Naproxen treatment prevents periprocedural inflammatory response but not myocardial injury after percutaneous coronary intervention.


BACKGROUND AND AIM:Recent studies have documented that elevation of C-reactive protein (CRP) levels after percutaneous coronary intervention (PCI) have been predictive of adverse outcome. This study was performed to test the hypothesis that preprocedural use of naproxen sodium is associated with a reduction in the extent of inflammatory response and myocardial injury after PCI. METHODS:Ninety-seven patients who were scheduled for elective PCI were randomized either for naproxen sodium (500 mg bid) (n:39, 75% male, 59+/-10 years) or control (n:58, 76% male, 60+/-10 years). All patients were troponin negative before the procedure. Blood samples for CRP, Troponin I and CK-MB were collected at baseline and after the procedure. RESULTS:The characteristics were similar between the two groups. After coronary stenting, the rise in CRP levels was significantly higher in controls than those treated with naproxen (DeltaCRP=6.4 mg/L in the controls and 0.43 mg/L in the naproxen group, p<0.0001). The incidence of any troponin I elevation or CK-MB elevation above upper limit of normal was not statistically different between groups. During follow up (12+/-2 months), major cardiac adverse events (death, myocardial infarction, and revascularization of target lesion) was similar between groups. CONCLUSION:Our data show that naproxen pretreatment leads to significant suppression in PCI related CRP elevation. However this improvement in CRP levels was not associated with any significant reduction in post-PCI myonecrosis.


Thromb Res


Thrombosis research


Ozdol C,Gulec S,Rahimov U,Atmaca Y,Turhan S,Erol C




Has Abstract


2007-01-01 00:00:00














  • The inhibition of thromboplastin by apolipoprotein-B and the effect of various associated lipids.

    abstract::Human apolipoprotein B was purified by barium sulphate adsorption, subsequent delipidation and gel filtration. The protein was then reconstituted in soya bean lecithin and its inhibitory effect towards thromboplastin was assayed by incubation with rabbit brain thromboplastin. The use of an antibody against human apoli...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Ettelaie C,Howell RM

    更新日期:1992-10-15 00:00:00

  • Social aspects of genetic testing for factor V Leiden mutation in healthy individuals and their importance for daily practice.

    abstract::To explore social aspects of asymptomatic carriership of factor V Leiden mutation (FVL) and how carriers have experienced procedure of screening for FVL, we have performed a qualitative study using semi-structured interviews. Seventeen carriers of FVL without history of venous thromboembolism (VTE) were interviewed. C...

    journal_title:Thrombosis research

    pub_type: 临床试验,杂志文章


    authors: Bank I,Scavenius MP,Büller HR,Middeldorp S

    更新日期:2004-01-01 00:00:00

  • The role of biomarkers of endothelial activation in predicting morbidity and mortality in patients with severe sepsis and septic shock in intensive care: A prospective observational study.

    abstract:INTRODUCTION:Endothelial dysfunction plays an essential role in the pathogenesis of sepsis. The study aimed to illustrate the associations between the dynamic change (from day 1 to day 7) in biomarker concentration of endothelial dysfunction and outcomes in severe sepsis and septic shock in the intensive care unit (ICU...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Fang Y,Li C,Shao R,Yu H,Zhang Q

    更新日期:2018-11-01 00:00:00

  • Thrombin-induced shape change in human megakaryoblastic leukemic cells, MEG-01, is mediated by protein kinase C.

    abstract::We investigated the intracellular processes of the shape change in human megakaryoblastic leukemic cells, MEG-01, by platelet agonists. Thrombin induced the formation of many pseudopods. This shape change was also induced by phorbol 12-myristate 13 acetate (TPA) and weakly by Ca2+ ionophore, A23187, but not by ADP, co...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Goto S,Kobayashi M,Murate T,Hotta T,Hagiwara M,Hoshino T,Hidaka H,Saito H

    更新日期:1992-10-01 00:00:00

  • Enhanced platelet aggregation in the coronary circulation after coronary spasm.

