Abstract：
:This study was aimed at the assessment of incidence of malignancies in type 2 diabetic patients treated with different sulphonylureas. A matched case-control study was performed. Cases were 195 diabetic patients aged 69.0 +/- 9.2 years who had an incident malignancy. Controls were 195 diabetic patients, unaffected by cancer, who were matched with the corresponding case for age, sex, duration of diabetes, BMI, HbA1(c), comorbidity, smoking and alcohol abuse. Exposure to hypoglycaemic drugs during the 10 years preceding the event (or matching index date) was assessed. After adjusting for concomitant therapies, exposure to metformin and gliclazide for more than 36 months was associated with a significant reduction in the risk of cancer (adj. ORs with 95% CI: 0.28 (0.13-0.57), p < 0.001, and 0.40 (0.21-0.57), p = 0.004, respectively). Conversely, use of glibenclamide for at least 36 months was associated with increased incidence of malignancies (adj. OR 2.62 (1.26-5.42); p = 0.009). Treatment with insulin, thiazolidinediones, or acarbose, was not associated with significant differences in the incidence of cancer. Long-term treatments with individual sulphonylureas could have differential effects on the risk of cancer. In particular, the possible protective effect of gliclazide, as well as the risk associated with glibenclamide, deserves further investigation.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Monami M,Lamanna C,Balzi D,Marchionni N,Mannucci Edoi
10.1007/s00592-008-0083-2subject
Has Abstractpub_date
2009-12-01 00:00:00pages
279-84issue
4eissn
0940-5429issn
1432-5233journal_volume
46pub_type
杂志文章abstract：AIMS:To define the possible effect of diabetic conditions on megakaryocytes, the long-know precursors of platelets and lately characterized modulator of hematopoietic stem quiescence-activation transition. METHODS:Megakaryoblastic MEG-01 cell culture and TPO/SCF/IL-3-induced differentiation of human umbilical blood mo...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-018-1109-z
更新日期：2018-05-01 00:00:00
abstract：:The title "Plasma fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus" should be replaced by "Serum fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus". ...
journal_title：Acta diabetologica
pub_type： 已发布勘误
doi：10.1007/s00592-018-1177-0
更新日期：2018-10-01 00:00:00
abstract：:To evaluate the effects of vasoactive intestinal peptide (VIP) on whole pancreatic blood flow and islet blood flow in the rat, anaesthetized adult rats were injected intravenously for 90 s with VIP (500 ng/kg body weight). Immediately after the injection, the whole pancreatic and islet blood flows were measured with a...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00570545
更新日期：1994-06-01 00:00:00
abstract：:We determined in non-diabetic persons the risk of fasting and non-fasting glucose levels for pre-diabetes, diabetes, and coronary heart disease (CHD), including the roles of serum C-reactive protein (CRP) and HDL cholesterol, and delineated risk profiles of the pre-diabetic states. Over 7¼ years, 2,619 middle-aged Tur...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-011-0313-x
更新日期：2013-08-01 00:00:00
abstract：:Anorectic patients who achieve complete recovery from the eating disorder can obtain a favorable psychosocial outcome but the long-term nutritional outcome is ill-defined. We investigated the time course of total and distrectual body composition during and after refeeding in 32 female patients with anorexia nervosa. P...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-004-0139-x
更新日期：2004-03-01 00:00:00
abstract：:Fasting glucose and oral glucose tolerance test (OGTT) criteria for glucose homeostasis were compared in a cross-sectional cluster, community study in Accra, Ghana. A total of 4636 subjects without prior diagnosis of diabetes had fasting plasma glucose, 2-hour OGTT and measurement of cardiovascular risk factors. Mean ...
journal_title：Acta diabetologica
pub_type： 杂志文章,多中心研究
doi：10.1007/s005920200006
更新日期：2002-04-01 00:00:00
abstract：AIMS:Although diabetes is rapidly increasing in India, there is no national consensus on best practices for screening, diagnosis, and management of gestational diabetes mellitus (GDM). The goal of this study was to systematically review the literature for studies reporting the prevalence and screening and diagnostic me...
