Abstract：
:Endothelial nitric oxide synthase (eNOS) has been shown to play an essential role in retinal vascular function, and disequilibrium in its production can lead to diabetic retinopathy (DR). Genetic polymorphisms of eNOS gene have been suggested to play a role in nitric oxide (NO) abnormalities which may contribute to the development and progression of DR. In view of the variable results that have been reported for the association between eNOS gene polymorphisms and DR, the present study was designed to study the association and interaction between eNOS gene polymorphisms and the development and progression of DR in Asian Indian type 2 diabetes mellitus patients (T2DM). We screened 1,720 T2DM patients, belonging to two independently ascertained cohorts out of which 1,446 were genotyped for three polymorphisms of eNOS (two SNPs: T-786C, G894T and one 27-bp repeat polymorphism in intron 4 (27VNTR)) using validated PCR-RFLP assays. In both the cohorts, consistently lower prevalence and decreased risk of DR was observed in patients with ba, aa and ba + aa genotype of 27VNTR (a/b), C-a-G and C-a-T haplotype (allele of T-786C, 27VNTR a/b and G894T) carrying "C" allele of T-786C and "a" allele of 27VNTR (a/b). Also, mean NO levels in T2DM subjects carrying ba + aa genotype were higher as compared to bb genotype. Our results suggest that eNOS genotypes 27VNTR carrying "aa" genotype is an independent protective factor for DR and is associated with low risk of DR.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Cheema BS,kohli HS,Sharma R,Bhansali A,Khullar Mdoi
10.1007/s00592-012-0437-7subject
Has Abstractpub_date
2012-12-01 00:00:00pages
481-8issue
6eissn
0940-5429issn
1432-5233journal_volume
49pub_type
杂志文章abstract：:We investigated whether food supplementation within the first year life or age at introduction of gluten-containing foods influenced the risk of developing islet autoimmunity and type 1 diabetes. A total of 2,291 children with a family history of type 1 diabetes were prospectively followed from birth for 28,983 patien...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0628-5
更新日期：2015-06-01 00:00:00
abstract：:Anti-myeloperoxidase (anti-MPO) antibodies were detected in 34 of 88 (38%) patients with type 1 diabetes mellitus but in only 3 of 55 (5.7%) healthy subjects and in 4 of 20 patients with autoimmune disease. Specificity of anti-MPO antibodies was assessed by MPO inhibition studies. No relationship was found between the...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00569418
更新日期：1996-07-01 00:00:00
abstract：AIMS:This subanalysis of a cross-sectional, nationwide study was undertaken to assess the relationship between healthy lifestyle behaviors and multiple cardiovascular risk factors among people with type 2 diabetes mellitus (T2DM). METHODS:Data collected from 25,454 participants, including demographics, lifestyle behav...
journal_title：Acta diabetologica
pub_type： 杂志文章,多中心研究
doi：10.1007/s00592-017-0981-2
更新日期：2017-06-01 00:00:00
abstract：:The objective is to assess the effect of TNF-alpha inhibition on urinary albumin excretion in experimental diabetic rats. Male Wistar rats, 8-week-old, were categorized into four groups, which were the control (n = 9), diabetes (n = 9), infliximab-treated diabetes (n = 10), and FR167653-treated diabetes (n = 9) groups...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-007-0007-6
更新日期：2007-12-01 00:00:00
abstract：:The title "Plasma fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus" should be replaced by "Serum fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus". ...
journal_title：Acta diabetologica
pub_type： 已发布勘误
doi：10.1007/s00592-018-1177-0
更新日期：2018-10-01 00:00:00
abstract：AIMS:To evaluate feasibility and effectiveness on short-term blood glucose control of using glycaemic load counting (GLC) versus carbohydrate counting (CC) for prandial insulin dosing in patients with type 1 diabetes (T1D). METHODS:Nine T1D patients on insulin pump, aged 26-58 years, HbA1c 7.7 ± 0.8 % (61 ± 8.7 mmol/m...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-015-0716-1
更新日期：2015-10-01 00:00:00
abstract：AIMS:The aim of our study was to estimate the overall rate of first hospitalizations for diabetic foot (DF) regardless of the outcome in amputations, as well as the mortality rate with their determinants in the period 2012-2016 in Piedmont Region in Italy. METHODS:The study included all the subjects registered in the ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-019-01412-8
更新日期：2020-02-01 00:00:00
abstract：AIMS:Observational studies and meta-analyses of randomized trials on dipeptidyl peptidase-4 inhibitors (DPP4i) reported discordant results on the risk of malignancies with this class of drugs. Aim of the present meta-analysis is the assessment of the effect of DPP4i treatment on the incidence of different types of canc...
