当前位置： SCI文献检索 > ACTA DIABETOLOGICA期刊下所有文献 > Joint and distinct risk factors associated with micro- and macrovascular complications in a cohort of type 2 diabetic patients cared through disease management.

Joint and distinct risk factors associated with micro- and macrovascular complications in a cohort of type 2 diabetic patients cared through disease management.

Abstract：

:We analysed the risk factors associated with diabetic complications in the cohort of patients assisted by a type 2 diabetes mellitus (T2DM) shared-care program. We analysed registry data from 16,136 T2DM patients. Of them, 4,781 had microangiopathy, 3,469 CV events. They were 70.5 ± 17.1 years old, 50% were male, disease duration 13.3 ± 7.8 years, BMI 28.7 ± 4.9 kg/m², HbA1c 7.08 ± 1.23%, FBG 134.7 ± 35.7 mg/dl, 2hPPBG 163.9 ± 47.8 mg/dl, 12.5% smokers. Cholesterol 202.5 ± 37.6 mg/dl, HDL 51.4 ± 20.4 mg/dl, LDL 126.5 ± 36.0 mg/dl, triglyceride 146.2 ± 72.4 mg/dl, SBP 137.8 ± 14.2 mmHg, DBP 80.7 ± 10.8 mmHg, 10-year CV risk score 13.7 ± 9.1; 70.4% had no microangiopathy-i.e. renal, retinal, peripheral nerve disease-and 78.5% of patients had no CV events. Age-adjusted risk factors associated with diabetic complications were male gender, HbA1c, 2hPPBG, HDL, and triglyceride. FBG and SBP were associated with microangiopathy, whereas smoking with cardiovascular events. Optimal targets were reached in: FBG 17%, 2hPPBG 8%, HbA1c 21%, cholesterol 17%, HDL 8%, LDL 5%, triglyceride 20%, SBP 13%, DBP 30%. Drug profiles showed 13% using metformin, 28% sulphonilureas, 26% bitherapy, 4% insulin; 12% statins, 16% anti-platelets, 27% anti-hypertensives, 2% anti-coagulants. T2DM patients showed an acceptable CV risk profile. Joint risk factors for diabetic complications were male gender, HbA1c, 2hPPBG, HDL, and triglyceride. Distinct risk factors were FBG and SBP for micro- and smoking for macrovascular disease. A targeted-to-treat approach needs more attention in the care of T2DM patients.

journal_name

Acta Diabetol

journal_title

Acta diabetologica

authors

Ciardullo AV,Daghio MM,Bevini M,Feltri G,Novi D,Fattori G,Borsari S,Donato CD

doi

10.1007/s00592-010-0186-4

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

301-8

issue

4

eissn

0940-5429

issn

1432-5233

journal_volume

47

pub_type

杂志文章

相关文献

ACTA DIABETOLOGICA文献大全
  • Accelerated gastric emptying during hypoglycaemia is not associated with changes in plasma motilin levels.

    abstract：:This study examined whether or not changes in plasma concentrations of motilin and other gastrointestinal hormones known to affect gastric motility are associated with the accelerated gastric emptying seen during hypoglycaemia. While studying gastric emptying by scintigraphy in eight healthy subjects, the plasma conce...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s005920050073

    authors： Schvarcz E,Palmér M,Aman J,Berne C

    更新日期：1997-10-01 00:00:00

  • Clinical reliability of multi-drug intracavernous vasoactive pharmacotherapy for diabetic impotence.

    abstract：:The aim of this study was to assess the effectiveness and safety of intracavernous injections of a four-drug vasoactive mixture in diabetic patients with organic impotence. A group of 60 diabetic patients with either pure neurogenic, pure vasculogenic or mixed neurovasculogenic impotence were treated with intracaverno...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/BF00580752

    authors： Montorsi F,Guazzoni G,Bergamaschi F,Zucconi M,Rigatti P,Pizzini G,Miani A,Pozza G

    更新日期：1994-04-01 00:00:00

  • Increased risk of severe diabetic ketoacidosis among Jewish ultra-orthodox children.

    abstract：AIMS:Diabetic ketoacidosis (DKA) at diabetes diagnosis is a dangerous yet potentially preventable condition. Young age, low socioeconomic status, and low parental education have been found to be associated with increased risk of DKA. We aimed to evaluate the impact of religious affiliation on presentation with DKA at t...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-014-0653-4

    authors： Gruber N,Reichman B,Lerner-Geva L,Pinhas-Hamiel O

    更新日期：2015-04-01 00:00:00

  • Metabolic syndrome: its history, mechanisms, and limitations.