    abstract::A recently developed platelet aggregometer using a laser light scattering method is capable of monitoring the increase in size of small-sized platelet aggregates (diameter 9-25 microm), which cannot be detected with the conventional methods. Whether coronary spasm can cause platelet aggregation in the coronary circula...

    journal_title:Thrombosis research

    pub_type: 临床试验,杂志文章


    authors: Miyamoto S,Ogawa H,Soejima H,Takazoe K,Kajiwara I,Shimomura H,Sakamoto T,Yoshimura M,Kugiyama K,Yasue H,Ozaki Y

    更新日期:2001-09-01 00:00:00

  • A review of current methods for assessing hemostasis in vivo and introduction to a potential alternative approach.

    abstract::A validated method for assessing hemostasis in vivo is critical for testing the hemostatic efficacy of therapeutic agents in preclinical animal models and in patients with inherited bleeding disorders, such as von Willebrand disease (VWD) and hemophilia A, or with acquired bleeding disorders such as those resulting fr...

    journal_title:Thrombosis research

    pub_type: 杂志文章,评审


    authors: Scola MR,Baggesen LM,Nichols TC,Key NS,Gallippi CM

    更新日期:2012-05-01 00:00:00

  • Cytokines, soluble thrombomodulin and disseminated intravascular coagulation in patients with systemic inflammatory response syndrome.

    abstract::To investigate the relationships between tumor necrosis factor-alpha (TNF), interleukin-1 beta (IL-1 beta), soluble thrombomodulin (TM), and disseminated intravascular coagulation (DIC) in patients with systemic inflammatory response syndrome (SIRS), twenty-nine SIRS patients were classified into three groups; 4 patie...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Gando S,Kameue T,Nanzaki S,Nakanishi Y

    更新日期:1995-12-15 00:00:00

  • Ischaemia-reperfusion injury with Pringle's maneuver induces unusually large von Willebrand factor multimers after hepatectomy.

    abstract:INTRODUCTION:von Willebrand factor (VWF) is synthesised in vascular endothelial cells and released into the plasma as unusually large VWF multimers (UL-VWFMs). Sinusoidal endothelial cells are a major target of ischaemia-reperfusion injury due to liver surgery. This study aimed to clarify the effect of hepatectomy on U...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Yoshikawa T,Nomi T,Sakai K,Hayakawa M,Hokuto D,Matsuo Y,Sho M,Matsumoto M

    更新日期:2019-11-01 00:00:00

  • Potentiation of wheat germ agglutinin aggregation of platelets by von Willebrand protein and by a 116,000 molecular weight tryptic fragment.

    abstract::This study compares selected properties of purified tryptic fragments of human von Willebrand (vW) protein in order to better understand how the M(r) 116,000 fragment retains activity in ristocetin-induced platelet agglutination. Wheat germ agglutinin (WGA) aggregation of platelet-rich plasma was potentiated by preinc...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Martin SE,Francis CW,Marder VJ

    更新日期:1983-08-01 00:00:00

  • Effects of balanced hydroxyethyl starch 6% (130/0.4) and albumin 5% on clot formation and glycocalyx shedding: Subgroup analysis of a prospective randomized trial.

    abstract:BACKGROUND:Intravenous fluids can impair coagulation and affect the endothelial glycocalyx, whereas glycocalyx shedding itself can cause an impairment of clot formation and firmness. We hypothesized that hydroxyethyl starch 6% (130/0.4) has a more distinct effect on coagulation and glycocalyx shedding than albumin 5%. ...

    journal_title:Thrombosis research

    pub_type: 杂志文章,随机对照试验


    authors: Kammerer T,Hulde N,Speck E,Hübner M,Crispin A,Zwissler B,Conzen P,von Dossow V,Schäfer ST,Hofmann-Kiefer K,Rehm M

    更新日期:2019-11-01 00:00:00

  • No firm association between N-terminal pro-brain natriuretic peptide and percentage of pulmonary vascular obstruction in patients with acute pulmonary embolism.

