Abstract:
:Kidney volume was measured during pregnancy in insulin-dependent diabetic women by an ultrasound technique and prognostic value of these measurements evaluated. A prospective study was performed on 87 pregnant women with insulin-dependent diabetes attending the maternity clinic of Aarhus Kommunehospital. Patients with proliferative retinopathy alone, hydronephrosis, or nephrotic syndrome were excluded. The patients were grouped according to onset and duration of diabetes and to vascular lesions; group I (n = 35, White class B+C), group II (n = 11, White class D0), group III (n = 26, White class D+), and group IV (n = 15, White class F+F/R). The patients visited the hospital every 2 weeks during pregnancy for general obstetric and glycaemic control and blood sampling. The volume of both kidneys was measured by a computerized nephrosonograph during the three terms of pregnancy, the puerperium and 4 months postpartum. The kidney volume increased significantly in all four groups from first to third trimester. In the third trimester the kidney volumes were 375 +/- 68 ml (I), 341 +/- 50 ml (II), 362 +/- 63 ml (III), and 343 +/- 54 ml (IV). The kidney volume in the third trimester was positively correlated with creatinine clearance (r = 0.33, P < 0.01) and inversely correlated with creatinine in serum (r = -0.27, P = < 0.02). Total kidney volume decrease (in percent) defined as the difference of maximal volume and value at 4 months postpartum was inversely correlated to albuminuria in the third trimester (r = -0.25, P < 0.05) and vascular lesions of the patients: (mean +/- SEM) 37 +/- 4% (I), 25 +/- 7% (II), 19 +/- 5% (III), and 11 +/- 7% (IV), P < 0.01. In the puerperium, kidney volume decreased significantly from third trimester in groups I, II, and III, whereas we observed no change in group IV. Six of 15 women in groups II and III with kidney volume < 300 ml and normoalbuminuria in the first trimester developed persistent microalbuminuria after pregnancy (P < 0.02). The renal volume in insulin-dependent diabetic women increases significantly during pregnancy and is inversely related to the vascular lesions of the patients. The decrease in renal volume after pregnancy is related to the albuminuria at the end of pregnancy. Women with longstanding diabetes, White class D (= groups II+III), and kidney volume < 300 ml in the first trimester have a high risk of developing permanent microalbuminuria after pregnancy.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Lauszus FF,Klebe JG,Rasmussen OW,Klebe TM,Dørup J,Christensen Tdoi
10.1007/BF00576254subject
Has Abstractpub_date
1995-12-01 00:00:00pages
225-9issue
4eissn
0940-5429issn
1432-5233journal_volume
32pub_type
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journal_title:Acta diabetologica
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更新日期:2007-06-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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journal_title:Acta diabetologica
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abstract::To determine the impact of glargine insulin therapy with different nutritional models on key parameters of diabetes including quality of life, behavior in children and adolescents with type 1 diabetes. Age, duration of diabetes, HbA1c, anthropometric data and episodes of severe hypoglycemia were taken from patients' c...
journal_title:Acta diabetologica
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doi:10.1007/s00592-007-0019-2
更新日期:2008-03-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00571935
更新日期:1996-03-01 00:00:00
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更新日期:2018-01-01 00:00:00
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更新日期:2018-01-01 00:00:00
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journal_title:Acta diabetologica
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更新日期:2017-11-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00580752
更新日期:1994-04-01 00:00:00
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journal_title:Acta diabetologica
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更新日期:2003-10-01 00:00:00
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journal_title:Acta diabetologica
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更新日期:2014-02-01 00:00:00
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更新日期:2019-01-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-011-0315-8
更新日期:2014-02-01 00:00:00
abstract:AIMS:Fetuin-A has been linked to insulin resistance and obesity. Its role in the pathogenesis of type 2 diabetes (T2DM) has also been discussed. We aimed to investigate the prospective association of fetuin-A and the risk of T2DM in a systematic review and meta-analysis. METHODS:A systematic search of studies from the...
journal_title:Acta diabetologica
pub_type: 杂志文章,meta分析,评审
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更新日期:2018-01-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章
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更新日期:1998-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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更新日期:2016-04-01 00:00:00
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更新日期:2019-12-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章,评审
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更新日期:2002-04-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-014-0581-3
更新日期:2014-10-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-009-0157-9
更新日期:2010-12-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00572873
更新日期:1993-01-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00592-017-1097-4
更新日期:2018-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00592-014-0661-4
更新日期:2015-04-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00578216
更新日期:1993-01-01 00:00:00
abstract:AIMS:The anti-inflammatory effects of the polyphenol resveratrol in patients with type 2 diabetes mellitus (T2DM) are controversial. Its role on pentraxin 3 (PTX3) concentrations, a human acute phase protein, has never been evaluated. Our aim was to determine whether a two-dosage resveratrol supplementation (500 and 40...
journal_title:Acta diabetologica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00592-017-0977-y
更新日期:2017-05-01 00:00:00
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journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-008-0041-z
更新日期:2008-09-01 00:00:00