当前位置： SCI文献检索 > ACTA DIABETOLOGICA期刊下所有文献 > Starting bedtime glargine versus NPH insulin in poorly controlled type 2 diabetic patients with various hyperglycemia types (fasting type or postprandial type).

Starting bedtime glargine versus NPH insulin in poorly controlled type 2 diabetic patients with various hyperglycemia types (fasting type or postprandial type).

Abstract：

:Our aim was to compare the effects of an intermediate acting human insulin (NPH) and a long-acting insulin analog, insulin glargine, in insulin naïve type 2 diabetes patients, stratified by the type of hyperglycemia (fasting or postprandial type). Based on different action profiles, we hypothesized that patients having different hyperglycemia types would react differently when treated with these insulins. This is a post hoc analysis of the Lanmet study data. The Lanmet study was a randomized, 36-week controlled insulin initiation study in type 2 diabetes patients. 109 subjects with baseline HbA1c >8.0% (64 mmol/mol) completed the study. The patients were divided into two groups according to fasting glucose (mmol/l)/HbA1c (%) ratio. Patients with a ratio ≥1.3 were defined as having fasting type and those with a ratio <1.3 as having postprandial type hyperglycemia. The main outcome measures were change in HbA1c and body weight, and final insulin dose. Independently of insulin type, compared to patients with postprandial type hyperglycemia, those with fasting type hyperglycemia had 2.1 kg/m(2) greater initial BMI (p = 0.044), gained 2.0 kg more weight (p = 0.020, adjusted for baseline BMI p = 0.035), and had 36% greater final insulin dose/kg (p = 0.001). With respect to hyperglycemia type, there was no difference between NPH and glargine in their effects on HbA1c. When starting bedtime insulin in type 2 diabetes patients, those with fasting type hyperglycemia are prone to greater weight gain. Hyperglycemia type does not help in identifying patients who would benefit specially from either NPH insulin or insulin glargine.

journal_name

Acta Diabetol

journal_title

Acta diabetologica

authors

Vähätalo MA,Viikari J,Rönnemaa T

doi

10.1007/s00592-013-0505-7

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

233-8

issue

2

eissn

0940-5429

issn

1432-5233

journal_volume

51

pub_type

杂志文章,随机对照试验

相关文献

ACTA DIABETOLOGICA文献大全
  • Serum ferritin, diabetes, diabetes control, and insulin resistance.

    abstract：AIMS:The present study aims to investigate the association between serum ferritin and diabetes, diabetes control, and insulin resistance (IR) and examine whether gender is a modifier for these associations in a community-based sample. METHODS:A cross-sectional survey of 8,235 participants was conducted in 2009. Serum ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-014-0656-1

    authors： Zhan Y,Tang Z,Yu J

    更新日期：2014-12-01 00:00:00

  • Plasma copeptin is associated with type 2 diabetes in men but not in women in the population-based KORA F4 study.

    abstract：:Elevated plasma CT-pro-vasopressin (copeptin) has been described as biomarkers for type 2 diabetes (T2D) and the metabolic syndrome (MetS), which, however, was not confirmed by all studies. Here, we analyzed the association of copeptin with T2D, MetS and MetS components in the population-based KORA F4 study. Plasma co...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-014-0609-8

    authors： Then C,Kowall B,Lechner A,Meisinger C,Heier M,Koenig W,Peters A,Rathmann W,Seissler J

    更新日期：2015-02-01 00:00:00

  • Long-term follow-up of diabetic macular edema treated with dexamethasone implant: a real-life study.

    abstract：AIMS:To evaluate the efficacy and safety of intravitreal dexamethasone implant (DEX-implant) for diabetic macular edema (DME) in real-life practice with an extended follow-up for up to 5 year. METHODS:This multicentric retrospective study reviewed 227 eyes of 152 patients with DME treated by DEX-implant. Main outcome ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00592-020-01561-1

    authors： Mathis T,Lereuil T,Abukashabah A,Voirin N,Sudhalkar A,Bilgic A,Denis P,Dot C,Kodjikian L

    更新日期：2020-12-01 00:00:00

  • Impaired in vivo insulin secretion in response to non-glucidic secretagogues in adult rats after neonatal streptozotocin.

