Bone metabolism in type 2 diabetes mellitus.

Abstract:

:Several conditions have been described to cause osteoporosis, including diabetes mellitus. While the relationship between type 1 diabetes and osteopenia is well documented in the literature, data on the presence of this complication in type 2 diabetes have not been well established. We studied a population composed of 66 post-menopausal women with type 2 diabetes and a control population. We examined bone mineral density with the dual-energy X-ray absorptiometry (DXA) technique at the lumbar and femoral levels and, in a subgroup of patients, we also measured the levels of markers of bone remodelling. We found significantly higher levels of bone mineral density at the femoral (but not lumbar) level in the diabetic subjects compared with the control population in all the examined subregions, except Ward's triangle. Moreover, we found higher levels of some markers of bone resorption (urinary calcium and hydroxyproline, telopeptide) in the patients with diabetes, while urinary crosslinks were higher in the controls. On the basis of these results, we suggest that osteoporosis cannot be considered a complication of type 2 diabetes and that, from a metabolic point of view, bone resorption is greater in diabetic patients than in normal subjects, as suggested by the high levels of most of the markers of osteoclastic activity.

journal_name

Acta Diabetol

journal_title

Acta diabetologica

authors

Isaia GC,Ardissone P,Di Stefano M,Ferrari D,Martina V,Porta M,Tagliabue M,Molinatti GM

doi

10.1007/s005920050142

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

35-8

issue

1-2

eissn

0940-5429

issn

1432-5233

pii

90360035.592

journal_volume

36

pub_type

杂志文章
  • Metabolic syndrome: its history, mechanisms, and limitations.

    abstract::In late twentieth century, Ruderman and Reaven showed that insulin resistance might be fundamental to metabolic syndrome (MetS) which means a constellation of obesity-related metabolic derangements predisposing to type 2 diabetes and cardiovascular disease. In 2001, user-friendly National Cholesterol Education Program...

    journal_title:Acta diabetologica

    pub_type: 历史文章,杂志文章,评审

    doi:10.1007/s00592-011-0309-6

    authors: Oda E

    更新日期:2012-04-01 00:00:00

  • Sleep quality and risk of diabetes and coronary artery disease among young men.

    abstract:AIMS:To assess the time-dependent effect of sleep quality on diabetes and coronary artery disease (CAD) incidence among young adults. METHODS:Incident rates of diabetes and CAD during a mean follow-up of 6.4 ± 4.1 years were assessed among 26,023 men (mean age 30.9 ± 5.6 years) of the Metabolic Lifestyle and Nutrition...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-015-0779-z

    authors: Twig G,Shina A,Afek A,Derazne E,Tzur D,Cukierman-Yaffe T,Shechter-Amir D,Gerstein HC,Tirosh A

    更新日期:2016-04-01 00:00:00

  • Trialogue Plus: Management of cardiovascular risk in hyperglycaemic/diabetic patients at hospital discharge.

    abstract::Diabetes mellitus and hyperglycaemia are both independent risk factors (RF) for cardiovascular (CV) events and increased general and CV mortality. Type 2 diabetes, which is often associated with obesity, hypertension and dyslipidaemia, is accompanied by an up to fourfold increase in the incidence of acute coronary hea...

    journal_title:Acta diabetologica

    pub_type: 共识发展会议,杂志文章

    doi:10.1007/s00592-013-0508-4

    authors: Beltramello G,Manicardi V,Mazzuoli F,Rivellese A,Associazione Medici Diabetologi (AMD), Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO), Federazione delle Associazioni dei Dirigenti Ospedalieri Internisti (FADOI) and Societa` Italia

    更新日期:2013-12-01 00:00:00

  • Correction to: Serum fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus.

    abstract::The title "Plasma fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus" should be replaced by "Serum fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus". ...

    journal_title:Acta diabetologica

    pub_type: 已发布勘误

    doi:10.1007/s00592-018-1177-0

    authors: Ning H,Tao H,Weng Z,Zhao X

    更新日期:2018-10-01 00:00:00

  • Myocardial dysfunction and chronic heart failure in patients with long-lasting type 1 diabetes: a 7-year prospective cohort study.

