Abstract：
:Selective loss of capillary pericytes occurs early and specifically in diabetic retinopathy. We have investigated whether blood derivatives from patients with long-term type 1 (insulin-dependent) diabetes and no retinopathy differ from those with retinopathy and/or non-diabetic controls in their ability to stimulate DNA synthesis in cultured bovine retinal pericytes and endothelial cells. As a general trend, whole blood serum, platelet-rich plasma and platelet-free plasma from patients without and with retinopathy stimulated thymidine incorporation in both cell types less than derivatives from controls. Serum, 0.1% v/v final concentration in culture medium, from patients without retinopathy was less active (114.5 +/- 24.5% of a standard stimulus produced by 0.1% fetal calf serum) than that from patients with the complication (132.6 +/- 20.8%, P = 0.003) and both were less potent than control sera (143.6 +/- 28.0%, P < 0.001 and P = 0.013, respectively). Lack of support from circulating factor(s) may contribute to the disappearance of pericytes from the capillary wall in diabetes but further investigations are necessary to clarify the mechanisms that prevent the development of microangiopathy in some patients.
journal_name
Acta Diabetoljournal_title
Acta diabetologicaauthors
Williams FM,Dosso AA,Kohner EM,Porta Mdoi
10.1007/BF00572854subject
Has Abstractpub_date
1993-01-01 00:00:00pages
123-7issue
3eissn
0940-5429issn
1432-5233journal_volume
30pub_type
杂志文章abstract：:Aim To summarize, critically review, and interpret the evidence related to the systematic reviews on health literacy (HL) amongst type 2 diabetes mellitus (T2DM). Methods The methodology for this study consisted of a systematic review of systematic reviews, using the PRISMA statement and flowchart to select studies, a...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-017-1071-1
更新日期：2018-01-01 00:00:00
abstract：:Cardiovascular risk is determined by multiple risk factors, all of which greatly increase the chance of morbidity and mortality. So-called "normal" levels of these factors are not biologically normal, so current strategy is based on estimations of a person's global cardiovascular risk, and then using appropriate combi...
journal_title：Acta diabetologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00592-005-0181-3
更新日期：2005-04-01 00:00:00
abstract：:Post-prandial hyperglycemia is considered a relevant therapeutic target in type 2 diabetic patients, and it could represent per se an independent risk factor for diabetic complications. Aim of the present systematic review is to collect and summarize evidence from observational studies on the relationship between post...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-011-0355-0
更新日期：2012-08-01 00:00:00
abstract：:To evaluate ex vivo/in vitro the binding and dissociation characteristics and the level of crossreactivity of insulin antibodies and insulin autoantibodies directed to three different insulin molecules (human, bovine and porcine insulin). In this study sera from 17 diabetic patients were included, who were exclusively...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-008-0041-z
更新日期：2008-09-01 00:00:00
abstract：:The aim of this study is to assess the impact of the internet-based upload blood glucose monitoring and therapy management system (Carelink(®)) in patients with type 1 diabetes. Diabetic patients treated with pump infusion for ≥3 months were prospectively randomized to use the CareLink(®) with (4 months) and without (...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-013-0510-x
更新日期：2014-04-01 00:00:00
abstract：:Administration of exogenous insulin for the treatment of diabetes is often accompanied by the development of insulin antibodies (IA). These antibodies may affect the patient's requirement for insulin by acting as an insulin binding reservoir. The improvement of insulin purification in the 1970s and the development of ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-009-0135-2
更新日期：2010-06-01 00:00:00
abstract：AIMS:The role of neutrophils in diabetes and its complications is unclear. Upon challenge with microbes and inflammatory triggers, neutrophils release enzymes and nuclear material, forming neutrophils extracellular traps (NETs) and thereby dying by NETosis. We herein tested NET formation and NETosis products in high gl...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0676-x
更新日期：2015-06-01 00:00:00
abstract：:The duration of diabetes before puberty is not considered relevant to the future development of complications. To evaluate the effects of diabetes on the neural retina, we analysed macular function by steady-state focal electroretinography in 20 prepubescent diabetic children without vascular retinopathy and in 39 sex...
