Abstract:
BACKGROUND:International comparisons of diabetes-related lower extremity amputation rates are still hampered by different criteria used for data collection and analysis. We aimed to evaluate trends and variation of major/minor amputations, using agreed definitions adopted by the Organization for Economic Cooperation and Development in 2015. METHODS:Direct age-sex standardized rates were calculated per 100,000 subjects per year between 2000 and 2013, using major/minor amputations with diabetes diagnosis as numerators and the total population or number of people with diabetes as denominators. Longitudinal trends were investigated using generalized estimating equations. RESULTS:Twenty-one countries reported major amputations referred to the general population, showing a mean reduction from 10.8 to 7.5 per 100,000 (- 30.6%). Eleven countries also reported major amputations among people with diabetes, showing a mean reduction from 182.9 to 128.3 per 100,000 (- 29.8%). Minor amputations remained stable over the study period. Longitudinal trends showed a significant average annual decrease of - 0.19 per 100,000 in the general population (95% CI - 0.36 to - 0.02; p = .03) and - 4.52 per 100,000 among subjects with diabetes (95% CI - 6.09 to - 2.94; p < .001). The coefficient of variation of major amputation rates between countries was fairly high (64%-in the total population, 67% among people with diabetes). CONCLUSIONS:The study highlighted a clinically significant reduction of major amputations, in both the general population and among people with diabetes. The use of standardized definitions, while increasing the comparability of multinational data, highlighted remarkable differences between countries. These results can help identifying and sharing best practices effectively on a global scale.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Carinci F,Uccioli L,Massi Benedetti M,Klazinga NSdoi
10.1007/s00592-019-01423-5subject
Has Abstractpub_date
2020-03-01 00:00:00pages
347-357issue
3eissn
0940-5429issn
1432-5233pii
10.1007/s00592-019-01423-5journal_volume
57pub_type
杂志文章abstract::Although the effects of sex, ageing, height, race, and current and past health on pulmonary function tests have been described, only non-significant associations have been observed between body weight and lung function among healthy persons after having accounted for the effects of age and height. However, few studies...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-003-0023-0
更新日期:2003-10-01 00:00:00
abstract::To evaluate the role of insulin resistance and beta cell function to increasing fasting plasma glucose (FPG), 1,272 Chinese subjects (18-80 years of age) were divided into normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), combined glucose intolerance (CGI), and type 2 di...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-010-0194-4
更新日期:2012-12-01 00:00:00
abstract::The aim of this study was to test whether the augmentation index adjusted for heart rate (AIx@HR75) can be used as a substitute for aortic pulse wave velocity (aPWV) in the measurement of arterial stiffness (AS) in type 1 diabetes. Sixty-eight patients with type 1 diabetes and 68 age- and sex-matched controls were eva...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-012-0433-y
更新日期:2012-12-01 00:00:00
abstract::Serum gamma-glutamyl transferase (gamma-GT), a marker of oxidative stress, predicts morbidity and mortality from cardiovascular disease. Plasma total homocysteine (tHcy), a pro-oxidant and also an independent risk factor for cardiovascular disease, correlates with gamma-GT among some populations. It is not known wheth...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-007-0001-z
更新日期:2007-12-01 00:00:00
abstract:AIM:To assess the association between alcohol consumption and/or cigarette smoking with other unhealthy behaviors and clinical cardiovascular risk factors in youth with type 1 diabetes. METHODS:Two hundred and twenty-eight youth with type 1 diabetes (age 13-19 years) were consecutively enrolled in three Regional Pedia...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-019-01415-5
更新日期:2019-12-01 00:00:00
abstract::Elevated plasma CT-pro-vasopressin (copeptin) has been described as biomarkers for type 2 diabetes (T2D) and the metabolic syndrome (MetS), which, however, was not confirmed by all studies. Here, we analyzed the association of copeptin with T2D, MetS and MetS components in the population-based KORA F4 study. Plasma co...