journal_title：Acta diabetologica
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00592-018-1131-1
更新日期：2018-06-01 00:00:00
abstract：AIMS:We studied mortality in individuals of diabetes with or without Charcot neuroarthropathy (CN). METHODS:People attending diabetic foot care facility with CN of foot (Cohort 1) were prospectively evaluated. Details pertaining to the duration of diabetes, microvascular and macrovascular complications, foot ulcer, am...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-019-01376-9
更新日期：2019-12-01 00:00:00
abstract：AIM:It is unclear whether any breastfeeding or a certain duration of breastfeeding is protective against the development of diabetes in adult offspring. METHODS:We followed a sub-sample of 3,595 offspring born in the Mater Hospital in Brisbane, Australia between 1981 and 1983 and for whom we had doctor diagnosed self-...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0690-z
更新日期：2015-10-01 00:00:00
abstract：:Aim To summarize, critically review, and interpret the evidence related to the systematic reviews on health literacy (HL) amongst type 2 diabetes mellitus (T2DM). Methods The methodology for this study consisted of a systematic review of systematic reviews, using the PRISMA statement and flowchart to select studies, a...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-017-1071-1
更新日期：2018-01-01 00:00:00
abstract：AIMS:Observational studies and meta-analyses of randomized trials on dipeptidyl peptidase-4 inhibitors (DPP4i) reported discordant results on the risk of malignancies with this class of drugs. Aim of the present meta-analysis is the assessment of the effect of DPP4i treatment on the incidence of different types of canc...
journal_title：Acta diabetologica
pub_type： 杂志文章,meta分析
doi：10.1007/s00592-020-01479-8
更新日期：2020-06-01 00:00:00
abstract：AIMS:Hypoglycaemia represents a critical burden with clinical and social consequences in the management of diabetes. Serum uric acid (SUA) has been associated with cardiovascular diseases (CVD), but no conclusive findings are available nowadays in patients suffering from hypoglycaemia. We investigated whether SUA level...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-017-1094-7
更新日期：2018-04-01 00:00:00
abstract：:The effect of the insulinotropic gut hormone glucagon-like-peptide-1 (GLP-1) was studied on the residual insulin capacity of prediabetic nonobese diabetic (NOD) mice, a model of insulin-dependent diabetes mellitus (type 1). This was done using isolated pancreas perfusion and dynamic islet perifusion. Prediabetes was d...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00571935
更新日期：1996-03-01 00:00:00
abstract：:Diabetic neuropathy is a significant complication of chronic diabetes. We wished to discover whether we were successfully identifying patients who had developed neuropathic problems. Specifically, Diabetologists are traditionally poor at asking about erectile dysfunction (ED) and patients themselves are not always for...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-008-0084-1
更新日期：2009-12-01 00:00:00
abstract：:In the present study, we investigated whether the ameliorating effect of aminoguanidine on diabetes-related proteinuria and nephropathy is associated with glomerular basement membrane heparan sulphate contents. STZ-induced diabetic rats developed proteinuria (at the tenth week: diabetic rats, 713 +/- 418 mg protein pe...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920070022
更新日期：2000-01-01 00:00:00
abstract：AIMS:To evaluate the efficacy and safety of intravitreal dexamethasone implant (DEX-implant) for diabetic macular edema (DME) in real-life practice with an extended follow-up for up to 5 year. METHODS:This multicentric retrospective study reviewed 227 eyes of 152 patients with DME treated by DEX-implant. Main outcome ...