journal_title：Acta diabetologica
pub_type： 临床试验,杂志文章
doi：10.1007/BF00570544
更新日期：1994-06-01 00:00:00
abstract：:The aim of the study was to evaluate the effects of a supervised physical training added to a healthy diet-rich in either carbohydrate and fibre (CHO/fibre) or monounsaturated fatty acids (MUFA)-on postprandial dyslipidaemia, an independent cardiovascular risk factor particularly relevant in type 2 diabetes (T2D). Par...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-013-0522-6
更新日期：2014-01-01 00:00:00
abstract：:We investigated whether food supplementation within the first year life or age at introduction of gluten-containing foods influenced the risk of developing islet autoimmunity and type 1 diabetes. A total of 2,291 children with a family history of type 1 diabetes were prospectively followed from birth for 28,983 patien...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0628-5
更新日期：2015-06-01 00:00:00
abstract：:The aim of this study was to evaluate lipid peroxidation and scavenging enzyme activity in streptozotocin-induced diabetes, and then to establish whether moderate doses of nonenzymatic antioxidant vitamin E play a role in the antioxidant defence system in diabetic pregnant rats and their offspring. The study group con...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920070002
更新日期：2000-01-01 00:00:00
abstract：AIMS:Hyperreflective foci (HF), detected in the retina of diabetic patients, suggest the presence of microglial activation and migration, while controversies still remain for the origin of HF to be precursors of hard exudates. We investigated the presence of HF and their association with dyslipidemia in serous retinal ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-020-01495-8
更新日期：2020-07-01 00:00:00
abstract：:We hypothesize that type 2 diabetic patients with different phenotypes may show different response to incretin-based therapies. Therefore, we tested whether the presence of metabolic syndrome (MS) influences glycemic response to these drugs. We prospectively followed 211 patients, treated with the GLP-1 analog exenati...
journal_title：Acta diabetologica
pub_type： 临床试验,杂志文章
doi：10.1007/s00592-011-0296-7
更新日期：2011-09-01 00:00:00
abstract：AIM:To identify the potential metabolite markers in diabetic retinopathy (DR) by using gas chromatography coupled with time-of-flight mass spectrometry (GC-TOFMS). METHODS:GC-TOFMS spectra were acquired from vitreous and aqueous humor (AH) samples of patients with DR and non-diabetic participants. Comparative analysis...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-019-01363-0
更新日期：2020-01-01 00:00:00
abstract：:Kidney volume was measured during pregnancy in insulin-dependent diabetic women by an ultrasound technique and prognostic value of these measurements evaluated. A prospective study was performed on 87 pregnant women with insulin-dependent diabetes attending the maternity clinic of Aarhus Kommunehospital. Patients with...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00576254
更新日期：1995-12-01 00:00:00
abstract：AIMS:To evaluate the methodological quality of systematic reviews (SRs), and summarize evidence of important outcomes from dipeptidyl peptidase-4 inhibitors (DPP4-I) in treating type 2 diabetes mellitus (T2DM). METHODS:We included SRs of DPP4-I for the treatment of T2DM until January, 2018 by searching the Cochrane Li...
journal_title：Acta diabetologica
pub_type： 杂志文章,评审
doi：10.1007/s00592-018-1164-5
更新日期：2019-01-01 00:00:00
abstract：AIMS:Many authors do not recommend hypoglycemic treatment during pregnancy in women affected by monogenic diabetes due to heterozygous glucokinase (GCK) mutations (MODY 2) in case of affected fetus, because maternal hyperglycemia would be necessary to achieve a normal birthweight. We aimed to evaluate differences in bi...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-018-1198-8
更新日期：2018-12-01 00:00:00
abstract：:Islet autotransplantation (IAT) is performed at the time of total pancreatectomy (TP) to prevent or minimize post-surgical diabetes. Corticosteroids induce insulin resistance and present a risk to islet autografts, through glucotoxicity and increased metabolic demand on a marginal islet mass. We present four IAT recip...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-011-0315-8
更新日期：2014-02-01 00:00:00
abstract：:To evaluate the effects of vasoactive intestinal peptide (VIP) on whole pancreatic blood flow and islet blood flow in the rat, anaesthetized adult rats were injected intravenously for 90 s with VIP (500 ng/kg body weight). Immediately after the injection, the whole pancreatic and islet blood flows were measured with a...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/BF00570545
更新日期：1994-06-01 00:00:00
abstract：:A meta-analysis was performed in order to test the hypothesis that Japanese have a greater amount of abdominal visceral fat (AVF) relative to abdominal subcutaneous fat (ASF) than Caucasians. Data were derived from published studies that included mean values for AVF and ASF areas, measured using computed tomography, a...