    abstract::The aim of the study is to evaluate the prevalence and incidence of myocardial dysfunction (MD) and heart failure (HF) in long-lasting (≥10 years) type 1 diabetes without cardiovascular disorders or with hypertension or coronary heart disease (CHD). The study included 1,685 patients with type 1 diabetes (mean baseline...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-013-0455-0

    authors: Konduracka E,Cieslik G,Galicka-Latala D,Rostoff P,Pietrucha A,Latacz P,Gajos G,Malecki MT,Nessler J

    更新日期:2013-08-01 00:00:00

  • Binding characteristics and crossreactivity of insulin autoantibodies and insulin antibodies directed to three different insulin molecules.

    abstract::To evaluate ex vivo/in vitro the binding and dissociation characteristics and the level of crossreactivity of insulin antibodies and insulin autoantibodies directed to three different insulin molecules (human, bovine and porcine insulin). In this study sera from 17 diabetic patients were included, who were exclusively...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-008-0041-z

    authors: Jaeger C,Winter S,Eckhard M,Hardt P,Brendel MD,Bretzel RG

    更新日期:2008-09-01 00:00:00

  • Early selective neuroretinal disorder in prepubertal type 1 (insulin-dependent) diabetic children without microvascular abnormalities.

    abstract::The duration of diabetes before puberty is not considered relevant to the future development of complications. To evaluate the effects of diabetes on the neural retina, we analysed macular function by steady-state focal electroretinography in 20 prepubescent diabetic children without vascular retinopathy and in 39 sex...

    journal_title:Acta diabetologica

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF00570544

    authors: Greco AV,Di Leo MA,Caputo S,Falsini B,Porciatti V,Marietti G,Ghirlanda G

    更新日期:1994-06-01 00:00:00

  • Serum gamma-glutamyl transferase is associated with plasma total homocysteine in Japanese patients with type 2 diabetes.

    abstract::Serum gamma-glutamyl transferase (gamma-GT), a marker of oxidative stress, predicts morbidity and mortality from cardiovascular disease. Plasma total homocysteine (tHcy), a pro-oxidant and also an independent risk factor for cardiovascular disease, correlates with gamma-GT among some populations. It is not known wheth...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-007-0001-z

    authors: Sakuta H,Suzuki T,Ito T

    更新日期:2007-12-01 00:00:00

  • Macrophage-derived cytokine and nitric oxide profiles in type I and type II diabetes mellitus: effect of thymoquinone.

    abstract::Comparing macrophage-derived cytokine and nitric oxide (NO) profiles in type I and type II diabetes mellitus (DM); and determining whether thymoquinone (TQ) has any modulatory effect were the main objectives of the present study. Peritoneal macrophages have been collected from Otsuka Long-Evans Tokushima Fatty (OLETF)...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-005-0170-6

    authors: El-Mahmoudy A,Shimizu Y,Shiina T,Matsuyama H,Nikami H,Takewaki T

    更新日期:2005-03-01 00:00:00

  • 31P-magnetic resonance spectroscopy (31P-MRS) detects early changes in kidney high-energy phosphate metabolism during a 6-month Valsartan treatment in diabetic and non-diabetic kidney-transplanted patients.

    abstract::(31)P-magnetic resonance spectroscopy ((31)P-MRS) is a non-invasive tool to study high-energy phosphate (HEP) metabolism. We evaluate whether 31P-MRS can detect early changes in kidney HEP metabolism during a 6-month trial with Valsartan. Twenty consecutive stable and normotensive kidney-transplanted patients were enr...

    journal_title:Acta diabetologica

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00592-012-0369-2

    authors: Fiorina P,Bassi R,Gremizzi C,Vergani A,Caldara R,Mello A,Del Maschio A,De Cobelli F,Perseghin G,Secchi A

    更新日期:2012-12-01 00:00:00

  • HLA-DQ screening for risk assessment of insulin dependent diabetes in northern Italy.

    abstract::Genetic markers may be used to improve the prediction of insulin-dependent diabetes mellitus (type 1) in individuals with islet autoantibodies. In order to develop a risk assessment strategy for the Lombardy region of northern Italy based on genetic and immunological markers, we analyzed HLA DQA1 and DQB1 alleles in 6...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/BF00838481

    authors: Lampasona V,Ferrari M,Bonifacio E,Pastore MR,Carrera P,Sergi A,Genovese S,Trucco M,Dorman J,Bosi E