    abstract：:In the perfused pancreas of adult rats that were injected with streptozotocin (STZ) during the neonatal period, the release of insulin caused by glucose is more severely affected than that evoked by other secretagogues. We have now examined whether a comparable situation prevails in vivo. In anesthetised rats, the 0-1...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/BF00570366

    authors： Vicent D,Villanueva-Peñacarrillo ML,Valverde I,Malaisse WJ

    更新日期：1994-09-01 00:00:00

  • DPP-4 inhibitors for the treatment of type 2 diabetes: a methodology overview of systematic reviews.

    abstract：AIMS:To evaluate the methodological quality of systematic reviews (SRs), and summarize evidence of important outcomes from dipeptidyl peptidase-4 inhibitors (DPP4-I) in treating type 2 diabetes mellitus (T2DM). METHODS:We included SRs of DPP4-I for the treatment of T2DM until January, 2018 by searching the Cochrane Li...

    journal_title：Acta diabetologica

    pub_type： 杂志文章,评审

    doi：10.1007/s00592-018-1164-5

    authors： Ling J,Ge L,Zhang DH,Wang YF,Xie ZL,Tian JH,Xiao XH,Yang KH

    更新日期：2019-01-01 00:00:00

  • Examining trends in prediabetes and its relationship with the metabolic syndrome in US adolescents, 1999-2014.

    abstract：AIMS:We sought to investigate temporal trends in prediabetes prevalence among US adolescents using two definitions and evaluate relationships with obesity and a MetS-severity score. METHODS:We evaluated data from 5418 non-Hispanic white, non-Hispanic black, and Hispanic adolescents aged 12-19 participating in the Nati...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-016-0958-6

    authors： Lee AM,Fermin CR,Filipp SL,Gurka MJ,DeBoer MD

    更新日期：2017-04-01 00:00:00

  • Renal function in non-insulin-dependent diabetes mellitus: purposes and design of the Diabetic Renal Disease Study.

    abstract：:Type 2, non-insulin-dependent diabetes mellitus accounts for 60% of the end-stage renal disease attributed to diabetes in the United States, yet little is known about glomerular function or the development of renal disease in this type of diabetes. The Diabetic Renal Disease Study (DRDS) is a longitudinal study design...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/BF00579717

    authors： Nelson RG

    更新日期：1991-01-01 00:00:00

  • Identification of megakaryocytes as a target of advanced glycation end products in diabetic complications in bone marrow.

    abstract：AIMS:To define the possible effect of diabetic conditions on megakaryocytes, the long-know precursors of platelets and lately characterized modulator of hematopoietic stem quiescence-activation transition. METHODS:Megakaryoblastic MEG-01 cell culture and TPO/SCF/IL-3-induced differentiation of human umbilical blood mo...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-018-1109-z

    authors： Wang B,Yu J,Wang T,Shen Y,Lin D,Xu X,Wang Y

    更新日期：2018-05-01 00:00:00

  • Relationship between serum apolipoproteins levels and retinopathy risk in subjects with type 2 diabetes mellitus.

    abstract：AIMS:Prognostic significance of apolipoproteins in diabetic retinopathy risk has not been well investigated. The aim of this study was to reveal the relationship between the risk of diabetic retinopathy and the levels of several apolipoproteins and their ratios in a 10-year prospective cohort. METHODS:A total of 1023 ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-018-1136-9

    authors： Zhang Q,Hu J,Hu Y,Ding Y,Zhu J,Zhuang C

    更新日期：2018-07-01 00:00:00

  • Markers of insulin resistance are associated with cardiovascular morbidity and predict overall mortality in long-standing non-insulin-dependent diabetes mellitus.

    abstract：:The aim of this study was to evaluate the influence of endogenous insulin levels and of insulin administration on coronary heart disease (CHD) and on mortality in a cohort of patients with long-standing non-insulin-dependent diabetes mellitus (type 2). In a cross-sectional study, 93 patients (known duration 17 +/- 8 y...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s005920050101

    authors： Pontiroli AE,Pacchioni M,Camisasca R,Lattanzio R

    更新日期：1998-04-01 00:00:00

  • Soybean oil treatment impairs glucose-stimulated insulin secretion and changes fatty acid composition of normal and diabetic islets.

