Abstract：
:Overload of reactive oxygen species during diabetes is known to impair cellular homeostasis and to promote deterioration of membrane function in the organism. The aim of the present study was to examine the effect of dietary supplementation with the pyridoindole atioxidant stobadine on functional properties of the renal Na, K-ATPase in diabetic rats. After 16 weeks of streptozotocin-induced diabetes (single intravenous dose of streptozotocin; 55 mg/kg), a significant inhibition (by 35%-42%) of the enzyme was observed throughout the range of NaCl 2-100 mmol/l, probably as an event of altered functional properties of Na,K-ATPase, suggested by the 42% decrease of the V(max) value. Administration of 0.05% (w/w) stobadine in the diet dramatically improved the function of renal Na,K-ATPase in diabetic rats with regard to sodium handling, as suggested by significant stimulation (by 104%-77% in accordance with increasing concentration of NaCl) of the enzyme over the whole NaCl concentration range investigated. This stimulatory effect was accompanied by an increase of V(max) value to the level of nondiabetic rats on standard diet. In conclusion, stobadine was found to antagonise the negative effects of diabetes on the renal Na,K-ATPase, preserving its normal function in regulation of intracellular homeostasis of Na(+) and K(+) ions.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Vrbjar N,Strelková S,Stefek M,Kyselová Z,Gajdosíková Adoi
10.1007/s00592-004-0162-ysubject
Has Abstractpub_date
2004-12-01 00:00:00pages
172-8issue
4eissn
0940-5429issn
1432-5233journal_volume
41pub_type
杂志文章abstract：:Our aim was to compare the effects of an intermediate acting human insulin (NPH) and a long-acting insulin analog, insulin glargine, in insulin naïve type 2 diabetes patients, stratified by the type of hyperglycemia (fasting or postprandial type). Based on different action profiles, we hypothesized that patients havin...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-013-0505-7
更新日期：2014-04-01 00:00:00
abstract：AIM:To identify the potential metabolite markers in diabetic retinopathy (DR) by using gas chromatography coupled with time-of-flight mass spectrometry (GC-TOFMS). METHODS:GC-TOFMS spectra were acquired from vitreous and aqueous humor (AH) samples of patients with DR and non-diabetic participants. Comparative analysis...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-019-01363-0
更新日期：2020-01-01 00:00:00
abstract：:Continuous subcutaneous insulin infusion (CSII) is effective and safe in children and adults with type 1 diabetes. Notwithstanding, some patients decide to discontinue using CSII. We evaluated the discontinuation rate, and its related factors, in a large group of children and adolescents with type 1 diabetes using CSI...
journal_title：Acta diabetologica
pub_type： 杂志文章,多中心研究
doi：10.1007/s00592-011-0344-3
更新日期：2012-12-01 00:00:00
abstract：AIMS:We studied mortality in individuals of diabetes with or without Charcot neuroarthropathy (CN). METHODS:People attending diabetic foot care facility with CN of foot (Cohort 1) were prospectively evaluated. Details pertaining to the duration of diabetes, microvascular and macrovascular complications, foot ulcer, am...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-019-01376-9
更新日期：2019-12-01 00:00:00
abstract：:Recent studies have reported that elevated proinsulin levels are indicative of an increased cardiovascular risk. Renal proximal tubular cells represent a major site for the metabolism of insulin-like hormones after glomerular filtration into the tubular lumen. To determine the binding and degradation of proinsulin in ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00569428
更新日期：1996-07-01 00:00:00
abstract：AIMS:The aim of the current study was to investigate the association of type 2 diabetes (T2D) and insulin treatment with changes in muscle mass, muscle strength, and physical performance in older adults. METHODS:In 731 participants of the population-based KORA-Age study aged 74.6 ± 6.2 years (T2D: n = 118; insulin tre...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-020-01523-7
更新日期：2020-09-01 00:00:00
abstract：AIMS:In patients with type 2 diabetes, non-alcoholic fatty liver disease (NAFLD) and liver fibrosis is frequent and presumably associated with increased cardiovascular disease risk and mortality. The objective was to investigate risk factors associated with hepatic fibrosis in patients with type 2 diabetes and NAFLD to...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-019-01374-x
更新日期：2019-11-01 00:00:00
abstract：:To evaluate ex vivo/in vitro the binding and dissociation characteristics and the level of crossreactivity of insulin antibodies and insulin autoantibodies directed to three different insulin molecules (human, bovine and porcine insulin). In this study sera from 17 diabetic patients were included, who were exclusively...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-008-0041-z
更新日期：2008-09-01 00:00:00
abstract：AIMS:Genetic polymorphisms may contribute to platelet reactivity in diabetic patients; however, the information on their influence on long-term antiplatelet therapy is lacking. Our aim was to evaluate the role of previously described genetic variants and platelet reactivity on risk of all-cause mortality and cardiovasc...
