Abstract：
AIMS:Glucose-dependent insulinotropic polypeptide (GIP) is released primarily from the proximal small intestine and glucagon-like peptide-1 (GLP-1) from the more distal small intestine and colon. Their relative importance to the incretin effect in health has been contentious in the past, although it now appears that GIP has the dominant role. It is uncertain whether there is a relationship between GIP and GLP-1 secretion. We aimed to evaluate the relationship between plasma GIP and GLP-1 responses to a 75-g oral glucose load in individuals with normal (NGT) and impaired glucose tolerance (IGT). METHODS:One hundred healthy subjects had measurements of blood glucose, serum insulin, plasma GIP and GLP-1 concentrations for 240 min after a 300 mL drink containing 75 g glucose. RESULTS:Fifty had NGT and 41 IGT; 9 had type 2 diabetes and were excluded from analysis. In both groups, there were increases in plasma GIP and GLP-1 following the glucose drink, with no difference in the magnitude of the responses between t = 0-240 min. There was a weak relationship between the iAUC0-240 min for GIP and GLP-1 in the combined (r = 0.23, P = 0.015) and in the IGT (r = 0.34, P = 0.01), but not in the NGT (r = 0.15, P = 0.14) group. CONCLUSIONS:There is a weak relationship between oral glucose-induced GIP and GLP-1 secretions in non-diabetic subjects.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Marathe CS,Pham H,Marathe JA,Trahair LG,Huynh L,Wu T,Phillips LK,Rayner CK,Nauck MA,Horowitz M,Jones KLdoi
10.1007/s00592-019-01461-zsubject
Has Abstractpub_date
2020-05-01 00:00:00pages
583-587issue
5eissn
0940-5429issn
1432-5233pii
10.1007/s00592-019-01461-zjournal_volume
57pub_type
杂志文章abstract：:The objective of this study was to describe spatial and space-time patterns of type 1 diabetes in children less than 15 years old, diagnosed between 2000 and 2005 with residence in the Metropolitan Region of Chile. Knox and Mantel tests were used to detect space-time interaction between cases. An ecological Bayesian m...
journal_title：Acta diabetologica
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更新日期：2010-09-01 00:00:00
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journal_title：Acta diabetologica
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