    abstract：:We investigated the effect of sub-chronic soybean oil (SO) treatment on the insulin secretion and fatty acid composition of islets of Langerhans obtained from Goto-Kakizaki (GK), a model of type 2 diabetes, and normal Wistar rats. We observed that soybean-treated Wistar rats present insulin resistance and defective is...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-007-0252-8

    authors： Nunes E,Peixoto F,Louro T,Sena CM,Santos MS,Matafome P,Moreira PI,Seiça R

    更新日期：2007-09-01 00:00:00

  • Anticoagulant protein C activity in non-insulin-dependent diabetic patients with normoalbuminuria and microalbuminuria.

    abstract：:Microalbuminuria in diabetic patients is associated with an increased cardiovascular risk which is not completely explained by an excess of conventional cardiovascular risk factors. A depression of physiologic inhibitors of blood coagulation could contribute to a thrombophilic state and to cardiovascular complications...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/BF00569567

    authors： Veglio M,Gruden G,Mormile A,Girotto M,Rossetto P,D'Este P,Cavallo-Perin P

    更新日期：1995-06-01 00:00:00

  • NETosis is induced by high glucose and associated with type 2 diabetes.

    abstract：AIMS:The role of neutrophils in diabetes and its complications is unclear. Upon challenge with microbes and inflammatory triggers, neutrophils release enzymes and nuclear material, forming neutrophils extracellular traps (NETs) and thereby dying by NETosis. We herein tested NET formation and NETosis products in high gl...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-014-0676-x

    authors： Menegazzo L,Ciciliot S,Poncina N,Mazzucato M,Persano M,Bonora B,Albiero M,Vigili de Kreutzenberg S,Avogaro A,Fadini GP

    更新日期：2015-06-01 00:00:00

  • The 16-year incidence, progression and regression of diabetic retinopathy in a young population-based Danish cohort with type 1 diabetes mellitus: The Danish cohort of pediatric diabetes 1987 (DCPD1987).

    abstract：:The aim was to investigate the long-term incidence of proliferative diabetic retinopathy (PDR), and progression and regression of diabetic retinopathy (DR) and associated risk factors in young Danish patients with Type 1 diabetes mellitus. In 1987-89, a pediatric cohort involving approximately 75 % of all children wit...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-013-0527-1

    authors： Broe R,Rasmussen ML,Frydkjaer-Olsen U,Olsen BS,Mortensen HB,Peto T,Grauslund J

    更新日期：2014-01-01 00:00:00

  • Total bilirubin is inversely associated with metabolic syndrome but not a risk factor for metabolic syndrome in Japanese men and women.

    abstract：:Serum total bilirubin (TB) is a potent antioxidant and inversely associated with metabolic syndrome (MetS) in Asian populations. However, there has been no study which is aimed to investigate whether TB is a risk factor for MetS or not. We investigated cross-sectional and longitudinal associations between TB and MetS ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-012-0447-5

    authors： Oda E,Aizawa Y

    更新日期：2013-06-01 00:00:00

  • Myocardial dysfunction and chronic heart failure in patients with long-lasting type 1 diabetes: a 7-year prospective cohort study.

    abstract：:The aim of the study is to evaluate the prevalence and incidence of myocardial dysfunction (MD) and heart failure (HF) in long-lasting (≥10 years) type 1 diabetes without cardiovascular disorders or with hypertension or coronary heart disease (CHD). The study included 1,685 patients with type 1 diabetes (mean baseline...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-013-0455-0

    authors： Konduracka E,Cieslik G,Galicka-Latala D,Rostoff P,Pietrucha A,Latacz P,Gajos G,Malecki MT,Nessler J

    更新日期：2013-08-01 00:00:00

  • Endothelial nitric oxide synthase gene polymorphism and type 2 diabetic retinopathy among Asian Indians.

