Pathophysiological characteristics in patients with latent autoimmune diabetes in adults using clamp tests: evidence of a continuous disease spectrum of diabetes.

abstract：:The aim of this article is to investigate the relation of the anti-inflammatory effect of pioglitazone with cardiac autonomic function and metabolic control in diabetic patients. In this prospective open label trial, 36 type 2 diabetic patients (age 60 ± 10, 20 M) without overt cardiovascular disease were randomized t...

journal_title：Acta diabetologica

authors： Nerla R,Pitocco D,Zaccardi F,Scalone G,Coviello I,Mollo R,Ghirlanda G,Lanza GA,Crea F

更新日期：2010-12-01 00:00:00

abstract：:The aim of this study is to assess the impact of the internet-based upload blood glucose monitoring and therapy management system (Carelink(®)) in patients with type 1 diabetes. Diabetic patients treated with pump infusion for ≥3 months were prospectively randomized to use the CareLink(®) with (4 months) and without (...

journal_title：Acta diabetologica

authors： Shalitin S,Ben-Ari T,Yackobovitch-Gavan M,Tenenbaum A,Lebenthal Y,de Vries L,Phillip M

更新日期：2014-04-01 00:00:00

abstract：:To study the immune response to glutamic acid decarboxylase (GAD) in insulin-dependent diabetes mellitus, monoclonal GAD antibodies after fusion of splenocytes from a nondiabetes-susceptible BALB/c mouse immunized with human recombinant GAD65 were generated. Of the 44 monoclonals, 35 are specific for the GAD65 isoform...

journal_title：Acta diabetologica

authors： Ziegler B,Schlosser M,Lühder F,Strebelow M,Augstein P,Northemann W,Powers AC,Ziegler M

更新日期：1996-09-01 00:00:00

abstract：:To evaluate the role of insulin resistance and beta cell function to increasing fasting plasma glucose (FPG), 1,272 Chinese subjects (18-80 years of age) were divided into normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), combined glucose intolerance (CGI), and type 2 di...

journal_title：Acta diabetologica

authors： Bi Y,Zhu D,Jing Y,Hu Y,Feng W,Shen S,Tong G,Shen X,Yu T,Song D,Yang D

更新日期：2012-12-01 00:00:00

abstract：:Administration of exogenous insulin for the treatment of diabetes is often accompanied by the development of insulin antibodies (IA). These antibodies may affect the patient's requirement for insulin by acting as an insulin binding reservoir. The improvement of insulin purification in the 1970s and the development of ...

journal_title：Acta diabetologica

authors： Oak S,Phan TH,Gilliam LK,Hirsch IB,Hampe CS

更新日期：2010-06-01 00:00:00

abstract：AIMS:Genetic polymorphisms may contribute to platelet reactivity in diabetic patients; however, the information on their influence on long-term antiplatelet therapy is lacking. Our aim was to evaluate the role of previously described genetic variants and platelet reactivity on risk of all-cause mortality and cardiovasc...

journal_title：Acta diabetologica

authors： Milanowski L,Pordzik J,Janicki PK,Kaplon-Cieslicka A,Rosiak M,Peller M,Tyminska A,Ozieranski K,Filipiak KJ,Opolski G,Mirowska-Guzel D,Postula M

更新日期：2017-04-01 00:00:00

abstract：AIMS:To investigate the possibility of identifying a subtype of latent autoimmune diabetes in adults (LADA), T-LADA (T cell responses-positive and autoantibody-negative) from patients with phenotypic type 2 diabetes (T2D) by enzyme-linked immunospot (ELISPOT). METHODS:Eighty-two patients with phenotypic T2D were studi...

journal_title：Acta diabetologica

authors： Liang H,Cheng Y,Tang W,Cui Q,Yuan J,Huang G,Yang L,Zhou Z

更新日期：2019-11-01 00:00:00

abstract：:The purification of large numbers of human pancreatic islets remains one of the limiting factors in islet transplantation. This paper describes and validates a method for accurately and reproducibly determining the density of islets and exocrine tissue in pancreatic digest on the basis of their isopycnic distribution ...

journal_title：Acta diabetologica

authors： Robertson GS,Chadwick DR,Contractor H,James RF,Bell PR,London NJ

更新日期：1993-01-01 00:00:00

abstract：:Several haemostatic abnormalities are associated with proliferative diabetic retinopathy. While abnormalities in plasma fibrinolytic activity have been described in diabetic retinopathy, platelets (a rich source of plasminogen activator inhibitor type 1, PAI-1) have received little attention. As a result, little is kn...

journal_title：Acta diabetologica

authors： Simpson AJ,Booth NA,Moore NR,Lewis SJ,Gray RS

更新日期：1999-09-01 00:00:00

abstract：:We investigated the effect of sub-chronic soybean oil (SO) treatment on the insulin secretion and fatty acid composition of islets of Langerhans obtained from Goto-Kakizaki (GK), a model of type 2 diabetes, and normal Wistar rats. We observed that soybean-treated Wistar rats present insulin resistance and defective is...