    abstract：:In late twentieth century, Ruderman and Reaven showed that insulin resistance might be fundamental to metabolic syndrome (MetS) which means a constellation of obesity-related metabolic derangements predisposing to type 2 diabetes and cardiovascular disease. In 2001, user-friendly National Cholesterol Education Program...

    journal_title：Acta diabetologica

    pub_type： 历史文章,杂志文章,评审

    doi：10.1007/s00592-011-0309-6

    authors： Oda E

    更新日期：2012-04-01 00:00:00

  • Role of the PKCβII/JNK signaling pathway in acute glucose fluctuation-induced apoptosis of rat vascular endothelial cells.

    abstract：AIMS:The purpose of this study was to investigate the mechanism of vascular endothelial cell apoptosis induced by acute blood glucose fluctuation. METHODS:Thirty rats were assigned to three groups: normal saline (SAL group), constant high glucose (CHG group) and acute blood glucose fluctuation (AFG) group. Other forty...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-017-0999-5

    authors： Wu N,Shen H,Wang Y,He B,Zhang Y,Bai Y,Du R,Du Q,Han P

    更新日期：2017-08-01 00:00:00

  • Glycaemic load versus carbohydrate counting for insulin bolus calculation in patients with type 1 diabetes on insulin pump.

    abstract：AIMS:To evaluate feasibility and effectiveness on short-term blood glucose control of using glycaemic load counting (GLC) versus carbohydrate counting (CC) for prandial insulin dosing in patients with type 1 diabetes (T1D). METHODS:Nine T1D patients on insulin pump, aged 26-58 years, HbA1c 7.7 ± 0.8 % (61 ± 8.7 mmol/m...

    journal_title：Acta diabetologica

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00592-015-0716-1

    authors： Bozzetto L,Giorgini M,Alderisio A,Costagliola L,Giacco A,Riccardi G,Rivellese AA,Annuzzi G

    更新日期：2015-10-01 00:00:00

  • Diabetes and the risk of sudden cardiac death, the Atherosclerosis Risk in Communities study.

    abstract：:Studies suggest that diabetes may specifically elevate the risk of sudden cardiac death in excess of other heart disease outcomes. In this study, we examined the association of type 2 diabetes with the incidence of sudden cardiac death when compared to the incidence of non-sudden cardiac death and non-fatal myocardial...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-009-0157-9

    authors： Kucharska-Newton AM,Couper DJ,Pankow JS,Prineas RJ,Rea TD,Sotoodehnia N,Chakravarti A,Folsom AR,Siscovick DS,Rosamond WD

    更新日期：2010-12-01 00:00:00

  • Comparison of insulin monotherapy and combination therapy with insulin and metformin or insulin and rosiglitazone or insulin and acarbose in type 2 diabetes.

    abstract：:The aim of this study was to compare the efficacy of treatment with insulin alone, insulin plus acarbose, insulin plus metformin, or insulin plus rosiglitazone in type 2 diabetic subjects who were previously on insulin monotherapy, and to evaluate the effects of these treatments on cardiovascular risk factors includin...

    journal_title：Acta diabetologica

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00592-007-0004-9

    authors： Yilmaz H,Gursoy A,Sahin M,Guvener Demirag N

    更新日期：2007-12-01 00:00:00

  • Glomerular endothelial cells versus podocytes as the cellular target in diabetic nephropathy.

    abstract：:It usually takes several years (in some cases, decades) for predisposed individuals to move from the onset of type 1 or type 2 diabetes to the development of microalbuminuria, the first sign of diabetic nephropathy. This long, complication-free, period represents the best possible moment to start a successful preventi...

    journal_title：Acta diabetologica

    pub_type： 杂志文章,评审

    doi：10.1007/s00592-018-1211-2

    authors： Maestroni S,Zerbini G

    更新日期：2018-11-01 00:00:00

  • Long-term fat-feeding-induced insulin resistance in normal NMRI mice: postreceptor changes of liver, muscle and adipose tissue metabolism resembling those of type 2 diabetes.

