Abstract:
AIMS:Fetuin-A has been linked to insulin resistance and obesity. Its role in the pathogenesis of type 2 diabetes (T2DM) has also been discussed. We aimed to investigate the prospective association of fetuin-A and the risk of T2DM in a systematic review and meta-analysis. METHODS:A systematic search of studies from the MEDLINE, EMBASE, Pubmed and Web of Science using fetuin-A, diabetes and various synonyms was conducted up to June 5, 2017. Relevant studies were extracted by two reviewers independently. The quality of studies was assessed using Newcastle-Ottawa scales. Overall estimates were pooled using fixed effect with inverse variance meta-analysis. Subgroup analyses by gender, study population, techniques of assessing fetuin-A, diabetes ascertainment methods, follow-up duration and measures of association were conducted. RESULTS:Seven studies comprising a total of 11,497 individuals and 2176 cases of T2DM were included in the systematic review and meta-analysis. Overall, one SD increment of fetuin-A level was associated with a 23% greater risk of incident T2DM (RR: 1.23, 95% CI 1.16-1.31). No significant heterogeneity or publication bias was found. The association was relatively stable across different subgroups. However, the association seemed only evident in women, but not in men. CONCLUSIONS:Higher circulating fetuin-A levels were associated with increased risk of T2DM. However, the causality deserved further analysis.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Guo VY,Cao B,Cai C,Cheng KK,Cheung BMYdoi
10.1007/s00592-017-1068-9subject
Has Abstractpub_date
2018-01-01 00:00:00pages
87-98issue
1eissn
0940-5429issn
1432-5233pii
10.1007/s00592-017-1068-9journal_volume
55pub_type
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