journal_title：Acta diabetologica

authors： Nunes E,Peixoto F,Louro T,Sena CM,Santos MS,Matafome P,Moreira PI,Seiça R

更新日期：2007-09-01 00:00:00

abstract：:Serum total bilirubin (TB) is a potent antioxidant and inversely associated with metabolic syndrome (MetS) in Asian populations. However, there has been no study which is aimed to investigate whether TB is a risk factor for MetS or not. We investigated cross-sectional and longitudinal associations between TB and MetS ...

journal_title：Acta diabetologica

authors： Oda E,Aizawa Y

更新日期：2013-06-01 00:00:00

abstract：:Urinary angiotensin-converting enzyme (ACE) and urinary N-acetyl-beta-D-glucosaminidase (NAG) were measured after a 5-year interval in 38 non-azotemic type 2 diabetic patients. Of these patients at baseline, 16 had nil nephropathy, 15 had incipient nephropathy, and 7 had overt nephropathy. During the follow-up, 6 and ...

journal_title：Acta diabetologica

authors： Miyauchi E,Hosojima H,Morimoto S

更新日期：1995-10-01 00:00:00

abstract：AIM:Infection of a diabetic foot ulcer (DFU) is common. More than the half of DFUs become infected and 15-20% of them necessitate amputation in course of treatment. Diabetic foot infection (DFI) is therefore the major cause for non-traumatic lower limb amputation in Germany. Prompt and effective treatment of DFI is man...

journal_title：Acta diabetologica

authors： Dörr S,Freier F,Schlecht M,Lobmann R

更新日期：2020-09-17 00:00:00

abstract：:In patients with type 1 diabetes (T1D), pancreatic β cells are destroyed by a selective autoimmune attack and their replacement with functional insulin-producing cells is the only possible cure for this disease. The field of islet transplantation has evolved significantly from the breakthrough of the Edmonton Protocol...

journal_title：Acta diabetologica

authors： Pellegrini S,Cantarelli E,Sordi V,Nano R,Piemonti L

更新日期：2016-10-01 00:00:00

abstract：:Islet autotransplantation (IAT) is performed at the time of total pancreatectomy (TP) to prevent or minimize post-surgical diabetes. Corticosteroids induce insulin resistance and present a risk to islet autografts, through glucotoxicity and increased metabolic demand on a marginal islet mass. We present four IAT recip...

journal_title：Acta diabetologica

authors： Ngo A,Sutherland DE,Beilman GJ,Bellin MD

更新日期：2014-02-01 00:00:00

abstract：AIMS:Inflammation and oxidative damage contribute significantly to the development of cardiovascular diseases (CVD). Postprandial oxidative stress and inflammation are characterized by an increased susceptibility of the organism toward oxidative damage after consumption of a meal rich in lipids and/or carbohydrates. Mi...

journal_title：Acta diabetologica

authors： De Lorenzo A,Bernardini S,Gualtieri P,Cabibbo A,Perrone MA,Giambini I,Di Renzo L

更新日期：2017-02-01 00:00:00

abstract：AIMS:To study the incidence of and the factors associated with renal dialysis and transplantation in type 1 (T1DM) and type 2 diabetes (T2DM). METHODS:Data on individuals who had received dialysis treatment or renal transplant between 1 January 2004 and 31 December 2013 were extracted from the regional administrative ...

journal_title：Acta diabetologica

authors： Giorda CB,Carnà P,Salomone M,Picariello R,Costa G,Tartaglino B,Gnavi R

更新日期：2018-07-01 00:00:00

abstract：:Genetic markers may be used to improve the prediction of insulin-dependent diabetes mellitus (type 1) in individuals with islet autoantibodies. In order to develop a risk assessment strategy for the Lombardy region of northern Italy based on genetic and immunological markers, we analyzed HLA DQA1 and DQB1 alleles in 6...

journal_title：Acta diabetologica

authors： Lampasona V,Ferrari M,Bonifacio E,Pastore MR,Carrera P,Sergi A,Genovese S,Trucco M,Dorman J,Bosi E

更新日期：1995-10-01 00:00:00

abstract：:Although the polymorphisms of PTPN22 and the variants of CTLA-4 have been reported to be the susceptibility genes, which increased risk of latent autoimmune diabetes in adults (LADA), the results remained inconclusive. The aim of this meta-analysis was to evaluate the association between the polymorphisms of two genes...

journal_title：Acta diabetologica

authors： Dong F,Yang G,Pan HW,Huang WH,Jing LP,Liang WK,Zhang N,Zhang BH,Wang M,Liu Y,Zhang LJ,Zhang SH,Li H,Chen C,Nie LH,Jing CX

更新日期：2014-10-01 00:00:00

abstract：AIMS:Glucagon is used to resolve severe hypoglycemia in unconscious patients with diabetes, requiring third-party assistance. A few studies have shown that intranasal (IN) glucagon causes resolution of hypoglycemia in insulin-treated patients with type 1 (T1DM) diabetes. This systematic review and meta-analysis updates...

