Abstract:
:We investigated whether food supplementation within the first year life or age at introduction of gluten-containing foods influenced the risk of developing islet autoimmunity and type 1 diabetes. A total of 2,291 children with a family history of type 1 diabetes were prospectively followed from birth for 28,983 patient years (median 13.1 years). Dietary exposure data were collected by questionnaires, food records and by family interview. Exposure to gluten-containing foods before age 3 months, which occurred in 19 children, increased the risk of developing islet autoantibodies (n = 4), multiple islet autoantibodies (n = 4), and type 1 diabetes (n = 3) compared to exclusive breastfeeding within the first 3 months [adjusted hazard ratio (HR) 3.97 (95 % confidence interval 1.41-11.17), 5.39 (1.89-15.35), and 3.45 (1.04-11.48), respectively] and also compared to first exposure to gluten between 3.1 and 6.0 months of age [adjusted HR 3.40 (1.19-9.70), 4.25 (1.47-12.26), and 3.43 (1.01-11.66), respectively]. Children who received infant formula or other solid food within the first 3 months and children who received gluten-containing foods after age 6 months did not have an increased risk of islet autoantibodies, multiple islet autoantibodies or type 1 diabetes. Our present data affirm that compliance to infant feeding guidelines is a possible way to reduce type 1 diabetes risk in genetically susceptible children.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Chmiel R,Beyerlein A,Knopff A,Hummel S,Ziegler AG,Winkler Cdoi
10.1007/s00592-014-0628-5subject
Has Abstractpub_date
2015-06-01 00:00:00pages
621-4issue
3eissn
0940-5429issn
1432-5233journal_volume
52pub_type
杂志文章abstract::To evaluate the role of insulin resistance and beta cell function to increasing fasting plasma glucose (FPG), 1,272 Chinese subjects (18-80 years of age) were divided into normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), combined glucose intolerance (CGI), and type 2 di...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-010-0194-4
更新日期:2012-12-01 00:00:00
abstract::Genetic markers may be used to improve the prediction of insulin-dependent diabetes mellitus (type 1) in individuals with islet autoantibodies. In order to develop a risk assessment strategy for the Lombardy region of northern Italy based on genetic and immunological markers, we analyzed HLA DQA1 and DQB1 alleles in 6...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00838481
更新日期:1995-10-01 00:00:00
abstract:AIMS:We sought to investigate temporal trends in prediabetes prevalence among US adolescents using two definitions and evaluate relationships with obesity and a MetS-severity score. METHODS:We evaluated data from 5418 non-Hispanic white, non-Hispanic black, and Hispanic adolescents aged 12-19 participating in the Nati...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-016-0958-6
更新日期:2017-04-01 00:00:00
abstract:AIMS:Type 2 diabetes (T2D) is a metabolic disorder requiring intensive self-care to maintain optimal glycemic control. Sleep disturbance is common in T2D patients and likely impairs glycemic control. Our aim was to examine the relationship between sleep disturbance and self-care in adults with T2D. METHODS:This study ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-018-1181-4
更新日期:2018-09-01 00:00:00
abstract::Diabetes mellitus is an independent risk factor for falling, particularly in the elderly. Due to chronic hyperglycemia and hyperinsulinemia patients with diabetes mellitus may have neurological deficits as peripheral neuropathy that is a debilitating micro-vascular complication affecting the proximal and distal periph...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-018-1183-2
更新日期:2018-12-01 00:00:00
abstract:AIMS:To evaluate the methodological quality of systematic reviews (SRs), and summarize evidence of important outcomes from dipeptidyl peptidase-4 inhibitors (DPP4-I) in treating type 2 diabetes mellitus (T2DM). METHODS:We included SRs of DPP4-I for the treatment of T2DM until January, 2018 by searching the Cochrane Li...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-018-1164-5
更新日期:2019-01-01 00:00:00
abstract::Consistent with the postulated role of oxidative stress in the etiology of late diabetic complications, pharmacological interventions based on biological antioxidants have been suggested. The aim of the present study was to investigate the effect of dietary supplementation with the pyridoindole antioxidant stobadine o...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920070012
更新日期:2000-01-01 00:00:00
abstract::The title "Plasma fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus" should be replaced by "Serum fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus". ...
