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Risk factors for non-alcoholic fatty liver disease-associated hepatic fibrosis in type 2 diabetes patients.

Abstract：

AIMS:In patients with type 2 diabetes, non-alcoholic fatty liver disease (NAFLD) and liver fibrosis is frequent and presumably associated with increased cardiovascular disease risk and mortality. The objective was to investigate risk factors associated with hepatic fibrosis in patients with type 2 diabetes and NAFLD to provide a basis for the prevention and treatment. METHODS:Liver stiffness measurements (LSM) expressed in kilopascals (kPa) and controlled attenuation parameter (CAP) expressed in dB/m were diagnosed by transient elastography. Hepatic steatosis and significant fibrosis were defined as having a CAP score ≥ 260 dB/m and an LSM score ≥ 8 kPa, respectively. Associations between fibrosis categories with anthropometric and metabolic variables were determined; then, variables with statistical significance in the univariate analysis were included in multivariate model. RESULTS:A total of 108 participant with type 2 diabetes and NAFLD (mean age: 44.69 ± 5.57 years; mean duration of diabetes 4.68 ± 4.24 years) were recruited. In these patients, body mass index, obesity, fat mass, waist circumferences, resting energy expenditure, CAP score, fasting insulin, C-peptide, HbA1C, hs-CRP as well as liver enzymes and systolic blood pressure and diastolic blood pressure were positively associated with fibrosis (all p < 0.05). Using multivariate logistic regression, serum aspartate aminotransferase (OR 1.12; 95% CI 1.06-1.19), waist circumferences (odds ratio [OR] 1.15; 95% CI 1.05-1.25) and C-peptide (OR 3.81; 95% CI 1.5-9.7) remained as independently associated with liver fibrosis. CONCLUSION:For participants with type 2 diabetes with coexisting NAFLD, stratification by independent risk factors for fibrosis could have important prognostic value.

journal_name

Acta Diabetol

journal_title

Acta diabetologica

authors

Mansour A,Mohajeri-Tehrani MR,Samadi M,Gerami H,Qorbani M,Bellissimo N,Poustchi H,Hekmatdoost A

doi

10.1007/s00592-019-01374-x

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

1199-1207

issue

eissn

0940-5429

issn

1432-5233

pii

10.1007/s00592-019-01374-x

journal_volume

pub_type

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Risk factors for non-alcoholic fatty liver disease-associated hepatic fibrosis in type 2 diabetes patients.