journal_title：Acta diabetologica
pub_type： 杂志文章,meta分析
doi：10.1007/s00592-020-01479-8
更新日期：2020-06-01 00:00:00
abstract：:Anorectic patients who achieve complete recovery from the eating disorder can obtain a favorable psychosocial outcome but the long-term nutritional outcome is ill-defined. We investigated the time course of total and distrectual body composition during and after refeeding in 32 female patients with anorexia nervosa. P...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-004-0139-x
更新日期：2004-03-01 00:00:00
abstract：:Insulin resistance is a major factor in the pathogenesis of type 2 diabetes mellitus (T2DM) and is related to the fatty acid profile of the plasma membranes. The purpose of the present study was to investigate fatty acid composition and cholesterol content of cell membranes in patients with type 2 diabetes and, thus, ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-007-0224-4
更新日期：2006-12-01 00:00:00
abstract：:Studies suggest that diabetes may specifically elevate the risk of sudden cardiac death in excess of other heart disease outcomes. In this study, we examined the association of type 2 diabetes with the incidence of sudden cardiac death when compared to the incidence of non-sudden cardiac death and non-fatal myocardial...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-009-0157-9
更新日期：2010-12-01 00:00:00
abstract：AIMS:Glucose-dependent insulinotropic polypeptide (GIP) is released primarily from the proximal small intestine and glucagon-like peptide-1 (GLP-1) from the more distal small intestine and colon. Their relative importance to the incretin effect in health has been contentious in the past, although it now appears that GI...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-019-01461-z
更新日期：2020-05-01 00:00:00
abstract：:Aim To summarize, critically review, and interpret the evidence related to the systematic reviews on health literacy (HL) amongst type 2 diabetes mellitus (T2DM). Methods The methodology for this study consisted of a systematic review of systematic reviews, using the PRISMA statement and flowchart to select studies, a...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-017-1071-1
更新日期：2018-01-01 00:00:00
abstract：:Changes in the amounts and localization of protein kinase C (PKC) isoforms occur in galactosaemic lens epithelial cells. A link between PKC changes and myo-inositol depletion has been suggested. Raf-1, a component of a Ras pathway, is a substrate for PKC. Raf-1 levels were measured in galactosaemic lens epithelial cel...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920050119
更新日期：1998-10-01 00:00:00
abstract：:Preliminary evidence from trials with the HMG-CoA reductase inhibitors (statins), simvastatin and pravastatin, suggests that aggressive treatment of diabetic dyslipidaemia will reduce coronary events. Questions regarding the prevention of cardiovascular events in diabetic patients are now being addressed in prospectiv...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s005920170005
更新日期：2001-01-01 00:00:00
abstract：:The recent efforts in the study of fetal compartments could help us to a better recognition of the proper fetal growth and well being. Fat content correlates directly with energy stores. Fat mass and lean body mass is often used in the nutritional assessment of the individual. Moreover chromosomal abnormalities may be...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-003-0033-y
更新日期：2003-10-01 00:00:00
abstract：AIMS:To study the incidence of and the factors associated with renal dialysis and transplantation in type 1 (T1DM) and type 2 diabetes (T2DM). METHODS:Data on individuals who had received dialysis treatment or renal transplant between 1 January 2004 and 31 December 2013 were extracted from the regional administrative ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-018-1142-y
更新日期：2018-07-01 00:00:00
abstract：AIMS:The importance of diabetes-related distress for the treatment of diabetes is emphasised in national and international guidelines recommending routinely screening for psychosocial problems. Data of investigations regarding diabetes-related distress on primary care are rare in Germany though most people with diabete...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-017-0972-3
更新日期：2017-05-01 00:00:00
abstract：:Several haemostatic abnormalities are associated with proliferative diabetic retinopathy. While abnormalities in plasma fibrinolytic activity have been described in diabetic retinopathy, platelets (a rich source of plasminogen activator inhibitor type 1, PAI-1) have received little attention. As a result, little is kn...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920050159
