Abstract：
:The aim of the study is to evaluate the prevalence and incidence of myocardial dysfunction (MD) and heart failure (HF) in long-lasting (≥10 years) type 1 diabetes without cardiovascular disorders or with hypertension or coronary heart disease (CHD). The study included 1,685 patients with type 1 diabetes (mean baseline age, 51 years; diabetes duration, 36 years). In all patients, echocardiography was performed, NT-proBNP levels were measured, and clinical symptoms were evaluated. A 7-year follow-up was conducted to monitor systolic and diastolic manifestations of MD and HF. At the end of the follow-up period, the prevalence of HF in the entire group was 3.7 %, and the incidence was 0.02 % per year. The prevalence of MD was 14.5 % and the incidence -0.1 % per year. MD and HF were observed only in hypertensive or CHD patients. At baseline, subjects with diastolic HF constituted 85 % of the HF population and those with systolic HF the remaining 15 %. Baseline HF predictors included age, diabetes duration, HbA1c levels, CHD, systolic blood pressure >140 mmHg, and GFR <60 mL/min/1.73 m(2). In patients with type 1 diabetes, MD and HF occurred only when diabetes coexisted with cardiovascular disorders affecting myocardial function. The prevalence and incidence of HF in patients with hypertension and CHD were relatively low. While the cause of this observation remains uncertain, it could probably be explained, at least partially, by the cardioprotective effect of concomitant treatment.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Konduracka E,Cieslik G,Galicka-Latala D,Rostoff P,Pietrucha A,Latacz P,Gajos G,Malecki MT,Nessler Jdoi
10.1007/s00592-013-0455-0subject
Has Abstractpub_date
2013-08-01 00:00:00pages
597-606issue
4eissn
0940-5429issn
1432-5233journal_volume
50pub_type
杂志文章abstract：:Preliminary evidence from trials with the HMG-CoA reductase inhibitors (statins), simvastatin and pravastatin, suggests that aggressive treatment of diabetic dyslipidaemia will reduce coronary events. Questions regarding the prevention of cardiovascular events in diabetic patients are now being addressed in prospectiv...
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pub_type： 杂志文章,多中心研究
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更新日期：2002-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-08-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 已发布勘误
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pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章,meta分析,评审
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更新日期：2014-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
abstract：AIMS:Our aims were to investigate in several large samples, with a wide range of adiposity, whether: (1) the effect of BMI on insulin sensitivity is different between sexes; (2) also waist circumference plays a sex-specific role on insulin sensitivity; and (3) serum adiponectin and resistin are mediators of such sex-di...
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更新日期：2015-10-01 00:00:00