    更新日期:1995-10-01 00:00:00

  • Serum miR-23a, a potential biomarker for diagnosis of pre-diabetes and type 2 diabetes.

    abstract::MicroRNAs (miRNAs) play a crucial role in the pathogenesis of type 2 diabetes (T2D); they regulate several metabolic pathways including insulin secretion, glucose homeostasis, so their potential as biomarkers of diagnosis and prognosis has became increasingly appreciated. In this study, we explore serum miRNA profiles...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-014-0617-8

    authors: Yang Z,Chen H,Si H,Li X,Ding X,Sheng Q,Chen P,Zhang H

    更新日期:2014-10-01 00:00:00

  • Fasting, non-fasting glucose and HDL dysfunction in risk of pre-diabetes, diabetes, and coronary disease in non-diabetic adults.

    abstract::We determined in non-diabetic persons the risk of fasting and non-fasting glucose levels for pre-diabetes, diabetes, and coronary heart disease (CHD), including the roles of serum C-reactive protein (CRP) and HDL cholesterol, and delineated risk profiles of the pre-diabetic states. Over 7¼ years, 2,619 middle-aged Tur...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-011-0313-x

    authors: Onat A,Can G,Çiçek G,Ayhan E,Doğan Y,Kaya H

    更新日期:2013-08-01 00:00:00

  • Effect of dietary supplementation with the pyridoindole antioxidant stobadine on antioxidant state and ultrastructure of diabetic rat myocardium.

    abstract::Consistent with the postulated role of oxidative stress in the etiology of late diabetic complications, pharmacological interventions based on biological antioxidants have been suggested. The aim of the present study was to investigate the effect of dietary supplementation with the pyridoindole antioxidant stobadine o...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s005920070012

    authors: Stefek M,Sotnikova R,Okruhlicova L,Volkovova K,Kucharska J,Gajdosik A,Gajdosikova A,Mihalova D,Hozova R,Tribulova N,Gvozdjakova A

    更新日期:2000-01-01 00:00:00

  • Beneficial effects of flexible insulin therapy in children and adolescents with type 1 diabetes mellitus.

    abstract::The purpose of this study was to determine the feasibility of a flexible multiple daily insulin (FMDI) regimen in routine pediatric diabetes care by comparing HbA(1c), body mass index (BMI), and episodes of severe hypoglycemia (SH) before and after initiation of FMDI therapy. Data from 44 patients (2-16 years old), on...

    journal_title:Acta diabetologica

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00592-003-0102-2

    authors: Alemzadeh R,Palma-Sisto P,Parton E,Totka J,Kirby M

    更新日期:2003-09-01 00:00:00

  • Metabolomic profile of diabetic retinopathy: a GC-TOFMS-based approach using vitreous and aqueous humor.

    abstract:AIM:To identify the potential metabolite markers in diabetic retinopathy (DR) by using gas chromatography coupled with time-of-flight mass spectrometry (GC-TOFMS). METHODS:GC-TOFMS spectra were acquired from vitreous and aqueous humor (AH) samples of patients with DR and non-diabetic participants. Comparative analysis...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-019-01363-0

    authors: Wang H,Fang J,Chen F,Sun Q,Xu X,Lin SH,Liu K

    更新日期:2020-01-01 00:00:00

  • Polymorphonuclear leukocyte membrane fluidity before and after activation in subjects with insulin resistance.

    abstract::The aim of this research was the evaluation of polymorphonuclear leukocyte (PMN) membrane fluidity in subjects with insulin resistance. Insulin sensitivity, in fact, may be influenced by plasma membrane fluidity. We enrolled 19 subjects with insulin resistance previously demonstrated during an euglycemic hyperinsuline...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s005920070029

    authors: Caimi G,Sinagra D,Canino B,Scarpitta AM,Montana M,Bonaventura V,Lo Presti R

    更新日期:2000-03-01 00:00:00

  • Diabetic cardiomyopathy: How can cardiac magnetic resonance help?

