Abstract:
:Several conditions have been described to cause osteoporosis, including diabetes mellitus. While the relationship between type 1 diabetes and osteopenia is well documented in the literature, data on the presence of this complication in type 2 diabetes have not been well established. We studied a population composed of 66 post-menopausal women with type 2 diabetes and a control population. We examined bone mineral density with the dual-energy X-ray absorptiometry (DXA) technique at the lumbar and femoral levels and, in a subgroup of patients, we also measured the levels of markers of bone remodelling. We found significantly higher levels of bone mineral density at the femoral (but not lumbar) level in the diabetic subjects compared with the control population in all the examined subregions, except Ward's triangle. Moreover, we found higher levels of some markers of bone resorption (urinary calcium and hydroxyproline, telopeptide) in the patients with diabetes, while urinary crosslinks were higher in the controls. On the basis of these results, we suggest that osteoporosis cannot be considered a complication of type 2 diabetes and that, from a metabolic point of view, bone resorption is greater in diabetic patients than in normal subjects, as suggested by the high levels of most of the markers of osteoclastic activity.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Isaia GC,Ardissone P,Di Stefano M,Ferrari D,Martina V,Porta M,Tagliabue M,Molinatti GMdoi
10.1007/s005920050142subject
Has Abstractpub_date
1999-06-01 00:00:00pages
35-8issue
1-2eissn
0940-5429issn
1432-5233pii
90360035.592journal_volume
36pub_type
杂志文章abstract::In late twentieth century, Ruderman and Reaven showed that insulin resistance might be fundamental to metabolic syndrome (MetS) which means a constellation of obesity-related metabolic derangements predisposing to type 2 diabetes and cardiovascular disease. In 2001, user-friendly National Cholesterol Education Program...
journal_title:Acta diabetologica
pub_type: 历史文章,杂志文章,评审
doi:10.1007/s00592-011-0309-6
更新日期:2012-04-01 00:00:00
abstract:AIMS:To assess the time-dependent effect of sleep quality on diabetes and coronary artery disease (CAD) incidence among young adults. METHODS:Incident rates of diabetes and CAD during a mean follow-up of 6.4 ± 4.1 years were assessed among 26,023 men (mean age 30.9 ± 5.6 years) of the Metabolic Lifestyle and Nutrition...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0779-z
更新日期:2016-04-01 00:00:00
abstract::Diabetes mellitus and hyperglycaemia are both independent risk factors (RF) for cardiovascular (CV) events and increased general and CV mortality. Type 2 diabetes, which is often associated with obesity, hypertension and dyslipidaemia, is accompanied by an up to fourfold increase in the incidence of acute coronary hea...
journal_title:Acta diabetologica
pub_type: 共识发展会议,杂志文章
doi:10.1007/s00592-013-0508-4
更新日期:2013-12-01 00:00:00
abstract::The title "Plasma fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus" should be replaced by "Serum fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus". ...
journal_title:Acta diabetologica
pub_type: 已发布勘误
doi:10.1007/s00592-018-1177-0
更新日期:2018-10-01 00:00:00
abstract::The aim of the study is to evaluate the prevalence and incidence of myocardial dysfunction (MD) and heart failure (HF) in long-lasting (≥10 years) type 1 diabetes without cardiovascular disorders or with hypertension or coronary heart disease (CHD). The study included 1,685 patients with type 1 diabetes (mean baseline...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-013-0455-0
更新日期:2013-08-01 00:00:00
abstract::To evaluate ex vivo/in vitro the binding and dissociation characteristics and the level of crossreactivity of insulin antibodies and insulin autoantibodies directed to three different insulin molecules (human, bovine and porcine insulin). In this study sera from 17 diabetic patients were included, who were exclusively...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-008-0041-z
更新日期:2008-09-01 00:00:00
abstract::The duration of diabetes before puberty is not considered relevant to the future development of complications. To evaluate the effects of diabetes on the neural retina, we analysed macular function by steady-state focal electroretinography in 20 prepubescent diabetic children without vascular retinopathy and in 39 sex...
