Abstract:
AIMS:Hyperreflective foci (HF), detected in the retina of diabetic patients, suggest the presence of microglial activation and migration, while controversies still remain for the origin of HF to be precursors of hard exudates. We investigated the presence of HF and their association with dyslipidemia in serous retinal detachment (SRD)-type diabetic macular edema (DME). METHODS:Forty-two eyes in 42 patients with diabetic retinopathy (DR) and 22 eyes in 22 patients with branch retinal vascular occlusion (BRVO) showing macular edema were included in this study. The medical records and OCT findings were retrospectively reviewed in patients with SRD-type DME and compared with those with BRVO. The mean number of HF, the mean choroidal thickness, and lipid profiles were analyzed and compared between groups. RESULTS:The mean number of HF was significantly higher in DR group compared to BRVO group. Significant correlation of HF was noted with triglycerides (r = 0.523, P = 0.002). Triglycerides were significantly associated with HF by linear regression (β = 0.012, 95% CI 0.001-0.024, P = 0.034) and remained significantly associated by multiple linear regression (β = 0.014, 95% CI 0.003-0.025, P = 0.014). CONCLUSIONS:HF on OCT of DME patients could be indicative of activated microglia. HF are associated with dyslipidemia, especially high triglycerides, suggesting inflammatory reaction from dyslipidemia in diabetic retina.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Chung YR,Lee SY,Kim YH,Byeon HE,Kim JH,Lee Kdoi
10.1007/s00592-020-01495-8subject
Has Abstractpub_date
2020-07-01 00:00:00pages
861-866issue
7eissn
0940-5429issn
1432-5233pii
10.1007/s00592-020-01495-8journal_volume
57pub_type
杂志文章abstract::Although the polymorphisms of PTPN22 and the variants of CTLA-4 have been reported to be the susceptibility genes, which increased risk of latent autoimmune diabetes in adults (LADA), the results remained inconclusive. The aim of this meta-analysis was to evaluate the association between the polymorphisms of two genes...
journal_title:Acta diabetologica
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00592-014-0613-z
更新日期:2014-10-01 00:00:00
abstract:AIMS:Fat accumulation in the liver and in the muscle results in hepatic and muscle insulin resistance and has been associated with increased cardiovascular risk. It is unclear whether the individual role of hepatic and muscle insulin resistance in the onset of dyslipidaemia is observed in nonalcoholic fatty liver disea...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-015-0816-y
更新日期:2016-06-01 00:00:00
abstract::Genetic linkage studies of families with early-onset type 2 diabetes have facilitated the identification of diabetes-susceptibility genes. In order to assess the feasibility of using linkage approaches to identify genes responsible for the development of type 2 diabetes in Japanese subjects, we examined our clinical r...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00581039
更新日期:1995-03-01 00:00:00
abstract:AIMS:The relationship between bisphenol A (BPA) and diabetes remains controversial. This study aims to investigate whether serum BPA level could predict the 5-year incidence of type 2 diabetes (T2D). METHODS:A nested case-control study was performed among Chinese who participated in the environment, inflammation and m...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-018-1104-4
更新日期:2018-04-01 00:00:00
abstract::Diabetes mellitus and hyperglycaemia are both independent risk factors (RF) for cardiovascular (CV) events and increased general and CV mortality. Type 2 diabetes, which is often associated with obesity, hypertension and dyslipidaemia, is accompanied by an up to fourfold increase in the incidence of acute coronary hea...
journal_title:Acta diabetologica
pub_type: 共识发展会议,杂志文章
doi:10.1007/s00592-013-0508-4
更新日期:2013-12-01 00:00:00
abstract:AIMS:Increasing evidence suggests a potential role of circulating miRNAs as clinical biomarkers, and loss of miRNA-126 has been proposed as a predictor of type 2 diabetes onset. However, a systematic analysis of circulating miRNAs in type 1 diabetic patients with micro-/macrovascular complications has not yet been perf...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-016-0915-4
更新日期:2017-02-01 00:00:00
abstract::(31)P-magnetic resonance spectroscopy ((31)P-MRS) is a non-invasive tool to study high-energy phosphate (HEP) metabolism. We evaluate whether 31P-MRS can detect early changes in kidney HEP metabolism during a 6-month trial with Valsartan. Twenty consecutive stable and normotensive kidney-transplanted patients were enr...