    abstract:INTRODUCTION:High concentrations of N-terminal-pro-brain natriuretic peptide (NT-proBNP) are found in patients with right ventricular overload. Right ventricular overload may be the result of large perfusion defects in patients with pulmonary embolism (PE). NT-proBNP levels are associated with poorer outcome in patient...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Agterof MJ,Schutgens RE,Verzijlbergen JF,van Buul MM,Tromp EA,Eijkemans MJ,van der Griend R,Biesma DH

    更新日期:2011-06-01 00:00:00

  • Comparison of the effects of streptokinase, t-PA and APSAC on human platelet aggregation in vitro in the absence and presence of aspirin.

    abstract::SK, t-PA or APSAC were incubated in human plasma (adjusted to 300,000 platelets/mm3), in vitro, for up to 90 minutes using concentrations which were equivalent to those achieved in the treatment of AMI patients. Aggregation was measured in response to ADP and collagen. SK inhibited platelet aggregation after a 60 minu...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Fears R,Ferres H,Greenwood HC

    更新日期:1990-11-15 00:00:00

  • An open-label, comparative study of the efficacy and safety of once-daily dose of enoxaparin versus unfractionated heparin in the treatment of proximal lower limb deep-vein thrombosis.

    abstract:BACKGROUND:Treatment of deep-vein thrombosis (DVT) with a once-daily regimen of enoxaparin, rather than a continuous infusion of unfractionated heparin (UFH) is more convenient and allows for home care in some patients. This study was designed to compare the efficacy and safety of these two regimens for the treatment o...

    journal_title:Thrombosis research

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Ramacciotti E,Araújo GR,Lastoria S,Maffei FH,Karaoglan de Moura L,Michaelis W,Sandri JL,Dietrich-Neto F,CLETRAT Investigators.

    更新日期:2004-01-01 00:00:00

  • Markers of hemostatic system activation during treatment of deep vein thrombosis with subcutaneous unfractionated or low-molecular weight heparin.

    abstract::Prothrombin fragments (F1+2), thrombin-antithrombin complexes (TAT) and D-dimers, markers of hemostatic system activation, were measured in 59 consecutive patients with deep vein thrombosis (DVT). Patients were randomly treated either with subcutaneous unfractionated heparin (UH) administered in two to three subcutane...

    journal_title:Thrombosis research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Peternel P,Terbizan M,Tratar G,Bozic M,Horvat D,Salobir B,Stegnar M

    更新日期:2002-02-01 00:00:00

  • Inhibitory effect of sodium salicylate on ADP-induced platelet aggregation and on 45Ca2+ uptake into platelets.

    abstract::The effects of sodium salicylate (SS) on ADP-induced platelet aggregation and on a metabolism of calcium in platelets were studied, using gel-filtrated platelets (GFP). SS inhibited dose-responsively ADP-induced aggregation in the presence of fibrinogen and Ca2+. It was found that extracellular 45Ca2+ was rapidly take...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Irino O,Saitoh K,Ohkubo K,Hashimoto S

    更新日期:1985-08-01 00:00:00

  • The inactivation of one- and two-chain forms of tissue plasminogen activator by a series of peptidyl chloromethyl ketones.

    abstract::The inhibition of one- and two-chain forms of tissue-type plasminogen activator by a series of peptide derivatives of arginine chloromethyl ketone was studied. Both forms of the enzyme were inhibited by such reagents at varying rates, dependent on the peptide sequence of the inhibitor. The order of relative effectiven...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Green GD

    更新日期:1986-10-15 00:00:00

  • Efficacy and safety of the use of heparin as thromboprophylaxis in patients with liver cirrhosis: a systematic review and meta-analysis.

    abstract:INTRODUCTION:Venous thromboembolism is a common cause of morbidity and mortality. Although cirrhosis has classically been considered as an acquired bleeding diathesis, there is increasing evidence that rejects the traditional belief that these patients are naturally protected against venous thromboembolism. However, an...

