Abstract：
:Hyperglycaemia caused by stress and inflammation is common during critical illness. We hypothesised that a latent glucose metabolism disturbance contributes to development of hyperglycaemia and that those patients have increased risk for diabetes. We included patients with sepsis, acute coronary syndrome and acute heart failure with no history of impaired glucose metabolism and divided them in the hyperglycaemia group (glucose ≥ 7.8 mmol/l) and normoglycaemia group. Patients were followed for 5 years. Follow-up was completed for 115 patients in the normoglycaemia group, of which 4 (3.5%) developed type 2 diabetes. In the hyperglycaemia group 51 patients finished follow-up and 8 (15.7%) developed type 2 diabetes. Relative risk in 5-year period for patients with hyperglycaemia was 4.51 for development of type 2 diabetes. Patients with hyperglycaemia during critical illness who are not diagnosed with diabetes before or during the hospitalisation should be considered a population at increased risk for developing diabetes.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Gornik I,Vujaklija A,Lukić E,Madžarac G,Gašparović Vdoi
10.1007/s00592-009-0115-6subject
Has Abstractpub_date
2010-12-01 00:00:00pages
29-33eissn
0940-5429issn
1432-5233journal_volume
47 Suppl 1pub_type
杂志文章abstract：AIMS:To study the incidence of and the factors associated with renal dialysis and transplantation in type 1 (T1DM) and type 2 diabetes (T2DM). METHODS:Data on individuals who had received dialysis treatment or renal transplant between 1 January 2004 and 31 December 2013 were extracted from the regional administrative ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-018-1142-y
更新日期：2018-07-01 00:00:00
abstract：:The objective of this study was to describe spatial and space-time patterns of type 1 diabetes in children less than 15 years old, diagnosed between 2000 and 2005 with residence in the Metropolitan Region of Chile. Knox and Mantel tests were used to detect space-time interaction between cases. An ecological Bayesian m...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-010-0189-1
更新日期：2010-09-01 00:00:00
abstract：AIMS:The purpose of this study was to investigate the mechanism of vascular endothelial cell apoptosis induced by acute blood glucose fluctuation. METHODS:Thirty rats were assigned to three groups: normal saline (SAL group), constant high glucose (CHG group) and acute blood glucose fluctuation (AFG) group. Other forty...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-017-0999-5
更新日期：2017-08-01 00:00:00
abstract：:Autonomic nervous dysfunction is considered to be one of the mechanisms of metabolic syndrome (MetS). The aim of this study is to investigate whether resting heart rate, a marker of autonomic nervous dysfunction, is a predictor of MetS in apparently healthy non-obese [body mass index (BMI) <25 kg/m(2)] Japanese men. T...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-013-0503-9
更新日期：2014-02-01 00:00:00
abstract：AIMS:The anti-inflammatory effects of the polyphenol resveratrol in patients with type 2 diabetes mellitus (T2DM) are controversial. Its role on pentraxin 3 (PTX3) concentrations, a human acute phase protein, has never been evaluated. Our aim was to determine whether a two-dosage resveratrol supplementation (500 and 40...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-017-0977-y
更新日期：2017-05-01 00:00:00
abstract：:Bacterial endotoxins have been associated with chronic inflammation and the development and progression of diabetic nephropathy. We hypothesized that subjects with high serum lipopolysaccharide activity also carry remains of bacterial DNA in their system. Serum-derived bacterial DNA clones were isolated and identified...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-012-0421-2
更新日期：2013-06-01 00:00:00
abstract：:The proinflammatory lysophosphatidic acid (LPA) is a potent activator of several transcriptional factors and signaling pathways and a potent modulator of genes involved in inflammation, angiogenesis and fibrosis. This study was conducted to measure the levels of LPA and LPA-producing enzymes, autotaxin (ATX) and acylg...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-012-0422-1
更新日期：2013-06-01 00:00:00
abstract：:In the present study our interests focused on the evaluation of a high capacity assay (MEIA) which allows true insulin determinations in the absence of cross-reactivity with proinsulin-like molecules. This method was compared to a commercially available radioimmunoassay (RIA) for insulin determination. As the latter g...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00581048