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pub_type: 杂志文章
doi:10.1007/s00592-014-0609-8
更新日期:2015-02-01 00:00:00
abstract::Obesity, insulin resistance (IR), and progressive decline in pancreatic β-cell function are major features of type 2 diabetes mellitus (T2DM). Altered adipokines contribute to obesity-induced IR. Hence understanding of adipokines' relation to obesity and glycemic control could be useful to improve disease outcomes. We...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-012-0373-6
更新日期:2013-10-01 00:00:00
abstract::Recent studies have reported that elevated proinsulin levels are indicative of an increased cardiovascular risk. Renal proximal tubular cells represent a major site for the metabolism of insulin-like hormones after glomerular filtration into the tubular lumen. To determine the binding and degradation of proinsulin in ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00569428
更新日期:1996-07-01 00:00:00
abstract::The objective is to assess the effect of TNF-alpha inhibition on urinary albumin excretion in experimental diabetic rats. Male Wistar rats, 8-week-old, were categorized into four groups, which were the control (n = 9), diabetes (n = 9), infliximab-treated diabetes (n = 10), and FR167653-treated diabetes (n = 9) groups...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-007-0007-6
更新日期:2007-12-01 00:00:00
abstract::Insulin resistance is a major factor in the pathogenesis of type 2 diabetes mellitus (T2DM) and is related to the fatty acid profile of the plasma membranes. The purpose of the present study was to investigate fatty acid composition and cholesterol content of cell membranes in patients with type 2 diabetes and, thus, ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-007-0224-4
更新日期:2006-12-01 00:00:00
abstract:AIMS:To evaluate the methodological quality of systematic reviews (SRs), and summarize evidence of important outcomes from dipeptidyl peptidase-4 inhibitors (DPP4-I) in treating type 2 diabetes mellitus (T2DM). METHODS:We included SRs of DPP4-I for the treatment of T2DM until January, 2018 by searching the Cochrane Li...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-018-1164-5
更新日期:2019-01-01 00:00:00
abstract:AIMS:Haptoglobin (Hp) genotype 2-2 increases cardiovascular diabetes complications. In type 2 diabetes, α-tocopherol was shown to lower cardiovascular risk in Hp 2-2, potentially through HDL function improvements. Similar type 1 diabetes data are lacking. We conducted a randomized crossover pilot of α-tocopherol supple...
journal_title:Acta diabetologica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00592-015-0770-8
更新日期:2016-04-01 00:00:00
abstract::The effect of the insulinotropic gut hormone glucagon-like-peptide-1 (GLP-1) was studied on the residual insulin capacity of prediabetic nonobese diabetic (NOD) mice, a model of insulin-dependent diabetes mellitus (type 1). This was done using isolated pancreas perfusion and dynamic islet perifusion. Prediabetes was d...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00571935
更新日期:1996-03-01 00:00:00
abstract::The objective of this study was to describe spatial and space-time patterns of type 1 diabetes in children less than 15 years old, diagnosed between 2000 and 2005 with residence in the Metropolitan Region of Chile. Knox and Mantel tests were used to detect space-time interaction between cases. An ecological Bayesian m...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-010-0189-1
更新日期:2010-09-01 00:00:00
abstract::We analysed the risk factors associated with diabetic complications in the cohort of patients assisted by a type 2 diabetes mellitus (T2DM) shared-care program. We analysed registry data from 16,136 T2DM patients. Of them, 4,781 had microangiopathy, 3,469 CV events. They were 70.5 ± 17.1 years old, 50% were male, dise...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-010-0186-4
更新日期:2010-12-01 00:00:00
abstract::To evaluate ex vivo/in vitro the binding and dissociation characteristics and the level of crossreactivity of insulin antibodies and insulin autoantibodies directed to three different insulin molecules (human, bovine and porcine insulin). In this study sera from 17 diabetic patients were included, who were exclusively...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-008-0041-z
更新日期:2008-09-01 00:00:00
abstract::To examine longitudinally the effect of diabetes on bone structure and metabolism, we measured bone mineral density (BMD) and turnover markers in 26 type 1 (mean age 49 years) and 27 type 2 (mean age 65 years) diabetic patients without known osteoporosis from a community-based sample at baseline and 5 years later. In ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-011-0324-7
更新日期:2012-04-01 00:00:00
abstract:AIMS:The aim of our study was to estimate the overall rate of first hospitalizations for diabetic foot (DF) regardless of the outcome in amputations, as well as the mortality rate with their determinants in the period 2012-2016 in Piedmont Region in Italy. METHODS:The study included all the subjects registered in the ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-019-01412-8