    abstract：:Endothelial nitric oxide synthase (eNOS) has been shown to play an essential role in retinal vascular function, and disequilibrium in its production can lead to diabetic retinopathy (DR). Genetic polymorphisms of eNOS gene have been suggested to play a role in nitric oxide (NO) abnormalities which may contribute to th...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-012-0437-7

    authors： Cheema BS,kohli HS,Sharma R,Bhansali A,Khullar M

    更新日期：2012-12-01 00:00:00

  • Breastfeeding is protective to diabetes risk in young adults: a longitudinal study.

    abstract：AIM:It is unclear whether any breastfeeding or a certain duration of breastfeeding is protective against the development of diabetes in adult offspring. METHODS:We followed a sub-sample of 3,595 offspring born in the Mater Hospital in Brisbane, Australia between 1981 and 1983 and for whom we had doctor diagnosed self-...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-014-0690-z

    authors： Al Mamun A,O'Callaghan MJ,Williams GM,Najman JM,Callaway L,McIntyre HD

    更新日期：2015-10-01 00:00:00

  • The effect of insulin glargine and nutritional model on metabolic control, quality of life and behavior in children and adolescents with type 1 diabetes mellitus.

    abstract：:To determine the impact of glargine insulin therapy with different nutritional models on key parameters of diabetes including quality of life, behavior in children and adolescents with type 1 diabetes. Age, duration of diabetes, HbA1c, anthropometric data and episodes of severe hypoglycemia were taken from patients' c...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-007-0019-2

    authors： Goksen D,Darcan S,Buyukinan M,Köse T,Erermis S,Coker M

    更新日期：2008-03-01 00:00:00

  • Diabetes-related burden and distress in people with diabetes mellitus at primary care level in Germany.

    abstract：AIMS:The importance of diabetes-related distress for the treatment of diabetes is emphasised in national and international guidelines recommending routinely screening for psychosocial problems. Data of investigations regarding diabetes-related distress on primary care are rare in Germany though most people with diabete...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-017-0972-3

    authors： Kuniss N,Rechtacek T,Kloos C,Müller UA,Roth J,Burghardt K,Kramer G

    更新日期：2017-05-01 00:00:00

  • Blood glucose self-monitoring from abdominal skin: a precise and virtually pain-free method.

    abstract：:For many diabetic patients, years of blood glucose self-monitoring (SM) with readings taken several times daily is an inevitable aspect of insulin therapy. We investigated whether SM from abdominal skin might be an alternative to the established fingertip method. A total of 63 diabetic patients and 16 nondiabetic volu...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s005920200020

    authors： Holstein A,Thiessen E,Kaufmann N,Plaschke A,Egberts EH

    更新日期：2002-06-01 00:00:00

  • Glycemic control and clinic attendance of emerging adults with type 1 diabetes at a transition care clinic.

    abstract：BACKGROUND:Emerging adulthood is a challenging period for diabetes management. Our aim was to determine whether a dedicated transition clinic for emerging adults with type 1 diabetes can improve glycemic control and visit attendance. METHODS:An observational study of 53 emerging adults (30 males) treated during 2010-2...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-015-0734-z

    authors： Levy-Shraga Y,Elisha N,Ben-Ami M,Boyko V,Lerner-Geva L,Ziv T,Konvalina N,Cohen O,Pinhas-Hamiel O

    更新日期：2016-02-01 00:00:00

  • HLA-DQ screening for risk assessment of insulin dependent diabetes in northern Italy.

    abstract：:Genetic markers may be used to improve the prediction of insulin-dependent diabetes mellitus (type 1) in individuals with islet autoantibodies. In order to develop a risk assessment strategy for the Lombardy region of northern Italy based on genetic and immunological markers, we analyzed HLA DQA1 and DQB1 alleles in 6...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/BF00838481

    authors： Lampasona V,Ferrari M,Bonifacio E,Pastore MR,Carrera P,Sergi A,Genovese S,Trucco M,Dorman J,Bosi E

    更新日期：1995-10-01 00:00:00

  • Can augmentation index substitute aortic pulse wave velocity in the assessment of central arterial stiffness in type 1 diabetes?

    abstract：:The aim of this study was to test whether the augmentation index adjusted for heart rate (AIx@HR75) can be used as a substitute for aortic pulse wave velocity (aPWV) in the measurement of arterial stiffness (AS) in type 1 diabetes. Sixty-eight patients with type 1 diabetes and 68 age- and sex-matched controls were eva...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-012-0433-y

    authors： Llauradó G,Simó R,Villaplana M,Berlanga E,Vendrell J,González-Clemente JM