    abstract::Diabetes cardiomyopathy is a specific form of cardiac disease characteristic for diabetic patients. Development of echocardiography enabled diagnosis of diabetic cardiomyopathy significantly before the occurrence of heart failure. Previously was believed that left ventricular (LV) diastolic dysfunction represents the ...

    journal_title:Acta diabetologica

    pub_type: 杂志文章,评审

    doi:10.1007/s00592-020-01528-2

    authors: Tadic M,Cuspidi C,Calicchio F,Grassi G,Mancia G

    更新日期:2020-09-01 00:00:00

  • Investigation of miRNA-binding site variants and risk of gestational diabetes mellitus in Chinese pregnant women.

    abstract:AIMS:Emerging evidence suggested genetic factor attributed as a major determinant for the complex pathogenic mechanism of gestational diabetes mellitus (GDM), but the related genetic study was limited. We aimed to investigate the impact of polymorphisms in miRNA-binding sites (miR-binding SNPs) on the risk of GDM in Ch...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-017-0969-y

    authors: Wang X,Li W,Ma L,Ping F,Liu J,Wu X,Mao J,Wang X,Nie M

    更新日期:2017-03-01 00:00:00

  • Soybean oil treatment impairs glucose-stimulated insulin secretion and changes fatty acid composition of normal and diabetic islets.

    abstract::We investigated the effect of sub-chronic soybean oil (SO) treatment on the insulin secretion and fatty acid composition of islets of Langerhans obtained from Goto-Kakizaki (GK), a model of type 2 diabetes, and normal Wistar rats. We observed that soybean-treated Wistar rats present insulin resistance and defective is...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-007-0252-8

    authors: Nunes E,Peixoto F,Louro T,Sena CM,Santos MS,Matafome P,Moreira PI,Seiça R

    更新日期:2007-09-01 00:00:00

  • Survey on the use of insulin pumps in Italy: comparison between pediatric and adult age groups (IMITA study).

    abstract:AIMS:The aim of the study was to evaluate and compare continuous subcutaneous insulin infusion (CSII) use in pediatric and adult age groups. METHODS:Data were collected with a questionnaire sent by e-mail to CSII-experienced Diabetes Centers. The questionnaire assessed: (1) number of CSII-treated patients; (2) patient...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-015-0810-4

    authors: Bonfanti R,Lepore G,Bozzetto L,Corsi A,Di Blasi V,Girelli A,Grassi G,Iafusco D,Rabbone I,Schiaffini R,Laviola L,Bruttomesso D,Italian Study Group on Diffusion of CSII in Italy.

    更新日期:2016-06-01 00:00:00

  • Patient education and diabetes research: a failure! Going beyond the empirical approaches.

    abstract::A literature review of 37 papers cited by MEDLINE between 1986 and April 1996 under the terms "diabetes", "patient education" and "randomized" was carried out. The articles were analysed on the basis of a check list (Educational Procedure Check List), which contains 27 items grouped into 8 areas: study objectives, edu...

    journal_title:Acta diabetologica

    pub_type: 杂志文章,评审

    doi:10.1007/s005920050133

    authors: Albano MG,Jacquemet S,Assal JP

    更新日期:1998-12-01 00:00:00

  • Analysis of the relationships between type 2 diabetes status, glycemic control, and neuroimaging measures in the Diabetes Heart Study Mind.

    abstract:AIMS:To examine the relationships between type 2 diabetes (T2D) status, glycemic control, and T2D duration with magnetic resonance imaging (MRI)-derived neuroimaging measures in European Americans from the Diabetes Heart Study (DHS) Mind cohort. METHODS:Relationships were examined using marginal models with generalize...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-015-0815-z

    authors: Raffield LM,Cox AJ,Freedman BI,Hugenschmidt CE,Hsu FC,Wagner BC,Xu J,Maldjian JA,Bowden DW

    更新日期:2016-06-01 00:00:00

  • A sensitive and reliable method for assaying true human insulin without interaction with human proinsulin-like molecules.