journal_title：Acta diabetologica
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00592-016-0945-y
更新日期：2017-04-01 00:00:00
abstract：:Genetic linkage studies of families with early-onset type 2 diabetes have facilitated the identification of diabetes-susceptibility genes. In order to assess the feasibility of using linkage approaches to identify genes responsible for the development of type 2 diabetes in Japanese subjects, we examined our clinical r...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00581039
更新日期：1995-03-01 00:00:00
abstract：:The purpose of this study was to determine the feasibility of a flexible multiple daily insulin (FMDI) regimen in routine pediatric diabetes care by comparing HbA(1c), body mass index (BMI), and episodes of severe hypoglycemia (SH) before and after initiation of FMDI therapy. Data from 44 patients (2-16 years old), on...
journal_title：Acta diabetologica
pub_type： 临床试验,杂志文章
doi：10.1007/s00592-003-0102-2
更新日期：2003-09-01 00:00:00
abstract：:The purification of large numbers of human pancreatic islets remains one of the limiting factors in islet transplantation. This paper describes and validates a method for accurately and reproducibly determining the density of islets and exocrine tissue in pancreatic digest on the basis of their isopycnic distribution ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00572864
更新日期：1993-01-01 00:00:00
abstract：:Elevated plasma CT-pro-vasopressin (copeptin) has been described as biomarkers for type 2 diabetes (T2D) and the metabolic syndrome (MetS), which, however, was not confirmed by all studies. Here, we analyzed the association of copeptin with T2D, MetS and MetS components in the population-based KORA F4 study. Plasma co...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0609-8
更新日期：2015-02-01 00:00:00
abstract：:Consistent with the postulated role of oxidative stress in the etiology of late diabetic complications, pharmacological interventions based on biological antioxidants have been suggested. The aim of the present study was to investigate the effect of dietary supplementation with the pyridoindole antioxidant stobadine o...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920070012
更新日期：2000-01-01 00:00:00
abstract：:To evaluate the effects of vasoactive intestinal peptide (VIP) on whole pancreatic blood flow and islet blood flow in the rat, anaesthetized adult rats were injected intravenously for 90 s with VIP (500 ng/kg body weight). Immediately after the injection, the whole pancreatic and islet blood flows were measured with a...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00570545
更新日期：1994-06-01 00:00:00
abstract：:We assessed the efficacy of noninsulin antidiabetic medications used in current clinical practice (metformin, sulfonylureas, α-glucosidase inhibitors, thiazolidinediones, glinides, dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 agonists) to reach the HbA1c target <7% in people with type 2 diabetes. MEDLINE...
journal_title：Acta diabetologica
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00592-012-0370-9
更新日期：2014-04-01 00:00:00
abstract：:Diabetes cardiomyopathy is a specific form of cardiac disease characteristic for diabetic patients. Development of echocardiography enabled diagnosis of diabetic cardiomyopathy significantly before the occurrence of heart failure. Previously was believed that left ventricular (LV) diastolic dysfunction represents the ...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-020-01528-2
更新日期：2020-09-01 00:00:00
abstract：:The aim of this study was to analyse the effect of the new oral antidiabetic drug repaglinide on antioxidant factors and lipid peroxidation in tissues of alloxan-induced diabetic rabbits after 4 and 8 weeks treatment. The activity of superoxide dismutase (diabetic vs. control values, mean+/-S.E.M., p<0.05) in diabetic...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-005-0182-2
更新日期：2005-06-01 00:00:00
abstract：:To determine the impact of glargine insulin therapy with different nutritional models on key parameters of diabetes including quality of life, behavior in children and adolescents with type 1 diabetes. Age, duration of diabetes, HbA1c, anthropometric data and episodes of severe hypoglycemia were taken from patients' c...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-007-0019-2
更新日期：2008-03-01 00:00:00
abstract：:Fasting glucose and oral glucose tolerance test (OGTT) criteria for glucose homeostasis were compared in a cross-sectional cluster, community study in Accra, Ghana. A total of 4636 subjects without prior diagnosis of diabetes had fasting plasma glucose, 2-hour OGTT and measurement of cardiovascular risk factors. Mean ...