更新日期:2020-02-01 00:00:00
abstract::Pancreatic volume and fat content might be associated with β-cell function or insulin resistance (IR). We investigated the difference in pancreatic volume and fat content between age- and body mass index (BMI)-matched normal subjects and patients with having different durations of type 2 diabetes (T2D). We compared pa...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-014-0581-3
更新日期:2014-10-01 00:00:00
abstract::The relationship between insulin responses to glucose and to arginine was studied in non-obese women with previous gestational diabetes (PGD). One group, n = 10, had normal glucose tolerance (NGT) by WHO criteria and another, n = 8, had impaired glucose tolerance (IGT). A third group of women without PGD, n = 12, was ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00569563
更新日期:1995-06-01 00:00:00
abstract::The objective of the study was to evaluate the association between infectious diseases and other events pertaining to childhood medical history and type 1 diabetes. A case-control study was carried out, taking as cases 159 type 1 diabetic patients (0-29 years) recorded from 1988 to 2000 within the population registry ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-007-0235-9
更新日期:2007-03-01 00:00:00
abstract::Bovine insulin was glycated by in vitro incubation with 20-220 mM D-glucose for 1-48 h. The percentage of glycation was dependent on time, glucose concentration, temperature and pH, attaining values up to 28%. Glucose-lowering activities of glycated and control (non-glycated) insulin preparations were assessed in mice...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920050086
更新日期:1997-12-01 00:00:00
abstract::We investigated whether food supplementation within the first year life or age at introduction of gluten-containing foods influenced the risk of developing islet autoimmunity and type 1 diabetes. A total of 2,291 children with a family history of type 1 diabetes were prospectively followed from birth for 28,983 patien...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-014-0628-5
更新日期:2015-06-01 00:00:00
abstract:AIMS:To evaluate the patients' perceptions of telemedicine visits during COVID-19 lockdown and their level of anxiety about COVID and diabetic foot (DF). METHODS:In May 2020, we contacted by phone all the patients who underwent in March and April to remote monitoring visits for DF during the lockdown for COVID-19, wit...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-020-01653-y
更新日期:2021-01-13 00:00:00
abstract::MicroRNAs (miRNAs) play a crucial role in the pathogenesis of type 2 diabetes (T2D); they regulate several metabolic pathways including insulin secretion, glucose homeostasis, so their potential as biomarkers of diagnosis and prognosis has became increasingly appreciated. In this study, we explore serum miRNA profiles...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-014-0617-8
更新日期:2014-10-01 00:00:00
abstract::The purpose of this study was to determine the feasibility of a flexible multiple daily insulin (FMDI) regimen in routine pediatric diabetes care by comparing HbA(1c), body mass index (BMI), and episodes of severe hypoglycemia (SH) before and after initiation of FMDI therapy. Data from 44 patients (2-16 years old), on...
journal_title:Acta diabetologica
pub_type: 临床试验,杂志文章
doi:10.1007/s00592-003-0102-2
更新日期:2003-09-01 00:00:00
abstract::Urinary angiotensin-converting enzyme (ACE) and urinary N-acetyl-beta-D-glucosaminidase (NAG) were measured after a 5-year interval in 38 non-azotemic type 2 diabetic patients. Of these patients at baseline, 16 had nil nephropathy, 15 had incipient nephropathy, and 7 had overt nephropathy. During the follow-up, 6 and ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00838491
更新日期:1995-10-01 00:00:00
abstract::The objective of this study is to explore the mechanism of oxidative stress induced by intermittent high glucose in porcine iliac endothelial cells (PIECs). The PIECs were exposed to intermittent or constant high glucose for 3 or 6 days, and the mean fluorescent intensity (MFI) was measured via intracellular reactive ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-009-0140-5
更新日期:2010-12-01 00:00:00
abstract::Diabetic neuropathy is a significant complication of chronic diabetes. We wished to discover whether we were successfully identifying patients who had developed neuropathic problems. Specifically, Diabetologists are traditionally poor at asking about erectile dysfunction (ED) and patients themselves are not always for...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-008-0084-1
更新日期:2009-12-01 00:00:00
abstract:AIMS:The aim of the current study was to investigate the association of type 2 diabetes (T2D) and insulin treatment with changes in muscle mass, muscle strength, and physical performance in older adults. METHODS:In 731 participants of the population-based KORA-Age study aged 74.6 ± 6.2 years (T2D: n = 118; insulin tre...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-020-01523-7
更新日期:2020-09-01 00:00:00