更新日期：1995-03-01 00:00:00
abstract：AIMS:To determine whether blood glucose test strip (BGTS) utilization in patients with type 2 diabetes (T2D) is associated with the type of diabetes therapy, classified according to hypoglycemic risk. METHODS:A retrospective, longitudinal (2006-2012) study of Canadian private drug plans (PDP) and Ontario Public Drug P...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-015-0823-z
更新日期：2016-06-01 00:00:00
abstract：:We analysed the risk factors associated with diabetic complications in the cohort of patients assisted by a type 2 diabetes mellitus (T2DM) shared-care program. We analysed registry data from 16,136 T2DM patients. Of them, 4,781 had microangiopathy, 3,469 CV events. They were 70.5 ± 17.1 years old, 50% were male, dise...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-010-0186-4
更新日期：2010-12-01 00:00:00
abstract：:Considering that changes in exercise routines might have relevance in treatment of adolescents with type 1 diabetes mellitus, we sought to assess whether spontaneous modifications to weekly exercise habits might occur in these patients and whether such variations would be accompanied by alterations in autonomic profil...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-012-0416-z
更新日期：2013-06-01 00:00:00
abstract：:Administration of exogenous insulin for the treatment of diabetes is often accompanied by the development of insulin antibodies (IA). These antibodies may affect the patient's requirement for insulin by acting as an insulin binding reservoir. The improvement of insulin purification in the 1970s and the development of ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-009-0135-2
更新日期：2010-06-01 00:00:00
abstract：:The aim of this study was to investigate the influence of homocysteine (hcy) levels on endothelial function by the method of brachial artery ultrasonography and their relation with microvascular complications in type 2 diabetes mellitus (T2DM) patients without macrovascular disease. Fifty-nine T2DM patients with a mea...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-007-0245-7
更新日期：2007-06-01 00:00:00
abstract：:Elevated plasma CT-pro-vasopressin (copeptin) has been described as biomarkers for type 2 diabetes (T2D) and the metabolic syndrome (MetS), which, however, was not confirmed by all studies. Here, we analyzed the association of copeptin with T2D, MetS and MetS components in the population-based KORA F4 study. Plasma co...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0609-8
更新日期：2015-02-01 00:00:00
abstract：:The purification of large numbers of human pancreatic islets remains one of the limiting factors in islet transplantation. This paper describes and validates a method for accurately and reproducibly determining the density of islets and exocrine tissue in pancreatic digest on the basis of their isopycnic distribution ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00572864
更新日期：1993-01-01 00:00:00
abstract：AIM:To identify the potential metabolite markers in diabetic retinopathy (DR) by using gas chromatography coupled with time-of-flight mass spectrometry (GC-TOFMS). METHODS:GC-TOFMS spectra were acquired from vitreous and aqueous humor (AH) samples of patients with DR and non-diabetic participants. Comparative analysis...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-019-01363-0
更新日期：2020-01-01 00:00:00
abstract：:Consistent with the postulated role of oxidative stress in the etiology of late diabetic complications, pharmacological interventions based on biological antioxidants have been suggested. The aim of the present study was to investigate the effect of dietary supplementation with the pyridoindole antioxidant stobadine o...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920070012
更新日期：2000-01-01 00:00:00
abstract：:The aim of the study was to evaluate the effects of a supervised physical training added to a healthy diet-rich in either carbohydrate and fibre (CHO/fibre) or monounsaturated fatty acids (MUFA)-on postprandial dyslipidaemia, an independent cardiovascular risk factor particularly relevant in type 2 diabetes (T2D). Par...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-013-0522-6
更新日期：2014-01-01 00:00:00
abstract：:We hypothesize that type 2 diabetic patients with different phenotypes may show different response to incretin-based therapies. Therefore, we tested whether the presence of metabolic syndrome (MS) influences glycemic response to these drugs. We prospectively followed 211 patients, treated with the GLP-1 analog exenati...