journal_title：Acta diabetologica
pub_type： 杂志文章,多中心研究
doi：10.1007/s00592-020-01561-1
更新日期：2020-12-01 00:00:00
abstract：AIMS:The anti-inflammatory effects of the polyphenol resveratrol in patients with type 2 diabetes mellitus (T2DM) are controversial. Its role on pentraxin 3 (PTX3) concentrations, a human acute phase protein, has never been evaluated. Our aim was to determine whether a two-dosage resveratrol supplementation (500 and 40...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-017-0977-y
更新日期：2017-05-01 00:00:00
abstract：:Changes in the amounts and localization of protein kinase C (PKC) isoforms occur in galactosaemic lens epithelial cells. A link between PKC changes and myo-inositol depletion has been suggested. Raf-1, a component of a Ras pathway, is a substrate for PKC. Raf-1 levels were measured in galactosaemic lens epithelial cel...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920050119
更新日期：1998-10-01 00:00:00
abstract：:Diabetic kidney disease (DKD) is a devastating complication of Type 1 and Type 2 diabetes and leads to increased morbidity and mortality. Earlier work in families has provided strong evidence that heredity is a major determinant of DKD. Previous linkage analyses and candidate gene studies have identified potential DKD...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-018-1193-0
更新日期：2018-11-01 00:00:00
abstract：:Several haemostatic abnormalities are associated with proliferative diabetic retinopathy. While abnormalities in plasma fibrinolytic activity have been described in diabetic retinopathy, platelets (a rich source of plasminogen activator inhibitor type 1, PAI-1) have received little attention. As a result, little is kn...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920050159
更新日期：1999-09-01 00:00:00
abstract：:The objective of this study was to verify the impact of various sports on body cell mass (BCM). Ninety-eight male subjects, 17-33 years of age, participated in the study. The sample included athletes from three professional Italian football (soccer) teams, representing three different divisions (A, n=16; B, n=14; and ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-003-0043-9
更新日期：2003-10-01 00:00:00
abstract：AIMS:We sought to investigate temporal trends in prediabetes prevalence among US adolescents using two definitions and evaluate relationships with obesity and a MetS-severity score. METHODS:We evaluated data from 5418 non-Hispanic white, non-Hispanic black, and Hispanic adolescents aged 12-19 participating in the Nati...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-016-0958-6
更新日期：2017-04-01 00:00:00
abstract：:We report the results of bone mineral density (BMD) measurements in type 2 diabetic patients, in comparison to healthy controls. In this prospective study, a total of 277 subjects (aged 30-60 years) with type 2 diabetes mellitus, outpatients at the Cukurova Medical School Hospital, were evaluated for BMD at L(1)-L(4) ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920300014
更新日期：2003-06-01 00:00:00
abstract：AIMS:The importance of diabetes-related distress for the treatment of diabetes is emphasised in national and international guidelines recommending routinely screening for psychosocial problems. Data of investigations regarding diabetes-related distress on primary care are rare in Germany though most people with diabete...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-017-0972-3
更新日期：2017-05-01 00:00:00
abstract：:The aim of this article is to investigate the relation of the anti-inflammatory effect of pioglitazone with cardiac autonomic function and metabolic control in diabetic patients. In this prospective open label trial, 36 type 2 diabetic patients (age 60 ± 10, 20 M) without overt cardiovascular disease were randomized t...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-009-0150-3
更新日期：2010-12-01 00:00:00
abstract：:The effect of sucrose in the diet of children and adolescents with type I diabetes on long-term metabolic control was studied. For a mean observation period of 83 (range 42-127) days, a diet containing 5% of total calories as refined sugar was recommended to 11 children (group A, mean age 15.0, SD 5.4 years), while an...
journal_title：Acta diabetologica
pub_type： 临床试验,杂志文章
doi：10.1007/BF00571952
更新日期：1994-12-01 00:00:00
abstract：:To determine the impact of glargine insulin therapy with different nutritional models on key parameters of diabetes including quality of life, behavior in children and adolescents with type 1 diabetes. Age, duration of diabetes, HbA1c, anthropometric data and episodes of severe hypoglycemia were taken from patients' c...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-007-0019-2
更新日期：2008-03-01 00:00:00
abstract：:The aim of this study was to evaluate the prevalence of thyroid autoantibodies and clinical significance of thyroid autoimmunity in children with the diagnosis of diabetes mellitus type 1. The study group comprised 222 children all with newly diagnosed diabetes mellitus type 1 (122 boys) with a mean age 9.92 +/- 4.5 y...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-007-0017-4
更新日期：2008-03-01 00:00:00
abstract：AIMS:This subanalysis of a cross-sectional, nationwide study was undertaken to assess the relationship between healthy lifestyle behaviors and multiple cardiovascular risk factors among people with type 2 diabetes mellitus (T2DM). METHODS:Data collected from 25,454 participants, including demographics, lifestyle behav...
journal_title：Acta diabetologica
pub_type： 杂志文章,多中心研究
doi：10.1007/s00592-017-0981-2
更新日期：2017-06-01 00:00:00
abstract：:The effect of a phenacyl imidazolium compound (LY177507 or Proglycosyn, Eli Lilly) on the direct (glucose-->glucose-6-phosphate-->glycogen) and indirect (three-carbon compounds-->glucose-6-phosphate-->glycogen) pathways of liver glycogen synthesis was studied in conscious rats. [1-13C]Glucose (99% enriched) was infuse...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00578216
更新日期：1993-01-01 00:00:00