journal_title：Acta diabetologica

authors： Pontiroli AE,Tagliabue E

更新日期：2020-06-01 00:00:00

abstract：:Left atrial (LA) structural, functional and mechanical changes have important role in development of diabetic cardiomyopathy and it was discovered that LA remodeling has important prognostic role in the patients with diabetes (DM). Previously the focus of echocardiographic studies in DM population was on the left vent...

journal_title：Acta diabetologica

authors： Tadic M,Cuspidi C

更新日期：2020-06-09 00:00:00

abstract：:For many diabetic patients, years of blood glucose self-monitoring (SM) with readings taken several times daily is an inevitable aspect of insulin therapy. We investigated whether SM from abdominal skin might be an alternative to the established fingertip method. A total of 63 diabetic patients and 16 nondiabetic volu...

journal_title：Acta diabetologica

authors： Holstein A,Thiessen E,Kaufmann N,Plaschke A,Egberts EH

更新日期：2002-06-01 00:00:00

abstract：AIMS:To evaluate feasibility and effectiveness on short-term blood glucose control of using glycaemic load counting (GLC) versus carbohydrate counting (CC) for prandial insulin dosing in patients with type 1 diabetes (T1D). METHODS:Nine T1D patients on insulin pump, aged 26-58 years, HbA1c 7.7 ± 0.8 % (61 ± 8.7 mmol/m...

journal_title：Acta diabetologica

authors： Bozzetto L,Giorgini M,Alderisio A,Costagliola L,Giacco A,Riccardi G,Rivellese AA,Annuzzi G

更新日期：2015-10-01 00:00:00

abstract：:To define whether reference values for bioimpedance analysis (BIA) can be predicted in healthy individuals, individual characteristics and BIA variables (resistance index=height(2)/parallel resistance and reactance index= height(2)/parallel reactance) were evaluated in non-obese healthy individuals: 863 men and 769 wo...

journal_title：Acta diabetologica

authors： Bellizzi V,Scalfi L,Terracciano V,Marra M,Di Iorio B

更新日期：2003-10-01 00:00:00

abstract：:Comparing macrophage-derived cytokine and nitric oxide (NO) profiles in type I and type II diabetes mellitus (DM); and determining whether thymoquinone (TQ) has any modulatory effect were the main objectives of the present study. Peritoneal macrophages have been collected from Otsuka Long-Evans Tokushima Fatty (OLETF)...

journal_title：Acta diabetologica

authors： El-Mahmoudy A,Shimizu Y,Shiina T,Matsuyama H,Nikami H,Takewaki T

更新日期：2005-03-01 00:00:00

abstract：:We investigated whether food supplementation within the first year life or age at introduction of gluten-containing foods influenced the risk of developing islet autoimmunity and type 1 diabetes. A total of 2,291 children with a family history of type 1 diabetes were prospectively followed from birth for 28,983 patien...

journal_title：Acta diabetologica

authors： Chmiel R,Beyerlein A,Knopff A,Hummel S,Ziegler AG,Winkler C

更新日期：2015-06-01 00:00:00

abstract：:The aim of the present work was to investigate the impact of gender on resting cerebral blood flow velocity and cerebrovascular reserve capacity among diabetic patients. Middle cerebral artery mean blood flow velocity (MCAV) was measured in 72 patients suffering from type 1 diabetes mellitus at rest and 5, 10, 15 and ...

journal_title：Acta diabetologica

authors： Fülesdi B,Limburg M,Oláh L,Bereczki D,Csiba L,Kollár J

更新日期：2001-01-01 00:00:00

abstract：AIMS:To assess the metabolic health of obese and non-obese women at high GDM risk 5 years postpartum. METHODS:This is a secondary analysis of the 5-year follow-up of the RADIEL GDM prevention study including 333 women at high GDM risk (BMI ≥ 30 kg/m2 and/or previous GDM). Five years postpartum metabolic health was ass...

journal_title：Acta diabetologica

authors： Huvinen E,Eriksson JG,Koivusalo SB,Grotenfelt N,Tiitinen A,Stach-Lempinen B,Rönö K

更新日期：2018-05-01 00:00:00

abstract：AIMS:The purpose of this study was to investigate the mechanism of vascular endothelial cell apoptosis induced by acute blood glucose fluctuation. METHODS:Thirty rats were assigned to three groups: normal saline (SAL group), constant high glucose (CHG group) and acute blood glucose fluctuation (AFG) group. Other forty...

journal_title：Acta diabetologica

authors： Wu N,Shen H,Wang Y,He B,Zhang Y,Bai Y,Du R,Du Q,Han P

更新日期：2017-08-01 00:00:00

abstract：:Endothelial nitric oxide synthase (eNOS) has been shown to play an essential role in retinal vascular function, and disequilibrium in its production can lead to diabetic retinopathy (DR). Genetic polymorphisms of eNOS gene have been suggested to play a role in nitric oxide (NO) abnormalities which may contribute to th...

journal_title：Acta diabetologica

authors： Cheema BS,kohli HS,Sharma R,Bhansali A,Khullar M

更新日期：2012-12-01 00:00:00