journal_title：Acta diabetologica
pub_type： 杂志文章,多中心研究
doi：10.1007/s005920200006
更新日期：2002-04-01 00:00:00
abstract：:The objective is to assess the effect of TNF-alpha inhibition on urinary albumin excretion in experimental diabetic rats. Male Wistar rats, 8-week-old, were categorized into four groups, which were the control (n = 9), diabetes (n = 9), infliximab-treated diabetes (n = 10), and FR167653-treated diabetes (n = 9) groups...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-007-0007-6
更新日期：2007-12-01 00:00:00
abstract：:Positron emission tomography/computed tomography (PET/CT) is a standard procedure for imaging cancer commonly used in the clinical practice for several diseases, in particular for cancer staging, restaging, treatment monitoring and radiation therapy planning. Despite the availability of many radiotracers, 18F-fluoro-2...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-019-01385-8
更新日期：2020-03-01 00:00:00
abstract：:Hemoglobin A1c (HbA1c) has been recommended as an optional method for diagnosing diabetes. The impact of HbA1c on the diagnosis of diabetes has not been evaluated in China, a country with the greatest number of people with diabetes in the world. Hence, we aim to examine how well HbA1c performs as compared with fasting...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-013-0515-5
更新日期：2014-01-01 00:00:00
abstract：AIMS:Radiolabeled Exendin-4 has been proposed as suitable imaging marker for pancreatic beta cell mass quantification mediated by Glucagon-like peptide-1 receptor (GLP-1R). However, noticeable species variations in basal pancreatic uptake as well as uptake reduction degree due to selective beta cell ablation were obser...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-017-1046-2
更新日期：2017-11-01 00:00:00
abstract：:The aim of this study was to test whether the augmentation index adjusted for heart rate (AIx@HR75) can be used as a substitute for aortic pulse wave velocity (aPWV) in the measurement of arterial stiffness (AS) in type 1 diabetes. Sixty-eight patients with type 1 diabetes and 68 age- and sex-matched controls were eva...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-012-0433-y
更新日期：2012-12-01 00:00:00
abstract：:Diabetic kidney disease (DKD) is a devastating complication of Type 1 and Type 2 diabetes and leads to increased morbidity and mortality. Earlier work in families has provided strong evidence that heredity is a major determinant of DKD. Previous linkage analyses and candidate gene studies have identified potential DKD...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-018-1193-0
更新日期：2018-11-01 00:00:00
abstract：AIMS:Hypoglycaemia represents a critical burden with clinical and social consequences in the management of diabetes. Serum uric acid (SUA) has been associated with cardiovascular diseases (CVD), but no conclusive findings are available nowadays in patients suffering from hypoglycaemia. We investigated whether SUA level...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-017-1094-7
更新日期：2018-04-01 00:00:00
abstract：:We have measured protein phosphatase (PP) activity in crude homogenates as well as in the total 105.000 x g supernatant and precipitate fractions from normal rat pancreatic islets. On the basis of the inhibition produced by either 1 nM or 1 microM okadaic acid, both PP1 and PP2A activity were present in crude islet ho...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920050057
更新日期：1997-03-01 00:00:00
abstract：:Diabetes mellitus and hyperglycaemia are both independent risk factors (RF) for cardiovascular (CV) events and increased general and CV mortality. Type 2 diabetes, which is often associated with obesity, hypertension and dyslipidaemia, is accompanied by an up to fourfold increase in the incidence of acute coronary hea...
journal_title：Acta diabetologica
pub_type： 共识发展会议,杂志文章
doi：10.1007/s00592-013-0508-4
更新日期：2013-12-01 00:00:00
abstract：AIMS:Our aims were to investigate in several large samples, with a wide range of adiposity, whether: (1) the effect of BMI on insulin sensitivity is different between sexes; (2) also waist circumference plays a sex-specific role on insulin sensitivity; and (3) serum adiponectin and resistin are mediators of such sex-di...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-015-0804-2
更新日期：2015-10-01 00:00:00