journal_title:Acta diabetologica
pub_type: 临床试验,杂志文章
doi:10.1007/s00592-012-0369-2
更新日期:2012-12-01 00:00:00
abstract::Insulin resistance is a major factor in the pathogenesis of type 2 diabetes mellitus (T2DM) and is related to the fatty acid profile of the plasma membranes. The purpose of the present study was to investigate fatty acid composition and cholesterol content of cell membranes in patients with type 2 diabetes and, thus, ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-007-0224-4
更新日期:2006-12-01 00:00:00
abstract::MicroRNAs (miRNAs) play a crucial role in the pathogenesis of type 2 diabetes (T2D); they regulate several metabolic pathways including insulin secretion, glucose homeostasis, so their potential as biomarkers of diagnosis and prognosis has became increasingly appreciated. In this study, we explore serum miRNA profiles...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-014-0617-8
更新日期:2014-10-01 00:00:00
abstract:AIMS:Genetic polymorphisms may contribute to platelet reactivity in diabetic patients; however, the information on their influence on long-term antiplatelet therapy is lacking. Our aim was to evaluate the role of previously described genetic variants and platelet reactivity on risk of all-cause mortality and cardiovasc...
journal_title:Acta diabetologica
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00592-016-0945-y
更新日期:2017-04-01 00:00:00
abstract:AIMS:The importance of diabetes-related distress for the treatment of diabetes is emphasised in national and international guidelines recommending routinely screening for psychosocial problems. Data of investigations regarding diabetes-related distress on primary care are rare in Germany though most people with diabete...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-017-0972-3
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:International comparisons of diabetes-related lower extremity amputation rates are still hampered by different criteria used for data collection and analysis. We aimed to evaluate trends and variation of major/minor amputations, using agreed definitions adopted by the Organization for Economic Cooperation an...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-019-01423-5
更新日期:2020-03-01 00:00:00
abstract::The renin-angiotensin system (RAS) has an important role in the endocrine pancreas. Multiple researches have shown that even in the insulin resistance phase, there are many abnormalities in islets morphology and function. This study aimed at investigating the effects of RAS blockade on the islets function in rats with...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-010-0210-8
更新日期:2013-08-01 00:00:00
abstract::Autonomic nervous dysfunction is considered to be one of the mechanisms of metabolic syndrome (MetS). The aim of this study is to investigate whether resting heart rate, a marker of autonomic nervous dysfunction, is a predictor of MetS in apparently healthy non-obese [body mass index (BMI) <25 kg/m(2)] Japanese men. T...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-013-0503-9
更新日期:2014-02-01 00:00:00
abstract::The purpose of this study was to compare bioelectrical impedance analysis (BIA) to hydrostatic weighing (HW) in male weight lifters and body builders. Twenty-two male body builders and weight lifters, 23 +/- 3 years of age (mean +/- SD), were studied to determine the efficacy of BIA to HW in this population. Subjects ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-009-0098-3
更新日期:2010-03-01 00:00:00
abstract::Type 2, non-insulin-dependent diabetes mellitus accounts for 60% of the end-stage renal disease attributed to diabetes in the United States, yet little is known about glomerular function or the development of renal disease in this type of diabetes. The Diabetic Renal Disease Study (DRDS) is a longitudinal study design...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00579717
更新日期:1991-01-01 00:00:00
abstract::The aim of this study is to assess the impact of the internet-based upload blood glucose monitoring and therapy management system (Carelink(®)) in patients with type 1 diabetes. Diabetic patients treated with pump infusion for ≥3 months were prospectively randomized to use the CareLink(®) with (4 months) and without (...
journal_title:Acta diabetologica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00592-013-0510-x
更新日期:2014-04-01 00:00:00
abstract:AIMS:Many authors do not recommend hypoglycemic treatment during pregnancy in women affected by monogenic diabetes due to heterozygous glucokinase (GCK) mutations (MODY 2) in case of affected fetus, because maternal hyperglycemia would be necessary to achieve a normal birthweight. We aimed to evaluate differences in bi...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-018-1198-8
更新日期:2018-12-01 00:00:00
abstract:AIMS:The aims of this study were: to develop new equations for predicting resting energy expenditure (REE) in obese Italian subjects according to body composition parameters; to compare them with predicted values estimated by other REE prediction equations; and to cross-validate our equations using a validation set coh...