    journal_title:Thrombosis research

    pub_type: 杂志文章,meta分析,评审


    authors: Gómez Cuervo C,Bisbal Pardo O,Pérez-Jacoiste Asín MA

    更新日期:2013-10-01 00:00:00

  • Signs of thrombin generation in pediatric cardiac catheterization with unfractionated heparin bolus or subcutaneous low molecular weight heparin for antithrombotic cover.

    abstract:INTRODUCTION:Thrombosis is one of the most frequent adverse events after cardiac catheterization, which can be reduced by anticoagulation with unfractionated heparin (UFH) in both children and adults. Low molecular weight heparin (LMWH) might possibly offer advantages. Laboratory signs of thrombin generation during ped...

    journal_title:Thrombosis research

    pub_type: 临床试验,杂志文章


    authors: Roschitz B,Beitzke A,Gamillscheg A,Sudi K,Koestenberger M,Leschnik B,Muntean W

    更新日期:2003-01-01 00:00:00

  • Analysis of serum cancer procoagulant activity and its possible use as a tumor marker.

    abstract::The two objectives of the study were to determine whether a procedure could be developed for measuring cancer procoagulant (CP) activity in human serum and if this procedure provided a method for distinguishing people with cancer from those without cancer. A procedure was developed for processing human serum such that...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Gordon SG,Benson B

    更新日期:1989-11-01 00:00:00

  • Protease action and generation of beta-thromboglobulin-like protein followed by platelet activation.

    abstract::Beta-thromboglobulin (beta-TG) is a platelet-specific protein present in the alpha-granules and secreted into the surrounding medium on cell activation. The sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) of platelet releasate after inhibition of metalloproteinases with ethyleneglycol-bis-(beta-a...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Resmi KR,Krishnan LK

    更新日期:2002-05-15 00:00:00

  • Identification of four novel polymorphisms in the Aalpha and gamma fibrinogen genes and analysis of association with plasma levels of the protein.

    abstract::Four novel polymorphisms were identified in the fibrinogen gene cluster. Three of them were localized in the promoter regions of the Aalpha-chain (alpha -128 C/G, alpha -58 G/A) or the gamma-chain (gamma -239 A/G) gene, while the remaining one was identified in intron 9 of the gamma-chain gene (gamma 7792 C/T). Genoty...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Menegatti M,Asselta R,Duga S,Malcovati M,Bucciarelli P,Mannucci PM,Tenchini ML

    更新日期:2001-08-15 00:00:00

  • Point of Care Testing (POCT) to assess drug concentration in patients treated with non-vitamin K antagonist oral anticoagulants (NOACs).

    abstract:BACKGROUND:Non-vitamin K antagonist oral anticoagulants (NOACs) do not need routine laboratory monitoring but measurement of drug concentration is important in emergency conditions. Specific laboratory tests are not readily available or not implemented in every hospital. Point-of-Care Tests (POCT) may bridge this gap a...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Padayattil Jose S,Banzato A,Carraro P,Haleh A,Rossi K,Nante G,Denas G,Zoppellaro G,Pengo V

    更新日期:2018-03-01 00:00:00

  • Changes in thrombomodulin level in plasma of endotoxin-infused rabbits.

    abstract::Changes in the plasma thrombomodulin (TM) level were examined in endotoxin-infused rabbits. The plasma TM level in normal rabbits was 143.8 +/- 8.4 ng/ml (n = 67) and the molecular weight of the major TM was about 55 kd. Endotoxin (lipopolysaccharide, LPS, E. Coli B8:0127) was intravenously infused. LPS infusion incre...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Sawada K,Yamamoto H,Matsumoto K,Yago H,Suehiro S,Tahara C,Ishii H,Kazama M,Abe T

    更新日期:1992-01-15 00:00:00

  • Turnover of tPA in rabbits: influence of carbohydrate moieties.

    abstract::The turnover of tissue plasminogen activator (tPA) was studied in rabbits using a double-label technique which allowed the comparison of various tPA derivatives with a standard tPA in individual animals. Purified recombinant tPA (Alteplase) was labelled with 125I and used as a standard for each experiment. Various tPA...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Beebe DP,Aronson DL