    abstract::In the present study our interests focused on the evaluation of a high capacity assay (MEIA) which allows true insulin determinations in the absence of cross-reactivity with proinsulin-like molecules. This method was compared to a commercially available radioimmunoassay (RIA) for insulin determination. As the latter g...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/BF00581048

    authors: Monti LD,Sandoli EP,Phan VC,Piatti PM,Costa S,Secchi A,Pozza G

    更新日期:1995-03-01 00:00:00

  • Index of glucose effectiveness derived from oral glucose tolerance test.

    abstract::Aim of this study was to formulate an index for glucose effectiveness (Sg), SgIo, based on 3-point (0, 30 and 120 min) 75 g oral glucose tolerance test (OGTT). The equation for SgI(O) was developed in the Chikuma cohort (n = 502). Firstly, post-loading plasma glucose without insulin action and Sg (PPG-without insulin ...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-012-0417-y

    authors: Nagasaka S,Kusaka I,Yamashita K,Funase Y,Yamauchi K,Katakura M,Ishibashi S,Aizawa T

    更新日期:2012-12-01 00:00:00

  • Diabetes and the risk of sudden cardiac death, the Atherosclerosis Risk in Communities study.

    abstract::Studies suggest that diabetes may specifically elevate the risk of sudden cardiac death in excess of other heart disease outcomes. In this study, we examined the association of type 2 diabetes with the incidence of sudden cardiac death when compared to the incidence of non-sudden cardiac death and non-fatal myocardial...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-009-0157-9

    authors: Kucharska-Newton AM,Couper DJ,Pankow JS,Prineas RJ,Rea TD,Sotoodehnia N,Chakravarti A,Folsom AR,Siscovick DS,Rosamond WD

    更新日期:2010-12-01 00:00:00

  • An in-depth assessment of diabetes-related lower extremity amputation rates 2000-2013 delivered by twenty-one countries for the data collection 2015 of the Organization for Economic Cooperation and Development (OECD).

    abstract:BACKGROUND:International comparisons of diabetes-related lower extremity amputation rates are still hampered by different criteria used for data collection and analysis. We aimed to evaluate trends and variation of major/minor amputations, using agreed definitions adopted by the Organization for Economic Cooperation an...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-019-01423-5

    authors: Carinci F,Uccioli L,Massi Benedetti M,Klazinga NS

    更新日期:2020-03-01 00:00:00

  • Clinical reliability of multi-drug intracavernous vasoactive pharmacotherapy for diabetic impotence.

    abstract::The aim of this study was to assess the effectiveness and safety of intracavernous injections of a four-drug vasoactive mixture in diabetic patients with organic impotence. A group of 60 diabetic patients with either pure neurogenic, pure vasculogenic or mixed neurovasculogenic impotence were treated with intracaverno...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/BF00580752

    authors: Montorsi F,Guazzoni G,Bergamaschi F,Zucconi M,Rigatti P,Pizzini G,Miani A,Pozza G

    更新日期:1994-04-01 00:00:00

  • The influence of homocysteine levels on endothelial function and their relation with microvascular complications in T2DM patients without macrovascular disease.

    abstract::The aim of this study was to investigate the influence of homocysteine (hcy) levels on endothelial function by the method of brachial artery ultrasonography and their relation with microvascular complications in type 2 diabetes mellitus (T2DM) patients without macrovascular disease. Fifty-nine T2DM patients with a mea...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-007-0245-7

    authors: Karabag T,Kaya A,Temizhan A,Koç F,Yavuz S,Cam S

    更新日期:2007-06-01 00:00:00

  • Real-world adherence, persistence, and in-class switching during use of dipeptidyl peptidase-4 inhibitors: a systematic review and meta-analysis involving 594,138 patients with type 2 diabetes.

    abstract:AIMS:Medication adherence and persistence are important determinants of treatment success in type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis evaluated the real-world adherence, persistence, and in-class switching among patients with T2DM prescribed dipeptidyl peptidase-4 (DPP4) inhibitors. ME...

    journal_title:Acta diabetologica

    pub_type: 杂志文章

    doi:10.1007/s00592-020-01590-w

    authors: Ogundipe O,Mazidi M,Chin KL,Gor D,McGovern A,Sahle BW,Jermendy G,Korhonen MJ,Appiah B,Ademi Z,De Bruin ML,Liew D,Ofori-Asenso R

    更新日期:2021-01-01 00:00:00