journal_title:Acta diabetologica
pub_type: 已发布勘误
doi:10.1007/s00592-018-1177-0
更新日期:2018-10-01 00:00:00
abstract::We assessed the efficacy of noninsulin antidiabetic medications used in current clinical practice (metformin, sulfonylureas, α-glucosidase inhibitors, thiazolidinediones, glinides, dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 agonists) to reach the HbA1c target <7% in people with type 2 diabetes. MEDLINE...
journal_title:Acta diabetologica
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00592-012-0370-9
更新日期:2014-04-01 00:00:00
abstract::Most reports of outcome following obesity surgery report weight and co-morbidity changes only. We studied body composition changes in 17 adult patients (15 F, 2 M, age 43+/-2 years, range 28-58 years), with morbid obesity (initial BMI 40.4+/-4.9 kg/m(2), range 34.7-48.8) who were managed surgically by laparoscopically...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-003-0083-1
更新日期:2003-10-01 00:00:00
abstract:AIMS:Fat accumulation in the liver and in the muscle results in hepatic and muscle insulin resistance and has been associated with increased cardiovascular risk. It is unclear whether the individual role of hepatic and muscle insulin resistance in the onset of dyslipidaemia is observed in nonalcoholic fatty liver disea...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0816-y
更新日期:2016-06-01 00:00:00
abstract:AIMS:Glucose-dependent insulinotropic polypeptide (GIP) is released primarily from the proximal small intestine and glucagon-like peptide-1 (GLP-1) from the more distal small intestine and colon. Their relative importance to the incretin effect in health has been contentious in the past, although it now appears that GI...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-019-01461-z
更新日期:2020-05-01 00:00:00
abstract:AIMS:In patients with type 2 diabetes, non-alcoholic fatty liver disease (NAFLD) and liver fibrosis is frequent and presumably associated with increased cardiovascular disease risk and mortality. The objective was to investigate risk factors associated with hepatic fibrosis in patients with type 2 diabetes and NAFLD to...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-019-01374-x
更新日期:2019-11-01 00:00:00
abstract::Few studies were performed to evaluate the prevalence of latent autoimmune diabetes in adults (LADA) and the difference of chronic complications between LADA, T1DM, and T2DM in Korean. The aim of this study is to establish the prevalence of LADA in a diabetic clinic of Soonchunhyang University hospital and to compare ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-010-0228-y
更新日期:2013-04-01 00:00:00
abstract::The assessment of body composition and energy requirements is important for the nutrition of healthy and pathological states such as gastrointestinal disorders, which are known to be associated with abnormalities in body composition among persons with malnutrition and malabsorption. Careful monitoring of body composit...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-003-0053-7
更新日期:2003-10-01 00:00:00
abstract:AIMS:The aim of our study was to estimate the overall rate of first hospitalizations for diabetic foot (DF) regardless of the outcome in amputations, as well as the mortality rate with their determinants in the period 2012-2016 in Piedmont Region in Italy. METHODS:The study included all the subjects registered in the ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-019-01412-8
更新日期:2020-02-01 00:00:00
abstract:AIMS:Emerging evidence suggested genetic factor attributed as a major determinant for the complex pathogenic mechanism of gestational diabetes mellitus (GDM), but the related genetic study was limited. We aimed to investigate the impact of polymorphisms in miRNA-binding sites (miR-binding SNPs) on the risk of GDM in Ch...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-017-0969-y
更新日期:2017-03-01 00:00:00
abstract:AIMS:To evaluate feasibility and effectiveness on short-term blood glucose control of using glycaemic load counting (GLC) versus carbohydrate counting (CC) for prandial insulin dosing in patients with type 1 diabetes (T1D). METHODS:Nine T1D patients on insulin pump, aged 26-58 years, HbA1c 7.7 ± 0.8 % (61 ± 8.7 mmol/m...
