug vasoactive mixture in diabetic patients with organic impotence. A group of 60 diabetic patients with either pure neurogenic, pure vasculogenic or mixed neurovasculogenic impotence were treated with intracaverno...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00580752
更新日期：1994-04-01 00:00:00
abstract：:The aim of this study was to investigate the influence of homocysteine (hcy) levels on endothelial function by the method of brachial artery ultrasonography and their relation with microvascular complications in type 2 diabetes mellitus (T2DM) patients without macrovascular disease. Fifty-nine T2DM patients with a mea...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-007-0245-7
更新日期：2007-06-01 00:00:00
abstract：:Although reactive oxygen species (ROS) contribute to glucose intolerance induced by the renin-angiotensin system (RAS) is well documented, the role of the newly discovered pathway of RAS, angiotensin (Ang)-(1-7)/Mas axis, in this process remains unknown. Here, we examined the effect of Ang-(1-7) on oxidative stress an...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-011-0348-z
更新日期：2012-08-01 00:00:00
abstract：AIM:It is unclear whether any breastfeeding or a certain duration of breastfeeding is protective against the development of diabetes in adult offspring. METHODS:We followed a sub-sample of 3,595 offspring born in the Mater Hospital in Brisbane, Australia between 1981 and 1983 and for whom we had doctor diagnosed self-...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0690-z
更新日期：2015-10-01 00:00:00
abstract：:The duration of diabetes before puberty is not considered relevant to the future development of complications. To evaluate the effects of diabetes on the neural retina, we analysed macular function by steady-state focal electroretinography in 20 prepubescent diabetic children without vascular retinopathy and in 39 sex...
journal_title：Acta diabetologica
pub_type： 临床试验,杂志文章
doi：10.1007/BF00570544
更新日期：1994-06-01 00:00:00
abstract：:The assessment of body composition and energy requirements is important for the nutrition of healthy and pathological states such as gastrointestinal disorders, which are known to be associated with abnormalities in body composition among persons with malnutrition and malabsorption. Careful monitoring of body composit...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-003-0053-7
更新日期：2003-10-01 00:00:00
abstract：:Diabetes mellitus is an independent risk factor for falling, particularly in the elderly. Due to chronic hyperglycemia and hyperinsulinemia patients with diabetes mellitus may have neurological deficits as peripheral neuropathy that is a debilitating micro-vascular complication affecting the proximal and distal periph...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-018-1183-2
更新日期：2018-12-01 00:00:00
abstract：:To examine longitudinally the effect of diabetes on bone structure and metabolism, we measured bone mineral density (BMD) and turnover markers in 26 type 1 (mean age 49 years) and 27 type 2 (mean age 65 years) diabetic patients without known osteoporosis from a community-based sample at baseline and 5 years later. In ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-011-0324-7
更新日期：2012-04-01 00:00:00
abstract：:Hypertriglyceridaemia is associated with insulin resistance of both lipid and glucose metabolism. It is not known whether the insulin resistance affects both glucose oxidation and glycogen formation. To study the oxidative and non-oxidative pathways of non-esterified fatty acids (NEFA) and glucose metabolism, eight ma...
journal_title：Acta diabetologica
pub_type： 临床试验,杂志文章
doi：10.1007/BF00580753
更新日期：1994-04-01 00:00:00
abstract：:MicroRNAs (miRNAs) play a crucial role in the pathogenesis of type 2 diabetes (T2D); they regulate several metabolic pathways including insulin secretion, glucose homeostasis, so their potential as biomarkers of diagnosis and prognosis has became increasingly appreciated. In this study, we explore serum miRNA profiles...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0617-8
更新日期：2014-10-01 00:00:00
abstract：:Serum total bilirubin (TB) is a potent antioxidant and inversely associated with metabolic syndrome (MetS) in Asian populations. However, there has been no study which is aimed to investigate whether TB is a risk factor for MetS or not. We investigated cross-sectional and longitudinal associations between TB and MetS ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-012-0447-5
更新日期：2013-06-01 00:00:00
abstract：:Diabetic neuropathy is a significant complication of chronic diabetes. We wished to discover whether we were successfully identifying patients who had developed neuropathic problems. Specifically, Diabetologists are traditionally poor at asking about erectile dysfunction (ED) and patients themselves are not always for...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-008-0084-1
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:International comparisons of diabetes-related lower extremity amputation rates are still hampered by different criteria used for data collection and analysis. We aimed to evaluate trends and variation of major/minor amputations, using agreed definitions adopted by the Organization for Economic Cooperation an...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-019-01423-5
更新日期：2020-03-01 00:00:00
abstract：:This study examined whether or not changes in plasma concentrations of motilin and other gastrointestinal hormones known to affect gastric motility are associated with the accelerated gastric emptying seen during hypoglycaemia. While studying gastric emptying by scintigraphy in eight healthy subjects, the plasma conce...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920050073
更新日期：1997-10-01 00:00:00
abstract：:It usually takes several years (in some cases, decades) for predisposed individuals to move from the onset of type 1 or type 2 diabetes to the development of microalbuminuria, the first sign of diabetic nephropathy. This long, complication-free, period represents the best possible moment to start a successful preventi...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-018-1211-2
更新日期：2018-11-01 00:00:00
abstract：AIMS:Fat accumulation in the liver and in the muscle results in hepatic and muscle insulin resistance and has been associated with increased cardiovascular risk. It is unclear whether the individual role of hepatic and muscle insulin resistance in the onset of dyslipidaemia is observed in nonalcoholic fatty liver disea...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-015-0816-y
更新日期：2016-06-01 00:00:00