    abstract：:Postreceptor insulin resistance was studied in liver, muscle and adipose tissue from NMRI mice of both sexes made diabetic by long-term fat-feeding. Intravenous glucose tolerance tests showed a combination of impaired glucose tolerance and increased plasma insulin concentrations consistent with insulin resistance and ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/BF00572823

    authors： Hedeskov CJ,Capito K,Islin H,Hansen SE,Thams P

    更新日期：1992-01-01 00:00:00

  • Effects of 6 months of resveratrol versus placebo on pentraxin 3 in patients with type 2 diabetes mellitus: a double-blind randomized controlled trial.

    abstract：AIMS:The anti-inflammatory effects of the polyphenol resveratrol in patients with type 2 diabetes mellitus (T2DM) are controversial. Its role on pentraxin 3 (PTX3) concentrations, a human acute phase protein, has never been evaluated. Our aim was to determine whether a two-dosage resveratrol supplementation (500 and 40...

    journal_title：Acta diabetologica

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00592-017-0977-y

    authors： Bo S,Ponzo V,Evangelista A,Ciccone G,Goitre I,Saba F,Procopio M,Cassader M,Gambino R

    更新日期：2017-05-01 00:00:00

  • Prospective study of cytomegalovirus seropositivity and risk of mortality from diabetes.

    abstract：:Cytomegalovirus (CMV) infects 40 % of the world population and has been suggested to be associated with diabetes; however, no prospective study has ever examined diabetes mortality associated with the infection. A cohort of 14,404 non-diabetic adult participants aged 17-90 years from the Third National Health and Nutr...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-014-0573-3

    authors： Mendy A,Gasana J,Vieira ER,Diallo H

    更新日期：2014-10-01 00:00:00

  • Expression of lysophosphatidic acid, autotaxin and acylglycerol kinase as biomarkers in diabetic retinopathy.

    abstract：:The proinflammatory lysophosphatidic acid (LPA) is a potent activator of several transcriptional factors and signaling pathways and a potent modulator of genes involved in inflammation, angiogenesis and fibrosis. This study was conducted to measure the levels of LPA and LPA-producing enzymes, autotaxin (ATX) and acylg...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-012-0422-1

    authors： Abu El-Asrar AM,Mohammad G,Nawaz MI,Siddiquei MM,Kangave D,Opdenakker G

    更新日期：2013-06-01 00:00:00

  • Profile of patients with diabetes in Eritrea: results of first phase registry analyses.

    abstract：:A cross-sectional descriptive study was done on patients recently entered into the National Diabetes Registry in Eritrea where the prevalence was estimated to be 2.2% based on patient information in 2004. Of the 627 patients with diabetes, two thirds were type 2. Although type 1 had poorer control (42.9%) than type 2 ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-009-0093-8

    authors： Seyum B,Mebrahtu G,Usman A,Mufunda J,Tewolde B,Haile S,Kosia A,Negassi E

    更新日期：2010-03-01 00:00:00

  • Effects of intermittent high glucose on oxidative stress in endothelial cells.

    abstract：:The objective of this study is to explore the mechanism of oxidative stress induced by intermittent high glucose in porcine iliac endothelial cells (PIECs). The PIECs were exposed to intermittent or constant high glucose for 3 or 6 days, and the mean fluorescent intensity (MFI) was measured via intracellular reactive ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-009-0140-5

    authors： Ge QM,Dong Y,Zhang HM,Su Q

    更新日期：2010-12-01 00:00:00

  • Fenofibrate prevents the disruption of the outer blood retinal barrier through downregulation of NF-κB activity.

    abstract：AIMS:There is clinical evidence that fenofibrate, a PPARα agonist, arrests the progression of diabetic macular edema (DME). However, the underlying mechanisms of this beneficial effect remain to be elucidated. We previously reported that fenofibric acid (FA), the active metabolite of fenofibrate, prevents the disorgani...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-015-0759-3

    authors： Garcia-Ramírez M,Hernández C,Palomer X,Vázquez-Carrera M,Simó R

    更新日期：2016-02-01 00:00:00

  • Effect of dietary supplementation with the pyridoindole antioxidant stobadine on antioxidant state and ultrastructure of diabetic rat myocardium.