journal_title：Acta diabetologica
pub_type： 杂志文章,meta分析
doi：10.1007/s00592-003-0093-z
更新日期：2003-10-01 00:00:00
abstract：:Several conditions have been described to cause osteoporosis, including diabetes mellitus. While the relationship between type 1 diabetes and osteopenia is well documented in the literature, data on the presence of this complication in type 2 diabetes have not been well established. We studied a population composed of...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920050142
更新日期：1999-06-01 00:00:00
abstract：:Concentrations of soluble receptors for tumor necrosis factor (p55 and p75) strongly correlate with clinical stage and progression of infectious diseases, and may be useful in monitoring autoimmune diseases. However, the role of soluble TNF receptors in insulin-dependent diabetes mellitus (type 1 DM) is not clear. We ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s005920050152
更新日期：1999-06-01 00:00:00
abstract：:Our aim was to compare the effects of an intermediate acting human insulin (NPH) and a long-acting insulin analog, insulin glargine, in insulin naïve type 2 diabetes patients, stratified by the type of hyperglycemia (fasting or postprandial type). Based on different action profiles, we hypothesized that patients havin...
journal_title：Acta diabetologica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00592-013-0505-7
更新日期：2014-04-01 00:00:00
abstract：:This study was aimed at the assessment of incidence of malignancies in type 2 diabetic patients treated with different sulphonylureas. A matched case-control study was performed. Cases were 195 diabetic patients aged 69.0 +/- 9.2 years who had an incident malignancy. Controls were 195 diabetic patients, unaffected by ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-008-0083-2
更新日期：2009-12-01 00:00:00
abstract：AIMS:This subanalysis of a cross-sectional, nationwide study was undertaken to assess the relationship between healthy lifestyle behaviors and multiple cardiovascular risk factors among people with type 2 diabetes mellitus (T2DM). METHODS:Data collected from 25,454 participants, including demographics, lifestyle behav...
journal_title：Acta diabetologica
pub_type： 杂志文章,多中心研究
doi：10.1007/s00592-017-0981-2
更新日期：2017-06-01 00:00:00
abstract：:Cytomegalovirus (CMV) infects 40 % of the world population and has been suggested to be associated with diabetes; however, no prospective study has ever examined diabetes mortality associated with the infection. A cohort of 14,404 non-diabetic adult participants aged 17-90 years from the Third National Health and Nutr...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0573-3
更新日期：2014-10-01 00:00:00
abstract：AIMS:The present study aims to investigate the association between serum ferritin and diabetes, diabetes control, and insulin resistance (IR) and examine whether gender is a modifier for these associations in a community-based sample. METHODS:A cross-sectional survey of 8,235 participants was conducted in 2009. Serum ...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-014-0656-1
更新日期：2014-12-01 00:00:00
abstract：:The objective is to assess the effect of TNF-alpha inhibition on urinary albumin excretion in experimental diabetic rats. Male Wistar rats, 8-week-old, were categorized into four groups, which were the control (n = 9), diabetes (n = 9), infliximab-treated diabetes (n = 10), and FR167653-treated diabetes (n = 9) groups...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-007-0007-6
更新日期：2007-12-01 00:00:00
abstract：AIMS:Our previous studies demonstrated that serum 1,5-anhydroglucitol (1,5-AG) levels increased slightly rather than declined after an acute glucose load. Therefore, the current study aims at exploring the transport and metabolic characteristics of 1,5-AG, as well as the effect of glucose on 1,5-AG transport. METHODS:...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-017-1093-8
更新日期：2018-03-01 00:00:00
abstract：:The objective of this study was to describe spatial and space-time patterns of type 1 diabetes in children less than 15 years old, diagnosed between 2000 and 2005 with residence in the Metropolitan Region of Chile. Knox and Mantel tests were used to detect space-time interaction between cases. An ecological Bayesian m...
journal_title：Acta diabetologica
pub_type： 杂志文章
doi：10.1007/s00592-010-0189-1
更新日期：2010-09-01 00:00:00