journal_title:Acta diabetologica
pub_type: 临床试验,杂志文章
doi:10.1007/BF00570544
更新日期:1994-06-01 00:00:00
abstract::Serum gamma-glutamyl transferase (gamma-GT), a marker of oxidative stress, predicts morbidity and mortality from cardiovascular disease. Plasma total homocysteine (tHcy), a pro-oxidant and also an independent risk factor for cardiovascular disease, correlates with gamma-GT among some populations. It is not known wheth...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-007-0001-z
更新日期:2007-12-01 00:00:00
abstract::Comparing macrophage-derived cytokine and nitric oxide (NO) profiles in type I and type II diabetes mellitus (DM); and determining whether thymoquinone (TQ) has any modulatory effect were the main objectives of the present study. Peritoneal macrophages have been collected from Otsuka Long-Evans Tokushima Fatty (OLETF)...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-005-0170-6
更新日期:2005-03-01 00:00:00
abstract::(31)P-magnetic resonance spectroscopy ((31)P-MRS) is a non-invasive tool to study high-energy phosphate (HEP) metabolism. We evaluate whether 31P-MRS can detect early changes in kidney HEP metabolism during a 6-month trial with Valsartan. Twenty consecutive stable and normotensive kidney-transplanted patients were enr...
journal_title:Acta diabetologica
pub_type: 临床试验,杂志文章
doi:10.1007/s00592-012-0369-2
更新日期:2012-12-01 00:00:00
abstract::Genetic markers may be used to improve the prediction of insulin-dependent diabetes mellitus (type 1) in individuals with islet autoantibodies. In order to develop a risk assessment strategy for the Lombardy region of northern Italy based on genetic and immunological markers, we analyzed HLA DQA1 and DQB1 alleles in 6...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00838481
更新日期:1995-10-01 00:00:00
abstract::MicroRNAs (miRNAs) play a crucial role in the pathogenesis of type 2 diabetes (T2D); they regulate several metabolic pathways including insulin secretion, glucose homeostasis, so their potential as biomarkers of diagnosis and prognosis has became increasingly appreciated. In this study, we explore serum miRNA profiles...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-014-0617-8
更新日期:2014-10-01 00:00:00
abstract::We determined in non-diabetic persons the risk of fasting and non-fasting glucose levels for pre-diabetes, diabetes, and coronary heart disease (CHD), including the roles of serum C-reactive protein (CRP) and HDL cholesterol, and delineated risk profiles of the pre-diabetic states. Over 7¼ years, 2,619 middle-aged Tur...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-011-0313-x
更新日期:2013-08-01 00:00:00
abstract::Consistent with the postulated role of oxidative stress in the etiology of late diabetic complications, pharmacological interventions based on biological antioxidants have been suggested. The aim of the present study was to investigate the effect of dietary supplementation with the pyridoindole antioxidant stobadine o...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920070012
更新日期:2000-01-01 00:00:00
abstract::The purpose of this study was to determine the feasibility of a flexible multiple daily insulin (FMDI) regimen in routine pediatric diabetes care by comparing HbA(1c), body mass index (BMI), and episodes of severe hypoglycemia (SH) before and after initiation of FMDI therapy. Data from 44 patients (2-16 years old), on...