journal_title：Acta diabetologica
pub_type： 临床试验,杂志文章
doi：10.1007/s00592-011-0296-7
更新日期：2011-09-01 00:00:00
abstract：:Preliminary evidence from trials with the HMG-CoA reductase inhibitors (statins), simvastatin and pravastatin, suggests that aggressive treatment of diabetic dyslipidaemia will reduce coronary events. Questions regarding the prevention of cardiovascular events in diabetic patients are now being addressed in prospectiv...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s005920170005
更新日期：2001-01-01 00:00:00
abstract：:Diabetic neuropathy is a significant complication of chronic diabetes. We wished to discover whether we were successfully identifying patients who had developed neuropathic problems. Specifically, Diabetologists are traditionally poor at asking about erectile dysfunction (ED) and patients themselves are not always for...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-008-0084-1
更新日期：2009-12-01 00:00:00
abstract：AIMS:Many authors do not recommend hypoglycemic treatment during pregnancy in women affected by monogenic diabetes due to heterozygous glucokinase (GCK) mutations (MODY 2) in case of affected fetus, because maternal hyperglycemia would be necessary to achieve a normal birthweight. We aimed to evaluate differences in bi...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-018-1198-8
更新日期：2018-12-01 00:00:00
abstract：:Although the polymorphisms of PTPN22 and the variants of CTLA-4 have been reported to be the susceptibility genes, which increased risk of latent autoimmune diabetes in adults (LADA), the results remained inconclusive. The aim of this meta-analysis was to evaluate the association between the polymorphisms of two genes...
journal_title：Acta diabetologica
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00592-014-0613-z
更新日期：2014-10-01 00:00:00
abstract：AIMS:Medication adherence and persistence are important determinants of treatment success in type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis evaluated the real-world adherence, persistence, and in-class switching among patients with T2DM prescribed dipeptidyl peptidase-4 (DPP4) inhibitors. ME...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-020-01590-w
更新日期：2021-01-01 00:00:00
abstract：:In the present study, we investigated whether the ameliorating effect of aminoguanidine on diabetes-related proteinuria and nephropathy is associated with glomerular basement membrane heparan sulphate contents. STZ-induced diabetic rats developed proteinuria (at the tenth week: diabetic rats, 713 +/- 418 mg protein pe...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920070022
更新日期：2000-01-01 00:00:00
abstract：:Studies suggest that diabetes may specifically elevate the risk of sudden cardiac death in excess of other heart disease outcomes. In this study, we examined the association of type 2 diabetes with the incidence of sudden cardiac death when compared to the incidence of non-sudden cardiac death and non-fatal myocardial...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-009-0157-9
更新日期：2010-12-01 00:00:00
abstract：AIMS:Observational studies and meta-analyses of randomized trials on dipeptidyl peptidase-4 inhibitors (DPP4i) reported discordant results on the risk of malignancies with this class of drugs. Aim of the present meta-analysis is the assessment of the effect of DPP4i treatment on the incidence of different types of canc...
journal_title：Acta diabetologica
pub_type： 杂志文章,meta分析
doi：10.1007/s00592-020-01479-8
更新日期：2020-06-01 00:00:00
abstract：AIMS:Sirtuin-1 (SIRT-1) down-regulation in type 2 diabetes mellitus (T2DM) has been associated with epigenetic markers of oxidative stress. We herein aim to evaluate whether an increase in SIRT-1 expression affects histone 3 acetylation at the 56 lysine residue (H3K56ac) in T2DM patients randomly selected to receive ei...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-017-1097-4
更新日期：2018-04-01 00:00:00
abstract：:The relationship between insulin responses to glucose and to arginine was studied in non-obese women with previous gestational diabetes (PGD). One group, n = 10, had normal glucose tolerance (NGT) by WHO criteria and another, n = 8, had impaired glucose tolerance (IGT). A third group of women without PGD, n = 12, was ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00569563
更新日期：1995-06-01 00:00:00
abstract：AIM:The study evaluated the effect of different concentrations of sildenafil-containing ointment on wound healing in healthy and streptozotocin (STZ)-induced diabetic rats. METHODS:A total of 108 Sprague Dawley male rats aged 5 months were randomly divided into two groups: healthy and diabetes-inducing rats. Following...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-020-01562-0
更新日期：2020-11-01 00:00:00