    abstract：:Consistent with the postulated role of oxidative stress in the etiology of late diabetic complications, pharmacological interventions based on biological antioxidants have been suggested. The aim of the present study was to investigate the effect of dietary supplementation with the pyridoindole antioxidant stobadine o...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s005920070012

    authors： Stefek M,Sotnikova R,Okruhlicova L,Volkovova K,Kucharska J,Gajdosik A,Gajdosikova A,Mihalova D,Hozova R,Tribulova N,Gvozdjakova A

    更新日期：2000-01-01 00:00:00

  • Macrophage-derived cytokine and nitric oxide profiles in type I and type II diabetes mellitus: effect of thymoquinone.

    abstract：:Comparing macrophage-derived cytokine and nitric oxide (NO) profiles in type I and type II diabetes mellitus (DM); and determining whether thymoquinone (TQ) has any modulatory effect were the main objectives of the present study. Peritoneal macrophages have been collected from Otsuka Long-Evans Tokushima Fatty (OLETF)...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-005-0170-6

    authors： El-Mahmoudy A,Shimizu Y,Shiina T,Matsuyama H,Nikami H,Takewaki T

    更新日期：2005-03-01 00:00:00

  • An in-depth assessment of diabetes-related lower extremity amputation rates 2000-2013 delivered by twenty-one countries for the data collection 2015 of the Organization for Economic Cooperation and Development (OECD).

    abstract：BACKGROUND:International comparisons of diabetes-related lower extremity amputation rates are still hampered by different criteria used for data collection and analysis. We aimed to evaluate trends and variation of major/minor amputations, using agreed definitions adopted by the Organization for Economic Cooperation an...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-019-01423-5

    authors： Carinci F,Uccioli L,Massi Benedetti M,Klazinga NS

    更新日期：2020-03-01 00:00:00

  • Clinical manifestation and islet β-cell function of a subtype of latent autoimmune diabetes in adults (LADA): positive for T cell responses in phenotypic type 2 diabetes.

    abstract：AIMS:To investigate the possibility of identifying a subtype of latent autoimmune diabetes in adults (LADA), T-LADA (T cell responses-positive and autoantibody-negative) from patients with phenotypic type 2 diabetes (T2D) by enzyme-linked immunospot (ELISPOT). METHODS:Eighty-two patients with phenotypic T2D were studi...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-019-01391-w

    authors： Liang H,Cheng Y,Tang W,Cui Q,Yuan J,Huang G,Yang L,Zhou Z

    更新日期：2019-11-01 00:00:00

  • Hepatic insulin resistance in NAFLD: relationship with markers of atherosclerosis and metabolic syndrome components.

    abstract：AIMS:Fat accumulation in the liver and in the muscle results in hepatic and muscle insulin resistance and has been associated with increased cardiovascular risk. It is unclear whether the individual role of hepatic and muscle insulin resistance in the onset of dyslipidaemia is observed in nonalcoholic fatty liver disea...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-015-0816-y

    authors： Privitera G,Spadaro L,Alagona C,Calanna S,Piro S,Rabuazzo AM,Purrello F

    更新日期：2016-06-01 00:00:00

  • Murine monoclonal glutamic acid decarboxylase (GAD)65 antibodies recognize autoimmune-associated GAD epitope regions targeted in patients with type 1 diabetes mellitus and stiff-man syndrome.

    abstract：:To study the immune response to glutamic acid decarboxylase (GAD) in insulin-dependent diabetes mellitus, monoclonal GAD antibodies after fusion of splenocytes from a nondiabetes-susceptible BALB/c mouse immunized with human recombinant GAD65 were generated. Of the 44 monoclonals, 35 are specific for the GAD65 isoform...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/BF02048548

    authors： Ziegler B,Schlosser M,Lühder F,Strebelow M,Augstein P,Northemann W,Powers AC,Ziegler M

    更新日期：1996-09-01 00:00:00

  • Major childhood infectious diseases and other determinants associated with type 1 diabetes: a case-control study.

    abstract：:The objective of the study was to evaluate the association between infectious diseases and other events pertaining to childhood medical history and type 1 diabetes. A case-control study was carried out, taking as cases 159 type 1 diabetic patients (0-29 years) recorded from 1988 to 2000 within the population registry ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-007-0235-9

    authors： Tenconi MT,Devoti G,Comelli M,Pinon M,Capocchiano A,Calcaterra V,Pretti G,Pavia T1DM Registry Group.