journal_title:Acta diabetologica
pub_type: 临床试验,杂志文章
doi:10.1007/s00592-003-0102-2
更新日期:2003-09-01 00:00:00
abstract:AIM:To identify the potential metabolite markers in diabetic retinopathy (DR) by using gas chromatography coupled with time-of-flight mass spectrometry (GC-TOFMS). METHODS:GC-TOFMS spectra were acquired from vitreous and aqueous humor (AH) samples of patients with DR and non-diabetic participants. Comparative analysis...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-019-01363-0
更新日期:2020-01-01 00:00:00
abstract::The aim of this research was the evaluation of polymorphonuclear leukocyte (PMN) membrane fluidity in subjects with insulin resistance. Insulin sensitivity, in fact, may be influenced by plasma membrane fluidity. We enrolled 19 subjects with insulin resistance previously demonstrated during an euglycemic hyperinsuline...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920070029
更新日期:2000-03-01 00:00:00
abstract::Diabetes cardiomyopathy is a specific form of cardiac disease characteristic for diabetic patients. Development of echocardiography enabled diagnosis of diabetic cardiomyopathy significantly before the occurrence of heart failure. Previously was believed that left ventricular (LV) diastolic dysfunction represents the ...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-020-01528-2
更新日期:2020-09-01 00:00:00
abstract:AIMS:Emerging evidence suggested genetic factor attributed as a major determinant for the complex pathogenic mechanism of gestational diabetes mellitus (GDM), but the related genetic study was limited. We aimed to investigate the impact of polymorphisms in miRNA-binding sites (miR-binding SNPs) on the risk of GDM in Ch...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-017-0969-y
更新日期:2017-03-01 00:00:00
abstract::We investigated the effect of sub-chronic soybean oil (SO) treatment on the insulin secretion and fatty acid composition of islets of Langerhans obtained from Goto-Kakizaki (GK), a model of type 2 diabetes, and normal Wistar rats. We observed that soybean-treated Wistar rats present insulin resistance and defective is...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-007-0252-8
更新日期:2007-09-01 00:00:00
abstract:AIMS:The aim of the study was to evaluate and compare continuous subcutaneous insulin infusion (CSII) use in pediatric and adult age groups. METHODS:Data were collected with a questionnaire sent by e-mail to CSII-experienced Diabetes Centers. The questionnaire assessed: (1) number of CSII-treated patients; (2) patient...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0810-4
更新日期:2016-06-01 00:00:00
abstract::A literature review of 37 papers cited by MEDLINE between 1986 and April 1996 under the terms "diabetes", "patient education" and "randomized" was carried out. The articles were analysed on the basis of a check list (Educational Procedure Check List), which contains 27 items grouped into 8 areas: study objectives, edu...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s005920050133
更新日期:1998-12-01 00:00:00
abstract:AIMS:To examine the relationships between type 2 diabetes (T2D) status, glycemic control, and T2D duration with magnetic resonance imaging (MRI)-derived neuroimaging measures in European Americans from the Diabetes Heart Study (DHS) Mind cohort. METHODS:Relationships were examined using marginal models with generalize...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0815-z
更新日期:2016-06-01 00:00:00
abstract::In the present study our interests focused on the evaluation of a high capacity assay (MEIA) which allows true insulin determinations in the absence of cross-reactivity with proinsulin-like molecules. This method was compared to a commercially available radioimmunoassay (RIA) for insulin determination. As the latter g...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00581048
更新日期:1995-03-01 00:00:00
abstract::Aim of this study was to formulate an index for glucose effectiveness (Sg), SgIo, based on 3-point (0, 30 and 120 min) 75 g oral glucose tolerance test (OGTT). The equation for SgI(O) was developed in the Chikuma cohort (n = 502). Firstly, post-loading plasma glucose without insulin action and Sg (PPG-without insulin ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-012-0417-y
更新日期:2012-12-01 00:00:00
abstract::Studies suggest that diabetes may specifically elevate the risk of sudden cardiac death in excess of other heart disease outcomes. In this study, we examined the association of type 2 diabetes with the incidence of sudden cardiac death when compared to the incidence of non-sudden cardiac death and non-fatal myocardial...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-009-0157-9
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:International comparisons of diabetes-related lower extremity amputation rates are still hampered by different criteria used for data collection and analysis. We aimed to evaluate trends and variation of major/minor amputations, using agreed definitions adopted by the Organization for Economic Cooperation an...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-019-01423-5
更新日期:2020-03-01 00:00:00
abstract::The aim of this study was to assess the effectiveness and safety of intracavernous injections of a four-drug vasoactive mixture in diabetic patients with organic impotence. A group of 60 diabetic patients with either pure neurogenic, pure vasculogenic or mixed neurovasculogenic impotence were treated with intracaverno...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00580752
更新日期:1994-04-01 00:00:00
abstract::The aim of this study was to investigate the influence of homocysteine (hcy) levels on endothelial function by the method of brachial artery ultrasonography and their relation with microvascular complications in type 2 diabetes mellitus (T2DM) patients without macrovascular disease. Fifty-nine T2DM patients with a mea...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-007-0245-7
更新日期:2007-06-01 00:00:00
abstract:AIMS:Medication adherence and persistence are important determinants of treatment success in type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis evaluated the real-world adherence, persistence, and in-class switching among patients with T2DM prescribed dipeptidyl peptidase-4 (DPP4) inhibitors. ME...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-020-01590-w
更新日期:2021-01-01 00:00:00