    更新日期：2012-12-01 00:00:00

  • Glycation of insulin results in reduced biological activity in mice.

    abstract：:Bovine insulin was glycated by in vitro incubation with 20-220 mM D-glucose for 1-48 h. The percentage of glycation was dependent on time, glucose concentration, temperature and pH, attaining values up to 28%. Glucose-lowering activities of glycated and control (non-glycated) insulin preparations were assessed in mice...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s005920050086

    authors： Abdel-Wahab YH,O'Harte FP,Boyd AC,Barnett CR,Flatt PR

    更新日期：1997-12-01 00:00:00

  • Different binding and degradation of proinsulin, insulin and insulin-like growth factor-1 (IGF-1) in cultured renal proximal tubular cells. Implications for the prolonged serum half-life of proinsulin.

    abstract：:Recent studies have reported that elevated proinsulin levels are indicative of an increased cardiovascular risk. Renal proximal tubular cells represent a major site for the metabolism of insulin-like hormones after glomerular filtration into the tubular lumen. To determine the binding and degradation of proinsulin in ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/BF00569428

    authors： Jehle PM,Fussgänger RD,Stracke S,Grunewald RW,Keller F

    更新日期：1996-07-01 00:00:00

  • Resting heart rate predicts metabolic syndrome in apparently healthy non-obese Japanese men.

    abstract：:Autonomic nervous dysfunction is considered to be one of the mechanisms of metabolic syndrome (MetS). The aim of this study is to investigate whether resting heart rate, a marker of autonomic nervous dysfunction, is a predictor of MetS in apparently healthy non-obese [body mass index (BMI) <25 kg/m(2)] Japanese men. T...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-013-0503-9

    authors： Oda E,Aizawa Y

    更新日期：2014-02-01 00:00:00

  • Fenofibrate prevents the disruption of the outer blood retinal barrier through downregulation of NF-κB activity.

    abstract：AIMS:There is clinical evidence that fenofibrate, a PPARα agonist, arrests the progression of diabetic macular edema (DME). However, the underlying mechanisms of this beneficial effect remain to be elucidated. We previously reported that fenofibric acid (FA), the active metabolite of fenofibrate, prevents the disorgani...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/s00592-015-0759-3

    authors： Garcia-Ramírez M,Hernández C,Palomer X,Vázquez-Carrera M,Simó R

    更新日期：2016-02-01 00:00:00

  • 31P-magnetic resonance spectroscopy (31P-MRS) detects early changes in kidney high-energy phosphate metabolism during a 6-month Valsartan treatment in diabetic and non-diabetic kidney-transplanted patients.

    abstract：:(31)P-magnetic resonance spectroscopy ((31)P-MRS) is a non-invasive tool to study high-energy phosphate (HEP) metabolism. We evaluate whether 31P-MRS can detect early changes in kidney HEP metabolism during a 6-month trial with Valsartan. Twenty consecutive stable and normotensive kidney-transplanted patients were enr...

    journal_title：Acta diabetologica

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00592-012-0369-2

    authors： Fiorina P,Bassi R,Gremizzi C,Vergani A,Caldara R,Mello A,Del Maschio A,De Cobelli F,Perseghin G,Secchi A

    更新日期：2012-12-01 00:00:00

  • Long-term fat-feeding-induced insulin resistance in normal NMRI mice: postreceptor changes of liver, muscle and adipose tissue metabolism resembling those of type 2 diabetes.

    abstract：:Postreceptor insulin resistance was studied in liver, muscle and adipose tissue from NMRI mice of both sexes made diabetic by long-term fat-feeding. Intravenous glucose tolerance tests showed a combination of impaired glucose tolerance and increased plasma insulin concentrations consistent with insulin resistance and ...

    journal_title：Acta diabetologica

    pub_type： 杂志文章

    doi：10.1007/BF00572823

    authors： Hedeskov CJ,Capito K,Islin H,Hansen SE,Thams P

    更新日期：1992-01-01 00:00:00