    更新日期:1988-07-01 00:00:00

  • Platelet aggregation monitored in a 96 well microplate reader is useful for evaluation of platelet agonists and antagonists.

    abstract::Optimal conditions for a method to simultaneously measure aggregation in 96 samples using a microplate reader were developed. The temperature of the assay was set at 25 degrees C, the optimal platelet concentration range was determined to be from 1-3 x 10(8) per mL, the assay volume was determined to be best at 100 mi...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Bednar B,Condra C,Gould RJ,Connolly TM

    更新日期:1995-03-01 00:00:00

  • Human in vitro pharmacodynamic profile of the selective Factor Xa inhibitor ZK-807834 (CI-1031).

    abstract::ZK-807834 (also known as CI-1031) is a small molecule that potently and selectively inhibits Factor Xa. Studies in animals have shown that ZK-807834 attenuates thrombosis and thrombus progression after fibrinolysis and exhibits an increased antithrombotic-to-bleeding risk ratio compared with conventional agents. The p...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Post JM,Sullivan ME,Abendschein D,Ewing J,Hinchman JW,Light DR

    更新日期:2002-02-15 00:00:00

  • Differences in the inhibition of coagulation factor XIII-A from animal species revealed by Michael Acceptor- and thioimidazol based blockers.

    abstract:INTRODUCTION:The A-subunit of blood coagulation factor XIII is a pro-transglutaminase, which cross-links α- and γ-fibrin-chains in its activated form. Selective inhibitors against FXIII-A may be desirable drugs to prevent the development of thromboses. Animal models are generally used for proof of principle and for tox...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Heil A,Weber J,Büchold C,Pasternack R,Hils M

    更新日期:2013-05-01 00:00:00

  • Efficacy and safety of prolonged thromboprophylaxis with a low molecular weight heparin (dalteparin) after total hip arthroplasty--the Danish Prolonged Prophylaxis (DaPP) Study.

    abstract::The aim of this study was to compare the efficacy and safety of prolonged (35 days) thromboprophylaxis with a standard length (7 days) regimen of a low molecular weight heparin in patients undergoing total hip arthroplasty. The study was multicentre, randomised, double-blind, and prospective with two groups. Following...

    journal_title:Thrombosis research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lassen MR,Borris LC,Anderson BS,Jensen HP,Skejø Bro HP,Andersen G,Petersen AO,Siem P,Hørlyck E,Jensen BV,Thomsen PB,Hansen BR,Erin-Madsen J,Møller JC,Rotwitt L,Christensen F,Nielsen JB,Jørgensen PS,Paaske B,Tørholm

    更新日期:1998-03-15 00:00:00

  • Impact of clopidogrel resistance on thrombotic events after percutaneous coronary intervention with drug-eluting stent.

    abstract:OBJECTIVES:This study examines whether patient resistance to clopidogrel is associated with long-term thrombotic events after elective coronary drug-eluting stent (DES) implantation. METHODS:We prospectively enrolled 386 patients with stable angina who received elective percutaneous coronary intervention (PCI) with DE...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Wang ZJ,Zhou YJ,Liu YY,Yu M,Shi DM,Zhao YX,Guo YH,Cheng WJ,Jia de A,Cao Z,Nie B,Ge HL,Yang SW,Yan ZX

    更新日期:2009-05-01 00:00:00

  • Diabetes mellitus and thrombosis.

    abstract::Atherothrombosis is the leading cause of morbidity and mortality in patients with diabetes mellitus. Several mechanisms contribute to the diabetic prothrombotic state, including endothelial dysfunction, coagulative activation and platelet hyper-reactivity. In particular, diabetic platelets are characterised by dysregu...

    journal_title:Thrombosis research

    pub_type: 杂志文章,评审


    authors: Vazzana N,Ranalli P,Cuccurullo C,Davì G

    更新日期:2012-03-01 00:00:00