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The relationship between plasma and placental tissue factor, and tissue factor pathway inhibitors in severe pre-eclampsia patients.

Abstract：

OBJECTIVE:To investigate the mechanism underlying the hypercoagulable state in severe pre-eclampsia. METHODS:Plasma tissue factor (TF) and tissue factor pathway inhibitor (TFPI) expression from pre-eclampsia patients and healthy pregnant controls were determined by ELISA. Placental TF and TFPI gene and protein expression were detected by quantitative RT-PCR, immunohistochemistry, and Western analysis. RESULTS:The plasma TF level in the pre-eclampsia group was significantly higher than the control group (p<0.01), and surprisingly, the plasma TFPI-1 and TFPI-2 in the pre-eclampsia group were significantly lower (p<0.01). Placental TF gene and protein expression levels in the pre-eclampsia group was significantly higher than the control group, while TFPI-1 and TFPI-2 levels were significantly lower (p<0.05). Lastly, a significant correlation was found between plasma and placental TF protein levels in the pre-eclampsia group (p<0.01). CONCLUSION:Higher expression and/or release of TF from the placenta may contribute towards a pathological hypercoagulable state in pre-eclampsia patients.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Teng Y,Jiang R,Lin Q,Ding C,Ye Z

doi

10.1016/j.thromres.2010.02.012

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

e41-5

issue

1

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(10)00159-3

journal_volume

126

pub_type

杂志文章

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