    更新日期：2007-03-01 00:00:00

  • Rosiglitazone decreases fasting plasma peptide YY3-36 in type 2 diabetic women: a possible role in weight gain?

    abstract：:Rosiglitazone often results in weight gain. We hypothesized that rosiglitazone may modulate circulating levels of ghrelin and peptide YY(3-36) and this modulation may be related to weight-gaining effect of this agent. This study was designed as an open-label, randomized, controlled trial of 3-month duration. Women wit...

    journal_title：Acta diabetologica

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00592-011-0352-3

    authors： Berberoglu Z,Yazici AC,Bayraktar N,Demirag NG

    更新日期：2012-12-01 00:00:00

  • Failure of glycated hemoglobin drop after continuous subcutaneous insulin infusion initiation may indicate patients who discontinue: a 4-year follow-up study in children and adolescents with type 1 diabetes.

    abstract：:Continuous subcutaneous insulin infusion (CSII) is effective and safe in children and adults with type 1 diabetes. Notwithstanding, some patients decide to discontinue using CSII. We evaluated the discontinuation rate, and its related factors, in a large group of children and adolescents with type 1 diabetes using CSI...

    journal_title：Acta diabetologica

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00592-011-0344-3

    authors： Lombardo F,Scaramuzza AE,Iafusco D

    更新日期：2012-12-01 00:00:00

  • Effect of TNF-alpha inhibition on urinary albumin excretion in experimental diabetic rats.

    abstract：:The objective is to assess the effect of TNF-alpha inhibition on urinary albumin excretion in experimental diabetic rats. Male Wistar rats, 8-week-old, were categorized into four groups, which were the control (n = 9), diabetes (n = 9), infliximab-treated diabetes (n = 10), and FR167653-treated diabetes (n = 9) groups...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-007-0007-6

    authors： Moriwaki Y,Inokuchi T,Yamamoto A,Ka T,Tsutsumi Z,Takahashi S,Yamamoto T

    更新日期：2007-12-01 00:00:00

  • Early infant feeding and risk of developing islet autoimmunity and type 1 diabetes.

    abstract：:We investigated whether food supplementation within the first year life or age at introduction of gluten-containing foods influenced the risk of developing islet autoimmunity and type 1 diabetes. A total of 2,291 children with a family history of type 1 diabetes were prospectively followed from birth for 28,983 patien...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-014-0628-5

    authors： Chmiel R,Beyerlein A,Knopff A,Hummel S,Ziegler AG,Winkler C

    更新日期：2015-06-01 00:00:00

  • Deterioration of glycemic control after corticosteroid administration in islet autotransplant recipients: a cautionary tale.

    abstract：:Islet autotransplantation (IAT) is performed at the time of total pancreatectomy (TP) to prevent or minimize post-surgical diabetes. Corticosteroids induce insulin resistance and present a risk to islet autografts, through glucotoxicity and increased metabolic demand on a marginal islet mass. We present four IAT recip...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-011-0315-8

    authors： Ngo A,Sutherland DE,Beilman GJ,Bellin MD

    更新日期：2014-02-01 00:00:00

  • Lack of gender difference in acetazolamide-induced cerebral vasomotor reactivity in patients suffering from type-1 diabetes mellitus.

    abstract：:The aim of the present work was to investigate the impact of gender on resting cerebral blood flow velocity and cerebrovascular reserve capacity among diabetic patients. Middle cerebral artery mean blood flow velocity (MCAV) was measured in 72 patients suffering from type 1 diabetes mellitus at rest and 5, 10, 15 and ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s005920170006

    authors： Fülesdi B,Limburg M,Oláh L,Bereczki D,Csiba L,Kollár J

    更新日期：2001-01-01 00:00:00

  • Sleep quality and risk of diabetes and coronary artery disease among young men.

    abstract：AIMS:To assess the time-dependent effect of sleep quality on diabetes and coronary artery disease (CAD) incidence among young adults. METHODS:Incident rates of diabetes and CAD during a mean follow-up of 6.4 ± 4.1 years were assessed among 26,023 men (mean age 30.9 ± 5.6 years) of the Metabolic Lifestyle and Nutrition...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-015-0779-z

    authors： Twig G,Shina A,Afek A,Derazne E,Tzur D,Cukierman-Yaffe T,Shechter-Amir D,Gerstein HC,Tirosh A

    更新日期：2016-04-01 00:00:00