更新日期：1999-09-01 00:00:00
abstract：:The possible occurrence of increased non-enzymatic glycosylation of serum insulin-like growth factor binding protein-3 (IGFBP-3) in vivo and the changes that would simultaneously occur in serum levels of IGFBP-3 and insulin-like growth factor-1 (IGF-I) were investigated. We measured levels of IGF-I and IGFBP-3 and the...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920050109
更新日期：1998-07-01 00:00:00
abstract：AIMS:The aim of the current study was to investigate the association of type 2 diabetes (T2D) and insulin treatment with changes in muscle mass, muscle strength, and physical performance in older adults. METHODS:In 731 participants of the population-based KORA-Age study aged 74.6 ± 6.2 years (T2D: n = 118; insulin tre...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-020-01523-7
更新日期：2020-09-01 00:00:00
abstract：AIMS:Increasing evidence suggests a potential role of circulating miRNAs as clinical biomarkers, and loss of miRNA-126 has been proposed as a predictor of type 2 diabetes onset. However, a systematic analysis of circulating miRNAs in type 1 diabetic patients with micro-/macrovascular complications has not yet been perf...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-016-0915-4
更新日期：2017-02-01 00:00:00
abstract：:We assessed the efficacy of noninsulin antidiabetic medications used in current clinical practice (metformin, sulfonylureas, α-glucosidase inhibitors, thiazolidinediones, glinides, dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 agonists) to reach the HbA1c target <7% in people with type 2 diabetes. MEDLINE...
journal_title：Acta diabetologica
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00592-012-0370-9
更新日期：2014-04-01 00:00:00
abstract：AIM:Cardio-metabolic disease and physical activity are closely related but large-scale objective studies which measure physical activity are lacking. Using the largest accelerometer cohort to date, we aimed to investigate whether there is an association between disease status and accelerometer variables after a 5-year ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-018-1161-8
更新日期：2018-09-01 00:00:00
abstract：:Patients with diabetes represent an increasing proportion of end-stage renal disease (ESRD) patients. Cardiovascular risk, already formidable among patients on dialysis, is significantly higher among those who also have diabetes. Diabetic ESRD patients are not only at higher risk of ischaemic events, but are also subj...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s005920200003
更新日期：2002-04-01 00:00:00
abstract：:Autonomic nervous dysfunction is considered to be one of the mechanisms of metabolic syndrome (MetS). The aim of this study is to investigate whether resting heart rate, a marker of autonomic nervous dysfunction, is a predictor of MetS in apparently healthy non-obese [body mass index (BMI) <25 kg/m(2)] Japanese men. T...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-013-0503-9
更新日期：2014-02-01 00:00:00
abstract：:The objective of this study was to verify the impact of various sports on body cell mass (BCM). Ninety-eight male subjects, 17-33 years of age, participated in the study. The sample included athletes from three professional Italian football (soccer) teams, representing three different divisions (A, n=16; B, n=14; and ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-003-0043-9
更新日期：2003-10-01 00:00:00
abstract：:The effect of the insulinotropic gut hormone glucagon-like-peptide-1 (GLP-1) was studied on the residual insulin capacity of prediabetic nonobese diabetic (NOD) mice, a model of insulin-dependent diabetes mellitus (type 1). This was done using isolated pancreas perfusion and dynamic islet perifusion. Prediabetes was d...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00571935
更新日期：1996-03-01 00:00:00
abstract：:In late twentieth century, Ruderman and Reaven showed that insulin resistance might be fundamental to metabolic syndrome (MetS) which means a constellation of obesity-related metabolic derangements predisposing to type 2 diabetes and cardiovascular disease. In 2001, user-friendly National Cholesterol Education Program...
journal_title：Acta diabetologica
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s00592-011-0309-6
更新日期：2012-04-01 00:00:00
abstract：:For many diabetic patients, years of blood glucose self-monitoring (SM) with readings taken several times daily is an inevitable aspect of insulin therapy. We investigated whether SM from abdominal skin might be an alternative to the established fingertip method. A total of 63 diabetic patients and 16 nondiabetic volu...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920200020
更新日期：2002-06-01 00:00:00