journal_title:Acta diabetologica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00592-017-1061-3
更新日期:2018-01-01 00:00:00
abstract::Few studies were performed to evaluate the prevalence of latent autoimmune diabetes in adults (LADA) and the difference of chronic complications between LADA, T1DM, and T2DM in Korean. The aim of this study is to establish the prevalence of LADA in a diabetic clinic of Soonchunhyang University hospital and to compare ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-010-0228-y
更新日期:2013-04-01 00:00:00
abstract::To evaluate ex vivo/in vitro the binding and dissociation characteristics and the level of crossreactivity of insulin antibodies and insulin autoantibodies directed to three different insulin molecules (human, bovine and porcine insulin). In this study sera from 17 diabetic patients were included, who were exclusively...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-008-0041-z
更新日期:2008-09-01 00:00:00
abstract:AIMS:To evaluate the efficacy and safety of intravitreal dexamethasone implant (DEX-implant) for diabetic macular edema (DME) in real-life practice with an extended follow-up for up to 5 year. METHODS:This multicentric retrospective study reviewed 227 eyes of 152 patients with DME treated by DEX-implant. Main outcome ...
journal_title:Acta diabetologica
pub_type: 杂志文章,多中心研究
doi:10.1007/s00592-020-01561-1
更新日期:2020-12-01 00:00:00
abstract::Islet autotransplantation (IAT) is performed at the time of total pancreatectomy (TP) to prevent or minimize post-surgical diabetes. Corticosteroids induce insulin resistance and present a risk to islet autografts, through glucotoxicity and increased metabolic demand on a marginal islet mass. We present four IAT recip...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-011-0315-8
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Psychosocial factors like diabetes distress and social support, as well as the presence of complications, affect an individual's self-management ability; however, their role in adherence behaviours is not yet clear. We examined the role of psychosocial factors and complications in non-adherence behaviours in...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-020-01609-2
更新日期:2020-11-19 00:00:00
abstract::Although the effects of sex, ageing, height, race, and current and past health on pulmonary function tests have been described, only non-significant associations have been observed between body weight and lung function among healthy persons after having accounted for the effects of age and height. However, few studies...
journal_title:Acta diabetologica
pub_type: 杂志文章,评审
doi:10.1007/s00592-003-0023-0
更新日期:2003-10-01 00:00:00
abstract::Administration of exogenous insulin for the treatment of diabetes is often accompanied by the development of insulin antibodies (IA). These antibodies may affect the patient's requirement for insulin by acting as an insulin binding reservoir. The improvement of insulin purification in the 1970s and the development of ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-009-0135-2
更新日期:2010-06-01 00:00:00
abstract::The purification of large numbers of human pancreatic islets remains one of the limiting factors in islet transplantation. This paper describes and validates a method for accurately and reproducibly determining the density of islets and exocrine tissue in pancreatic digest on the basis of their isopycnic distribution ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/BF00572864
更新日期:1993-01-01 00:00:00
abstract:AIMS:Hypoglycaemia represents a critical burden with clinical and social consequences in the management of diabetes. Serum uric acid (SUA) has been associated with cardiovascular diseases (CVD), but no conclusive findings are available nowadays in patients suffering from hypoglycaemia. We investigated whether SUA level...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-017-1094-7
更新日期:2018-04-01 00:00:00
abstract::The aim of the present work was to investigate the impact of gender on resting cerebral blood flow velocity and cerebrovascular reserve capacity among diabetic patients. Middle cerebral artery mean blood flow velocity (MCAV) was measured in 72 patients suffering from type 1 diabetes mellitus at rest and 5, 10, 15 and ...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s005920170006
更新日期:2001-01-01 00:00:00
abstract::The aim of this study was to test whether the augmentation index adjusted for heart rate (AIx@HR75) can be used as a substitute for aortic pulse wave velocity (aPWV) in the measurement of arterial stiffness (AS) in type 1 diabetes. Sixty-eight patients with type 1 diabetes and 68 age- and sex-matched controls were eva...
journal_title:Acta diabetologica
pub_type: 杂志文章
doi:10.1007/s00592-012-0433-y
更新日期:2012-12-01 00:00:00