journal_title:Acta diabetologica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00592-015-0716-1
更新日期:2015-10-01 00:00:00
abstract::Insulin resistance is a major factor in the pathogenesis of type 2 diabetes mellitus (T2DM) and is related to the fatty acid profile of the plasma membranes. The purpose of the present study was to investigate fatty acid composition and cholesterol content of cell membranes in patients with type 2 diabetes and, thus, ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-007-0224-4
更新日期:2006-12-01 00:00:00
abstract:AIMS:Haptoglobin (Hp) genotype 2-2 increases cardiovascular diabetes complications. In type 2 diabetes, α-tocopherol was shown to lower cardiovascular risk in Hp 2-2, potentially through HDL function improvements. Similar type 1 diabetes data are lacking. We conducted a randomized crossover pilot of α-tocopherol supple...
journal_title:Acta diabetologica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00592-015-0770-8
更新日期:2016-04-01 00:00:00
abstract::This study was aimed at the assessment of incidence of malignancies in type 2 diabetic patients treated with different sulphonylureas. A matched case-control study was performed. Cases were 195 diabetic patients aged 69.0 +/- 9.2 years who had an incident malignancy. Controls were 195 diabetic patients, unaffected by ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-008-0083-2
更新日期:2009-12-01 00:00:00
abstract::The aim of the study is to evaluate the prevalence and incidence of myocardial dysfunction (MD) and heart failure (HF) in long-lasting (≥10 years) type 1 diabetes without cardiovascular disorders or with hypertension or coronary heart disease (CHD). The study included 1,685 patients with type 1 diabetes (mean baseline...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-013-0455-0
更新日期:2013-08-01 00:00:00
abstract::To evaluate ex vivo/in vitro the binding and dissociation characteristics and the level of crossreactivity of insulin antibodies and insulin autoantibodies directed to three different insulin molecules (human, bovine and porcine insulin). In this study sera from 17 diabetic patients were included, who were exclusively...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-008-0041-z
更新日期:2008-09-01 00:00:00
abstract::The purpose of this study was to compare bioelectrical impedance analysis (BIA) to hydrostatic weighing (HW) in male weight lifters and body builders. Twenty-two male body builders and weight lifters, 23 +/- 3 years of age (mean +/- SD), were studied to determine the efficacy of BIA to HW in this population. Subjects ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-009-0098-3
更新日期:2010-03-01 00:00:00
abstract::Genetic linkage studies of families with early-onset type 2 diabetes have facilitated the identification of diabetes-susceptibility genes. In order to assess the feasibility of using linkage approaches to identify genes responsible for the development of type 2 diabetes in Japanese subjects, we examined our clinical r...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00581039
更新日期:1995-03-01 00:00:00
abstract:AIMS:To assess the time-dependent effect of sleep quality on diabetes and coronary artery disease (CAD) incidence among young adults. METHODS:Incident rates of diabetes and CAD during a mean follow-up of 6.4 ± 4.1 years were assessed among 26,023 men (mean age 30.9 ± 5.6 years) of the Metabolic Lifestyle and Nutrition...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0779-z
更新日期:2016-04-01 00:00:00
abstract::Concentrations of soluble receptors for tumor necrosis factor (p55 and p75) strongly correlate with clinical stage and progression of infectious diseases, and may be useful in monitoring autoimmune diseases. However, the role of soluble TNF receptors in insulin-dependent diabetes mellitus (type 1 DM) is not clear. We ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920050152
更新日期:1999-06-01 00:00:00
abstract:AIMS:To evaluate the patients' perceptions of telemedicine visits during COVID-19 lockdown and their level of anxiety about COVID and diabetic foot (DF). METHODS:In May 2020, we contacted by phone all the patients who underwent in March and April to remote monitoring visits for DF during the lockdown for COVID-19, wit...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-020-01653-y
更新日期:2021-01-13 00:00:00
abstract::Aim of this study was to formulate an index for glucose effectiveness (Sg), SgIo, based on 3-point (0, 30 and 120 min) 75 g oral glucose tolerance test (OGTT). The equation for SgI(O) was developed in the Chikuma cohort (n = 502). Firstly, post-loading plasma glucose without insulin action and Sg (PPG-without insulin ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-012-0417-y
更新日期:2012-12-01 00:00:00
abstract::Despite advances in technology, the frequent self-measurement of blood glucose (SMBG) remains fundamental to the management of 1 diabetes mellitus (T1DM). Once measured, SMBG results are routinely reported back to health professionals and other interested parties, either verbally, via a logbook, or electronically down...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-016-0907-4
更新日期:2017-01-01 00:00:00